J F Paton

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. doi request reprint Translational examination of changes in baroreflex function after renal denervation in hypertensive rats and humans
    Emma C Hart
    School of Physiology and Pharmacology, Bristol Heart Institute, Medical Science Bldg, University of Bristol, Bristol, United Kingdom
    Hypertension 62:533-41. 2013
  2. pmc Revelations about carotid body function through its pathological role in resistant hypertension
    Julian F R Paton
    School of Physiology and Pharmacology, Bristol Heart Institute, University of Bristol, Medical Sciences Building, Bristol, England, UK
    Curr Hypertens Rep 15:273-80. 2013
  3. doi request reprint Excessive leukotriene B4 in nucleus tractus solitarii is prohypertensive in spontaneously hypertensive rats
    Hidefumi Waki
    School of Physiology and Pharmacology, Bristol Heart Institute, Medical Sciences Building, University of Bristol, Bristol, United Kingdom
    Hypertension 61:194-201. 2013
  4. pmc Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat
    Ana P Abdala
    School of Physiology and Pharmacology, Bristol Heart Institute, Medical Science Building, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 590:4269-77. 2012
  5. pmc Cell- and region-specific miR30-based gene knock-down with temporal control in the rat brain
    Beihui Liu
    Department of Physiology and Pharmacology, Bristol Heart Institute, University of Bristol, UK
    BMC Mol Biol 11:93. 2010
  6. pmc Viral vectors based on bidirectional cell-specific mammalian promoters and transcriptional amplification strategy for use in vitro and in vivo
    Beihui Liu
    Department of Physiology and Pharmacology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    BMC Biotechnol 8:49. 2008
  7. doi request reprint Is neurogenic hypertension related to vascular inflammation of the brainstem?
    Julian F R Paton
    Department of Physiology and Pharmacology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Neurosci Biobehav Rev 33:89-94. 2009
  8. ncbi request reprint Vascular-brain signaling in hypertension: role of angiotensin II and nitric oxide
    Julian F R Paton
    Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Curr Hypertens Rep 9:242-7. 2007
  9. ncbi request reprint Response properties of baroreceptive NTS neurons
    J F Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Ann N Y Acad Sci 940:157-68. 2001
  10. ncbi request reprint Counterpoint: Medullary pacemaker neurons are essential for gasping, but not eupnea, in mammals
    Julian F R Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    J Appl Physiol 103:718-20; discussion 721-2. 2007

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. doi request reprint Translational examination of changes in baroreflex function after renal denervation in hypertensive rats and humans
    Emma C Hart
    School of Physiology and Pharmacology, Bristol Heart Institute, Medical Science Bldg, University of Bristol, Bristol, United Kingdom
    Hypertension 62:533-41. 2013
    ..Determining procedural success will be crucial in advancing this treatment modality. ..
  2. pmc Revelations about carotid body function through its pathological role in resistant hypertension
    Julian F R Paton
    School of Physiology and Pharmacology, Bristol Heart Institute, University of Bristol, Medical Sciences Building, Bristol, England, UK
    Curr Hypertens Rep 15:273-80. 2013
    ....
  3. doi request reprint Excessive leukotriene B4 in nucleus tractus solitarii is prohypertensive in spontaneously hypertensive rats
    Hidefumi Waki
    School of Physiology and Pharmacology, Bristol Heart Institute, Medical Sciences Building, University of Bristol, Bristol, United Kingdom
    Hypertension 61:194-201. 2013
    ..Thus, inflammatory reactions in the brain stem are causally associated with neurogenic hypertension...
  4. pmc Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat
    Ana P Abdala
    School of Physiology and Pharmacology, Bristol Heart Institute, Medical Science Building, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 590:4269-77. 2012
    ..In conclusion, carotid sinus nerve inputs from the carotid body are, in part, responsible for elevated sympathetic tone and critical for the genesis of hypertension in the developing SHR and its maintenance in later life...
  5. pmc Cell- and region-specific miR30-based gene knock-down with temporal control in the rat brain
    Beihui Liu
    Department of Physiology and Pharmacology, Bristol Heart Institute, University of Bristol, UK
    BMC Mol Biol 11:93. 2010
    ..We have evaluated this issue using a tetracycline (Tet)-controllable and cell-specific miRNA 30 (miR30)-based short hairpin (shRNA) interference system...
  6. pmc Viral vectors based on bidirectional cell-specific mammalian promoters and transcriptional amplification strategy for use in vitro and in vivo
    Beihui Liu
    Department of Physiology and Pharmacology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    BMC Biotechnol 8:49. 2008
    ..Originally TAS involved the use of two copies of a cell-specific promoter leading to generation of large expression cassettes, which can be hard to use given the space limitations of the conventional viral gene expression vectors...
  7. doi request reprint Is neurogenic hypertension related to vascular inflammation of the brainstem?
