Steve Paterson

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. ncbi request reprint The immunology and ecology of co-infection
    Steve Paterson
    Institute of Integrative Biology, University of Liverpool, Liverpool, UK
    Mol Ecol 22:2603-4. 2013
  2. doi request reprint How effective is recognition of siblings on the basis of genotype?
    S Paterson
    School of Biological Sciences, University of Liverpool, Liverpool, UK
    J Evol Biol 22:1875-81. 2009
  3. pmc Immunological responses elicited by different infection regimes with Strongyloides ratti
    Steve Paterson
    School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 3:e2509. 2008
  4. ncbi request reprint No evidence for specificity between host and parasite genotypes in experimental Strongyloides ratti (Nematoda) infections
    S Paterson
    School of Biological Sciences, University of Liverpool, UK
    Int J Parasitol 35:1539-45. 2005
  5. pmc Experimental evolution of parasite life-history traits in Strongyloides ratti (Nematoda)
    Steve Paterson
    School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
    Proc Biol Sci 274:1467-74. 2007
  6. pmc Density-dependent immune responses against the gastrointestinal nematode Strongyloides ratti
    Colin Bleay
    School of Biological Sciences, University of Bristol, Bristol, UK
    Int J Parasitol 37:1501-9. 2007
  7. doi request reprint Effects of abundance on infection in natural populations: field voles and cowpox virus
    Michael Begon
    School of Biological Sciences, The University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7ZB, UK
    Epidemics 1:35-46. 2009
  8. pmc Identification of novel aspartic proteases from Strongyloides ratti and characterisation of their evolutionary relationships, stage-specific expression and molecular structure
    Luciane V Mello
    University of Liverpool, UK
    BMC Genomics 10:611. 2009
  9. pmc Sub-inhibitory concentrations of some antibiotics can drive diversification of Pseudomonas aeruginosa populations in artificial sputum medium
    Elli A Wright
    Institute of Infection and Global Health, University of Liverpool, The Ronald Ross Building, 8 West Derby Street, Liverpool, L69 7BE, UK
    BMC Microbiol 13:170. 2013
  10. doi request reprint Evidence for selection at cytokine loci in a natural population of field voles (Microtus agrestis)
    Andrew K Turner
    Institute of Integrative Biology, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
    Mol Ecol 21:1632-46. 2012

Detail Information

Publications36

  1. ncbi request reprint The immunology and ecology of co-infection
    Steve Paterson
    Institute of Integrative Biology, University of Liverpool, Liverpool, UK
    Mol Ecol 22:2603-4. 2013
    ..In this issue of Molecular Ecology, Friberg et al. (2013) ask what effect worm infections have on a host's ability to mount antimicrobial responses...
  2. doi request reprint How effective is recognition of siblings on the basis of genotype?
    S Paterson
    School of Biological Sciences, University of Liverpool, Liverpool, UK
    J Evol Biol 22:1875-81. 2009
    ..Nevertheless, incorporating partial-matching information across multiple, independent loci are likely to be difficult. Further empirical work needs to establish the mechanistic basis of genetic kin recognition used by different taxa...
  3. pmc Immunological responses elicited by different infection regimes with Strongyloides ratti
    Steve Paterson
    School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 3:e2509. 2008
    ..ratti IgG(1) and IgG(2a) and RMCPII were affected. However, these differences were quantitatively relatively modest compared with the temporal dynamics of the anti-S. ratti immune response as a whole...
  4. ncbi request reprint No evidence for specificity between host and parasite genotypes in experimental Strongyloides ratti (Nematoda) infections
    S Paterson
    School of Biological Sciences, University of Liverpool, UK
    Int J Parasitol 35:1539-45. 2005
    ..It is concluded that a specificity between host and parasite genotypes is unlikely in this system...
