Ian D Pavord

Summary

Affiliation: University Hospitals of Leicester
Country: UK

Publications

  1. ncbi request reprint Evidence of a role of tumor necrosis factor alpha in refractory asthma
    Mike A Berry
    Institute for Lung Health, University Hospital of Leicester National Health Service Trust, Glenfield Hospital, Leicester, United Kingdom
    N Engl J Med 354:697-708. 2006
  2. ncbi request reprint Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial
    R Siva
    Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester, LE3 9PQ, UK
    Eur Respir J 29:906-13. 2007
  3. doi request reprint Complex airway disease: an approach to assessment and management
    Ian D Pavord
    University Hospitals of Leicester NHS Trust, Institute for Lung Health, Glenfield Hospital, Leicester, UK Electronic address
    Lancet Respir Med 1:84-90. 2013
  4. doi request reprint Safety of bronchial thermoplasty in patients with severe refractory asthma
    Ian D Pavord
    Glenfield General Hospital, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom Electronic address
    Ann Allergy Asthma Immunol 111:402-7. 2013
  5. doi request reprint Asthma phenotypes
    Ian D Pavord
    Department of Respiratory Medicine, Thoracic Surgery, and Allergy, Institute for Lung and Health, Glenfield Hospital, Leicester, United Kingdom
    Semin Respir Crit Care Med 33:645-52. 2012
  6. doi request reprint Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
    Ian D Pavord
    Institute for Lung Health, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester, UK
    Lancet 380:651-9. 2012
  7. pmc The assessment of quality of life in acute cough with the Leicester Cough Questionnaire (LCQ-acute)
    Nadia Yousaf
    King s College London, Division of Asthma, Allergy and Lung Biology, London, UK
    Cough 7:4. 2011
  8. pmc Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial
    Neil C Thomson
    Gartnavel General Hospital, University of Glasgow, Glasgow, UK
    BMC Pulm Med 11:8. 2011
  9. doi request reprint Inflammometry to assess airway diseases
    Ian D Pavord
    Department of Respiratory Medicine, Allergy and Thoracic Surgery, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester LE3 9QP, UK
    Lancet 372:1017-9. 2008
  10. ncbi request reprint Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma
    Ian D Pavord
    Glenfield General Hospital, University Hospitals of Leicester NHS Trust, Groby Road, Leicester LE3 9QP, United Kingdom
    Am J Respir Crit Care Med 176:1185-91. 2007

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Evidence of a role of tumor necrosis factor alpha in refractory asthma
    Mike A Berry
    Institute for Lung Health, University Hospital of Leicester National Health Service Trust, Glenfield Hospital, Leicester, United Kingdom
    N Engl J Med 354:697-708. 2006
    ..The development of tumor necrosis factor alpha (TNF-alpha) antagonists has made it feasible to investigate the role of this cytokine in refractory asthma...
  2. ncbi request reprint Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial
    R Siva
    Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester, LE3 9PQ, UK
    Eur Respir J 29:906-13. 2007
    ..A management strategy that aims to minimise eosinophilic airway inflammation, as well as symptoms, is associated with a reduction in severe exacerbations of chronic obstructive pulmonary disease...
  3. doi request reprint Complex airway disease: an approach to assessment and management
    Ian D Pavord
    University Hospitals of Leicester NHS Trust, Institute for Lung Health, Glenfield Hospital, Leicester, UK Electronic address
    Lancet Respir Med 1:84-90. 2013
    ..This approach will help rather than hinder identification of clinically important phenotypes of disease and will facilitate the development of new phenotype-specific treatment options. ..
  4. doi request reprint Safety of bronchial thermoplasty in patients with severe refractory asthma
    Ian D Pavord
    Glenfield General Hospital, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom Electronic address
    Ann Allergy Asthma Immunol 111:402-7. 2013
    ....
  5. doi request reprint Asthma phenotypes
    Ian D Pavord
    Department of Respiratory Medicine, Thoracic Surgery, and Allergy, Institute for Lung and Health, Glenfield Hospital, Leicester, United Kingdom
    Semin Respir Crit Care Med 33:645-52. 2012
    ..This article discusses attempts to do this in asthma and speculates on the clinical implications of this new information...
  6. doi request reprint Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
    Ian D Pavord
    Institute for Lung Health, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester, UK
    Lancet 380:651-9. 2012
    ..We aimed to establish efficacy, safety, and patient characteristics associated with the response to mepolizumab...