    Julian F R Paton
    Department of Physiology and Pharmacology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Neurosci Biobehav Rev 33:89-94. 2009
    ..High brainstem vascular resistance and its inflammation may release pathological paracrine signaling molecules affecting central neural cardiovascular activity conducive to neurogenic hypertension...
  8. ncbi request reprint Vascular-brain signaling in hypertension: role of angiotensin II and nitric oxide
    Julian F R Paton
    Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Curr Hypertens Rep 9:242-7. 2007
    ..We propose that eNOS-generated NO in the SHR may be a compensatory mechanism for any potential threat to an adequate blood supply to the brain (eg, from genetically small arteries supplying the brainstem)...
  9. ncbi request reprint Response properties of baroreceptive NTS neurons
    J F Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Ann N Y Acad Sci 940:157-68. 2001
    ..Modulation of such conductances during either physiological (exercise) or pathophysiological (essential hypertension) conditions may lead to changes in both the operating point and gain of the baroreceptor reflex...
  10. ncbi request reprint Counterpoint: Medullary pacemaker neurons are essential for gasping, but not eupnea, in mammals
    Julian F R Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    J Appl Physiol 103:718-20; discussion 721-2. 2007
  11. doi request reprint Signalling across the blood brain barrier by angiotensin II: novel implications for neurogenic hypertension
    Julian F R Paton
    Department of Physiology and Pharmacology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol, UK
    J Mol Med (Berl) 86:705-10. 2008
    ..We speculate on why eNOS activity may be up regulated in the NTS of the SHR and propose that it is a consequence of high cerebral vascular resistance and inadequate blood perfusion of the brainstem...
  12. pmc Central control of upper airway resistance regulating respiratory airflow in mammals
    Julian F R Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    J Anat 201:319-23. 2002
    ..Based on these data, we predict that periods of prolonged hypoxia, such as those that occur during sleep apnoeas, will constrain inspiratory glottic abduction thereby impeding inhalation...
  13. doi request reprint Harvey Cushing and the regulation of blood pressure in giraffe, rat and man: introducing 'Cushing's mechanism'
    J F R Paton
    Department of Physiology and Pharmacology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Exp Physiol 94:11-7. 2009
    ..If we are correct, future successful treatment of essential hypertension in man will include methods of reducing cerebral arterial resistance...
  14. ncbi request reprint In vivo gene transfer to dissect neuronal mechanisms regulating cardiorespiratory function
    Julian F R Paton
    Cardio Respiratory Control Group, Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, England
    Can J Physiol Pharmacol 81:311-6. 2003
    ..Our findings have led us to hypothesize a novel form of intercellular communication within the NTS, one of vascular-neuronal signaling...
  15. ncbi request reprint Reflexly evoked coactivation of cardiac vagal and sympathetic motor outflows: observations and functional implications
    Julian F R Paton
    Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol, UK
    Clin Exp Pharmacol Physiol 33:1245-50. 2006
    ..This may be important when pumping blood into a constricted vascular tree, such as is the case during the peripheral chemoreceptor reflex and the diving response...
  16. ncbi request reprint Long-term intracellular recordings of respiratory neuronal activities in situ during eupnea, gasping and blockade of synaptic transmission
    Julian F R Paton
    Department of Physiology, School of Medical Science, University of Bristol, Bristol, England BS8 1TD, UK
    J Neurosci Methods 147:138-45. 2005
    ....
  17. ncbi request reprint Detection of angiotensin II mediated nitric oxide release within the nucleus of the solitary tract using electron-paramagnetic resonance (EPR) spectroscopy
    J F R Paton
    Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    Auton Neurosci 126:193-201. 2006
    ..The present study supports the novel concept that AngII can trigger NO release in the NTS by a mechanism of vascular-neuronal signalling that affects central neuronal networks regulating cardiovascular function...
  18. ncbi request reprint Respiratory rhythm generation during gasping depends on persistent sodium current
    Julian F R Paton
    Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol, UK
    Nat Neurosci 9:311-3. 2006
    ..We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism...
  19. ncbi request reprint Neurokininergic mechanism within the lateral crescent nucleus of the parabrachial complex participates in the heart-rate response to nociception
    Pedro Boscan
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 25:1412-20. 2005
    ....
  20. ncbi request reprint Properties of solitary tract neurones responding to peripheral arterial chemoreceptors
    J F Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    Neuroscience 105:231-48. 2001
    ..In summary, this study provides new data on the neurophysiological, anatomical and morphological properties of nucleus of the solitary tract neurones responding to arterial chemoreceptors in the rat...
  21. pmc The ventral medullary respiratory network of the mature mouse studied in a working heart-brainstem preparation
    J F Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    J Physiol 493:819-31. 1996
    ..The possibility of a mutual inhibitory interaction between PreI and PI neurones is discussed in terms of the functional organization of the respiratory network in the mouse...