  5. pmc Experimental evolution of parasite life-history traits in Strongyloides ratti (Nematoda)
    Steve Paterson
    School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
    Proc Biol Sci 274:1467-74. 2007
    ..Our results confirm the general prediction that parasite life-history traits can evolve in response to selection and indicate that such evolutionary responses may have significant implications for the epidemiology of infectious disease...
  6. pmc Density-dependent immune responses against the gastrointestinal nematode Strongyloides ratti
    Colin Bleay
    School of Biological Sciences, University of Bristol, Bristol, UK
    Int J Parasitol 37:1501-9. 2007
    ..Parasite survivorship was significantly negatively related to the concentration of parasite-specific IgG(1) and IgA, whereas parasite fecundity was significantly negatively related to the concentration of IgA only...
  7. doi request reprint Effects of abundance on infection in natural populations: field voles and cowpox virus
    Michael Begon
    School of Biological Sciences, The University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7ZB, UK
    Epidemics 1:35-46. 2009
    ..Nonetheless, overall, we contend that while monitoring numbers susceptible has most to offer, monitoring overall abundance may provide valuable insights into the dynamics of infection...
  8. pmc Identification of novel aspartic proteases from Strongyloides ratti and characterisation of their evolutionary relationships, stage-specific expression and molecular structure
    Luciane V Mello
    University of Liverpool, UK
    BMC Genomics 10:611. 2009
    ..In the present work, we investigate the evolution and expression of aspartic proteases in Strongyloides ratti, which permits a unique comparison between parasitic and free-living adult forms within its life-cycle...
  9. pmc Sub-inhibitory concentrations of some antibiotics can drive diversification of Pseudomonas aeruginosa populations in artificial sputum medium
    Elli A Wright
    Institute of Infection and Global Health, University of Liverpool, The Ronald Ross Building, 8 West Derby Street, Liverpool, L69 7BE, UK
    BMC Microbiol 13:170. 2013
    ..We then characterised diversification with respect to 13 phenotypic and genotypic characteristics...
  10. doi request reprint Evidence for selection at cytokine loci in a natural population of field voles (Microtus agrestis)
    Andrew K Turner
    Institute of Integrative Biology, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
    Mol Ecol 21:1632-46. 2012
    ..These results also suggest that, along with the MHC, preservation of genetic variation within cytokine genes should be a priority for the conservation genetics of threatened wildlife populations...
  11. pmc The effect of host heterogeneity and parasite intragenomic interactions on parasite population structure
    Ruth Hamilton
    School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK
    Proc Biol Sci 272:1647-53. 2005
    ..A key finding is that polymorphism is not stable and that, with respect to functionally important antigenic peptides, parasite populations are dominated by a single genotype...
  12. doi request reprint Microarray analysis of gender- and parasite-specific gene transcription in Strongyloides ratti
    Helen Evans
    School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK
    Int J Parasitol 38:1329-41. 2008
    ..The present findings for S. ratti provide a basis for a detailed exploration of differentially regulated molecules and might assist in the search for novel drug or vaccine targets in parasitic nematodes...
  13. pmc Seasonal host dynamics drive the timing of recurrent epidemics in a wildlife population
    Michael Begon
    School of Biological Sciences, The University of Liverpool, Liverpool L69 7ZB, UK
    Proc Biol Sci 276:1603-10. 2009
    ..Model results emphasize the importance of the interplay between seasonal infection and recruitment and suggest that our empirical patterns have a relevance extending beyond our own system...
  14. ncbi request reprint The effect of the host immune response on the parasitic nematode Strongyloides ratti
    C P Wilkes
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    Parasitology 128:661-9. 2004
    ..This description of these phenomena pave the way for a molecular biological analysis of how these changes in infection parameters are brought about by the host immune response...
  15. ncbi request reprint Host immune responses are necessary for density dependence in nematode infections
    S Paterson
    School of Biological Sciences, University of Bristol, UK
    Parasitology 125:283-92. 2002
    ..We conclude that density-dependent effects due to the immune response will act to regulate S. ratti infections before competition for space or nutrients within the host gut ever occurs...
