Ralf Paus

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. doi request reprint Pathobiology of chemotherapy-induced hair loss
    Ralf Paus
    Department of Dermatology, University of Lubeck, Lübeck D 23538, Germany
    Lancet Oncol 14:e50-9. 2013
  2. doi request reprint Thyroid-stimulating hormone, a novel, locally produced modulator of human epidermal functions, is regulated by thyrotropin-releasing hormone and thyroid hormones
    Eniko Bodo
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Endocrinology 151:1633-42. 2010
  3. doi request reprint Profiling the response of human hair follicles to ultraviolet radiation
    Zhongfa Lu
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, Lubeck, Germany
    J Invest Dermatol 129:1790-804. 2009
  4. doi request reprint Hypothalamic-pituitary-thyroid axis hormones stimulate mitochondrial function and biogenesis in human hair follicles
    Silvia Vidali
    Department of Dermatology, University of Luebeck, Luebeck, Germany
    J Invest Dermatol 134:33-42. 2014
  5. ncbi request reprint Prolactin--a novel neuroendocrine regulator of human keratin expression in situ
    Yuval Ramot
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    FASEB J 24:1768-79. 2010
  6. doi request reprint An improved, standardised protocol for the isolation, enrichment and targeted neural differentiation of Nestin+ progenitors from adult human dermis
    Nancy Ernst
    Department of Dermatology, Allergology and Venerology, University of Lubeck, Lubeck, Germany
    Exp Dermatol 19:549-55. 2010
  7. pmc Probing the effects of stress mediators on the human hair follicle: substance P holds central position
    Eva M J Peters
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Am J Pathol 171:1872-86. 2007
  8. ncbi request reprint Neurotrophin-3 regulates mast cell functions in neonatal mouse skin
    Martin Metz
    Department of Dermatology, University Hospital Mainz, Mainz, Germany
    Exp Dermatol 13:273-81. 2004
  9. doi request reprint Thyrotropin-releasing hormone selectively stimulates human hair follicle pigmentation
    Erzsébet Gáspár
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    J Invest Dermatol 131:2368-77. 2011
  10. ncbi request reprint Substantial sex-dependent differences in the response of human scalp hair follicles to estrogen stimulation in vitro advocate gender-tailored management of female versus male pattern balding
    Franziska Conrad
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    J Investig Dermatol Symp Proc 10:243-6. 2005

Detail Information

Publications67

  1. doi request reprint Pathobiology of chemotherapy-induced hair loss
    Ralf Paus
    Department of Dermatology, University of Lubeck, Lübeck D 23538, Germany
    Lancet Oncol 14:e50-9. 2013
    ..We highlight the need for carefully designed preclinical research models to generate novel, clinically relevant pointers to how this condition may be overcome...
  2. doi request reprint Thyroid-stimulating hormone, a novel, locally produced modulator of human epidermal functions, is regulated by thyrotropin-releasing hormone and thyroid hormones
    Eniko Bodo
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Endocrinology 151:1633-42. 2010
    ..Intraepidermal TSH expression appears to be regulated by the classical endocrine controls that determine the systemic HPT axis...
  3. doi request reprint Profiling the response of human hair follicles to ultraviolet radiation
    Zhongfa Lu
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, Lubeck, Germany
    J Invest Dermatol 129:1790-804. 2009
    ....
  4. doi request reprint Hypothalamic-pituitary-thyroid axis hormones stimulate mitochondrial function and biogenesis in human hair follicles
    Silvia Vidali
    Department of Dermatology, University of Luebeck, Luebeck, Germany
    J Invest Dermatol 134:33-42. 2014
    ..The neuroendocrine control of mitochondrial biology in a complex human mini-organ revealed here may be therapeutically exploitable...
  5. ncbi request reprint Prolactin--a novel neuroendocrine regulator of human keratin expression in situ
    Yuval Ramot
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    FASEB J 24:1768-79. 2010
    ..Therefore, our study identifies PRL as a major, clinically relevant, novel neuroendocrine regulator of both human keratin expression and human epithelial stem cell biology in situ...
