David J Paterson

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi request reprint Defining the neurocircuitry of exercise hyperpnoea
    David J Paterson
    Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
    J Physiol 592:433-44. 2014
  2. pmc L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats
    Chee Wan Lee
    Department of Physiology, Anatomy and Genetics, University of Oxford, UK
    J Mol Cell Cardiol 47:149-55. 2009
  3. ncbi request reprint Gene transfer of neuronal nitric oxide synthase into intracardiac Ganglia reverses vagal impairment in hypertensive rats
    Daniel A Heaton
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Hypertension 49:380-8. 2007
  4. doi request reprint Identifying cardiovascular neurocircuitry involved in the exercise pressor reflex in humans using functional neurosurgery
    Shanika D Basnayake
    Dept of Physiology, Anatomy and Genetics, Univ of Oxford, Oxford OX1 3PT, UK
    J Appl Physiol (1985) 110:881-91. 2011
  5. ncbi request reprint Noradrenergic cell specific gene transfer with neuronal nitric oxide synthase reduces cardiac sympathetic neurotransmission in hypertensive rats
    Dan Li
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, UK
    Hypertension 50:69-74. 2007
  6. pmc Cardiac sympathetic dysfunction in the prehypertensive spontaneously hypertensive rat
    Julia Shanks
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford, United Kingdom
    Am J Physiol Heart Circ Physiol 305:H980-6. 2013
  7. doi request reprint Ventral periaqueductal grey stimulation alters heart rate variability in humans with chronic pain
    Erlick A C Pereira
    Nuffield Department of Surgery, University of Oxford, Oxford, UK
    Exp Neurol 223:574-81. 2010
  8. pmc The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability
    Neil Herring
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Parks Road, OX1 3PT, UK
    J Mol Cell Cardiol 52:667-76. 2012
  9. doi request reprint Sustained reduction of hypertension by deep brain stimulation
    Erlick A C Pereira
    Nuffield Department of Surgery, University of Oxford, Oxford, UK
    J Clin Neurosci 17:124-7. 2010
  10. ncbi request reprint Remodeling of the cardiac pacemaker L-type calcium current and its beta-adrenergic responsiveness in hypertension after neuronal NO synthase gene transfer
    Daniel A Heaton
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom
    Hypertension 48:443-52. 2006

Collaborators

Detail Information

Publications38

  1. doi request reprint Defining the neurocircuitry of exercise hyperpnoea
    David J Paterson
    Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
    J Physiol 592:433-44. 2014
    ....
  2. pmc L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats
    Chee Wan Lee
    Department of Physiology, Anatomy and Genetics, University of Oxford, UK
    J Mol Cell Cardiol 47:149-55. 2009
    ..In conclusion, l-arginine supplementation corrects local cardiac noradrenergic hyperactivity in the SHR, probably via increased pre-synaptic substrate availability of NOS-sGC-cGMP pathway and reduced tyrosine hydroxylase levels...
  3. ncbi request reprint Gene transfer of neuronal nitric oxide synthase into intracardiac Ganglia reverses vagal impairment in hypertensive rats
    Daniel A Heaton
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Hypertension 49:380-8. 2007
    ..In conclusion, a significant component of cardiac vagal dysfunction in hypertension is attributed to an impairment of the postganglionic presynaptic NO-cGMP pathway and that overexpression of nNOS can reverse this neural phenotype...
  4. doi request reprint Identifying cardiovascular neurocircuitry involved in the exercise pressor reflex in humans using functional neurosurgery
    Shanika D Basnayake
    Dept of Physiology, Anatomy and Genetics, Univ of Oxford, Oxford OX1 3PT, UK
    J Appl Physiol (1985) 110:881-91. 2011
    ..No significant changes were seen in the activity of other nuclei during occlusion. These electrophysiological data provide direct evidence for a role of the PAG in the integrating neurocircuitry of the exercise pressor reflex in humans...
  5. ncbi request reprint Noradrenergic cell specific gene transfer with neuronal nitric oxide synthase reduces cardiac sympathetic neurotransmission in hypertensive rats
    Dan Li
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, UK
    Hypertension 50:69-74. 2007
    ..We conclude that artificial upregulation of sympathetic nNOS via gene transfer with a noradrenergic promoter may provide a novel approach for correcting peripheral sympathetic hyperactivity in hypertension...