  22. pmc Adenoviral vector demonstrates that angiotensin II-induced depression of the cardiac baroreflex is mediated by endothelial nitric oxide synthase in the nucleus tractus solitarii of the rat
    J F Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 531:445-58. 2001
    ..Endothelial cells were also double labelled for eNOS and AT1 receptors. We suggest that ANGII activates eNOS located in either neurones and/or endothelial cells to release NO, which acts selectively to depress the baroreflex...
  23. pmc Differential effects of angiotensin II on cardiorespiratory reflexes mediated by nucleus tractus solitarii - a microinjection study in the rat
    J F Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 521:213-25. 1999
    ....
  24. pmc Differential effects of angiotensin II in the nucleus tractus solitarii of the rat--plausible neuronal mechanism
    S Kasparov
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 521:227-38. 1999
    ..The balance of these actions of ANGII could be reflex specific: for the baroreflex circuitry the inhibitory action might predominate while the peripheral chemoreceptor reflex may be facilitated due to enhanced excitatory transmission...
  25. ncbi request reprint Importance of neurokinin-1 receptors in the nucleus tractus solitarii of mice for the integration of cardiac vagal inputs
    J F Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    Eur J Neurosci 10:2261-75. 1998
    ..These data support a selective involvement of NK1 receptors in the transmission of cardiac vagal afferent inputs to NTS neurons integrating cardiorespiratory information...
  26. pmc Convergence properties of solitary tract neurones driven synaptically by cardiac vagal afferents in the mouse
    J F Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 508:237-52. 1998
    ..The specific convergence pattern of baroreceptors and chemoreceptors to these cardioreceptive NTS neurones is discussed in relation to a common afferent modality integration within the NTS...
  27. pmc Rhythmic bursting of pre- and post-inspiratory neurones during central apnoea in mature mice
    J F Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    J Physiol 502:623-39. 1997
    ..It is suggested that this rhythmic bursting depends on inhibitory connections from PreI neurones. The functional significance of these central 'apnoeic rhythms' are discussed...
  28. ncbi request reprint Similarities in reflex control of laryngeal and cardiac vagal motor neurones
    J F Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, UK
    Respir Physiol 119:101-11. 2000
    ..Our observations lend further support to models of cardiorespiratory control which propose close coupling and shared central mechanisms for the regulation of the cardiovascular and respiratory systems...
  29. ncbi request reprint Angiotensin II receptors within the nucleus of the solitary tract mediate the developmental attenuation of the baroreceptor vagal reflex in pre-weaned rats
    S Kasparov
    Department of Physiology, University of Bristol, UK
    J Auton Nerv Syst 74:160-8. 1998
    ..An AT2-antagonist, PD123-319 did not restore the BVR sensitivity in pre-weaned rats. Thus, AT1 receptors located within the NTS play a pivotal role in the developmental attenuation of the BVR in pre-weaned rats...
  30. pmc Disinhibition of the cardiac limb of the arterial baroreflex in rat: a role for metabotropic glutamate receptors in the nucleus tractus solitarii
    Annabel E Simms
    Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 575:727-38. 2006
    ....
  31. ncbi request reprint Cardiorespiratory reflexes in mice
    J F Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    J Auton Nerv Syst 68:115-24. 1998
    ..It is concluded that the qualitatively similar reflex performances between the in vivo anaesthetised mouse and the WHBP make the latter an adequate model for studying central mechanisms controlling the cardiorespiratory system...
  32. ncbi request reprint Glutamate stimulation of raphe pallidus attenuates the cardiopulmonary reflex in anaesthetised rats
    E Edwards
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    Auton Neurosci 82:87-96. 2000
    ..We propose that neurones in raphe pallidus that project to the NTS can release serotonin which acts via 5-HT4 receptors to attenuate the reflex phrenic nerve activity and heart rate components of the cardiopulmonary reflex...
  33. ncbi request reprint Respiratory activity in neonatal rats
    M Dutschmann
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    Auton Neurosci 84:19-29. 2000
    ..We conclude that the neonatal rat WHBP is an in situ preparation because it produces a respiratory rhythm similar to that of adult in vivo mammal preparations but distinct from in vitro preparations...
  34. ncbi request reprint Baroreflex inhibition of cardiac sympathetic outflow is attenuated by angiotensin II in the nucleus of the solitary tract
    P Boscan
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Neuroscience 103:153-60. 2001
    ..We suggest that our data may have clinical implications relating to hypertension, a condition when angiotensin II activity is heightened in the brain and the efficacy of the baroreflex is reduced...
  35. pmc Chronic inhibition of endothelial nitric oxide synthase activity in nucleus tractus solitarii enhances baroreceptor reflex in conscious rats
    Hidefumi Waki
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 546:233-42. 2003
    ..p.m., n = 4, P < 0.05). Gene transfer did not affect arterial pressure. These findings suggest that in the conscious rat eNOS is constitutively active within the NTS and is a factor regulating baroreceptor reflex gain and heart rate...
