Zdenka Pausova

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint Genes, maternal smoking, and the offspring brain and body during adolescence: design of the Saguenay Youth Study
    Zdenka Pausova
    Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
    Hum Brain Mapp 28:502-18. 2007
  2. ncbi request reprint From big fat cells to high blood pressure: a pathway to obesity-associated hypertension
    Zdenka Pausova
    Brain and Body Centre, University of Nottingham, Nottingham, UK
    Curr Opin Nephrol Hypertens 15:173-8. 2006
  3. ncbi request reprint Genome-wide scan for linkage to obesity-associated hypertension in French Canadians
    Zdenka Pausova
    Brain and Body Centre, University of Nottingham, United Kingdom
    Hypertension 46:1280-5. 2005
  4. doi request reprint Functional variation in the androgen-receptor gene is associated with visceral adiposity and blood pressure in male adolescents
    Zdenka Pausova
    Brain and Body Centre, University of Nottingham, Nottingham NG7 2RD, UK
    Hypertension 55:706-14. 2010
  5. ncbi request reprint A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French Canadians
    Zdenka Pausova
    Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
    Circ Cardiovasc Genet 2:260-9. 2009
  6. ncbi request reprint Orbitofrontal cortex and drug use during adolescence: role of prenatal exposure to maternal smoking and BDNF genotype
    Shahrdad Lotfipour
    Brain and Body Centre, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    Arch Gen Psychiatry 66:1244-52. 2009
  7. doi request reprint Sex differences in blood pressure and its relationship to body composition and metabolism in adolescence
    Catriona Syme
    Brain and Body Centre, University of Nottingham, University Park, Nottingham, England
    Arch Pediatr Adolesc Med 163:818-25. 2009
  8. doi request reprint Handedness, motor skills and maturation of the corticospinal tract in the adolescent brain
    Pierre Yves Hervé
    Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
    Hum Brain Mapp 30:3151-62. 2009
  9. doi request reprint Prenatal exposure to maternal cigarette smoking and accumulation of intra-abdominal fat during adolescence
    Catriona Syme
    Brain and Body Centre, University of Nottingham, Nottingham, UK
    Obesity (Silver Spring) 18:1021-5. 2010
  10. ncbi request reprint Intra-abdominal adiposity and individual components of the metabolic syndrome in adolescence: sex differences and underlying mechanisms
    Catriona Syme
    Brain and Body Centre, University of Nottingham, Nottingham, England
    Arch Pediatr Adolesc Med 162:453-61. 2008

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Genes, maternal smoking, and the offspring brain and body during adolescence: design of the Saguenay Youth Study
    Zdenka Pausova
    Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
    Hum Brain Mapp 28:502-18. 2007
    ....
  2. ncbi request reprint From big fat cells to high blood pressure: a pathway to obesity-associated hypertension
    Zdenka Pausova
    Brain and Body Centre, University of Nottingham, Nottingham, UK
    Curr Opin Nephrol Hypertens 15:173-8. 2006
    ....
  3. ncbi request reprint Genome-wide scan for linkage to obesity-associated hypertension in French Canadians
    Zdenka Pausova
    Brain and Body Centre, University of Nottingham, United Kingdom
    Hypertension 46:1280-5. 2005
    ..These results suggest that investigating clinically defined subtypes of hypertension, such as obesity-associated hypertension, may facilitate the search for genes of this complex disorder...
  4. doi request reprint Functional variation in the androgen-receptor gene is associated with visceral adiposity and blood pressure in male adolescents
    Zdenka Pausova
    Brain and Body Centre, University of Nottingham, Nottingham NG7 2RD, UK
    Hypertension 55:706-14. 2010
    ..In adolescent boys, low CAG-repeat numbers in AR may be a genetic risk factor for intra-abdominal obesity and hypertension; sympathoactivation may be an underlying link between the 2 conditions...
  5. ncbi request reprint A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French Canadians
    Zdenka Pausova
    Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
    Circ Cardiovasc Genet 2:260-9. 2009
    ..Therefore, we investigated whether the FTO-risk variant is associated not only with increased adiposity but also with elevated BP and whether the latter may be mediated, in part, by increased sympathetic modulation of vasomotor tone...
