Ian Paterson

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. Paterson I, Gardner N, Guzman E, Wright A. Total synthesis and biological evaluation of potent analogues of dictyostatin: modification of the C2-C6 dienoate region. Bioorg Med Chem Lett. 2008;18:6268-72 pubmed publisher
    ..As with dictyostatin, these simplified analogues act through a mechanism of microtubule stabilisation, G2/M arrest and apoptosis. ..
  2. Paterson I, Naylor G, Fujita T, Guzman E, Wright A. Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin. Chem Commun (Camb). 2010;46:261-3 pubmed publisher
  3. Phillips A, Anketell M, Balan T, Lam N, Williams S, Paterson I. Toward the total synthesis of patellazole B: synthesis of an advanced C1-C25 fragment corresponding to the macrocyclic skeleton. Org Biomol Chem. 2018;16:8286-8291 pubmed publisher
  4. Han B, Lam N, MacGregor C, Goodman J, Paterson I. A synthesis-enabled relative stereochemical assignment of the C1-C28 region of hemicalide. Chem Commun (Camb). 2018;54:3247-3250 pubmed publisher
    ..A flexible and modular strategy using an advanced C1-C28 ketone fragment 22 is outlined to elucidate the remaining stereochemical features and achieve a total synthesis. ..
  5. Paterson I, Coster M, Chen D, Oballa R, Wallace D, Norcross R. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the AB-spiroacetal segment. Org Biomol Chem. 2005;3:2399-409 pubmed
    ..The scalable synthetic sequence developed provided access to multi-gram quantities of , thus enabling the successful completion of the total synthesis of altohyrtin A/spongistatin 1, as reported in Part 4. ..
  6. Paterson I, Housden M, Cordier C, Burton P, Mühlthau F, Loiseleur O. Synthetic studies toward the brasilinolides: controlled assembly of a protected C1-C38 polyol based on fragment union by complex aldol reactions. Org Biomol Chem. 2015;13:5716-33 pubmed publisher
    ..Throughout this work, asymmetric boron-mediated aldol reactions of chiral ketones with aldehydes proved effective both for controlled fragment assembly and coupling with predictable stereoinduction from the enolate component. ..
  7. Paterson I, Coster M, Chen D, Aceña J, Bach J, Keown L, et al. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the southern hemisphere EF segment. Org Biomol Chem. 2005;3:2420-30 pubmed
  8. Paterson I, Findlay A, Noti C. Total synthesis of (-)-spirangien A, an antimitotic polyketide isolated from the myxobacterium Sorangium cellulosum. Chem Asian J. 2009;4:594-611 pubmed publisher
    ..Subsequent careful hydrolysis afforded (-)-spirangien A, validating the relative and absolute configuration. ..
  9. Paterson I, Naylor G, Gardner N, Guzman E, Wright A. Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol. Chem Asian J. 2011;6:459-73 pubmed publisher
    ..This led to the identification of a potent macrocyclic discodermolide/dictyostatin hybrid 12 and its C9 methoxy derivative 38, accessible by an efficient total synthesis and with a similar biological profile to dictyostatin. ..

More Information

Publications14

  1. Paterson I, Ng K, Williams S, Millican D, Dalby S. Total synthesis of the antimitotic marine macrolide (-)-leiodermatolide. Angew Chem Int Ed Engl. 2014;53:2692-5 pubmed publisher
    ..Boron-mediated aldol reactions were used to configure the three key fragments 2, 5, and 6 by employing the appropriate enantiomer of the lactate-derived ketone 7. ..
  2. Paterson I, Xuan M, Dalby S. Total synthesis of jiadifenolide. Angew Chem Int Ed Engl. 2014;53:7286-9 pubmed publisher
  3. Field J, Northcote P, Paterson I, Altmann K, Díaz J, Miller J. Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration. Int J Mol Sci. 2017;18: pubmed publisher
  4. AnŽiček N, Williams S, Housden M, Paterson I. Toward aplyronine payloads for antibody-drug conjugates: total synthesis of aplyronines A and D. Org Biomol Chem. 2018;16:1343-1350 pubmed publisher
    ..Toward the assembly of ADCs incorporating an aplyronine warhead, the C29-ester derivative 4 featuring an Fmoc-amino substituted linker attached to the actin-binding tail region was also prepared by adapting this flexible endgame. ..
  5. Paterson I, Anderson E, Dalby S, Lim J, Maltas P, Loiseleur O, et al. The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments. Org Biomol Chem. 2012;10:5861-72 pubmed publisher
    ..The remaining C43-C47 vinyl stannane fragment required for introduction of the unsaturated side chain was prepared from (R)-malic acid...