  36. ncbi request reprint Differential sensitivity of excitatory and inhibitory synaptic transmission to modulation by nitric oxide in rat nucleus tractus solitarii
    Sheng Wang
    Department of Physiology, School of Medical Sciences, Bristol Heart Institute, University of Bristol, Bristol, BS8 1TD, UK
    Exp Physiol 92:371-82. 2007
    ..This differential sensitivity of excitatory and inhibitory connections to NO may be important for determining the specificity of the effects of this freely diffusible gaseous messenger...
  37. ncbi request reprint Unravelling mechanisms of action of angiotensin II on cardiorespiratory function using in vivo gene transfer
    J F Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, UK
    Acta Physiol Scand 173:127-37. 2001
    ..These data have relevance to patients with essential hypertension and left heart failure, conditions in which ANGII activity is elevated and the baroreceptor reflex is depressed...
  38. ncbi request reprint The Sharpey-Schafer prize lecture: nucleus tractus solitarii: integrating structures
    J F Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Exp Physiol 84:815-33. 1999
    ..The lecture attempts to demonstrate why this is important for enhancing the functional significance and relevance of physiological data as well as for validating predictions...
  39. ncbi request reprint Cardiorespiratory reflexes in a working heart-brainstem preparation of the house musk shrew, Suncus murinus
    J E Smith
    Department of Physiology, St George s Hospital Medical School, London, UK
    Auton Neurosci 89:54-9. 2001
    ..We conclude that viable WHBP can be prepared from Suncus and that Suncus WHBP is a novel non-rodent model in which to study brainstem-mediated reflexes...
  40. ncbi request reprint A working heart-brainstem preparation of the mouse
    J F Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    J Neurosci Methods 65:63-8. 1996
    ..The WH-BP may provide an advantaged environment for analysis of both synaptic and cellular mechanisms within the medulla that regulate cardio-respiratory activity...
  41. ncbi request reprint Effect of anesthetic on sympathetic responses evoked from cerebellar uvula in decerebrate cats
    J F Paton
    Department of Physiology, Royal Free Hospital School of Medicine, London, United Kingdom
    Am J Physiol 263:H1285-91. 1992
    ..It appears that anesthesia does not block the sympathoexcitatory response but acts to augment sympathoinhibitory processes associated with uvula stimulation; some possible mechanisms are discussed...
  42. ncbi request reprint Somatic gene transfer: implications for cardiovascular control
    S Kasparov
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    Exp Physiol 85:747-55. 2000
    ..We conclude that the use of adenoviruses to manipulate genes offers a new avenue for physiologists studying neuronal mechanisms in integrative models...
  43. ncbi request reprint Role of the solitary tract nucleus in mediating nociceptive evoked cardiorespiratory responses
    P Boscan
    Department of Physiology, School of Medical Science, University of Bristol, Bristol, BS8 1TD, UK
    Auton Neurosci 86:170-82. 2001
    ..In the WHBP, NTS neurones appear important for mediating the cardiac component of the reflex response following stimulation of nociceptive reflex pathways...
  44. ncbi request reprint Dynamic exercise attenuates spontaneous baroreceptor reflex sensitivity in conscious rats
    Hidefumi Waki
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Exp Physiol 88:517-26. 2003
    ....
  45. pmc Hierarchical recruitment of the sympathetic and parasympathetic limbs of the baroreflex in normotensive and spontaneously hypertensive rats
    Annabel E Simms
    Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 579:473-86. 2007
    ....
  46. ncbi request reprint Genetic and pharmacological dissection of pathways involved in the angiotensin II-mediated depression of baroreflex function
    Liang Fong Wong
    University Research Centre for Neuroendocrinology, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    FASEB J 16:1595-601. 2002
    ..In contrast, multiple site disruption of a pathway leading to eNOS activation via the serine/threonine kinase Akt was ineffective..
  47. ncbi request reprint Endothelial NO synthase activity in nucleus tractus solitarii contributes to hypertension in spontaneously hypertensive rats
    Hidefumi Waki
    Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    Hypertension 48:644-50. 2006
    ..Thus, endogenous eNOS activity in the NTS plays a major role in determining the set point of arterial pressure in the SHR and contributes to maintaining high arterial blood pressure in this animal model of human hypertension...
  48. pmc GABA(A) receptor epsilon-subunit may confer benzodiazepine insensitivity to the caudal aspect of the nucleus tractus solitarii of the rat
    S Kasparov
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 536:785-96. 2001
    ..This is the first demonstration of a possible physiological impact of the epsilon-subunit on native GABA(A) receptors...