  16. pmc Parasite interactions in natural populations: insights from longitudinal data
    S Telfer
    School of Biological Sciences, University of Liverpool, Biosciences Building, Liverpool L69 7LB, UK
    Parasitology 135:767-81. 2008
    ....
  17. pmc Baculum morphology predicts reproductive success of male house mice under sexual selection
    Paula Stockley
    Mammalian Behaviour and Evolution Group, Department of Evolution, Ecology and Behaviour, University of Liverpool, Leahurst Campus, Chester High Road, Neston CH64 7TE, UK
    BMC Biol 11:66. 2013
    ..According to this hypothesis, the baculum should influence the outcome of reproductive competition among males within promiscuous mating systems. However, a test of this key prediction is currently lacking...
  18. doi request reprint The analysis of immunological profiles in wild animals: a case study on immunodynamics in the field vole, Microtus agrestis
    Joseph A Jackson
    Institute of Integrative Biology, The University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7ZB, UK
    Mol Ecol 20:893-909. 2011
    ..Pinpointing the causes and consequences of such variation may help identify underlying environmental drivers of individual fitness and demographic fluctuation...
  19. ncbi request reprint Host availability and the evolution of parasite life-history strategies
    Jenny Crossan
    School of Biological Sciences, University of Liverpool, Biosciences Building, Crown Street, Liverpool, L69 7ZB, United Kingdom
    Evolution 61:675-84. 2007
    ..Incorporating parasite evolution in response to host availability would therefore enhance the predictive ability of current epidemiological models of infectious disease...
  20. doi request reprint Response of the Strongyloides ratti transcriptome to host immunological environment
    Helen O'Meara
    School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK
    Int J Parasitol 40:1609-17. 2010
    ..Differences in transcription between selection lines of S. ratti were only observed in immunised hosts and included genes associated with the response to the host's immunological environment...
  21. pmc Functional consequences of genetic diversity in Strongyloides ratti infections
    S Paterson
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    Proc Biol Sci 270:1023-32. 2003
    ..However, we find little evidence of interactions between genotypes within hosts under a variety of trickle- and single-infected infection regimes...
  22. pmc The immune response during a Strongyloides ratti infection of rats
    C P Wilkes
    School of Biological Sciences, University of Bristol, Bristol, UK
    Parasite Immunol 29:339-46. 2007
    ..In all, this suggests that there is a T-helper 2-type immune response during a primary S. ratti infection. These data also show the temporal changes in these components of the host immune response during a primary S. ratti infection...
  23. pmc Genomic diversity of the human intestinal parasite Entamoeba histolytica
    Gareth D Weedall
    Institute of Integrative Biology, University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7AH, UK
    Genome Biol 13:R38. 2012
    ..We re-sequenced the genomes of ten laboratory cultured lines of the eukaryotic pathogen Entamoeba histolytica in order to develop a picture of genetic diversity across the genome...
  24. pmc Genetic diversity in cytokines associated with immune variation and resistance to multiple pathogens in a natural rodent population
    Andrew K Turner
    Institute of Integrative Biology, Biosciences Building, University of Liverpool, Liverpool, United Kingdom
    PLoS Genet 7:e1002343. 2011
    ..Our study also highlights the utility of wild rodents as a model of ecological immunology, to better understand the causes and consequences of variation in immune function in natural populations including humans...
  25. doi request reprint How do insects react to novel inherited symbionts? A microarray analysis of Drosophila melanogaster response to the presence of natural and introduced Spiroplasma
    Kate J Hutchence
    Institute of Integrative Biology, University of Liverpool, Biosciences Building, Crown Street, Liverpool, Merseyside L69 7ZB, UK
    Mol Ecol 20:950-8. 2011
    ..We conclude that the failure of Spiroplasma in novel host species is associated either with causing harm to their new hosts or through a failure to thrive in the new host that occurs independently of host responses to infection...