  7. pmc The assessment of quality of life in acute cough with the Leicester Cough Questionnaire (LCQ-acute)
    Nadia Yousaf
    King s College London, Division of Asthma, Allergy and Lung Biology, London, UK
    Cough 7:4. 2011
    ..abstract:..
  8. pmc Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial
    Neil C Thomson
    Gartnavel General Hospital, University of Glasgow, Glasgow, UK
    BMC Pulm Med 11:8. 2011
    ..Bronchial thermoplasty (BT) is a bronchoscopic procedure that improves asthma control by reducing excess airway smooth muscle. Treated patients have been followed out to 5 years to evaluate long-term safety of this procedure...
  9. doi request reprint Inflammometry to assess airway diseases
    Ian D Pavord
    Department of Respiratory Medicine, Allergy and Thoracic Surgery, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester LE3 9QP, UK
    Lancet 372:1017-9. 2008
  10. ncbi request reprint Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma
    Ian D Pavord
    Glenfield General Hospital, University Hospitals of Leicester NHS Trust, Groby Road, Leicester LE3 9QP, United Kingdom
    Am J Respir Crit Care Med 176:1185-91. 2007
    ..Bronchial thermoplasty (BT) is designed to reduce airway smooth muscle and improve asthma control...
  11. doi request reprint Airway inflammation in patients with asthma with high-fixed or low-fixed plus as-needed budesonide/formoterol
    Ian D Pavord
    Department of Respiratory Medicine, Institute for Lung Health, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom
    J Allergy Clin Immunol 123:1083-9, 1089.e1-7. 2009
    ..Its effects on eosinophilic airway inflammation and structure are unknown...
  12. doi request reprint The use of exhaled nitric oxide in the management of asthma
    Ian D Pavord
    Glenfield Hospital, Institute for Lung Health, Leicester
    J Asthma 45:523-31. 2008
    ..In this review we outline essential background information on the use of FE(NO) in clinical practice and discuss some recent work evaluating the clinical value of this technique...
  13. doi request reprint The A to E of airway disease
    I D Pavord
    Department of Respiratory Medicine, Institute for Lung Health, University Hospitals of Leicester, Leicester, UK
    Clin Exp Allergy 40:62-7. 2010
    ..We speculate that the use of this system to characterize airway disease will improve outcomes by promoting better targeting of new and existing treatments...
  14. pmc Salmeterol plus fluticasone propionate versus fluticasone propionate plus montelukast: a randomised controlled trial investigating the effects on airway inflammation in asthma
    Ian Pavord
    Glenfield Hospital, Leicester, UK
    Respir Res 8:67. 2007
    ....
  15. ncbi request reprint Will exhaled nitric oxide monitoring become routine in managing asthma?
    Ian D Pavord
    Expert Rev Respir Med 3:107-11. 2009
    ..However, the optimum use of FE(NO) in clinical practice remains to be established...
  16. ncbi request reprint Cough and asthma
    Ian D Pavord
    Department of Respiratory Medicine, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Pulm Pharmacol Ther 17:399-402. 2004
    ..Further study of this interesting asthma variant may increase our understanding of the relationship between airway inflammation and airway dysfunction...
  17. ncbi request reprint Multiple inflammatory hits and the pathogenesis of severe airway disease
    I D Pavord
    Institute for Lung Health, Dept of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, LE3 9QP, UK
    Eur Respir J 27:884-8. 2006
    ....
  18. ncbi request reprint Clinical applications of assessment of airway inflammation using induced sputum
    I D Pavord
    Institute for Lung Health, Dept of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, UK Leiden University
    Eur Respir J Suppl 37:40s-43s. 2002
  19. ncbi request reprint Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease
    Neil C Barnes
    Department of Respiratory Medicine, London Chest Hospital, London, UK
    Am J Respir Crit Care Med 173:736-43. 2006
    ..No currently available treatment is reported to reduce the exaggerated airway wall inflammation of chronic obstructive pulmonary disease...
  20. pmc Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma
    Mike Berry
    Institute for Lung Health, Glenfield Hospital, Leicester LE3 9QP, UK
    Thorax 62:1043-9. 2007
    ..However, little is known about the underlying airway immunopathology and there are no data from placebo-controlled studies examining the effect of inhaled corticosteroids...
  21. doi request reprint Increased sputum and bronchial biopsy IL-13 expression in severe asthma
    Shironjit K Saha
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 121:685-91. 2008
    ..The importance of IL-13 in the asthma paradigm is supported by increased expression in human subjects, particularly in patients with mild-to-moderate asthma. However, the role of IL-13 in severe asthma needs to be further defined...
