Research Topics
Genomes and GenesSpecies | Zdenka PausovaSummaryAffiliation: University of Nottingham Country: UK Publications
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Detail Information
Publications
Genes, maternal smoking, and the offspring brain and body during adolescence: design of the Saguenay Youth StudyZdenka Pausova
Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
Hum Brain Mapp 28:502-18. 2007....
Functional variation in the androgen-receptor gene is associated with visceral adiposity and blood pressure in male adolescentsZdenka Pausova
Brain and Body Centre, University of Nottingham, Nottingham NG7 2RD, UK
Hypertension 55:706-14. 2010..In adolescent boys, low CAG-repeat numbers in AR may be a genetic risk factor for intra-abdominal obesity and hypertension; sympathoactivation may be an underlying link between the 2 conditions...- A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French CanadiansZdenka Pausova
Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
Circ Cardiovasc Genet 2:260-9. 2009..Therefore, we investigated whether the FTO-risk variant is associated not only with increased adiposity but also with elevated BP and whether the latter may be mediated, in part, by increased sympathetic modulation of vasomotor tone... - Genome-wide scan for linkage to obesity-associated hypertension in French CanadiansZdenka Pausova
Brain and Body Centre, University of Nottingham, United Kingdom
Hypertension 46:1280-5. 2005..These results suggest that investigating clinically defined subtypes of hypertension, such as obesity-associated hypertension, may facilitate the search for genes of this complex disorder... - From big fat cells to high blood pressure: a pathway to obesity-associated hypertensionZdenka Pausova
Brain and Body Centre, University of Nottingham, Nottingham, UK
Curr Opin Nephrol Hypertens 15:173-8. 2006.... - Orbitofrontal cortex and drug use during adolescence: role of prenatal exposure to maternal smoking and BDNF genotypeShahrdad Lotfipour
Brain and Body Centre, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
Arch Gen Psychiatry 66:1244-52. 2009..Prenatal exposure to maternal cigarette smoking (PEMCS) may affect brain development and behavior in adolescent offspring... - Sex differences in blood pressure and its relationship to body composition and metabolism in adolescenceCatriona Syme
Brain and Body Centre, University of Nottingham, University Park, Nottingham, England
Arch Pediatr Adolesc Med 163:818-25. 2009.... - Prenatal exposure to maternal cigarette smoking and accumulation of intra-abdominal fat during adolescenceCatriona Syme
Brain and Body Centre, University of Nottingham, Nottingham, UK
Obesity (Silver Spring) 18:1021-5. 2010..As such, our results suggest that PEMCS may represent a major risk factor for the development of abdominal obesity at the later stages of puberty... - Handedness, motor skills and maturation of the corticospinal tract in the adolescent brainPierre Yves Hervé
Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
Hum Brain Mapp 30:3151-62. 2009..We conclude that the leftward asymmetry of the pCST may reflect an early established asymmetry in the number of large corticomotoneuronal fibres in the pCST... - Intra-abdominal adiposity and individual components of the metabolic syndrome in adolescence: sex differences and underlying mechanismsCatriona Syme
Brain and Body Centre, University of Nottingham, Nottingham, England
Arch Pediatr Adolesc Med 162:453-61. 2008..To investigate the association between intra-abdominal adiposity and individual components of the metabolic syndrome (MS) in adolescent males and females... - Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspringMaria Toledo-Rodriguez
Brain and Body Centre, University of Nottingham, Nottingham, UK
Am J Med Genet B Neuropsychiatr Genet 153:1350-4. 2010..Such mechanisms could, in turn, lead to modifications in both development and plasticity of the brain exposed in utero to maternal cigarette smoking... - Growth of white matter in the adolescent brain: role of testosterone and androgen receptorJennifer S Perrin
Brain and Body Centre, University of Nottingham, Nottingham NG72RD, United Kingdom
J Neurosci 28:9519-24. 2008..The MTR results suggest that this growth is not related to myelination; the MTR decreased with age in male adolescents. We speculate that testosterone affects axonal caliber rather than the thickness of the myelin sheath... - Brain volumes and Val66Met polymorphism of the BDNF gene: local or global effects?Roberto Toro
Brain and Body Centre, University of Nottingham, Nottingham, UK
Brain Struct Funct 213:501-9. 2009.... - Effect of prenatal exposure to nicotine on kidney glomerular mass and AT1R expression in genetically diverse strains of ratsMaria Toledo-Rodriguez
School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom
