Research Topics
Genomes and GenesSpecies | Tomas PausSummaryAffiliation: University of Nottingham Country: UK Publications
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Publications
Mapping brain maturation and cognitive development during adolescenceTomas Paus
Brain and Body Centre, University of Nottingham, Nottingham, UK
Trends Cogn Sci 9:60-8. 2005..Future directions for research in this area are discussed in the context of processing biological motion and matching perceptions and actions...
Sexual dimorphism in the adolescent brain: Role of testosterone and androgen receptor in global and local volumes of grey and white matterT Paus
Brain and Body Centre, University of Nottingham, UK
Horm Behav 57:63-75. 2010..Following a discussion of several methodological and interpretational issues, we outline future directions in investigating brain-behavior relationships vis-à-vis psychopathology...- Growth of white matter in the adolescent brain: myelin or axon?Tomas Paus
Brain and Body Centre, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
Brain Cogn 72:26-35. 2010..I conclude by re-focusing the interpretations of MR-based studies of white matter from myelin to axon... 
Why do many psychiatric disorders emerge during adolescence?Tomas Paus
Brain and Body Centre, University of Nottingham, Nottingham, NG7 2RD, UK
Nat Rev Neurosci 9:947-57. 2008....- Morphological properties of the action-observation cortical network in adolescents with low and high resistance to peer influenceTomas Paus
University of Nottingham, Nottingham, UK
Soc Neurosci 3:303-16. 2008..We suggest that these morphological findings might reflect differences, between adolescents with high vs. low resistance to peer influences, in a repeated and concurrent engagement of these networks in social context... - Corpus callosum in adolescent offspring exposed prenatally to maternal cigarette smokingT Paus
Brain and Body Centre, University of Nottingham, UK
Neuroimage 40:435-41. 2008..Given the lack of exposure effect on the myelination index, this finding might reflect a lower number of inter-hemispheric connections in female offspring of mothers who smoked during pregnancy... - Inferring causality in brain images: a perturbation approachTomas Paus
Brain and Body Centre, University of Nottingham, UK
Philos Trans R Soc Lond B Biol Sci 360:1109-14. 2005..Here, I will illustrate this approach by reviewing some of our TMS/PET work, and will conclude by discussing a few methodological and theoretical challenges facing those studying neural connectivity using a perturbation... - Orbitofrontal cortex and drug use during adolescence: role of prenatal exposure to maternal smoking and BDNF genotypeShahrdad Lotfipour
Brain and Body Centre, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
Arch Gen Psychiatry 66:1244-52. 2009..Prenatal exposure to maternal cigarette smoking (PEMCS) may affect brain development and behavior in adolescent offspring... - Functional variation in the androgen-receptor gene is associated with visceral adiposity and blood pressure in male adolescentsZdenka Pausova
Brain and Body Centre, University of Nottingham, Nottingham NG7 2RD, UK
Hypertension 55:706-14. 2010..In adolescent boys, low CAG-repeat numbers in AR may be a genetic risk factor for intra-abdominal obesity and hypertension; sympathoactivation may be an underlying link between the 2 conditions... - A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French CanadiansZdenka Pausova
Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
Circ Cardiovasc Genet 2:260-9. 2009..Therefore, we investigated whether the FTO-risk variant is associated not only with increased adiposity but also with elevated BP and whether the latter may be mediated, in part, by increased sympathetic modulation of vasomotor tone... - Sex differences in blood pressure and its relationship to body composition and metabolism in adolescenceCatriona Syme
Brain and Body Centre, University of Nottingham, University Park, Nottingham, England
Arch Pediatr Adolesc Med 163:818-25. 2009.... - Growth of white matter in the adolescent brain: role of testosterone and androgen receptorJennifer S Perrin
Brain and Body Centre, University of Nottingham, Nottingham NG72RD, United Kingdom
J Neurosci 28:9519-24. 2008..The MTR results suggest that this growth is not related to myelination; the MTR decreased with age in male adolescents. We speculate that testosterone affects axonal caliber rather than the thickness of the myelin sheath... - Prenatal exposure to maternal cigarette smoking and the adolescent cerebral cortexRoberto Toro
Brain and Body Centre, University of Nottingham, Nottingham, UK
Neuropsychopharmacology 33:1019-27. 2008..These findings provide evidence of the long-term impact of prenatal environment on a neural substrate of cognition and social behavior... - Handedness, motor skills and maturation of the corticospinal tract in the adolescent brainPierre Yves Hervé
Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
Hum Brain Mapp 30:3151-62. 2009..We conclude that the leftward asymmetry of the pCST may reflect an early established asymmetry in the number of large corticomotoneuronal fibres in the pCST... - Prenatal exposure to maternal cigarette smoking and accumulation of intra-abdominal fat during adolescenceCatriona Syme
Brain and Body Centre, University of Nottingham, Nottingham, UK
Obesity (Silver Spring) 18:1021-5. 2010..As such, our results suggest that PEMCS may represent a major risk factor for the development of abdominal obesity at the later stages of puberty... - Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspringMaria Toledo-Rodriguez