  22. doi request reprint Mepolizumab and exacerbations of refractory eosinophilic asthma
    Pranabashis Haldar
    Institute for Lung Health, Glenfield Hospital, University Hospitals of Leicester National Health Service Trust, Leicester, United Kingdom
    N Engl J Med 360:973-84. 2009
    ..Preventing exacerbations remains an important goal of therapy. There is evidence that eosinophilic inflammation of the airway is associated with the risk of exacerbations...
  23. pmc Qualitative analysis of high-resolution CT scans in severe asthma
    Sumit Gupta
    Institute for Lung Health, University of Leicester, Leicester, UK
    Chest 136:1521-8. 2009
    ..We sought to describe the HRCT scan abnormalities of a large severe asthma cohort and to determine the utility of clinical features to direct the use of HRCT scanning in this group of patients...
  24. pmc Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function
    Maria Soler Artigas
    Department of Health Sciences, University of Leicester, Leicester, UK
    Am J Respir Crit Care Med 184:786-95. 2011
    ....
  25. pmc The role of CT scanning in multidimensional phenotyping of COPD
    Mona Bafadhel
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, England
    Chest 140:634-42. 2011
    ..CT imaging is emerging as an important, noninvasive tool in phenotyping COPD. However, the use of CT imaging in defining the disease heterogeneity above lung function is not fully known...
  26. pmc Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes
    Sumit Gupta
    Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Leicester LE3 9QP, UK
    Thorax 65:775-81. 2010
    ..The aim of this study was to assess whether airway remodelling is restricted to specific subphenotypes of severe asthma...
  27. ncbi request reprint The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial
    Dominick E Shaw
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, United Kingdom
    Am J Respir Crit Care Med 176:231-7. 2007
    ..Current asthma guidelines recommend adjusting antiinflammatory treatment on the basis of the results of lung function tests and symptom assessment, neither of which are closely associated with airway inflammation...
  28. pmc IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma
    Abbie Fairs
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Glenfield Hospital, UK
    Am J Respir Crit Care Med 182:1362-8. 2010
    ..The importance of Aspergillus fumigatus sensitization and colonization of the airways in patients with asthma is unclear. Objectives: To define the relationship between the clinical and laboratory features of A. fumigatus-associated asthma...
  29. ncbi request reprint Association between neutrophilic airway inflammation and airflow limitation in adults with asthma
    Dominick E Shaw
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester LE3 9QP, UK
    Chest 132:1871-5. 2007
    ..Chronic inflammation is assumed to be important, although there is limited and contradictory information about the relationship between airway inflammation and postbronchodilator FEV1...
  30. ncbi request reprint Induced sputum inflammatory mediator concentrations in chronic cough
    Surinder S Birring
    Department of Respiratory Medicine, Institute for Lung Health, Glenfield Hospital, Leicester, United Kingdom
    Am J Respir Crit Care Med 169:15-9. 2004
    ..Our findings support the view that there is release of inflammatory and tussive mediators in patients with chronic cough and suggest that there might be similarities in the mechanism of cough in a diverse range of conditions...
  31. pmc Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation
    Neil Martin
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, United Kingdom
    PLoS ONE 7:e43545. 2012
    ..The aim of this study was to examine the regulation of HLMC degranulation by primary AEC from healthy and asthmatic subjects, and investigate further the inhibitory mechanism...
  32. ncbi request reprint Chemokine concentrations and mast cell chemotactic activity in BAL fluid in patients with eosinophilic bronchitis and asthma, and in normal control subjects
    Lucy Woodman
    Insitute for Lung Health, University of Leicester, Glenfield Hospital, UK
    Chest 130:371-8. 2006
    ..The mast cell chemotactic activity of airway secretions has not been assessed in patients with eosinophilic bronchitis...
  33. ncbi request reprint TH2 cytokine expression in bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis
    Christopher E Brightling
    Division of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 110:899-905. 2002
    ..Eosinophilic bronchitis has similar immunopathology to asthma but without disordered airway physiology. Whether eosinophilic bronchitis is associated with increased expression of T(H)2 cytokines is unknown...
  34. doi request reprint Cluster analysis and clinical asthma phenotypes
    Pranab Haldar
    Institute for Lung Health, Glenfield Hospital, Leicester LE39QP, UK
    Am J Respir Crit Care Med 178:218-24. 2008
    ..Heterogeneity in asthma expression is multidimensional, including variability in clinical, physiologic, and pathologic parameters. Classification requires consideration of these disparate domains in a unified model...