  26. doi request reprint Pseudomonas aeruginosa population diversity and turnover in cystic fibrosis chronic infections
    Eilidh Mowat
    Institute of Infection and Global Health, University of Liverpool, Liverpool L69 3GA, UK
    Am J Respir Crit Care Med 183:1674-9. 2011
    ..Pseudomonas aeruginosa isolates from chronic cystic fibrosis lung infections display multiple phenotypes indicating extensive population diversity...
  27. pmc The effect of infection history on the fitness of the gastrointestinal nematode Strongyloides ratti
    C Bleay
    School of Biological Sciences, University of Bristol, Bristol, UK
    Parasitology 136:567-77. 2009
    ..The overall conclusion of these experiments is that the major immunological effect acting against an infection is induced by the infection itself and that there is little effect of prior infections of the host...
  28. doi request reprint How to measure maturation: a comparison of probabilistic methods used to test for genotypic variation and plasticity in the decision to mature
    Ewan Harney
    Institute of Integrative Biology, University of Liverpool, Biosciences Building, Crown Street, Liverpool, L69 7ZB, United Kingdom
    Evolution 67:525-38. 2013
    ..Our results support the idea that maturation thresholds can evolve but also suggest that the notion of a threshold based on a single fixed state is an oversimplification that underestimates the adaptability of these important traits...
  29. pmc The genetic basis of inbreeding avoidance in house mice
    Amy L Sherborne
    Population and Evolutionary Biology Group, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, United Kingdom
    Curr Biol 17:2061-6. 2007
    ..Recognition of close kin as unsuitable mates might be more variable across species than a generic vertebrate-wide ability to avoid inbreeding based on MHC...
  30. pmc Predicting the impact of long-term temperature changes on the epidemiology and control of schistosomiasis: a mechanistic model
    Tara D Mangal
    School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 3:e1438. 2008
    ....
  31. pmc Antagonistic coevolution accelerates molecular evolution
    Steve Paterson
    School of Biological Sciences, Biosciences Building, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
    Nature 464:275-8. 2010
    ..These results demonstrate, at both the genomic and phenotypic level, that antagonistic coevolution is a cause of rapid and divergent evolution, and is likely to be a major driver of evolutionary change within species...
  32. doi request reprint Wild immunology: converging on the real world
    Simon A Babayan
    Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Kings Buildings, Edinburgh, United Kingdom
    Ann N Y Acad Sci 1236:17-29. 2011
    ..The meeting on wild immunology, organized by Amy Pedersen, Simon Babayan, and Rick Maizels, was held at the University of Edinburgh on 30 June 2011...
  33. pmc Evidence of gene conversion in genes encoding the Gal/GalNac lectin complex of Entamoeba
    Gareth D Weedall
    Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom
    PLoS Negl Trop Dis 5:e1209. 2011
    ..histolytica strain HM1:IMSS and E. dispar strain SAW760. This evolutionary mechanism generates diversity and could contribute to immune evasion by the parasites...
  34. pmc Species interactions in a parasite community drive infection risk in a wildlife population
    Sandra Telfer
    School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
    Science 330:243-6. 2010
    ..We highlight the danger of mistaken inference when considering parasite species in isolation rather than parasite communities...
  35. ncbi request reprint Mixed models: getting the best use of parasitological data
    Steve Paterson
    Department of Biological Sciences, University of Stirling, Stirling FK9 4LA, UK
    Trends Parasitol 19:370-5. 2003
    ..Mixed models, which allow multiple error terms, provide an excellent opportunity to overcome these problems, and their application to the analysis of various types of parasitological data are reviewed here...
  36. ncbi request reprint Determining the optimal developmental route of Strongyloides ratti: an evolutionarily stable strategy approach
    Andrew Fenton
    Institute of Zoology, The Zoological Society of London, Regents Park, London NW1 4RY, United Kingdom
    Evolution 58:989-1000. 2004
    ....