David J Paterson

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi request reprint Ganglion-specific impairment of the norepinephrine transporter in the hypertensive rat
    Julia Shanks
    Department of Physiology, Anatomy, and Genetics, Burdon Sanderson Cardiac Science Centre, BHF Centre of Research Excellence, University of Oxford, Oxford, United Kingdom
    Hypertension 61:187-93. 2013
  2. pmc Pravastatin normalises peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive rat
    Neil Herring
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, OX1 3PT, UK
    J Mol Cell Cardiol 50:99-106. 2011
  3. pmc L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats
    Chee Wan Lee
    Department of Physiology, Anatomy and Genetics, University of Oxford, UK
    J Mol Cell Cardiol 47:149-55. 2009
  4. doi request reprint Mapping the central neurocircuitry that integrates the cardiovascular response to exercise in humans
    Shanika D Basnayake
    Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
    Exp Physiol 97:29-38. 2012
  5. pmc Electrical stimulation of the midbrain increases heart rate and arterial blood pressure in awake humans
    Judith M Thornton
    University Laboratory of Physiology, Parks Road, Oxford, OX1 3PT, UK
    J Physiol 539:615-21. 2002
  6. doi request reprint Controlling the lungs via the brain: a novel neurosurgical method to improve lung function in humans
    Jonathan A Hyam
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Neurosurgery 70:469-77; discussion 477-8. 2012
  7. ncbi request reprint Deep brain stimulation can regulate arterial blood pressure in awake humans
    Alexander L Green
    Department of Neurosurgery, Radcliffe Infirmary, University of Oxford, Oxford, UK
    Neuroreport 16:1741-5. 2005
  8. doi request reprint Identification of neurocircuitry controlling cardiovascular function in humans using functional neurosurgery: implications for exercise control
    Alexander L Green
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    Exp Physiol 93:1022-8. 2008
  9. ncbi request reprint Cardiac neurobiology of nitric oxide synthases
    Edward J Danson
    University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    Ann N Y Acad Sci 1047:183-96. 2005
  10. pmc Identifying cardiorespiratory neurocircuitry involved in central command during exercise in humans
    Alexander L Green
    Department of Neurosurgery, Radcliffe Infirmary, Oxford OX2 6HE, UK
    J Physiol 578:605-12. 2007