  35. doi request reprint Long-term low-dose erythromycin in patients with unexplained chronic cough: a double-blind placebo controlled trial
    Nadia Yousaf
    Institute for Lung Health, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Groby Road, Leicester LE3 9QP, UK
    Thorax 65:1107-10. 2010
    ..This study tested the hypothesis that long-term low-dose erythromycin reduces the induced sputum neutrophil count and 24 h cough frequency in patients with unexplained chronic cough...
  36. ncbi request reprint Eosinophilic bronchitis: clinical features, management and pathogenesis
    Surinder S Birring
    Department of Respiratory Medicine, Institute for Lung Health, Glenfield Hospital, Leicester, UK
    Am J Respir Med 2:169-73. 2003
    ..Further study of this interesting condition will increase our understanding of airway inflammation and airway responsiveness, leading to novel targets for therapeutics for both eosinophilic bronchitis and asthma...
  37. ncbi request reprint Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    Ruth H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, LE3 9PQ, Leicester, UK
    Lancet 360:1715-21. 2002
    ..We aimed to assess whether a management strategy that minimises eosinophilic inflammation reduces asthma exacerbations compared with a standard management strategy...
  38. ncbi request reprint Clinical, radiologic, and induced sputum features of chronic obstructive pulmonary disease in nonsmokers: a descriptive study
    Surinder S Birring
    Department of Respiratory Medicine, Radiology, and Respiratory Physiology, and Leicester Children s Asthma Centre, Institute for Lung Health, Glenfield Hospital, Leicester, United Kingdom
    Am J Respir Crit Care Med 166:1078-83. 2002
    ..Further investigation of this group may disclose novel mechanisms of fixed airflow obstruction...
  39. doi request reprint Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers
    Mona Bafadhel
    Institute for Lung Health, University of Leicester, Leicester, United Kingdom
    Am J Respir Crit Care Med 184:662-71. 2011
    ..Exacerbations of chronic obstructive pulmonary disease (COPD) are heterogeneous with respect to inflammation and etiology...
  40. pmc Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial
    Mona Bafadhel
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Leicester, UK
    Am J Respir Crit Care Med 186:48-55. 2012
    ..Exacerbations of chronic obstructive pulmonary disease (COPD) and responses to treatment are heterogeneous...
  41. ncbi request reprint Cough and glottic-stop reflex sensitivity in health and disease
    Benjamin Prudon
    MB ChB, Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, LE3 9QP UK
    Chest 127:550-7. 2005
    ..We set out to define the normal range of cough reflex sensitivity and its repeatability in health and disease, and to assess its relationship to the glottic-stop reflex...
  42. pmc Sputum eosinophilia and the short term response to inhaled mometasone in chronic obstructive pulmonary disease
    C E Brightling
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Groby Road, Leicester LE3 9QP, UK
    Thorax 60:193-8. 2005
    ..Whether the response to inhaled corticosteroids is related to the presence of eosinophilic inflammation is unclear...
  43. ncbi request reprint A comparison of the validity of different diagnostic tests in adults with asthma
    Cameron J Hunter
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, UK
    Chest 121:1051-7. 2002
    ..We set out to compare the sensitivity and specificity of different tests in this setting...
  44. doi request reprint The long term outcome of patients with unexplained chronic cough
    Nadia Yousaf
    Institute for Lung Health, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Groby Road, Leicester LE3 9QP, United Kingdom
    Respir Med 107:408-12. 2013
    ..Up to 40% of patients seen in a cough clinic have unexplained chronic cough. The long term outcome of these patients is uncertain...
  45. doi request reprint Airway dysfunction and inflammation in pool- and non-pool-based elite athletes
    Neil Martin
    Institute for Lung Health, Department for Respiratory Medicine, Glenfield Hospital, University Hospitals Leicester NHS Trust, Leicester, England, United Kingdom
    Med Sci Sports Exerc 44:1433-9. 2012
    ..This study sought to determine and compare the levels of airway dysfunction and inflammation in a large cohort of symptomatic international athletes from pool- and non-pool-based sporting backgrounds. In total, 118 athletes were recruited...
  46. ncbi request reprint Mast-cell infiltration of airway smooth muscle in asthma
    Christopher E Brightling
    Division of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, United Kingdom
    N Engl J Med 346:1699-705. 2002
    ..We tested the hypothesis that there were differences between the two conditions in the microlocalization of mast cells within the airway smooth muscle...