  6. ncbi request reprint Orbitofrontal cortex and drug use during adolescence: role of prenatal exposure to maternal smoking and BDNF genotype
    Shahrdad Lotfipour
    Brain and Body Centre, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    Arch Gen Psychiatry 66:1244-52. 2009
    ..Prenatal exposure to maternal cigarette smoking (PEMCS) may affect brain development and behavior in adolescent offspring...
  7. doi request reprint Sex differences in blood pressure and its relationship to body composition and metabolism in adolescence
    Catriona Syme
    Brain and Body Centre, University of Nottingham, University Park, Nottingham, England
    Arch Pediatr Adolesc Med 163:818-25. 2009
    ....
  8. doi request reprint Handedness, motor skills and maturation of the corticospinal tract in the adolescent brain
    Pierre Yves Hervé
    Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
    Hum Brain Mapp 30:3151-62. 2009
    ..We conclude that the leftward asymmetry of the pCST may reflect an early established asymmetry in the number of large corticomotoneuronal fibres in the pCST...
  9. doi request reprint Prenatal exposure to maternal cigarette smoking and accumulation of intra-abdominal fat during adolescence
    Catriona Syme
    Brain and Body Centre, University of Nottingham, Nottingham, UK
    Obesity (Silver Spring) 18:1021-5. 2010
    ..As such, our results suggest that PEMCS may represent a major risk factor for the development of abdominal obesity at the later stages of puberty...
  10. ncbi request reprint Intra-abdominal adiposity and individual components of the metabolic syndrome in adolescence: sex differences and underlying mechanisms
    Catriona Syme
    Brain and Body Centre, University of Nottingham, Nottingham, England
    Arch Pediatr Adolesc Med 162:453-61. 2008
    ..To investigate the association between intra-abdominal adiposity and individual components of the metabolic syndrome (MS) in adolescent males and females...
  11. doi request reprint Growth of white matter in the adolescent brain: role of testosterone and androgen receptor
    Jennifer S Perrin
    Brain and Body Centre, University of Nottingham, Nottingham NG72RD, United Kingdom
    J Neurosci 28:9519-24. 2008
    ..The MTR results suggest that this growth is not related to myelination; the MTR decreased with age in male adolescents. We speculate that testosterone affects axonal caliber rather than the thickness of the myelin sheath...
  12. doi request reprint Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspring
    Maria Toledo-Rodriguez
    Brain and Body Centre, University of Nottingham, Nottingham, UK
    Am J Med Genet B Neuropsychiatr Genet 153:1350-4. 2010
    ..Such mechanisms could, in turn, lead to modifications in both development and plasticity of the brain exposed in utero to maternal cigarette smoking...
  13. doi request reprint Brain volumes and Val66Met polymorphism of the BDNF gene: local or global effects?
    Roberto Toro
    Brain and Body Centre, University of Nottingham, Nottingham, UK
    Brain Struct Funct 213:501-9. 2009
    ....
  14. ncbi request reprint Effect of prenatal exposure to nicotine on kidney glomerular mass and AT1R expression in genetically diverse strains of rats
    Maria Toledo-Rodriguez
    School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom
    Toxicol Lett 213:228-34. 2012
    ..These results suggest that, in genetically vulnerable individuals, PEN leads to morphological and molecular changes in the kidneys that may contribute to fetal programming of hypertension...
  15. doi request reprint Brain size and folding of the human cerebral cortex
    Roberto Toro
    Brain and Body Centre, University of Nottingham, Nottingham NG7 2RD, United Kingdom
    Cereb Cortex 18:2352-7. 2008
    ..Our results suggest that this may be, at least in part, a natural outcome of increasing brain size...
  16. doi request reprint Testosterone-mediated sex differences in the face shape during adolescence: subjective impressions and objective features
    Klára Marečková
    Rotman Research Institute, University of Toronto, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
    Horm Behav 60:681-90. 2011
    ..Perceptible sex differences in face shape are thus associated with specific facial features whose emergence may be, in part, driven by testosterone...
  17. ncbi request reprint Prenatal exposure to maternal cigarette smoking and the adolescent cerebral cortex
    Roberto Toro
    Brain and Body Centre, University of Nottingham, Nottingham, UK
    Neuropsychopharmacology 33:1019-27. 2008
    ..These findings provide evidence of the long-term impact of prenatal environment on a neural substrate of cognition and social behavior...