  49. ncbi request reprint Evidence for cardiovascular autonomic dysfunction in neonates with coarctation of the aorta
    Jaimie W Polson
    Department of Clinical Sciences at South Bristol, School of Medical Sciences, Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
    Circulation 113:2844-50. 2006
    ..We hypothesized that early pathological adjustment of autonomic cardiovascular function may already be established in the neonate with coarctation...
  50. ncbi request reprint Junctional adhesion molecule-1 is upregulated in spontaneously hypertensive rats: evidence for a prohypertensive role within the brain stem
    Hidefumi Waki
    Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    Hypertension 49:1321-7. 2007
    ..When JAM-1 is expressed in the nucleus tractus solitarii, it raises arterial pressure, suggesting a novel prohypertensive role for this protein within the brain stem...
  51. ncbi request reprint A micro-optrode for simultaneous extracellular electrical and intracellular optical recording from neurons in an intact oscillatory neuronal network
    Peter M J Bradley
    Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Neurosci Methods 168:383-95. 2008
    ....
  52. doi request reprint Kidney-induced hypertension depends on superoxide signaling in the rostral ventrolateral medulla
    Elizabeth B Oliveira-Sales
    Department of Physiology and Pharmacology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, UK
    Hypertension 56:290-6. 2010
    ..In Goldblatt hypertension, superoxide signaling in the RVLM plays a major role in the generation of sympathetic vasomotor tone and the chronic sustained hypertension in this animal model...
  53. pmc Area-specific differences in transmitter release in central catecholaminergic neurons of spontaneously hypertensive rats
    Anja G Teschemacher
    Department of Physiology and Pharmacology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS81TD, United Kingdom
    Hypertension 52:351-8. 2008
    ..Both effects could contribute to elevated sympathetic activity and blood pressure in the spontaneously hypertensive rat...
  54. pmc Chronic blockade of phosphatidylinositol 3-kinase in the nucleus tractus solitarii is prohypertensive in the spontaneously hypertensive rat
    Jasenka Zubcevic
    Department of Physiology and Pharmacology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, United Kingdom
    Hypertension 53:97-103. 2009
    ..7+/-0.07 to 0.5+/-0.04 ms/mm Hg; P<0.001) in the SHRs. Thus, PI3K signaling in the nucleus tractus solitarii of SHR restrains arterial pressure in this animal model of neurogenic hypertension...
  55. ncbi request reprint Nitric oxide and autonomic control of heart rate: a question of specificity
    Julian F R Paton
    Dept of Physiology, School of Medical Sciences, University of Bristol, UK
    Trends Neurosci 25:626-31. 2002
    ....
  56. pmc Sensory afferent selective role of P2 receptors in the nucleus tractus solitarii for mediating the cardiac component of the peripheral chemoreceptor reflex in rats
    Julian F R Paton
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 2TD, UK
    J Physiol 543:995-1005. 2002
    ..This effect is highly selective in that the chemoreceptor afferent-evoked tachypnoea, as well as other visceral receptor-mediated reflex bradycardia, remain unaffected...
  57. ncbi request reprint Excitatory convergence of periaqueductal gray and somatic afferents in the solitary tract nucleus: role for neurokinin 1 receptors
    Pedro Boscan
    Department of Physiology, School of Medical Sciences, University of Bristol, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 288:R262-9. 2005
    ..01). We conclude that 1) somatic brachial and PAG afferents can converge onto single NTS neurons; 2) this convergence occurs via either direct or indirect pathways; and 3) NK(1) receptors are activated by some of these inputs...
  58. ncbi request reprint An arterially-perfused trunk-hindquarters preparation of adult mouse in vitro
    B A Chizh
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    J Neurosci Methods 76:177-82. 1997
    ..The choice of the mouse will furthermore permit studies to be performed on genetically mutant strains...
  59. ncbi request reprint Osmotic regulation of neuronal nitric oxide synthase expression in the rat amygdala: functional role for nitric oxide in adaptive responses?
    Song T Yao
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, United Kingdom
    J Neurosci Res 85:410-22. 2007
    ....
  60. doi request reprint Dominant role of aortic baroreceptors in the cardiac baroreflex of the rat in situ
    Anthony E Pickering
    Department of Physiology and Pharmacology, Bristol Heart Institute, School of Medical Sciences, University Walk, University of Bristol, Bristol BS81TD, UK
    Auton Neurosci 142:32-9. 2008
    ....
  61. pmc Nociception attenuates parasympathetic but not sympathetic baroreflex via NK1 receptors in the rat nucleus tractus solitarii
    Anthony E Pickering
    Sir Humphry Davy Department of Anaesthesia, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    J Physiol 551:589-99. 2003
    ..Further, these findings confirm that baroreflex sympathetic and parasympathetic pathways diverge, and can be independently controlled, within the NTS...
  62. ncbi request reprint Mechanism of nitric oxide action on inhibitory GABAergic signaling within the nucleus tractus solitarii
    Sheng Wang
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    FASEB J 20:1537-9. 2006
    ..Thus, the NO-cGMP-cADPR-Ca2+ pathway, previously described in sea urchin eggs, also operates in mammalian GABAergic neurons. Potentiation of GABA release by NO may have implications for numerous brain functions...