  6. doi request reprint An improved, standardised protocol for the isolation, enrichment and targeted neural differentiation of Nestin+ progenitors from adult human dermis
    Nancy Ernst
    Department of Dermatology, Allergology and Venerology, University of Lubeck, Lubeck, Germany
    Exp Dermatol 19:549-55. 2010
    ..These methodological advances should greatly facilitate the isolation, culture and targeted differentiation of primary, adult human scalp skin dermis-derived Nestin+ cells...
  7. pmc Probing the effects of stress mediators on the human hair follicle: substance P holds central position
    Eva M J Peters
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Am J Pathol 171:1872-86. 2007
    ..The data obtained therewith allow one to sketch the first evidence-based biological explanation for how stress may trigger or aggravate telogen effluvium and alopecia areata...
  8. ncbi request reprint Neurotrophin-3 regulates mast cell functions in neonatal mouse skin
    Martin Metz
    Department of Dermatology, University Hospital Mainz, Mainz, Germany
    Exp Dermatol 13:273-81. 2004
    ..Our data suggest a role for NT-3 in the maturation of MCs, such as a TrkC-mediated stimulation of the differentiation of pre-existing, less mature MCs and/or by enhancing the migration of circulating MC precursors into the skin...
  9. doi request reprint Thyrotropin-releasing hormone selectively stimulates human hair follicle pigmentation
    Erzsébet Gáspár
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    J Invest Dermatol 131:2368-77. 2011
    ..This physiologically relevant and melanocyte sub-population-specific neuroendocrine control of human pigmentation deserves clinical exploration, e.g., for preventing or reversing hair graying...
  10. ncbi request reprint Substantial sex-dependent differences in the response of human scalp hair follicles to estrogen stimulation in vitro advocate gender-tailored management of female versus male pattern balding
    Franziska Conrad
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    J Investig Dermatol Symp Proc 10:243-6. 2005
    ..Recognition and systematic dissection of the E2-dependent gene regulation will be crucial for the development of more effective, gender-tailored management strategies for female versus male pattern balding...
  11. doi request reprint Thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation
    Nina van Beek
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    J Clin Endocrinol Metab 93:4381-8. 2008
    ..g. effluvium). However, it is still unclear whether T3 and T4 exert any direct effects on human hair follicles (HFs), and if so, how exactly human HFs respond to T3/T4 stimulation...
  12. pmc Dissecting the impact of chemotherapy on the human hair follicle: a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy
    Eniko Bodo
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, D 23538 Lubeck, Ratzeburger Allee 160, Germany
    Am J Pathol 171:1153-67. 2007
    ..Thus, this novel system serves as a powerful yet pragmatic tool for dissecting and manipulating the impact of chemotherapy on the human HF...
  13. pmc Human scalp hair follicles are both a target and a source of prolactin, which serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle regression
    Kerstin Foitzik
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    Am J Pathol 168:748-56. 2006
    ....
  14. ncbi request reprint Nestin in human skin: exclusive expression in intramesenchymal skin compartments and regulation by leptin
    Stephan Tiede
    Department of Dermatology, Allergology and Venerology, University of Lubeck, Lubeck, Germany
    J Invest Dermatol 129:2711-20. 2009
    ..Therefore, nestin expression at the gene and protein levels in human scalp skin is restricted to the periappendage mesenchyme and can be stimulated by leptin...
  15. ncbi request reprint A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors
    Hiromi Kobayashi
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Lubeck, University of Lubeck, Lubeck, Germany
    FASEB J 19:1710-2. 2005
    ..As a prototypic neuroectodermal-mesodermal interaction model, the HF can be exploited for dissecting the obscure role of melatonin in such interactions in peripheral tissues...
  16. doi request reprint Human female hair follicles are a direct, nonclassical target for thyroid-stimulating hormone
    Eniko Bodo
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, Lubeck, Germany
    J Invest Dermatol 129:1126-39. 2009
    ..This suggests that organ-cultured scalp HFs provide an instructive and physiologically relevant human model for exploring nonclassical functions of TSH, in and beyond the skin...
