Research Topics
| P N PatsalosSummaryAffiliation: University College London Country: UK Publications
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Publications
The importance of drug interactions in epilepsy therapyPhilip N Patsalos
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, England, UK
Epilepsia 43:365-85. 2002....- Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugsPhilip N Patsalos
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, UK
Lancet Neurol 2:473-81. 2003..Careful monitoring of clinical response is recommended whenever a drug is added or removed from a patient's AED regimen... - Clinical pharmacokinetics of levetiracetamPhilip N Patsalos
Pharmacology and Therapeutics Unit, Department of Clinical and Experimental Epilepsy, Institute of Neurology The National Hospital for Neurology and Neurosurgery, London, UK
Clin Pharmacokinet 43:707-24. 2004..Overall, the pharmacokinetic characteristics of levetiracetam are highly favourable and make its clinical use simple and straightforward... - The pharmacokinetic characteristics of levetiracetamP N Patsalos
Institute of Neurology The National Hospital for Neurology and Neurosurgery, Pharmacology and Therapeutics Unit, Department of Clinical and Experimental Epilepsy, London, UK
Methods Find Exp Clin Pharmacol 25:123-9. 2003..Overall, the pharmacokinetic characteristics of levetiracetam can be considered highly desirable... - Properties of antiepileptic drugs in the treatment of idiopathic generalized epilepsiesPhilip N Patsalos
Pharmacology and Therapeutics Unit, Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, United Kingdom
Epilepsia 46:140-8. 2005..Levetiracetam rates highest with topiramate in second place... - Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugsPhilip N Patsalos
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, UK
Lancet Neurol 2:347-56. 2003..Interactions involving enzyme inhibition include the increase in plasma concentrations of lamotrigine and phenobarbital caused by valproic acid. Among AEDs, the least potential interaction is associated with gabapentin and levetiracetam... - In situ metabolism of levetiracetam in blood of patients with epilepsyPhilip N Patsalos
Pharmacology and Therapeutics Unit, Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, United Kingdom
Epilepsia 47:1818-21. 2006.... - Pharmacokinetic profile of levetiracetam: toward ideal characteristicsP N Patsalos
Institute of Neurology, Pharmacology and Therapeutics Unit, University Department of Clinical Neurology, London, UK
Pharmacol Ther 85:77-85. 2000..This profile may facilitate the clinical management of patients with epilepsy by providing a safer and less-complicated therapeutic strategy... 
Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic StrategiesPhilip N Patsalos
Institute of Neurology The National Hospital for Neurology and Neurosurgery, London and The Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom
Epilepsia 49:1239-76. 2008..g., in pregnancy, or when an interacting drug is added or removed); (6) to guide dose adjustments for AEDs with dose-dependent pharmacokinetics, particularly phenytoin...- Caffeine has no effect on measures of cortical excitabilityM Orth
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, London, UK
Clin Neurophysiol 116:308-14. 2005..To assess the effect of caffeine on motor thresholds, short interval intra-cortical inhibition (SICI), intra-cortical facilitation (ICF) and cortical silent periods in a placebo controlled double-blinded trial... - Carbamazepine toxicity during combination therapy with levetiracetam: a pharmacodynamic interactionSanjay M Sisodiya
Pharmacology and Therapeutics Unit, Department of Clinical and Experimental Epilepsy, University College London, UK
Epilepsy Res 48:217-9. 2002..Therefore, during levetiracetam co-medication with carbamazepine, patients should be monitored closely for symptoms of carbamazepine toxicity... - Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsyYvonne M Langan
Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, and The National Society for Epilepsy, Chalfont St Peter, UK
Epilepsia 44:46-53. 2003..Talampanel was well tolerated, although adverse events occurred at lower doses compared with those in healthy subjects, probably because of the additive effect of concomitant AEDs... 