  63. ncbi request reprint Investigation of systemic bupivacaine toxicity using the in situ perfused working heart-brainstem preparation of the rat
    Anthony E Pickering
    Sir Humphry Davy Department of Anaesthesia, Royal Infirmary, University of Bristol, Bristol BS2 8HW, UK
    Anesthesiology 97:1550-6. 2002
    ..The study tested the hypothesis that systemic bupivacaine has toxic effects on brainstem cardiorespiratory control...
  64. doi request reprint The transcriptome of the medullary area postrema: the thirsty rat, the hungry rat and the hypertensive rat
    Charles C T Hindmarch
    The Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol BS1 3NY, UK
    Exp Physiol 96:495-504. 2011
    ..Finally, analysis of these 'hypertension-related' elements revealed genes that are involved in the regulation of both blood pressure and immune function and as such are excellent targets for further study...
  65. ncbi request reprint Somatic nociception activates NK1 receptors in the nucleus tractus solitarii to attenuate the baroreceptor cardiac reflex
    Pedro Boscan
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Eur J Neurosci 16:907-20. 2002
    ..We conclude that nociceptive afferents activate NK1 receptors, which in turn excite GABAergic interneurons impinging on cells mediating the cardiac component of the baroreceptor reflex...
  66. ncbi request reprint Integration of cornea and cardiorespiratory afferents in the nucleus of the solitary tract of the rat
    Pedro Boscan
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    Am J Physiol Heart Circ Physiol 282:H1278-87. 2002
    ..Thus the NTS integrates information from corneal receptors, some of which converges onto neurons mediating reflexes from baroreceptors and chemoreceptors to inhibit these inputs...
  67. ncbi request reprint Restraining influence of A2 neurons in chronic control of arterial pressure in spontaneously hypertensive rats
    Hanad Duale
    Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK
    Cardiovasc Res 76:184-93. 2007
    ..We aimed to genetically target A2 neurons and induce expression of a potassium channel to reduce their electrical excitability and study how this impacts on long-term blood pressure control...
  68. doi request reprint NOS antagonism using viral vectors as an experimental strategy: implications for in vivo studies of cardiovascular control and peripheral neuropathies
    Beihui Liu
    Department of Physiology and Pharmacology, University of Bristol, Bristol, UK
    Methods Mol Biol 704:197-223. 2011
    ....
  69. ncbi request reprint Automation of analysis of cardiovascular autonomic function from chronic measurements of arterial pressure in conscious rats
    Hidefumi Waki
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Exp Physiol 91:201-13. 2006
    ..Moreover, we have confirmed its versatility by demonstrating its application to man...
  70. ncbi request reprint Water deprivation increases the expression of neuronal nitric oxide synthase (nNOS) but not orexin-A in the lateral hypothalamic area of the rat
    Song T Yao
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
    J Comp Neurol 490:180-93. 2005
    ..This altered neurochemistry within the LHA further highlights the potential importance of nitric oxide and the LHA in central regulation of fluid homeostasis...
  71. ncbi request reprint A decerebrate, artificially-perfused in situ preparation of rat: utility for the study of autonomic and nociceptive processing
    Anthony E Pickering
    Department of Anaesthesia, Bristol Royal Infirmary, University of Bristol, Bristol BS2 8HW, UK
    J Neurosci Methods 155:260-71. 2006
    ..The decerebrate, artificially-perfused rat (DAPR) provides a powerful methodology with which to study peripheral and central control of the autonomic nervous system with many of the benefits of an in vitro environment...
  72. pmc Macrophage migration inhibitory factor in the paraventricular nucleus plays a major role in the sympathoexcitatory response to salt
    Eduardo Colombari
    School of Physiology and Pharmacology, Bristol Heart Institute, University of Bristol, Bristol, UK
    Hypertension 56:956-63. 2010
    ..05). We propose that MIF acting within the PVN is a major counterregulator of HS-induced sympathoexcitation, an effect that depends on thiol-protein oxidoreductase activity...
  73. ncbi request reprint Differences in transductional tropism of adenoviral and lentiviral vectors in the rat brainstem
    Hanad Duale
    Department of Pharmacology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Exp Physiol 90:71-8. 2005
    ..Thus, the present study provides compelling evidence that VSVG-coated LVVs significantly shift transgene expression towards neurones while transduction with AVVs favours glia...
  74. ncbi request reprint The nucleus of the solitary tract: an integrating station for nociceptive and cardiorespiratory afferents
    Pedro Boscan
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Exp Physiol 87:259-66. 2002
    ..The functional interpretation we propose is that by depressing homeostatic reflexes at the NTS, noxious stimulation-evoked cardiorespiratory changes can be expressed and maintained, which may be essential for the survival of the animal...