  47. ncbi request reprint IL-4-expressing bronchoalveolar T cells from asthmatic and healthy subjects preferentially express CCR 3 and CCR 4
    Angela J Morgan
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, Leicester University, Leicester, UK
    J Allergy Clin Immunol 116:594-600. 2005
    ....
  48. ncbi request reprint Biomarkers predicting response to corticosteroid therapy in asthma
    Christopher E Brightling
    Institute for Lung Health, University of Leicester and University Hospitals of Leicester, Leicester, UK
    Treat Respir Med 4:309-16. 2005
    ....
  49. ncbi request reprint Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis
    Mike A Berry
    Institute for Lung Health, University Hospitals of Leicester, Groby Road, Leicester LE3 9QP, UK
    J Allergy Clin Immunol 114:1106-9. 2004
    ..In asthma, the T H 2-type cytokine IL-13 has been implicated in the development of airway inflammation and hyperresponsiveness. Whether the expression of IL-13 is different between these 2 conditions is unknown...
  50. ncbi request reprint Cough frequency, cough sensitivity and health status in patients with chronic cough
    Surinder S Birring
    Department of Respiratory Medicine, Institute for Lung Health, Glenfield Hospital, Leicester, LE3 9QP, UK
    Respir Med 100:1105-9. 2006
    ..Little is known about the frequency of cough in health and in patients with chronic cough...
  51. ncbi request reprint The influence of age on induced sputum differential cell counts in normal subjects
    Rebecca A Thomas
    Department of Respiratory Medicine, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Chest 126:1811-4. 2004
    ..This study was undertaken to assess whether there are age-related differences in sputum cell differential cell counts in a population of normal, healthy volunteers...
  52. ncbi request reprint Observational study of the natural history of eosinophilic bronchitis
    M A Berry
    Institute of Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Clin Exp Allergy 35:598-601. 2005
    ..Eosinophilic bronchitis is an important cause of chronic cough. Treatment with inhaled corticosteroids is associated with a short-term improvement in cough and reduced sputum eosinophil count but the long-term outcome is uncertain...
  53. pmc Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
    R H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9PQ, UK
    Thorax 57:875-9. 2002
    ....
  54. ncbi request reprint Noneosinophilic asthma: a distinct clinical and pathologic phenotype
    Pranab Haldar
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    J Allergy Clin Immunol 119:1043-52; quiz 1053-4. 2007
    ..We particularly highlight evidence that noneosinophilic asthma is associated with a reduced short-term and long-term response to corticosteroid therapy...
  55. ncbi request reprint Idiopathic chronic cough and organ-specific autoimmune diseases: a case-control study
    Surinder S Birring
    Department of Respiratory Medicine, Institute for Lung Health, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Respir Med 98:242-6. 2004
    ..001). Organ-specific autoantibodies were present in a significantly higher proportion of cases than controls (40% vs. 13%; P = 0.047). These findings suggest a relationship between idiopathic chronic cough and organ-specific autoimmunity...
  56. ncbi request reprint Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma
    M Berry
    Dept of Respiratory Medicine and Thoracic Surgery, Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Eur Respir J 25:986-91. 2005
    ..In conclusion, these findings support the hypothesis that alveolar nitric oxide is a measure of distal airway inflammation and suggest that distal lung inflammation is present in refractory asthma...
  57. doi request reprint Peptic ulceration, Helicobacter pylori seropositivity and chronic obstructive pulmonary disease
    Roshan Siva
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, UK
    Respirology 18:728-31. 2013
    ..We tested the hypothesis that peptic ulceration and H. Pylori seropositivity are associated with COPD independently of other shared risk factors...
  58. pmc Body mass and fat mass in refractory asthma: an observational 1 year follow-up study
    Mona Bafadhel
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Groby Road, Leicester LE3 9QP, UK
    J Allergy (Cairo) 2010:251758. 2010
    ..Conclusion. Increased fat mass is common in refractory asthma and is associated with asthma symptom control in men. Loss of weight is associated with improvement in lung function in refractory asthma...
  59. pmc Genome-wide association study identifies five loci associated with lung function
    Emmanouela Repapi
    Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK
    Nat Genet 42:36-44. 2010
    ..These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease...
  60. ncbi request reprint Detection of cough signals in continuous audio recordings using hidden Markov models
    Sergio Matos
    Department of Medical Physics, University Hospitals of Leicester, UK
    IEEE Trans Biomed Eng 53:1078-83. 2006
    ..A postprocessing stage to perform a more detailed analysis on the detected events is under development, and could allow the rejection of some of the incorrectly detected events...