  17. doi request reprint Thyrotropin-releasing hormone controls mitochondrial biology in human epidermis
    Jana Knuever
    Department of Dermatology, University of Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    J Clin Endocrinol Metab 97:978-86. 2012
    ..The most proximal regulator of the hypothalamic-pituitary-thyroid (HPT) axis, TRH, is the key hypothalamic integrator of energy metabolism via its impact on thyroid hormone secretion...
  18. ncbi request reprint Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin
    Eniko Bodo
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    FASEB J 21:3346-54. 2007
    ..They may recruit EPO/EPO-R signaling e.g., for modulating HF apoptosis under conditions of hypoxia and chemotherapy-induced stress...
  19. doi request reprint Cannabinoid receptor 1 controls human mucosal-type mast cell degranulation and maturation in situ
    Koji Sugawara
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    J Allergy Clin Immunol 132:182-93. 2013
    ....
  20. doi request reprint T-oligos as differential modulators of human scalp hair growth and pigmentation: a new "time lapse system" for studying human skin and hair follicle biology in vitro?
    Ina Hadshiew
    Department of Dermatology, University Hospital Hamburg Eppendorf, Martinistrabe 52, 20246, Hamburg, Germany
    Arch Dermatol Res 300:155-9. 2008
    ....
  21. doi request reprint Endocannabinoids limit excessive mast cell maturation and activation in human skin
    Koji Sugawara
    Department of Dermatology, University of Lubeck, Lubeck, Germany Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Allergy Clin Immunol 129:726-738.e8. 2012
    ..Mast cells (MCs) crucially contribute to many inflammatory diseases. However, the physiological controls preventing excessive activities of MCs in human skin are incompletely understood...
  22. doi request reprint Thyrotropin releasing hormone (TRH): a new player in human hair-growth control
    Erzsébet Gáspár
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160 D 23538 Lübeck, Germany
    FASEB J 24:393-403. 2010
    ..Human HFs provide an excellent discovery tool for identifying and dissecting nonclassical functions of TRH and TRH-mediated signaling in situ, which emerge as novel players in human epithelial biology...
  23. pmc Collapse and restoration of MHC class-I-dependent immune privilege: exploiting the human hair follicle as a model
    Taisuke Ito
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    Am J Pathol 164:623-34. 2004
    ....
  24. doi request reprint Cutaneous consequences of inhibiting EGF receptor signaling in vivo: normal hair follicle development, but retarded hair cycle induction and inhibition of adipocyte growth in Egfr(Wa5) mice
    Koji Sugawara
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    J Dermatol Sci 57:155-61. 2010
    ..However, detailed dissection of the role of the EGFR in hair follicle development and cycling have been impaired by the early mortality of EGFR knockout mice...
  25. ncbi request reprint Hair cycle control by estrogens: catagen induction via estrogen receptor (ER)-alpha is checked by ER beta signaling
    Ulrich Ohnemus
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Endocrinology 146:1214-25. 2005
    ..Our study also underscores that the hair cycling response to estrogens offers an ideal model for studying the controls and dynamics of wave propagation in biological systems...
  26. doi request reprint Thyrotropin powers human mitochondria
    Burkhard Poeggeler
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    FASEB J 24:1525-31. 2010
    ....
  27. pmc Thyrotropin-releasing hormone (TRH) promotes wound re-epithelialisation in frog and human skin
    Natalia T Meier
    Department of Dermatology, University of Luebeck, Luebeck, Germany Department of Pathology, University of Luebeck, Luebeck, Germany
    PLoS ONE 8:e73596. 2013
    ....
  28. doi request reprint Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair
    Tobias W Fischer
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, Lubeck, Germany
    Exp Dermatol 17:713-30. 2008
    ..After listing a number of key open questions, we conclude by defining particularly important, clinically relevant perspectives for how melatonin may become therapeutically exploitable in cutaneous medicine...
  29. doi request reprint Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture
    Jennifer Elisabeth Kloepper
    Department of Dermatology, Allergology and Venerology, University of Luebeck, Luebeck, Germany
    Exp Dermatol 19:305-12. 2010
    ..Therefore, this classification system offers a standardized, objective and reproducible new experimental method to reliably distinguish between human anagen VI and early catagen HFs in organ culture...