  6. pmc Cardiac sympathetic dysfunction in the prehypertensive spontaneously hypertensive rat
    Julia Shanks
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford, United Kingdom
    Am J Physiol Heart Circ Physiol 305:H980-6. 2013
    ..Increased cardiac sympathetic neurotransmission driven by larger neuronal calcium transients and reduced NE reuptake translates into enhanced cardiac sympathetic responsiveness at the end organ in prehypertensive SHRs...
  7. doi request reprint Ventral periaqueductal grey stimulation alters heart rate variability in humans with chronic pain
    Erlick A C Pereira
    Nuffield Department of Surgery, University of Oxford, Oxford, UK
    Exp Neurol 223:574-81. 2010
    ..Heart rate variability (HRV) is an established measure of cardiovascular regulation, and an index of autonomic function...
  8. pmc The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability
    Neil Herring
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Parks Road, OX1 3PT, UK
    J Mol Cell Cardiol 52:667-76. 2012
    ..The role of galanin may become more important following an acute injury response where galanin expression is increased...
  9. doi request reprint Sustained reduction of hypertension by deep brain stimulation
    Erlick A C Pereira
    Nuffield Department of Surgery, University of Oxford, Oxford, UK
    J Clin Neurosci 17:124-7. 2010
    ..6mm Hg and diastolic by 11.0mm Hg, alongside reductions in variability of heart rate and pulse pressure. This neurosurgical treatment may prove beneficial for medically refractory hypertension...
  10. ncbi request reprint Remodeling of the cardiac pacemaker L-type calcium current and its beta-adrenergic responsiveness in hypertension after neuronal NO synthase gene transfer
    Daniel A Heaton
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom
    Hypertension 48:443-52. 2006
    ..Decreased calcium current after cardiac nNOS gene transfer contributes to the normalization of beta-adrenergic hyperresponsiveness in the SAN from hypertensive rats by modulating cyclic nucleotide signaling...
  11. doi request reprint Targeted neuronal nitric oxide synthase transgene delivery into stellate neurons reverses impaired intracellular calcium transients in prehypertensive rats
    Dan Li
    Department of Physiology, Anatomy and Genetics, University of Oxford, Burdon Sanderson Cardiac Science Centre and BHF Centre of Research Excellence, Oxford, United Kingdom
    Hypertension 61:202-7. 2013
    ..We conclude that artificial upregulation of stellate sympathetic nNOS via targeted gene transfer can directly attenuate intracellular Ca(2+) and may provide a novel method for decreasing enhanced cardiac sympathetic neurotransmission...
  12. doi request reprint Mapping the central neurocircuitry that integrates the cardiovascular response to exercise in humans
    Shanika D Basnayake
    Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
    Exp Physiol 97:29-38. 2012
    ....
  13. ncbi request reprint Neuronal nitric oxide synthase gene transfer decreases [Ca2+]i in cardiac sympathetic neurons
    Lijun Wang
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford, UK
    J Mol Cell Cardiol 43:717-25. 2007
    ..Therefore, we propose this as a possible key step involved in NO decreasing cardiac sympathetic neurotransmission...
  14. ncbi request reprint Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway
    Neil Herring
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Parks Road, Oxford University OX1 3PT, UK
    J Mol Cell Cardiol 44:477-85. 2008
    ..These results show that NPY attenuates vagal bradycardia via a pre-synaptic decrease in acetylcholine release that appears to be mediated by a Y2 receptor pathway involving modulation of PKC...
  15. doi request reprint Controlling the lungs via the brain: a novel neurosurgical method to improve lung function in humans
    Jonathan A Hyam
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Neurosurgery 70:469-77; discussion 477-8. 2012
    ..The supramedullary circuitry controlling respiratory airways is not well defined and has not been tested in humans...
  16. pmc Long-term effect of neuronal nitric oxide synthase over-expression on cardiac neurotransmission mediated by a lentiviral vector
    Lijun Wang
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford Parks Road, Oxford, UK
    J Physiol 587:3629-37. 2009
    ..This approach may provide a new tool to target impaired cardiac autonomic phenotypes that are disrupted by several cardiovascular pathologies...