  75. pmc Correction of respiratory disorders in a mouse model of Rett syndrome
    Ana P L Abdala
    Department of Physiology and Pharmacology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    Proc Natl Acad Sci U S A 107:18208-13. 2010
    ..The results indicate that GABA and serotonin 1a receptor activity are candidates for treatment of the respiratory disorders in Rett syndrome...
  76. ncbi request reprint Characterisation of c-Fos expression in the central nervous system of mice following right atrial injections of the 5-HT3 receptor agonist phenylbiguanide
    Annick de Vries
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, Bristol, UK
    Auton Neurosci 123:62-75. 2005
    ....
  77. pmc Elevated vertebrobasilar artery resistance in neonatal spontaneously hypertensive rats
    Matthew J Cates
    School of Physiology and Pharmacology, Bristol Heart Institute, Medical Sciences Bldg, University of Bristol, Bristol BS8 1TD, UK
    J Appl Physiol (1985) 111:149-56. 2011
    ....
  78. doi request reprint Surgical approach for aortic coarctation influences arterial compliance and blood pressure control
    Damien Kenny
    Bristol Congenital Heart Centre, Bristol Royal Hospital for Children, Bristol, United Kingdom
    Ann Thorac Surg 90:600-4. 2010
    ....
  79. ncbi request reprint Inhibitory synaptic mechanisms regulating upper airway patency
    Mathias Dutschmann
    Department of Animal Physiology, University of Tubingen, Auf der Morgenstelle 28, 72076 Tubingen, Germany
    Respir Physiol Neurobiol 131:57-63. 2002
    ..The effect of blocking glycine receptors was the same in both mature and newborn rats suggesting that glycinergic inhibition is essential for co-ordinating cranial and spinal motor outputs from birth...
  80. ncbi request reprint Potential switch from eupnea to fictive gasping after blockade of glycine transmission and potassium channels
    Walter M St -John
    Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Am J Physiol Regul Integr Comp Physiol 283:R721-31. 2002
    ..Results are consistent with the concept that the elicitation of gasping represents a switch from a network-based rhythmogenesis for eupnea to a pacemaker-driven mechanism...
  81. ncbi request reprint Neurogenesis of gasping does not require inhibitory transmission using GABA(A) or glycine receptors
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03755, USA
    Respir Physiol Neurobiol 132:265-77. 2002
    ..We conclude that the neurogenesis of gasping is not dependent upon fast, chloride-mediated inhibitory synaptic transmission...
  82. ncbi request reprint Trigeminal reflex regulation of the glottis depends on central glycinergic inhibition in the rat
    Mathias Dutschmann
    Department of Animal Physiology, University of Tubingen, Auf der Morgenstelle 28, 72076 Tubingen, Germany
    Am J Physiol Regul Integr Comp Physiol 282:R999-R1005. 2002
    ..Thus the integrity of glycinergic inhibition within the pontomedullary respiratory network is critical for the coordination of cranial and spinal motor outflows during eupnea but also for protective reflex regulation of the upper airway...
  83. ncbi request reprint Respiratory rhythm entrainment by somatic afferent stimulation
    Jeffrey T Potts
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosci 25:1965-78. 2005
    ....
  84. ncbi request reprint Endogenous rhythm generation in the pre-Bötzinger complex and ionic currents: modelling and in vitro studies
    Ilya A Rybak
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Eur J Neurosci 18:239-57. 2003
    ..These findings are discussed in the context of the role of endogenous bursting activity in the respiratory rhythm generation in vivo vs. in vitro and during normal breathing in vivo vs. gasping...
  85. pmc Increased sympathetic outflow in juvenile rats submitted to chronic intermittent hypoxia correlates with enhanced expiratory activity
    Daniel B Zoccal
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
    J Physiol 586:3253-65. 2008
    ..Thus, CIH alters the coupling between the central respiratory generator and sympathetic networks that may contribute to the induced hypertension in this experimental model...
  86. ncbi request reprint Dynamic changes in glottal resistance during exposure to severe hypoxia in neonatal rats in situ
    Mathias Dutschmann
    Department of Physiology, University of Gottingen, 37076 Göttingen, Germany
    Pediatr Res 58:193-8. 2005
    ..The latter is of clinical interest, because this may relate to the finding of cot death victims who died as a result of upper airway obstruction but without apparent apnea or rebreathing...
  87. ncbi request reprint Role of pontile mechanisms in the neurogenesis of eupnea
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Borwell Bldg, Lebanon, NH 03756, USA
    Respir Physiol Neurobiol 143:321-32. 2004
    ..Evidence from previous studies that support the validity of these criteria is presented herein. We conclude that pontile mechanisms play a critical role in the neurogenesis of eupnea...