  30. doi request reprint Nonviral in situ green fluorescent protein labeling and culture of primary, adult human hair follicle epithelial progenitor cells
    Stephan Tiede
    Department of Dermatology, University of Lubeck, D 23538 Lubeck, Germany
    Stem Cells 27:2793-803. 2009
    ....
  31. ncbi request reprint Towards dissecting the pathogenesis of retinoid-induced hair loss: all-trans retinoic acid induces premature hair follicle regression (catagen) by upregulation of transforming growth factor-beta2 in the dermal papilla
    Kerstin Foitzik
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    J Invest Dermatol 124:1119-26. 2005
    ..Therefore, topical TGF-beta2/TGF-beta receptor II antagonists deserve to be explored for the prevention and management of retinoid-induced hair loss...
  32. ncbi request reprint Kit is expressed by epithelial cells in vivo
    Eva M J Peters
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    J Invest Dermatol 121:976-84. 2003
    ..The expression of Kit in the most rapidly proliferating compartment of the hair follicle epithelium suggests intriguing, as yet unexplored new functions of Kit signaling in epithelial cell biology...
  33. ncbi request reprint FOXN1 is critical for onycholemmal terminal differentiation in nude (Foxn1) mice
    Lars Mecklenburg
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    J Invest Dermatol 123:1001-11. 2004
    ..The nails of nude mice provide new insights into the molecular controls of onychocyte differentiation, and they offer a useful model to investigate the pathogenesis of nail hypergranulosis, a common feature in human nail diseases...
  34. ncbi request reprint The hair follicle as an estrogen target and source
    Ulrich Ohnemus
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Lubeck, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Endocr Rev 27:677-706. 2006
    ....
  35. doi request reprint Erythropoietin and the skin: a role for epidermal oxygen sensing?
    Ralf Paus
    Department of Dermatology, University of Luebeck, Luebeck, Germany
    Bioessays 31:344-8. 2009
    ..Mainly, we propose that the skin itself directly contributes to the up-regulation of EPO plasma levels in response to hypoxia...
  36. doi request reprint Neuroendocrine perspectives in alopecia areata: does stress play a role?
    Ralf Paus
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    J Invest Dermatol 129:1324-6. 2009
    ..This has triggered debates about whether AA should be considered a psychosomatic disorder (Misery and Rousset, 2001; Willemsen et al., 2009)...
  37. ncbi request reprint Melatonin and the hair follicle
    Tobias W Fischer
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, Lubeck, Germany
    J Pineal Res 44:1-15. 2008
    ....
  38. doi request reprint Leptin and the skin: a new frontier
    Burkhard Poeggeler
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Exp Dermatol 19:12-8. 2010
    ....
  39. doi request reprint Basic fibroblast growth factor: a potential new therapeutic tool for the treatment of hypertrophic and keloid scars
    Stephan Tiede
    Allergology and Venerology, Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Ann Anat 191:33-44. 2009
    ..This interesting discovery may help in the prevention and treatment of tissue fibrosis and in particular in the eradication of hypertrophic and keloid scars...
  40. doi request reprint A function for Rac1 in the terminal differentiation and pigmentation of hair
    Kristina Behrendt
    Department of Dermatology, University of Cologne, Kerpener Strasse 62, D 50924 Cologne, Germany
    J Cell Sci 125:896-905. 2012
    ..Our study demonstrates regulatory functions for Rac1 in the formation of hair structure and pigmentation and thereby identifies, for the first time, a role for Rac1 in terminal differentiation...
  41. ncbi request reprint A 'hairy' privilege
    Ralf Paus
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Trends Immunol 26:32-40. 2005
    ....
  42. doi request reprint Highly complex peptide aggregates of the S100 fused-type protein hornerin are present in human skin
    Zhihong Wu
    Department of Dermatology, University Hospital of Schleswig Holstein, Kiel, Germany
    J Invest Dermatol 129:1446-58. 2009
    ..Our findings suggest that HRNR is expressed in healthy skin and give insight into the complex biology of this protein. HRNR and its degradation products might contribute to the barrier function of healthy human skin...
