Dominic C Paviour
Affiliation: University College London
- Can the frontal assessment battery (FAB) differentiate bradykinetic rigid syndromes? Relation of the FAB to formal neuropsychological testingD C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology, London, UK
Neurocase 11:274-82. 2005..These results suggest that the FAB is a valid and easily applicable bedside test to discriminate executive dysfunction in these three frequently confused bradykinetic rigid syndromes...
- Longitudinal MRI in progressive supranuclear palsy and multiple system atrophy: rates and regions of atrophyDominic C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology, UCL, London UK
Brain 129:1040-9. 2006..Clinico-radiological associations suggest these regional atrophy rates have potential as markers of disease progression in trials of novel therapies...
- Regional brain volumes distinguish PSP, MSA-P, and PD: MRI-based clinico-radiological correlationsDominic C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology UCL, London United Kingdom
Mov Disord 21:989-96. 2006..These distinct patterns of cortical and subcortical atrophy, when considered together rather than independently, better differentiate PSP and MSA-P from each other and also from healthy controls...
- Holmes tremor: Application of modern neuroimaging techniquesDominic C Paviour
The Sara Koe PSP Research Centre, The Institute of Neurology, UCL, London, United Kingdom
Mov Disord 21:2260-2. 2006..Modern neuroimaging techniques in this case confirm that a combination of damage to the cerebello-rubrothalamic pathway and the nigrostriatal pathway is required for the full Holmes tremor syndrome to occur...
- Quantitative MRI measurement of superior cerebellar peduncle in progressive supranuclear palsyD C Paviour
Dementia Research Centre UCL, Institute of Neurology UCL, London, UK
Neurology 64:675-9. 2005..It is not clear whether MRI-based measurements can differentiate this relative atrophy of the SCP during life...
- Pathological substrate for regional distribution of increased atrophy rates in progressive supranuclear palsyD C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology UCL, London, UK
J Neurol Neurosurg Psychiatry 75:1772-5. 2004..MRI features described previously in PSP correspond to regions of pathological involvement demonstrated in separate studies, but serial MRI with pathological follow up has not been undertaken...
- Diffusion-weighted magnetic resonance imaging differentiates Parkinsonian variant of multiple-system atrophy from progressive supranuclear palsyDominic C Paviour
Sara Koe PSP Research Centre, Institute of Neurology, University College London, London, United Kingdom
Mov Disord 22:68-74. 2007..Increased rADCs in the pons and MCP were associated with smaller pontine and cerebellar volumes in MSA-P. rADCs distinguish MSA-P from PSP. These have a clinical correlate and are associated with reduced brainstem and cerebellar volumes...
- MRI derived brain atrophy in PSP and MSA-P. Determining sample size to detect treatment effectsDominic C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology, 1 Wakefield Street, London WC1N, UK
J Neurol 254:478-81. 2007..Regional rather than whole brain atrophy rates calculated from volumetric serial MRI brain scans in PSP and MSA-P provide a more practical and powerful means of monitoring disease progression in clinical trials...
- Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophyLuke A Massey
Sara Koe PSP Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, University College London, London, United Kingdom Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, University College London, London, United Kingdom
Mov Disord 27:1754-62. 2012..However, the low sensitivity of these and macroscopic findings at autopsy suggest a need for imaging techniques sensitive to microstructural abnormalities without regional atrophy. © 2012 Movement Disorder Society...
- Does corticobasal degeneration exist? A clinicopathological re-evaluationHelen Ling
Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
Brain 133:2045-57. 2010..Despite these diagnostic difficulties we conclude that corticobasal degeneration is a discrete clinicopathological entity but with a broader clinical spectrum than was originally proposed...
- Delineating the sites and progression of in vivo atrophy in multiple system atrophy using fluid-registered MRIJonathan M Schott
Dementia Research Group, Institute of Neurology, London, United Kingdom
Mov Disord 18:955-8. 2003..The in vivo findings were consistent with those found at postmortem, including significant supratentorial atrophy concurrent with an unusual degree of cognitive impairment for MSA...
- Neuronal intranuclear inclusion disease: report on a case originally diagnosed as dopa-responsive dystonia with Lewy bodiesDominic C Paviour
The Sara Koe Progressive Supranuclear Palsy Research Centre, Institute of Neurology, University College London, London, United Kingdom
Mov Disord 20:1345-9. 2005..This rare condition, which may be diagnosed in life with a full thickness rectal biopsy, needs to be considered in the differential diagnosis of any case presenting as progressive juvenile parkinsonism (JP) or dystonia...
- Diagnostic considerations in juvenile parkinsonismDominic C Paviour
National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
Mov Disord 19:123-35. 2004..Lewy body pathology has only been reported in one case, suggesting that a juvenile form of idiopathic Parkinson's disease may be extremely rare...
- Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonismDavid R Williams
The Queen Square Brain Bank for Neurological Disorders, University College London, UK
Brain 128:1247-58. 2005..The different tau isoform deposition in the basal pons suggests that this may ultimately prove to be a discrete nosological entity...
- Is sphincter electromyography a helpful investigation in the diagnosis of multiple system atrophy? A retrospective study with pathological diagnosisDominic C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology, London, United Kingdom
Mov Disord 20:1425-30. 2005..A normal spEMG is unlikely in pathologically proven MSA, at least in cases with a mean symptom duration of more than 5 years when the test is performed...
- Frontotemporal lobar degeneration with ubiquitin-only-immunoreactive neuronal changes: broadening the clinical picture to include progressive supranuclear palsyD C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology, London, UK
Brain 127:2441-51. 2004..FTLD-U or FTLD-MND should be considered in the differential diagnosis of progressive frontal dementia with an akinetic rigid syndrome and supranuclear gaze palsy or Steele-Richardson-Olszewski disease...
- Rapidly progressive behavioral changes and parkinsonism in a 68-year-old manGalit Kleiner-Fisman
Department of Medicine, Division of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
Mov Disord 19:534-43. 2004