  61. ncbi request reprint Recent insights into the relationship between airway inflammation and asthma
    R Siva
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, LE3 9QP, UK
    Monaldi Arch Chest Dis 59:296-9. 2003
    ....
  62. ncbi request reprint Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma
    C E Brightling
    Glenfield Hospital, Leicester, United Kingdom and Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Respir Crit Care Med 162:878-82. 2000
    ..64 ng/ml [0.36 to 0.90] and 11-fold [3.3 to 36]), respectively. In conclusion, eosinophilic bronchitis is associated with active airway inflammation with increased release of vasoactive and bronchoconstrictor mediators...
  63. ncbi request reprint Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial
    C E Brightling
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Lancet 356:1480-5. 2000
    ..Whether these patients have different airway pathology from other COPD patients is unclear. We tested the hypothesis that response to prednisolone is related to the presence of eosinophilic airway inflammation...
  64. ncbi request reprint Sputum eosinophilia in idiopathic pulmonary fibrosis
    S S Birring
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, LE3 9QP, United Kingdom
    Inflamm Res 54:51-6. 2005
    ..We tested the hypothesis that the cough and increased cough reflex sensitivity seen in patients with idiopathic pulmonary fibrosis may be due to airway inflammation in a prospective, cross-sectional study...
  65. doi request reprint Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial
    Roshan Siva
    Department of Respiratory Medicine, Croydon University Hospital, Croydon Health Services NHS Trust, London, UK
    Int J Chron Obstruct Pulmon Dis 9:179-86. 2014
    ..Airway inflammation persists after smoking cessation in established chronic obstructive pulmonary disease (COPD), suggesting that other factors drive the airway inflammatory response...
  66. doi request reprint Management of chronic cough
    Ian D Pavord
    Institute for Lung Health, Department of Respiratory Medicine, Allergy and Thoracic Surgery, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK
    Lancet 371:1375-84. 2008
    ..We call for more research into the basic mechanisms and pharmacological control of an abnormally heightened cough reflex, and recommend ways to assess the effects of potentially antitussive treatments...
  67. ncbi request reprint Bronchial thermoplasty for the treatment of asthma
    Neil Martin
    Department of Respiratory Medicine, Allergy and Thoracic Surgery, Institute for Lung Health, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom
    Curr Allergy Asthma Rep 9:88-95. 2009
    ..In this article, we review the early animal and human development of the technique, summarize the randomized trials carried out in patients to date, discuss proposed mechanisms of action, and suggest directions for future work...
  68. doi request reprint Improvement in health status following bronchopulmonary hygiene physical therapy in patients with bronchiectasis
    Kugathasan Mutalithas
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Respir Med 102:1140-4. 2008
    ..001). Our findings suggest that bronchopulmonary hygiene physical therapy can lead to a significant improvement in cough-related quality of life...
  69. ncbi request reprint The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma
    M A Berry
    Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Clin Exp Allergy 35:1175-9. 2005
    ..Nitric oxide (NO) has potential advantages as a tool to monitor airway inflammation although little is known about the relationship between NO and eosinophilic airway inflammation and the factors which influence it...
  70. doi request reprint Prevalence of inflammatory bowel disease in patients with airways disease
    A A Raj
    Department of Respiratory Medicine, Institute for Lung Health, Glenfield Hospital, Leicester, LE3 9PQ, UK
    Respir Med 102:780-5. 2008
    ..Furthermore, no consistent radiological, pulmonary or pathological abnormalities have been demonstrated in patients with both conditions...
  71. ncbi request reprint Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness
    R H Green
    Institute for Lung Health, Dept of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9PQ, UK
    Eur Respir J 27:1144-51. 2006
    ..In conclusion, treatment given in addition to low-dose inhaled corticosteroids results in modest benefits. Formoterol and high-dose budesonide have contrasting effects on eosinophilic airway inflammation...
  72. pmc Management of asthma in adults: current therapy and future directions
    R H Green
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, UK
    Postgrad Med J 79:259-67. 2003
    ....
  73. pmc A case of cough, lymphocytic bronchoalveolitis and coeliac disease with improvement following a gluten free diet
    C E Brightling
    Institute for Lung Health, Department of Respiratory Medicine and Thoracic Surgery, University Hospitals of Leicester, Leicester LE3 9QP, UK
    Thorax 57:91-2. 2002
    ..All features improved markedly on a gluten free diet, suggesting a causal relationship between coeliac disease, cough, and lymphocytic bronchoalveolitis...