A microdialysis study of the novel antiepileptic drug levetiracetam: extracellular pharmacokinetics and effect on taurine in rat brainX Tong
Pharmacology and Therapeutics Unit, University Department of Clinical Neurology, Institute of Neurology, Queen Square, London
Br J Pharmacol 133:867-74. 2001..Its prolonged efflux from and slow equilibration within the brain may explain, in part, its long duration of action. The concurrent changes in taurine may contribute to its mechanism of action...- Comparison of serum, cerebrospinal fluid and brain extracellular fluid pharmacokinetics of lamotrigineM C Walker
Epilepsy Research Group, Pharmacology and Therapeutics Unit, University Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N 3BG
Br J Pharmacol 130:242-8. 2000..Furthermore, the free serum drug concentration is not the sole contributor to the CSF compartment, and the CSF concentration is an overestimate of the bECF concentration of lamotrigine... - Antiepileptic drug pharmacokinetics and neuropharmacokinetics in individual rats by repetitive withdrawal of blood and cerebrospinal fluid: milacemideJ Semba
Epilepsy Research Group, University Department of Clinical Neurology, Queen Square, London
Br J Pharmacol 108:1117-24. 1993..6. In conclusion, serum milacemide rapidly enters and equilibrates with the CNS compartment where it is metabolised primarily by MAO-B to glycinamide and finally to glycine. Metabolism in the peripheral compartment is negligible... - Comparison of single- and repeated-dose pharmacokinetics of diazepamM C Walker
University Department of Clinical Neurology, Institute of Neurology, London, UK
Epilepsia 39:283-9. 1998.... - A high-performance liquid chromatography assay to monitor the new antiepileptic drug lacosamide in patients with epilepsyClare Greenaway
Department of Clinical and Experimental Epilepsy, Pharmacology and Therapeutics Unit, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Ther Drug Monit 32:448-52. 2010.... - Cortical excitability predicts seizures in acutely drug-reduced temporal lobe epilepsy patientsM-A S Y Wright
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, UK
Neurology 67:1646-51. 2006..001). CONCLUSIONS: Change in cortical excitability, measured with transcranial magnetic brain stimulation, may reflect a long-lasting and widespread pre-ictal state... - Blood and cerebrospinal fluid pharmacokinetics of primidone and its primary pharmacologically active metabolites, phenobarbital and phenylethylmalonamide in the ratS Nagaki
Pharmacolgy and Therapeutics Unit, University Department of Clinical Neurology, Institute of Neurology, London, UK
Eur J Drug Metab Pharmacokinet 24:255-64. 1999..CSF mean t(1/2) values for primidone, phenylethylmalonamide and phenobarbital were similar to those of sera and essentially paralleled the pattern seen in sera... - A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsyH C Doheny
Pharmacology and Therapeutics Unit, Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London WC1N 3BG, UK
Br J Pharmacol 135:1425-34. 2002..Furthermore, levetiracetam probably does not act by preventing ictogenesis per se but acts to reduce seizure severity and seizure generalization... - The pharmacokinetics of vigabatrin in rat blood and cerebrospinal fluidX Tong
Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
Seizure 16:43-9. 2007..We therefore investigated the rate of penetration into and the inter-relationship between serum and CSF compartments following systemic administration of vigabatrin in the rat... - Omega-3 fatty acid supplementation in patients with chronic epilepsy: a randomized trialAlan W C Yuen
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK
Epilepsy Behav 7:253-8. 2005..No change in serum AED concentrations was detected. Further studies are required to examine different omega-3 FA preparations, different doses, longer treatment duration, and larger sample sizes... - The pharmacokinetic inter-relationship of tiagabine in blood, cerebrospinal fluid and brain extracellular fluid (frontal cortex and hippocampus)Xiaolan Wang
Pharmacology and Therapeutics Unit, Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London WC1N 3BG, UK
Seizure 13:574-81. 2004..The observation that tiagabine elimination from the brain is threefold slower than that seen in blood, may explain as to the relatively long duration of action of tiagabine... - Erythrocyte and plasma fatty acid profiles in patients with epilepsy: does carbamazepine affect omega-3 fatty acid concentrations?Alan W C Yuen
