Dominic C Paviour
Affiliation: University College London
- Can the frontal assessment battery (FAB) differentiate bradykinetic rigid syndromes? Relation of the FAB to formal neuropsychological testingD C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology, London, UK
Neurocase 11:274-82. 2005..These results suggest that the FAB is a valid and easily applicable bedside test to discriminate executive dysfunction in these three frequently confused bradykinetic rigid syndromes...
- MRI derived brain atrophy in PSP and MSA-P. Determining sample size to detect treatment effectsDominic C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology, 1 Wakefield Street, London WC1N, UK
J Neurol 254:478-81. 2007..Regional rather than whole brain atrophy rates calculated from volumetric serial MRI brain scans in PSP and MSA-P provide a more practical and powerful means of monitoring disease progression in clinical trials...
- Diffusion-weighted magnetic resonance imaging differentiates Parkinsonian variant of multiple-system atrophy from progressive supranuclear palsyDominic C Paviour
Sara Koe PSP Research Centre, Institute of Neurology, University College London, London, United Kingdom
Mov Disord 22:68-74. 2007..Increased rADCs in the pons and MCP were associated with smaller pontine and cerebellar volumes in MSA-P. rADCs distinguish MSA-P from PSP. These have a clinical correlate and are associated with reduced brainstem and cerebellar volumes...
- Holmes tremor: Application of modern neuroimaging techniquesDominic C Paviour
The Sara Koe PSP Research Centre, The Institute of Neurology, UCL, London, United Kingdom
Mov Disord 21:2260-2. 2006..Modern neuroimaging techniques in this case confirm that a combination of damage to the cerebello-rubrothalamic pathway and the nigrostriatal pathway is required for the full Holmes tremor syndrome to occur...
- Pathological substrate for regional distribution of increased atrophy rates in progressive supranuclear palsyD C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology UCL, London, UK
J Neurol Neurosurg Psychiatry 75:1772-5. 2004..MRI features described previously in PSP correspond to regions of pathological involvement demonstrated in separate studies, but serial MRI with pathological follow up has not been undertaken...
- Quantitative MRI measurement of superior cerebellar peduncle in progressive supranuclear palsyD C Paviour
Dementia Research Centre UCL, Institute of Neurology UCL, London, UK
Neurology 64:675-9. 2005..It is not clear whether MRI-based measurements can differentiate this relative atrophy of the SCP during life...
- Regional brain volumes distinguish PSP, MSA-P, and PD: MRI-based clinico-radiological correlationsDominic C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology UCL, London United Kingdom
Mov Disord 21:989-96. 2006..These distinct patterns of cortical and subcortical atrophy, when considered together rather than independently, better differentiate PSP and MSA-P from each other and also from healthy controls...
- Longitudinal MRI in progressive supranuclear palsy and multiple system atrophy: rates and regions of atrophyDominic C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology, UCL, London UK
Brain 129:1040-9. 2006..Clinico-radiological associations suggest these regional atrophy rates have potential as markers of disease progression in trials of novel therapies...
- The midbrain to pons ratio: a simple and specific MRI sign of progressive supranuclear palsyLuke A Massey
Sara Koe PSP Research Centre, Rita Lila Weston Institute for Neurology Studies and Queen Square Brain Bank, Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK
Neurology 80:1856-61. 2013..We aimed to develop in histologically proven disease a simple measure of the midbrain and pons on sagittal MRI to identify PSP...
- Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophyLuke A Massey
Sara Koe PSP Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom
Mov Disord 27:1754-62. 2012..However, the low sensitivity of these and macroscopic findings at autopsy suggest a need for imaging techniques sensitive to microstructural abnormalities without regional atrophy...
- Does corticobasal degeneration exist? A clinicopathological re-evaluationHelen Ling
Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
Brain 133:2045-57. 2010..Despite these diagnostic difficulties we conclude that corticobasal degeneration is a discrete clinicopathological entity but with a broader clinical spectrum than was originally proposed...
- Neuronal intranuclear inclusion disease: report on a case originally diagnosed as dopa-responsive dystonia with Lewy bodiesDominic C Paviour
The Sara Koe Progressive Supranuclear Palsy Research Centre, Institute of Neurology, University College London, London, United Kingdom
Mov Disord 20:1345-9. 2005..This rare condition, which may be diagnosed in life with a full thickness rectal biopsy, needs to be considered in the differential diagnosis of any case presenting as progressive juvenile parkinsonism (JP) or dystonia...
- Delineating the sites and progression of in vivo atrophy in multiple system atrophy using fluid-registered MRIJonathan M Schott
Dementia Research Group, Institute of Neurology, London, United Kingdom
Mov Disord 18:955-8. 2003..The in vivo findings were consistent with those found at postmortem, including significant supratentorial atrophy concurrent with an unusual degree of cognitive impairment for MSA...
- Diagnostic considerations in juvenile parkinsonismDominic C Paviour
National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
Mov Disord 19:123-35. 2004..Lewy body pathology has only been reported in one case, suggesting that a juvenile form of idiopathic Parkinson's disease may be extremely rare...
- Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonismDavid R Williams
The Queen Square Brain Bank for Neurological Disorders, University College London, UK
Brain 128:1247-58. 2005..The different tau isoform deposition in the basal pons suggests that this may ultimately prove to be a discrete nosological entity...
- Is sphincter electromyography a helpful investigation in the diagnosis of multiple system atrophy? A retrospective study with pathological diagnosisDominic C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology, London, United Kingdom
Mov Disord 20:1425-30. 2005..A normal spEMG is unlikely in pathologically proven MSA, at least in cases with a mean symptom duration of more than 5 years when the test is performed...
- Frontotemporal lobar degeneration with ubiquitin-only-immunoreactive neuronal changes: broadening the clinical picture to include progressive supranuclear palsyD C Paviour
The Sara Koe PSP Research Centre, Institute of Neurology, London, UK
Brain 127:2441-51. 2004..FTLD-U or FTLD-MND should be considered in the differential diagnosis of progressive frontal dementia with an akinetic rigid syndrome and supranuclear gaze palsy or Steele-Richardson-Olszewski disease...
- Rapidly progressive behavioral changes and parkinsonism in a 68-year-old manGalit Kleiner-Fisman
Department of Medicine, Division of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
Mov Disord 19:534-43. 2004