  17. pmc Pravastatin normalises peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive rat
    Neil Herring
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, OX1 3PT, UK
    J Mol Cell Cardiol 50:99-106. 2011
    ..These results suggest 2-week pravastatin treatment reduces cardiac ATII, and prevents its facilitatory effect on NE release thus normalising cardiac sympathetic hyper-responsiveness in SHRs...
  18. doi request reprint Human ventricular fibrillation during global ischemia and reperfusion: paradoxical changes in activation rate and wavefront complexity
    Chris P Bradley
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Circ Arrhythm Electrophysiol 4:684-91. 2011
    ..Ischemic ventricular fibrillation in experimental models has been shown to progress through a series of stages. Progression of ischemic VF in the in vivo human heart has not been determined...
  19. doi request reprint Neuromodulators of peripheral cardiac sympatho-vagal balance
    Neil Herring
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Parks Road, Oxford OX1 3PT, UK
    Exp Physiol 94:46-53. 2009
    ..This review will focus on recent evidence that nitric oxide, natriuretic peptides and neuropeptide Y act by converging on neuronal cyclic nucleotide-dependent pathways to alter the autonomic phenotype in both health and disease...
  20. pmc Abnormal intracellular calcium homeostasis in sympathetic neurons from young prehypertensive rats
    Dan Li
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy, and Genetics, Oxford, UK
    Hypertension 59:642-9. 2012
    ..This Ca(2+) phenotype seen in early development in cardiac stellate and superior cervical ganglion neurons may contribute to the sympathetic hyperresponsiveness that precedes the onset of hypertension...
  21. pmc Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin
    David Adlam
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Cardiovasc Res 93:694-701. 2012
    ..We investigate the effect of BH4 deficiency on the autonomic regulation of heart rate in the hph-1 mouse model of BH4 deficiency...
  22. doi request reprint Intra-operative deep brain stimulation of the periaqueductal grey matter modulates blood pressure and heart rate variability in humans
    Alexander L Green
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK Department of Neurosurgery, John Radcliffe Hospital, Oxford, UK and Department of Anaesthesia, John Radcliffe Hospital, Oxford, UK
    Neuromodulation 13:174-81. 2010
    ..Understanding of the mechanisms by which this therapy causes cardiovascular modulation will inform future innovation in this field with the aim of improving the efficacy and safety of patient treatment options...
  23. ncbi request reprint Cardiac neurobiology of nitric oxide synthases
    Edward J Danson
    University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    Ann N Y Acad Sci 1047:183-96. 2005
    ..The present idea, that divergent NO-signaling pathways from multiple sources within the heart and nervous system converge to modulate cardiac excitability and impact on morbidity and mortality in health and disease, is discussed...
  24. ncbi request reprint Reactive oxygen species and autonomic regulation of cardiac excitability
    Edward J F Danson
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK
    J Cardiovasc Electrophysiol 17:S104-S112. 2006
    ..This article reviews the roles of ROS in autonomic dysfunction and arrhythmia. In addition, novel research directed toward finding targets for modulating sympathovagal balance in cardiac disease is discussed...
  25. doi request reprint Identification of neurocircuitry controlling cardiovascular function in humans using functional neurosurgery: implications for exercise control
    Alexander L Green
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    Exp Physiol 93:1022-8. 2008
    ..The role of the PAG in cardiovascular control in humans, with reference to electrical stimulation experiments, is also described...
  26. doi request reprint Ganglion-specific impairment of the norepinephrine transporter in the hypertensive rat
    Julia Shanks
    Department of Physiology, Anatomy, and Genetics, Burdon Sanderson Cardiac Science Centre, BHF Centre of Research Excellence, University of Oxford, Oxford, United Kingdom
    Hypertension 61:187-93. 2013
    ....
  27. ncbi request reprint Controlling the heart via the brain: a potential new therapy for orthostatic hypotension
    Alexander L Green
    Department of Neurosurgery, Radcliffe Infirmary, Oxford, England
    Neurosurgery 58:1176-83; discussion 1176-83. 2006
    ..Our aim was to assess whether orthostatic hypotension can be successfully treated with deep brain stimulation of the periventricular/periaqueductal gray areas in humans...