Toxicol Lett 213:228-34. 2012..These results suggest that, in genetically vulnerable individuals, PEN leads to morphological and molecular changes in the kidneys that may contribute to fetal programming of hypertension... - Brain size and folding of the human cerebral cortexRoberto Toro
Brain and Body Centre, University of Nottingham, Nottingham NG7 2RD, United Kingdom
Cereb Cortex 18:2352-7. 2008..Our results suggest that this may be, at least in part, a natural outcome of increasing brain size... - Testosterone-mediated sex differences in the face shape during adolescence: subjective impressions and objective featuresKlára Marečková
Rotman Research Institute, University of Toronto, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
Horm Behav 60:681-90. 2011..Perceptible sex differences in face shape are thus associated with specific facial features whose emergence may be, in part, driven by testosterone... - Prenatal exposure to maternal cigarette smoking and the adolescent cerebral cortexRoberto Toro
Brain and Body Centre, University of Nottingham, Nottingham, UK
Neuropsychopharmacology 33:1019-27. 2008..These findings provide evidence of the long-term impact of prenatal environment on a neural substrate of cognition and social behavior... - High-fat diet induces emergence of brown-like adipocytes in white adipose tissue of spontaneously hypertensive ratsSilvie Hojna
Brain and Body Centre, University of Nottingham, Nottingham, UK
Hypertens Res 35:279-86. 2012..Thus, the SHR may be an important genetic model to uncover novel mechanisms of resistance to dietary obesity... 
Genetic locus on rat chromosome 20 regulates diet-induced adipocyte hypertrophy: a microarray gene expression studyCeline Bourdon
Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
Physiol Genomics 38:63-72. 2009..Our results suggest that a gene(s) within the RNO20 segment regulate(s) HFD-induced increases in adiposity, and that this effect may be mediated, at least in part, by the impact of that gene(s) on fat burning and energy expenditure...- Magnetic resonance imaging as a tool for in vivo and ex vivo anatomical phenotyping in experimental genetic modelsAlain Pitiot
Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
Hum Brain Mapp 28:555-66. 2007..We conclude by discussing the power of the population-based computational analysis of MR images, and their fusion with histology, in studies of complex traits... - TA repeat variation, Npr1 expression, and blood pressure: impact of the Ace locusJohanne Tremblay
Laboratory of Cellular Biology of Hypertension, Centre de Recherche du Centre Hospitalier de l Université de Montréal Hôtel Dieu, Montreal, Quebec, Canada
Hypertension 41:16-24. 2003..In conclusion, the longer TA repeat unit in the promoter of Npr1 of SHR, in tandem with a putative cGMP responsive element, regulates the transcription of the Npr1 gene with consequences on diastolic blood pressure... - Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systemsTakahiro Ueno
Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, 3850 Rue Saint Urbain, Montreal, Quebec, Canada
J Mol Med (Berl) 81:51-60. 2003..This pharmocogenetic approach enabled us to determine the main causative acute BP regulatory systems and should lead to better selection of suitable antihypertensive drugs for individual patients... - Segment of rat chromosome 20 regulates diet-induced augmentations in adiposity, glucose intolerance, and blood pressureZdenka Pausova
Laboratory of Functional Genomics, Centre de Recherche, CHUM Hôtel Die, 3850 St Urbain St, Montreal, Quebec H2W 1T7, Canada
Hypertension 41:1047-55. 2003.... - Hyperaldosteronism and hypertension: ethnic differencesClarence E Grim
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Hypertension 45:766-72. 2005..These observations are consistent with the hypothesis that aldosterone-induced volume expansion is an important contributor to hypertension, especially in blacks... - A genealogical study of essential hypertension with and without obesity in French CanadiansZdenka Pausova
University of Montreal Health Centre, Canada
Obes Res 10:463-70. 2002.... - Gender-specific correlates of leptin with hypertension-related phenotypes in African AmericansAreeg H El-Gharbawy
Department of Medicine, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
Am J Hypertens 15:989-93. 2002..01). Thus, in these obese hypertensive African American women, there is no direct or independent association of leptin with BP. However, leptin may contribute to hypertension in these women by increasing renal tubular sodium reabsorption... - Rat model of familial combined hyperlipidemia as a result of comparative mappingTakahiro Ueno
Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
Physiol Genomics 17:38-47. 2004..These data suggest the close relationship between dyslipidemia in HTG rats and human FCHL, establishing a novel animal model for exploration of pathophysiology and therapy based on genomic determinants...