Brain and Body Centre, University of Nottingham, Nottingham, UK
Am J Med Genet B Neuropsychiatr Genet 153:1350-4. 2010..Such mechanisms could, in turn, lead to modifications in both development and plasticity of the brain exposed in utero to maternal cigarette smoking... - Development of the action observation network during early adolescence: a longitudinal studyDaniel J Shaw
School of Psychology, University of Nottingham, Nottingham NG7 2RD, England, UK
Soc Cogn Affect Neurosci 7:64-80. 2012..Using this approach, we reveal quadratic trajectories within a fronto-parietal network previously shown to demonstrate correlated morphological development... - Brain size and folding of the human cerebral cortexRoberto Toro
Brain and Body Centre, University of Nottingham, Nottingham NG7 2RD, United Kingdom
Cereb Cortex 18:2352-7. 2008..Our results suggest that this may be, at least in part, a natural outcome of increasing brain size... - Intra-abdominal adiposity and individual components of the metabolic syndrome in adolescence: sex differences and underlying mechanismsCatriona Syme
Brain and Body Centre, University of Nottingham, Nottingham, England
Arch Pediatr Adolesc Med 162:453-61. 2008..To investigate the association between intra-abdominal adiposity and individual components of the metabolic syndrome (MS) in adolescent males and females... - Brain volumes and Val66Met polymorphism of the BDNF gene: local or global effects?Roberto Toro
Brain and Body Centre, University of Nottingham, Nottingham, UK
Brain Struct Funct 213:501-9. 2009.... - Development of functional connectivity during adolescence: a longitudinal study using an action-observation paradigmDaniel J Shaw
University of Nottingham, UK
J Cogn Neurosci 23:3713-24. 2011..These findings are discussed in terms of known sex differences in adolescent social behavior... - Neural mechanisms of resistance to peer influence in early adolescenceMarie Helene Grosbras
Brain and Body Centre, University of Nottingham, Nottingham NG7 2RD, United Kingdom
J Neurosci 27:8040-5. 2007..These findings suggest that the probability of resisting peer influence depends on neural interactions during observation of emotion-laden actions... - Testosterone-mediated sex differences in the face shape during adolescence: subjective impressions and objective featuresKlára Marečková
Rotman Research Institute, University of Toronto, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
Horm Behav 60:681-90. 2011..Perceptible sex differences in face shape are thus associated with specific facial features whose emergence may be, in part, driven by testosterone... - Maturation of EEG power spectra in early adolescence: a longitudinal studyLucy Cragg
School of Psychology, University of Nottingham, UK
Dev Sci 14:935-43. 2011.... - Genes, maternal smoking, and the offspring brain and body during adolescence: design of the Saguenay Youth StudyZdenka Pausova
Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
Hum Brain Mapp 28:502-18. 2007.... - Combining functional neuroimaging with off-line brain stimulation: modulation of task-related activity in language areasJamila Andoh
University of Nottingham, Nottingham, UK
J Cogn Neurosci 23:349-61. 2011.... - Cortical gray matter in attention-deficit/hyperactivity disorder: a structural magnetic resonance imaging studyMartin J Batty
University of Nottingham
J Am Acad Child Adolesc Psychiatry 49:229-38. 2010..We examined one such region, the pars opercularis, predicting a thinner cortex of the inferior frontal gyrus (IFG) in children with ADHD... - Structural properties of the corticospinal tract in the human brain: a magnetic resonance imaging study at 7 TeslaPierre Yves Hervé
School of Psychology, University of Nottingham, Nottingham, UK
Brain Struct Funct 216:255-62. 2011..This effect is consistent with the presence of sparsely distributed, large-diameter fibres described in previous histological studies and, as such, might reflect lower myelin density and/or different morphology of fibres in the CST... - Functional coactivation map of the human brainRoberto Toro
Brain and Body Centre, University of Nottingham, Nottingham NG7 2RD, United Kingdom
Cereb Cortex 18:2553-9. 2008.... - Stress during puberty boosts metabolic activation associated with fear-extinction learning in hippocampus, basal amygdala and cingulate cortexMaria Toledo-Rodriguez
School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom
Neurobiol Learn Mem 98:93-101. 2012..These results indicate that exposure to peri-pubertal stress affects behavior and brain metabolism when the individual is exposed to an additional stressful challenge. Some of these effects are sex-specific... - Magnetic resonance imaging as a tool for in vivo and ex vivo anatomical phenotyping in experimental genetic modelsAlain Pitiot
Brain and Body Centre, University of Nottingham, Nottingham, United Kingdom
Hum Brain Mapp 28:555-66. 2007..We conclude by discussing the power of the population-based computational analysis of MR images, and their fusion with histology, in studies of complex traits... - Could Sex Differences in White Matter be Explained by g ratio?Tomas Paus
Brain and Body Centre, University of Nottingham Nottingham, UK
Front Neuroanat 3:14. 2009..We conclude by pointing out possible implications of "suboptimal" g ratio for the emergence of "disconnection" disorders, such as schizophrenia, in late adolescence...