  43. ncbi request reprint (Neuro-)endocrinology of epithelial hair follicle stem cells
    Ralf Paus
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Mol Cell Endocrinol 288:38-51. 2008
    ..These considerations call for a concerted research effort to dissect the (neuro-)endocrinology of HFeSCs much more systematically than before...
  44. doi request reprint A neuroendocrinological perspective on human hair follicle pigmentation
    Ralf Paus
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Pigment Cell Melanoma Res 24:89-106. 2011
    ..In this context, novel neuroendocrinological strategies to retard or reverse greying and to reduce damage to the HFPU are discussed...
  45. ncbi request reprint L-carnitine-L-tartrate promotes human hair growth in vitro
    Kerstin Foitzik
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    Exp Dermatol 16:936-45. 2007
    ..They further encourage one to explore topical and nutraceutical administration of l-carnitine as a well-tolerated, relatively safe adjuvant treatment in the management of androgenetic alopecia and other forms of hair loss...
  46. pmc β1 Integrin Signaling Maintains Human Epithelial Progenitor Cell Survival In Situ and Controls Proliferation, Apoptosis and Migration of Their Progeny
    Nancy Ernst
    Department of Dermatology, University of Luebeck, Luebeck, Germany
    PLoS ONE 8:e84356. 2013
    ..These insights may be exploited for cell-based regenerative medicine strategies that employ human HF-derived ePCs. ..
  47. pmc Prolactin and its receptor are expressed in murine hair follicle epithelium, show hair cycle-dependent expression, and induce catagen
    Kerstin Foitzik
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    Am J Pathol 162:1611-21. 2003
    ..These data support the intriguing concept that PRL is generated locally in the hair follicle epithelium and acts directly in an autocrine or paracrine manner to modulate the hair cycle...
  48. ncbi request reprint Migration of melanoblasts into the developing murine hair follicle is accompanied by transient c-Kit expression
    Eva M J Peters
    Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Germany
    J Histochem Cytochem 50:751-66. 2002
    ..In addition, differentiated c-Kit-IR melanocytes target the bulb, while non-c-Kit-IR melanoblasts invade the outer root sheath and bulge in fully developed hair follicles...
  49. ncbi request reprint Estrogens and the hair follicle
    Franziska Conrad
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    J Dtsch Dermatol Ges 2:412-23. 2004
    ....
  50. ncbi request reprint Lhx2--decisive role in epithelial stem cell maintenance, or just the "tip of the iceberg"?
    Stephan Tiede
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, Germany
    Bioessays 28:1157-60. 2006
    ....
  51. ncbi request reprint Topical estrogen accelerates hair regrowth in mice after chemotherapy-induced alopecia by favoring the dystrophic catagen response pathway to damage
    Ulrich Ohnemus
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    J Invest Dermatol 122:7-13. 2004
    ..Our data encourage one to explore topical estrogens as a potential stimulant for hair re-growth after chemotherapy-induced alopecia...
  52. ncbi request reprint Hair follicle stem cells: walking the maze
    Stephan Tiede
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Eur J Cell Biol 86:355-76. 2007
    ....
  53. ncbi request reprint Expression of the human Cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis
    Markus Walz
    Department of Dermatology, Heinrich Heine University, Moorenstrasse 5, Dusseldorf, Germany
    Exp Dermatol 16:715-23. 2007
    ..Among others, differentially expressed genes are related to antigen presentation and angiogenesis. These results suggest an important role of Cat L regulation by hurpin which might be of clinical relevance in human skin diseases...
  54. doi request reprint Prolactin and the skin: a dermatological perspective on an ancient pleiotropic peptide hormone
    Kerstin Foitzik
    Department of Dermatology, Children s Hospital Wilhelmstift, Hamburg, Germany
    J Invest Dermatol 129:1071-87. 2009
    ....
  55. doi request reprint The immune system of mouse vibrissae follicles: cellular composition and indications of immune privilege
    Marta Bertolini
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Exp Dermatol 22:593-8. 2013
    ..This facilitates utilizing murine VHF as a versatile organ culture model for general immunology and immune privilege research in situ. ..