  88. ncbi request reprint Uncoupling of rhythmic hypoglossal from phrenic activity in the rat
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Exp Physiol 89:727-37. 2004
    ..Indeed, our results establish that hypoglossal discharge alone is an equivocal index of the pattern of overall ventilatory activity and that this is accentuated by hypercapnia and hypothermia...
  89. ncbi request reprint Optical imaging of medullary ventral respiratory network during eupnea and gasping in situ
    Jeffrey T Potts
    Department of Biomedical Science, College of Veterinary Medicine, Dalton Cardiovascular Research Center, University of Missouri, 134 Research Park Dr, Columbia, 65211, USA
    Eur J Neurosci 23:3025-33. 2006
    ....
  90. ncbi request reprint Maintenance of eupnea of in situ and in vivo rats following riluzole: a blocker of persistent sodium channels
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Borwell Bldg, Lebanon, NH 03756, USA
    Respir Physiol Neurobiol 155:97-100. 2007
    ..These administrations did cause sedation. We conclude that conductance through persistent sodium channels plays little role in the neurogenesis of eupnea...
  91. ncbi request reprint Defining eupnea
    Walter M St -John
    Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Respir Physiol Neurobiol 139:97-103. 2003
    ....
  92. ncbi request reprint Angiotensin type 1 receptor immunoreactivity in the thoracic spinal cord
    Zai Ahmad
    School of Biomedical Sciences, The Worsley Building, University of Leeds, Leeds LS2 9NQ, UK
    Brain Res 985:21-31. 2003
    ..These data show that the AT1R in the spinal cord is ideally located to influence autonomic outflow and hence participate in the CNS determination of blood pressure...
  93. ncbi request reprint Ischaemia-induced sympathoexcitation in spinalyzed rats
    Valdir A Braga
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Neurosci Lett 415:73-6. 2007
    ..We propose that neural mechanisms within the cervical-thoracic segments can make a substantial contribution to the sympathoexcitatory response during systemic ischaemia...
  94. pmc Involvement of L-glutamate and ATP in the neurotransmission of the sympathoexcitatory component of the chemoreflex in the commissural nucleus tractus solitarii of awake rats and in the working heart-brainstem preparation
    Valdir A Braga
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
    J Physiol 581:1129-45. 2007
    ..We conclude that glutamatergic and purinergic mechanisms are part of the complex neurotransmission system of the sympathoexcitatory component of the chemoreflex at the level of the commissural NTS...
  95. ncbi request reprint Respiratory-modulated neuronal activities of the rostral medulla which may generate gasping
    Walter M St-John
    Department of Physiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03755, USA
    Respir Physiol Neurobiol 135:97-101. 2003
    ..This discharge peaked at the onset of the gasp and then decremented during neural inspiration. We hypothesize that these 'pre-inspiratory' neuronal activities generate the gasp by intrinsic pacemaker mechanisms...
  96. ncbi request reprint Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo
    Jason E Coleman
    Department of Neuroscience, University of Florida McKnight Brain Institute and College of Medicine, Gainesville, FL 32610 0255, USA
    Physiol Genomics 12:221-8. 2003
    ..The method is reproducible and can be scaled up to facilitate the use of these vectors in animal studies...
  97. ncbi request reprint An arterially perfused decerebrate preparation of Suncus murinus (house musk shrew) for the study of emesis and swallowing
    Julia E Smith
    Exp Physiol 87:563-74. 2002
    ..0001). We conclude that the emetic reflex can be activated in our Suncus preparations and that this non-sentient small adult animal model can now be used to study the neurophysiology and pharmacology of swallowing and emesis...
  98. pmc Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generation
    Ilya A Rybak
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Prog Brain Res 165:201-20. 2007
    ..The model predicts a continuum of respiratory network states relying on different contributions of intrinsic cellular properties versus synaptic interactions for the generation and control of the respiratory rhythm and pattern...
  99. doi request reprint Pontomedullary transection attenuates central respiratory modulation of sympathetic discharge, heart rate and the baroreceptor reflex in the in situ rat preparation
    David M Baekey
    Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Case Western Reserve University, 11100 Euclid Avenue, Room 622 Mailstop 5067, Cleveland, OH 44106 5067, USA
    Exp Physiol 93:803-16. 2008
    ..both bradycardia and sympathoinhibition) was abolished after pontine removal. We propose that neural activity of the pons is essential for physiological coupling of centrally generated respiratory and cardiovascular efferent activities...
  100. ncbi request reprint Ionic currents and endogenous rhythm generation in the pre-Bötzinger complex: modelling and in vitro studies
    Olivier Pierrefiche
    GRAP JE UFR de Pharmacie, 80036 Amiens, France
    Adv Exp Med Biol 551:121-6. 2004
  101. ncbi request reprint Modelling respiratory rhythmogenesis: focus on phase switching mechanisms
    Ilya A Rybak
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 551:189-94. 2004