  28. ncbi request reprint Stimulating the human midbrain to reveal the link between pain and blood pressure
    Alexander L Green
    Department of Neurosurgery, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, United Kingdom
    Pain 124:349-59. 2006
    ..Thus stimulation of the PAG may partly control pain by reducing sympathetic activity as predicted by William James over a century ago...
  29. pmc Identifying cardiorespiratory neurocircuitry involved in central command during exercise in humans
    Alexander L Green
    Department of Neurosurgery, Radcliffe Infirmary, Oxford OX2 6HE, UK
    J Physiol 578:605-12. 2007
    ....
  30. doi request reprint Differentiated baroreflex modulation of sympathetic nerve activity during deep brain stimulation in humans
    Yrsa B Sverrisdottir
    Department of Physiology, Anatomy and Genetics, Sherrington Bldg, Parks Rd, University of Oxford, Oxford, OX1 3PT, United Kingdom
    Hypertension 63:1000-10. 2014
    ..These results may have implications in our understanding of abnormal sympathetic discharge in cardiovascular disease and provide an opportunity for therapeutic targeting. ..
  31. ncbi request reprint Deep brain stimulation can regulate arterial blood pressure in awake humans
    Alexander L Green
    Department of Neurosurgery, Radcliffe Infirmary, University of Oxford, Oxford, UK
    Neuroreport 16:1741-5. 2005
    ..05). These changes were accompanied by analogous changes in diastolic blood pressure, pulse pressure, maximum dP/dt but not in the time interval between each R wave on the electrocardiogram...
  32. ncbi request reprint Cardiac nitric oxide: emerging role for nNOS in regulating physiological function
    Edward J Danson
    University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
    Pharmacol Ther 106:57-74. 2005
    ..Functionally, alteration in nNOS-NO signalling in the heart may correlate with different cardiac regulatory states. The idea of this being associated with exercise-trained states and myocardial disease is discussed...
  33. doi request reprint Depiction of the neuroscientific principles of human motion 2 millennia ago by Lucretius
    Jonathan A Hyam
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Neurology 77:1000-4. 2011
    ..Lucretius was the first commentator to introduce into Epicurean poetry the concept of such a mechanism consisting of a logical order of processes which are still consistent with modern concepts...
  34. ncbi request reprint Nitric oxide and autonomic control of heart rate: a question of specificity
    Julian F R Paton
    Dept of Physiology, School of Medical Sciences, University of Bristol, UK
    Trends Neurosci 25:626-31. 2002
    ....
  35. ncbi request reprint The mechanism underlying the positive inotropic effect of angiotensin II in the isolated perfused rabbit heart: a 31P NMR study
    Marilyn Mielke
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Int J Biochem Cell Biol 35:984-91. 2003
    ..We conclude that the positive inotropic effect of AII is associated with, but not caused by, a decreased proton concentration due to stimulation of Na(+)/H(+) exchange in the whole rabbit heart...
  36. ncbi request reprint Cholinergic control of heart rate by nitric oxide is site specific
    Neil Herring
    University Laboratory of Physiology, Oxford University, Oxford OX1 3PT, UK
    News Physiol Sci 17:202-6. 2002
    ..Endogenous nitric oxide can potentially regulate all of these processes; however, recent work suggests that the main functional role of nitric oxide lies in the modulation of acetylcholine release...
  37. ncbi request reprint Imaging electrocardiographic dispersion of depolarization and repolarization during ischemia: simultaneous body surface and epicardial mapping
    Martyn P Nash
    University Laboratory of Physiology, University of Oxford, Oxford, UK
    Circulation 107:2257-63. 2003
    ..We investigated the sensitivity of torso measures, recorded simultaneously with epicardial electrograms, to changes in dispersion of depolarization and repolarization during localized ventricular ischemia...
  38. pmc Electrical stimulation of the midbrain increases heart rate and arterial blood pressure in awake humans
    Judith M Thornton
    University Laboratory of Physiology, Parks Road, Oxford, OX1 3PT, UK
    J Physiol 539:615-21. 2002
    ....