  56. ncbi request reprint Frontiers in the (neuro-)endocrine controls of hair growth
    Ralf Paus
    Department of Dermatology, University Hospital Schleswig Holstein, University of Luebeck, Lubeck, Germany
    J Investig Dermatol Symp Proc 12:20-2. 2007
    ..This presentation discusses these recent findings and their possible role in the control of the hair cycle and melanogenesis...
  57. ncbi request reprint Neuroimmunoendocrine circuitry of the 'brain-skin connection'
    Ralf Paus
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Lubeck, University of Lubeck, D 23538 Lubeck, Germany
    Trends Immunol 27:32-9. 2006
    ..Thus, the skin and its appendages enable the study of complex neuroimmunoendocrine responses that peripheral tissues launch upon stress exposure, as a basis for identifying new targets for therapeutic stress intervention...
  58. pmc The M4 muscarinic acetylcholine receptor plays a key role in the control of murine hair follicle cycling and pigmentation
    Sybille Hasse
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Luebeck, University of Luebeck, D 23538 Luebeck, Germany
    Life Sci 80:2248-52. 2007
    ..The current pilot study suggests that the M4R plays a fundamental role in the control of the murine hair follicle cycling and is an essential signaling element in the control of hair follicle pigmentation...
  59. doi request reprint Exploring the "thyroid-skin connection": concepts, questions, and clinical relevance
    Ralf Paus
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    J Invest Dermatol 130:7-10. 2010
    ..This provides a good opportunity to define the questions to be addressed when exploring the thyroid-skin connection...
  60. doi request reprint Modulation of basophil activity: a novel function of the neuropeptide α-melanocyte-stimulating hormone
    Markus Bohm
    Department of Dermatology, University of Munster, Munster, Germany
    J Allergy Clin Immunol 129:1085-93. 2012
    ..Little is known about the effect of neuropeptides on basophils, which are important effector cells in immune and allergic responses...
  61. ncbi request reprint Pro-inflammatory cytokines upregulate the skin immunoreactivity for NGF, NT-3, NT-4 and their receptor, p75NTR in vivo: a preliminary report
    Holger Bläsing
    Department of Dermatology, University Hospital Eppendorf, Hamburg University, Martinistrasse 52, 20246, Hamburg, Germany
    Arch Dermatol Res 296:580-4. 2005
    ..This raises the question to which extent several of the recognized cutaneous effects of IFNgamma, IL-1beta and TNF-alpha are mediated indirectly via modulating the expression of selected NTs and/or NTRs...
  62. ncbi request reprint Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin
    Motonobu Nakamura
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    FASEB J 17:497-9. 2003
    ..These observations suggest that follistatin and activin interaction plays an important role in both HF development and cycling, possibly in part by regulating expression of BMP-2 and its antagonist...
  63. ncbi request reprint The hair follicle and immune privilege
    Ralf Paus
    Department of Dermatology, University Hospital, Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    J Investig Dermatol Symp Proc 8:188-94. 2003
    ..Finally, we sketch some particularly promising avenues for future investigation into the far too long ignored hair follicle immune privilege...
  64. ncbi request reprint Burden of hair loss: stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia
    Ina M Hadshiew
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    J Invest Dermatol 123:455-7. 2004
    ....
  65. ncbi request reprint In search of the "hair cycle clock": a guided tour
    Ralf Paus
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Martinistr 52, D 20426 Hamburg, Germany
    Differentiation 72:489-511. 2004
    ....
  66. ncbi request reprint Developmental timing of hair follicle and dorsal skin innervation in mice
    Eva M J Peters
    Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Hamburg D 20246, Germany
    J Comp Neurol 448:28-52. 2002
    ..This sequence of developing innervation consistently correlates with hair follicle development, indicating a close interdependence of neuronal and epithelial morphogenesis...
  67. pmc Frontiers in pruritus research: scratching the brain for more effective itch therapy
    Ralf Paus
    Department of Dermatology and Allergy, University of Lubeck, Lubeck, Germany
    J Clin Invest 116:1174-86. 2006
    ....