  74. ncbi request reprint Induced sputum eicosanoid concentrations in asthma
    I D Pavord
    Department of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Leicester, United Kingdom
    Am J Respir Crit Care Med 160:1905-9. 1999
    ..The inverse relationship between eosinophilic airway inflammation and sputum PGE(2) concentration would be consistent, with the latter having an anti-inflammatory role...
  75. pmc Sputum IL-5 concentration is associated with a sputum eosinophilia and attenuated by corticosteroid therapy in COPD
    M Bafadhel
    Institute for Lung Health, Leicester, UK
    Respiration 78:256-62. 2009
    ..Whether these inflammatory phenotypes have differential cytokine and chemokine expression is unknown...
  76. pmc Idiopathic chronic cough: association with organ specific autoimmune disease and bronchoalveolar lymphocytosis
    S S Birring
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Thorax 58:1066-70. 2003
    ..An immunopathological study was undertaken to test the hypothesis that idiopathic chronic cough is associated with lymphocytic airway inflammation...
  77. ncbi request reprint Eosinophilic bronchitis: an important cause of prolonged cough
    C E Brightling
    Department of Respiratory Medicine and Thoracic Surgery, Institute of Lung Health, Leicester, UK
    Ann Med 32:446-51. 2000
    ..Further study of this interesting condition may shed light on the relationship between airway inflammation and airway responsiveness, leading to a greater understanding of both eosinophilic bronchitis and asthma...
  78. doi request reprint Rationale and clinical results of inhibiting interleukin-5 for the treatment of severe asthma
    Rachid Berair
    Department of Respiratory Medicine, Thoracic Surgery, and Allergy, Institute for Lung and Health, Glenfield Hospital, Leicester, LE3 9QP, UK
    Curr Allergy Asthma Rep 13:469-76. 2013
    ..We will review these developments and describe the clinical experience so far with treatment with monoclonal antibiotics against IL-5. ..
  79. ncbi request reprint Cough and asthma
    M A Berry
    Department of Respiratory Medicine, Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester, UK
    Clin Exp Allergy 33:1481-3. 2003
  80. ncbi request reprint Interleukin-4 and -13 expression is co-localized to mast cells within the airway smooth muscle in asthma
    C E Brightling
    Institute for Lung Health, Leicester Warwick Medical School and University Hospitals of Leicester, Leicester, UK
    Clin Exp Allergy 33:1711-6. 2003
    ..In asthma, Th2 cytokines have been implicated as playing a critical role in the development of airway inflammation and hyper-responsiveness. Whether inflammatory cells within the airway smooth muscle release these cytokines is unknown...
  81. ncbi request reprint Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis
    E Gamble
    Department of Respiratory Medicine, London Chest Hospital, Bonner Road, London, UK
    Eur Respir J 30:467-71. 2007
    ..It is concluded that, in established chronic obstructive pulmonary disease, the bronchial mucosal inflammatory cell infiltrate is similar in ex-smokers and those that continue to smoke...
  82. ncbi request reprint Chronic tonsillar enlargement and cough: preliminary evidence of a novel and treatable cause of chronic cough
    S S Birring
    Institute for Lung Health, Dept of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Eur Respir J 23:199-201. 2004
    ..These preliminary findings suggest for the first time a possible role for tonsillectomy in patients with enlarged tonsils in whom other causes of cough have been ruled out...
  83. pmc CRTH2 expression on T cells in asthma
    K Mutalithas
    Institute for Lung Health, Department of Infection Immunity and Inflammation, University Hospitals of Leicester, Leicester, UK
    Clin Exp Immunol 161:34-40. 2010
    ..However, given their small numbers they are unlikely to have a significant involvement in the pathogenesis of asthma. CRTH2 antagonism may not diminish T cell accumulation in the asthmatic lung...
  84. doi request reprint Induced sputum and bronchial mucosal expression of interleukin-13 is not increased in chronic obstructive pulmonary disease
    S Saha
    Institute of Lung Health, Leicester, UK
    Allergy 63:1239-43. 2008
    ..We sought to examine IL-13 expression in COPD subjects in induced sputum and bronchus specimens. We hypothesized that inflammatory cells expressing IL-13 localize to the airway smooth muscle bundle and bronchial glands...
  85. pmc Airway function and markers of airway inflammation in patients with treated hypothyroidism
    S S Birring
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester LE3 9QP, UK
    Thorax 60:249-53. 2005
    ..A study was undertaken to determine whether patients with autoimmune thyroid disease have objective evidence of airway inflammation and dysfunction...