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK
Epilepsy Behav 12:317-23. 2008.... - Synergism between topiramate and budipine in refractory status epilepticus in the ratAndrew Fisher
Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, London, United Kingdom
Epilepsia 45:1300-7. 2004..CONCLUSIONS: Budipine and TPM are an effective drug combination in stopping self-sustained status epilepticus, and TPM alone was neuroprotective, despite the continuation of seizure activity... - Vigabatrin extracellular pharmacokinetics and concurrent gamma-aminobutyric acid neurotransmitter effects in rat frontal cortex and hippocampus using microdialysisXin Tong
Department of Clinical and Experimental Epilepsy, Pharmacology and Therapeutics Unit, Institute of Neurology, London, United Kingdom
Epilepsia 50:174-83. 2009..hippocampus) and to ascertain the relationship between brain extracellular vigabatrin concentrations and concurrent gamma-aminobutyric acid (GABA) concentrations... - Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological studyR Katzenschlager
National Hospital for Neurology and Neurosurgery, London, UK
J Neurol Neurosurg Psychiatry 75:1672-7. 2004..Assessment of long term efficacy and tolerability in a randomised, controlled study is warranted... - The use of microdialysis for the study of drug kinetics: some methodological considerations illustrated with antipyrine in rat frontal cortexP N Patsalos
Pharmacology and Therapeutics Unit, University Department of Clinical Neurology, Queen Square, London
Br J Pharmacol 115:503-9. 1995..These considerations are particularly important in relation to microdialysis studies of pharmacokinetic-pharmacodynamic interrelationships and modelling... - A comparison of central brain (cerebrospinal and extracellular fluids) and peripheral blood kinetics of phenytoin after intravenous phenytoin and fosphenytoinXiaolan Wang
Pharmacology and Therapeutics Unit, Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London, UK
Seizure 12:330-6. 2003..Thus, overall, the central and peripheral kinetics of PHT are indistinguishable after PHT and FosPHT... - Long-term cohort study comparing medical (oxcarbazepine) and surgical management of intractable trigeminal neuralgiaJoanna M Zakrzewska
Oral Medicine, Dental Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Turner Street, 1E 2AD, London, UK
Pain 95:259-66. 2002..As these data cannot be extrapolated to other antineuralgic drugs, similar comparative studies would be appropriate... - Levetiracetam and felbamate interact both pharmacodynamically and pharmacokinetically: an isobolographic analysis in the mouse maximal electroshock modelJarogniew J Luszczki
Department of Pathophysiology, Medical University of Lublin, Jaczewskiego, Lublin, Poland
Epilepsia 48:806-15. 2007..The present study sought to ascertain the potential usefulness of levetiracetam (LEV) and felbamate (FBM) in combination in the mouse maximal electroshock (MES)-induced seizure model... - Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysisJarogniew J Luszczki
Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
Epilepsia 47:1841-54. 2006..The remaining combinations of STP with PB (1:1 and 3:1), CZP (1:3), ETS (1:3), and VPA (at all fixed ratios of 1:3, 1:1, and 3:1) do not appear to be potential favorable AED combinations... - Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshockKinga K Borowicz
Department of Pathophysiology, Medical University, Lublin, Poland
Epilepsy Behav 11:6-12. 2007..However, the concurrent pharmacokinetic interactions associated with remacemide complicate these observations and do not make remacemide a good candidate for adjunctive treatment of epilepsy... - Interactions between zonisamide and conventional antiepileptic drugs in the mouse maximal electroshock test modelKinga K Borowicz
Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
Eur Neuropsychopharmacol 17:265-72. 2007..Finally, one can conclude that because of the synergistic pharmacodynamic interaction between ZNS and VPA, this combination might be useful in clinical practice... - Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure modelJarogniew J Luszczki
Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090, Lublin, Poland