Collaborators

Detail Information

Publications24

  1. doi request reprint Ganglion-specific impairment of the norepinephrine transporter in the hypertensive rat
    Julia Shanks
    Department of Physiology, Anatomy, and Genetics, Burdon Sanderson Cardiac Science Centre, BHF Centre of Research Excellence, University of Oxford, Oxford, United Kingdom
    Hypertension 61:187-93. 2013
    ....
  2. pmc Pravastatin normalises peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive rat
    Neil Herring
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, OX1 3PT, UK
    J Mol Cell Cardiol 50:99-106. 2011
    ..These results suggest 2-week pravastatin treatment reduces cardiac ATII, and prevents its facilitatory effect on NE release thus normalising cardiac sympathetic hyper-responsiveness in SHRs...
  3. pmc L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats
    Chee Wan Lee
    Department of Physiology, Anatomy and Genetics, University of Oxford, UK
    J Mol Cell Cardiol 47:149-55. 2009
    ..In conclusion, l-arginine supplementation corrects local cardiac noradrenergic hyperactivity in the SHR, probably via increased pre-synaptic substrate availability of NOS-sGC-cGMP pathway and reduced tyrosine hydroxylase levels...
  4. doi request reprint Mapping the central neurocircuitry that integrates the cardiovascular response to exercise in humans
    Shanika D Basnayake
    Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
    Exp Physiol 97:29-38. 2012
    ....
  5. pmc Electrical stimulation of the midbrain increases heart rate and arterial blood pressure in awake humans
    Judith M Thornton
    University Laboratory of Physiology, Parks Road, Oxford, OX1 3PT, UK
    J Physiol 539:615-21. 2002
    ....
  6. doi request reprint Controlling the lungs via the brain: a novel neurosurgical method to improve lung function in humans
    Jonathan A Hyam
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Neurosurgery 70:469-77; discussion 477-8. 2012
    ..The supramedullary circuitry controlling respiratory airways is not well defined and has not been tested in humans...
  7. ncbi request reprint Deep brain stimulation can regulate arterial blood pressure in awake humans
    Alexander L Green
    Department of Neurosurgery, Radcliffe Infirmary, University of Oxford, Oxford, UK
    Neuroreport 16:1741-5. 2005
    ..05). These changes were accompanied by analogous changes in diastolic blood pressure, pulse pressure, maximum dP/dt but not in the time interval between each R wave on the electrocardiogram...
  8. doi request reprint Identification of neurocircuitry controlling cardiovascular function in humans using functional neurosurgery: implications for exercise control
    Alexander L Green
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    Exp Physiol 93:1022-8. 2008
    ..The role of the PAG in cardiovascular control in humans, with reference to electrical stimulation experiments, is also described...
  9. ncbi request reprint Cardiac neurobiology of nitric oxide synthases
    Edward J Danson
    University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    Ann N Y Acad Sci 1047:183-96. 2005
    ..The present idea, that divergent NO-signaling pathways from multiple sources within the heart and nervous system converge to modulate cardiac excitability and impact on morbidity and mortality in health and disease, is discussed...
  10. pmc Identifying cardiorespiratory neurocircuitry involved in central command during exercise in humans
    Alexander L Green
    Department of Neurosurgery, Radcliffe Infirmary, Oxford OX2 6HE, UK
    J Physiol 578:605-12. 2007
    ....
  11. ncbi request reprint Stimulating the human midbrain to reveal the link between pain and blood pressure
    Alexander L Green
    Department of Neurosurgery, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, United Kingdom
    Pain 124:349-59. 2006
    ..Thus stimulation of the PAG may partly control pain by reducing sympathetic activity as predicted by William James over a century ago...
  12. ncbi request reprint Controlling the heart via the brain: a potential new therapy for orthostatic hypotension
    Alexander L Green
    Department of Neurosurgery, Radcliffe Infirmary, Oxford, England
    Neurosurgery 58:1176-83; discussion 1176-83. 2006
    ..Our aim was to assess whether orthostatic hypotension can be successfully treated with deep brain stimulation of the periventricular/periaqueductal gray areas in humans...
  13. doi request reprint Depiction of the neuroscientific principles of human motion 2 millennia ago by Lucretius
    Jonathan A Hyam
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Neurology 77:1000-4. 2011
    ..Lucretius was the first commentator to introduce into Epicurean poetry the concept of such a mechanism consisting of a logical order of processes which are still consistent with modern concepts...
  14. doi request reprint Intra-operative deep brain stimulation of the periaqueductal grey matter modulates blood pressure and heart rate variability in humans
    Alexander L Green
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK Department of Neurosurgery, John Radcliffe Hospital, Oxford, UK and Department of Anaesthesia, John Radcliffe Hospital, Oxford, UK
    Neuromodulation 13:174-81. 2010
    ..Understanding of the mechanisms by which this therapy causes cardiovascular modulation will inform future innovation in this field with the aim of improving the efficacy and safety of patient treatment options...
  15. ncbi request reprint Reactive oxygen species and autonomic regulation of cardiac excitability
    Edward J F Danson
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK
    J Cardiovasc Electrophysiol 17:S104-S112. 2006
    ..This article reviews the roles of ROS in autonomic dysfunction and arrhythmia. In addition, novel research directed toward finding targets for modulating sympathovagal balance in cardiac disease is discussed...
  16. ncbi request reprint Nitric oxide and autonomic control of heart rate: a question of specificity
    Julian F R Paton
    Dept of Physiology, School of Medical Sciences, University of Bristol, UK
    Trends Neurosci 25:626-31. 2002
    ....
  17. ncbi request reprint Cardiac nitric oxide: emerging role for nNOS in regulating physiological function
    Edward J Danson
    University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
    Pharmacol Ther 106:57-74. 2005
    ..Functionally, alteration in nNOS-NO signalling in the heart may correlate with different cardiac regulatory states. The idea of this being associated with exercise-trained states and myocardial disease is discussed...
  18. ncbi request reprint Neuronal nitric oxide synthase gene transfer decreases [Ca2+]i in cardiac sympathetic neurons
    Lijun Wang
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford, UK
    J Mol Cell Cardiol 43:717-25. 2007
    ..Therefore, we propose this as a possible key step involved in NO decreasing cardiac sympathetic neurotransmission...
  19. ncbi request reprint Noradrenergic cell specific gene transfer with neuronal nitric oxide synthase reduces cardiac sympathetic neurotransmission in hypertensive rats
    Dan Li
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, UK
    Hypertension 50:69-74. 2007
    ..We conclude that artificial upregulation of sympathetic nNOS via gene transfer with a noradrenergic promoter may provide a novel approach for correcting peripheral sympathetic hyperactivity in hypertension...
  20. doi request reprint Identifying cardiovascular neurocircuitry involved in the exercise pressor reflex in humans using functional neurosurgery
    Shanika D Basnayake
    Dept of Physiology, Anatomy and Genetics, Univ of Oxford, Oxford OX1 3PT, UK
    J Appl Physiol 110:881-91. 2011
    ..No significant changes were seen in the activity of other nuclei during occlusion. These electrophysiological data provide direct evidence for a role of the PAG in the integrating neurocircuitry of the exercise pressor reflex in humans...
  21. ncbi request reprint Cholinergic control of heart rate by nitric oxide is site specific
    Neil Herring
    University Laboratory of Physiology, Oxford University, Oxford OX1 3PT, UK
    News Physiol Sci 17:202-6. 2002
    ..Endogenous nitric oxide can potentially regulate all of these processes; however, recent work suggests that the main functional role of nitric oxide lies in the modulation of acetylcholine release...
  22. doi request reprint Neuromodulators of peripheral cardiac sympatho-vagal balance
    Neil Herring
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Parks Road, Oxford OX1 3PT, UK
    Exp Physiol 94:46-53. 2009
    ..This review will focus on recent evidence that nitric oxide, natriuretic peptides and neuropeptide Y act by converging on neuronal cyclic nucleotide-dependent pathways to alter the autonomic phenotype in both health and disease...
  23. pmc Long-term effect of neuronal nitric oxide synthase over-expression on cardiac neurotransmission mediated by a lentiviral vector
    Lijun Wang
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford Parks Road, Oxford, UK
    J Physiol 587:3629-37. 2009
    ..This approach may provide a new tool to target impaired cardiac autonomic phenotypes that are disrupted by several cardiovascular pathologies...
  24. ncbi request reprint Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway
    Neil Herring
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Parks Road, Oxford University OX1 3PT, UK
    J Mol Cell Cardiol 44:477-85. 2008
    ..These results show that NPY attenuates vagal bradycardia via a pre-synaptic decrease in acetylcholine release that appears to be mediated by a Y2 receptor pathway involving modulation of PKC...