  18. doi request reprint High-fat diet induces emergence of brown-like adipocytes in white adipose tissue of spontaneously hypertensive rats
    Silvie Hojna
    Brain and Body Centre, University of Nottingham, Nottingham, UK
    Hypertens Res 35:279-86. 2012
    ..Thus, the SHR may be an important genetic model to uncover novel mechanisms of resistance to dietary obesity...
  19. pmc Genetic locus on rat chromosome 20 regulates diet-induced adipocyte hypertrophy: a microarray gene expression study
    Celine Bourdon
    Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
    Physiol Genomics 38:63-72. 2009
    ..Our results suggest that a gene(s) within the RNO20 segment regulate(s) HFD-induced increases in adiposity, and that this effect may be mediated, at least in part, by the impact of that gene(s) on fat burning and energy expenditure...
  20. pmc Maternal smoking during pregnancy and fetal organ growth: a magnetic resonance imaging study
    Devasuda Anblagan
    Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom
    PLoS ONE 8:e67223. 2013
    ..To study whether maternal cigarette smoking during pregnancy is associated with alterations in the growth of fetal lungs, kidneys, liver, brain, and placenta...
  21. ncbi request reprint Magnetic resonance imaging as a tool for in vivo and ex vivo anatomical phenotyping in experimental genetic models
    Alain Pitiot
    Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
    Hum Brain Mapp 28:555-66. 2007
    ..We conclude by discussing the power of the population-based computational analysis of MR images, and their fusion with histology, in studies of complex traits...
  22. ncbi request reprint Hyperaldosteronism and hypertension: ethnic differences
    Clarence E Grim
    Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 45:766-72. 2005
    ..These observations are consistent with the hypothesis that aldosterone-induced volume expansion is an important contributor to hypertension, especially in blacks...
  23. ncbi request reprint Segment of rat chromosome 20 regulates diet-induced augmentations in adiposity, glucose intolerance, and blood pressure
    Zdenka Pausova
    Laboratory of Functional Genomics, Centre de Recherche, CHUM Hôtel Die, 3850 St Urbain St, Montreal, Quebec H2W 1T7, Canada
    Hypertension 41:1047-55. 2003
    ....
  24. ncbi request reprint Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems
    Takahiro Ueno
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, 3850 Rue Saint Urbain, Montreal, Quebec, Canada
    J Mol Med (Berl) 81:51-60. 2003
    ..This pharmocogenetic approach enabled us to determine the main causative acute BP regulatory systems and should lead to better selection of suitable antihypertensive drugs for individual patients...
  25. ncbi request reprint TA repeat variation, Npr1 expression, and blood pressure: impact of the Ace locus
    Johanne Tremblay
    Laboratory of Cellular Biology of Hypertension, Centre de Recherche du Centre Hospitalier de l Université de Montréal Hôtel Dieu, Montreal, Quebec, Canada
    Hypertension 41:16-24. 2003
    ..In conclusion, the longer TA repeat unit in the promoter of Npr1 of SHR, in tandem with a putative cGMP responsive element, regulates the transcription of the Npr1 gene with consequences on diastolic blood pressure...
  26. ncbi request reprint A genealogical study of essential hypertension with and without obesity in French Canadians
    Zdenka Pausova
    University of Montreal Health Centre, Canada
    Obes Res 10:463-70. 2002
    ....
  27. ncbi request reprint Rat model of familial combined hyperlipidemia as a result of comparative mapping
    Takahiro Ueno
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Physiol Genomics 17:38-47. 2004
    ..These data suggest the close relationship between dyslipidemia in HTG rats and human FCHL, establishing a novel animal model for exploration of pathophysiology and therapy based on genomic determinants...
  28. ncbi request reprint Gender-specific correlates of leptin with hypertension-related phenotypes in African Americans
    Areeg H El-Gharbawy
    Department of Medicine, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Am J Hypertens 15:989-93. 2002
    ..01). Thus, in these obese hypertensive African American women, there is no direct or independent association of leptin with BP. However, leptin may contribute to hypertension in these women by increasing renal tubular sodium reabsorption...