Naunyn Schmiedebergs Arch Pharmacol 373:169-81. 2006..Furthermore, the fact that LCZ and PB have similar mechanisms of action would suggest that drugs with similar mechanisms of action may provide rational polytherapy regimens... - Therapeutic drug monitoring of the newer antiepileptic drugsSvein I Johannessen
The National Center for Epilepsy, Sandvika, Norway, Carlo Besta, Milan, Italy
Ther Drug Monit 25:347-63. 2003..Although routine monitoring in general cannot be recommended at present, measurements of some of the drugs is undoubtedly of help with individualization of treatment in selected cases in a particular clinical setting... - Interlaboratory variability in the quantification of new generation antiepileptic drugs based on external quality assessment dataJohn Williams
Subcommission on Therapeutic Drug Monitoring and Pharmacokinetics, ILAE Commission on Therapeutic Strategies, Department of Pharmacology, Therapeutics and Toxicology, University of Wales College of Medicine, Heath Park, Cardiff, Wales
Epilepsia 44:40-5. 2003..To assess interlaboratory variability in the determination of serum levels of new antiepileptic drugs (AEDs)... - Pharmacodynamic and pharmacokinetic interaction studies of loreclezole with felbamate, lamotrigine, topiramate, and oxcarbazepine in the mouse maximal electroshock seizure modelJarogniew J Luszczki
Department of Pathophysiology, Skubiszewski Medical University of Lublin, Lublin, Poland
Epilepsia 46:344-55. 2005..LCZ and OXC also is a favorable combination. However, these conclusions are confounded by the fact that LCZ is associated with significant pharmacokinetic interactions... - Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysisJarogniew J Luszczki
Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
Epilepsy Behav 7:639-51. 2005..75-0.91) used in this study. However, these conclusions are confounded by the fact that LCZ is associated with significant pharmacokinetic interactions... - Pharmacodynamic and pharmacokinetic characterization of interactions between levetiracetam and numerous antiepileptic drugs in the mouse maximal electroshock seizure model: an isobolographic analysisJarogniew J Luszczki
Department of Pathophysiology, Medical University of Lublin, Lublin, Poland
Epilepsia 47:10-20. 2006..CONCLUSIONS: These preclinical data would suggest that LEV in combination with TPM is associated with beneficial anticonvulsant pharmacodynamic interactions. Similar, but less profound effects were seen with OXC and CBZ... - Isobolographic analysis of interactions between losigamone and conventional antiepileptic drugs in the mouse maximal electroshock modelKinga K Borowicz
Department of Pathophysiology, Lublin Medical University, Jaczewskiego 8, 20 090 Lublin, Poland
Eur Neuropsychopharmacol 17:94-101. 2007.... - Levetiracetam selectively potentiates the acute neurotoxic effects of topiramate and carbamazepine in the rotarod test in miceJarogniew J Luszczki
Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, 20 090 Lublin, Poland
Eur Neuropsychopharmacol 15:609-16. 2005..These data support both experimental and clinical published data advocating that LEV may interact with some AEDs by pharmacodynamic mechanisms... - Treatment of phenytoin toxicity by the molecular adsorbents recirculating system (MARS)Sambit Sen
Institute of Hepatology, University College London Medical School and University College London Hospitals, England
Epilepsia 44:265-7. 2003..CONCLUSIONS: The observed removal of PHT by MARS, along with the clinical improvement of the patient and reduction of the associated oxidative stress after treatment, indicates that MARS offers a promising option in PHT toxicity... - Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsyJarogniew J Luszczki
Department of Pathophysiology, Medical University, Lublin, Poland
Eur J Pharmacol 595:13-21. 2008..Vigabatrin and gabapentin have a favorable pharmacodynamic interaction in animal seizure models in the absence of acute adverse effects or concurrent pharmacokinetic changes... - Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in rat brain and retinaGraeme J Sills
Epilepsy Unit, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
Epilepsia 44:886-92. 2003..We compared the concentration-related effects of VGB in rat brain and eye with those of gabapentin (GBP) and topiramate (TPM), both of which have been reported to elevate brain GABA concentrations in humans...