  86. ncbi request reprint Multi-dimensional phenotyping: towards a new taxonomy for airway disease
    A J Wardlaw
    Department of Respiratory Medicine, Department of Infection Immunity and Inflammation and Institute for Lung Health, Leicester, UK
    Clin Exp Allergy 35:1254-62. 2005
    ....
  87. ncbi request reprint New insights into the relationship between airway inflammation and asthma
    A J Wardlaw
    Department of Respiratory Medicine, Institute for Lung Health, Leicester Warwick Medical School, Glenfield Hospital, Groby Road, Leicester LE3 9QP, U K
    Clin Sci (Lond) 103:201-11. 2002
    ....
  88. pmc Respiratory symptoms in patients with treated hypothyroidism and inflammatory bowel disease
    S S Birring
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester LE3 9QP, UK
    Thorax 58:533-6. 2003
    ..Whether patients with hypothyroidism have an increased prevalence of respiratory symptoms is unknown...
  89. pmc Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ)
    S S Birring
    Institute for Lung Health, Department of Respiratory Medicine, Glenfield Hospital, Leicester, UK
    Thorax 58:339-43. 2003
    ..The development and validation of the Leicester Cough Questionnaire (LCQ), a self-completed health related quality of life measure of chronic cough, is presented...
  90. ncbi request reprint Expression of CXCR6 and its ligand CXCL16 in the lung in health and disease
    A J Morgan
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, Leicester University, Glenfield Hospital, Leicester, UK
    Clin Exp Allergy 35:1572-80. 2005
    ..Chemokine receptors (CR) play an important role in T cell migration, but their contribution to lung trafficking is unclear...
  91. ncbi request reprint New insights into the role of the mast cell in asthma
    C E Brightling
    University of Leicester and Warwick Medical School, Leicester, UK
    Clin Exp Allergy 33:550-6. 2003
  92. pmc Expression of CCR8 is increased in asthma
    K Mutalithas
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK
    Clin Exp Allergy 40:1175-85. 2010
    ..Chemokines and their receptors could play key roles in the recruitment of T cells to the asthmatic lung. CCR8 is preferentially expressed on T-helper type 2 cells, and is thought to play a role in the pathogenesis of human asthma...
  93. ncbi request reprint Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease
    Elizabeth Gamble
    Department of Pulmonology, Leiden University Medical Centre, Leiden, The Netherlands
    Am J Respir Crit Care Med 168:976-82. 2003
    ..Phosphodiesterase-4 inhibitors represent a promising new class of substances for use in antiinflammatory treatment of this disease...
  94. ncbi request reprint Monitoring of exhaled nitric oxide in primary care
    Ian D Pavord
    Prim Care Respir J 16:331-4. 2007
  95. ncbi request reprint Asthma control during the year after bronchial thermoplasty
    Gerard Cox
    St Joseph s Healthcare, McMaster University, Hamilton, ON, Canada
    N Engl J Med 356:1327-37. 2007
    ..Bronchial thermoplasty is a bronchoscopic procedure to reduce the mass of airway smooth muscle and attenuate bronchoconstriction. We examined the effect of bronchial thermoplasty on the control of moderate or severe persistent asthma...
  96. ncbi request reprint Eosinophils in asthma and airway hyperresponsiveness
    Christopher E Brightling
    Am J Respir Crit Care Med 169:131-2; author reply 132-3. 2004
  97. ncbi request reprint COPD and hepatitis C
    Ian D Pavord
    Chest 124:2035-6; author reply 2036. 2003
  98. ncbi request reprint Idiopathic chronic cough and organ-specific autoimmune disease
    Surinder S Birring
    Chest 129:213; author reply 213-4. 2006
  99. doi request reprint Antagonism of tumour necrosis factor alpha in refractory asthma
    Mike A Berry
    Thorax 63:571-2. 2008
  100. ncbi request reprint An automated system for 24-h monitoring of cough frequency: the leicester cough monitor
    Sergio Matos
    Department of Medical Physics, University Hospitals of Leicester, Leicester LE 5WW, U K
    IEEE Trans Biomed Eng 54:1472-9. 2007
    ..The result of the analysis of a recording session is presented as a concise, graphical-based report. The modular nature of the system interface facilitates its enhancement with the integration of further modules...
  101. doi request reprint Prevalence, pathogenesis, and causes of chronic cough
    Kian Fan Chung
    Experimental Studies, Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Lancet 371:1364-74. 2008
    ..Effective control of cough requires not only controlling the disease causing the cough but also desensitisation of cough pathways...