David J Paterson
Affiliation: University of Oxford
- Ganglion-specific impairment of the norepinephrine transporter in the hypertensive ratJulia Shanks
Department of Physiology, Anatomy, and Genetics, Burdon Sanderson Cardiac Science Centre, BHF Centre of Research Excellence, University of Oxford, Oxford, United Kingdom
Hypertension 61:187-93. 2013....
- Pravastatin normalises peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive ratNeil Herring
Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, OX1 3PT, UK
J Mol Cell Cardiol 50:99-106. 2011..These results suggest 2-week pravastatin treatment reduces cardiac ATII, and prevents its facilitatory effect on NE release thus normalising cardiac sympathetic hyper-responsiveness in SHRs...
- L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive ratsChee Wan Lee
Department of Physiology, Anatomy and Genetics, University of Oxford, UK
J Mol Cell Cardiol 47:149-55. 2009..In conclusion, l-arginine supplementation corrects local cardiac noradrenergic hyperactivity in the SHR, probably via increased pre-synaptic substrate availability of NOS-sGC-cGMP pathway and reduced tyrosine hydroxylase levels...
- Mapping the central neurocircuitry that integrates the cardiovascular response to exercise in humansShanika D Basnayake
Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, UK
Exp Physiol 97:29-38. 2012....
- Electrical stimulation of the midbrain increases heart rate and arterial blood pressure in awake humansJudith M Thornton
University Laboratory of Physiology, Parks Road, Oxford, OX1 3PT, UK
J Physiol 539:615-21. 2002....
- Controlling the lungs via the brain: a novel neurosurgical method to improve lung function in humansJonathan A Hyam
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
Neurosurgery 70:469-77; discussion 477-8. 2012..The supramedullary circuitry controlling respiratory airways is not well defined and has not been tested in humans...
- Deep brain stimulation can regulate arterial blood pressure in awake humansAlexander L Green
Department of Neurosurgery, Radcliffe Infirmary, University of Oxford, Oxford, UK
Neuroreport 16:1741-5. 2005..05). These changes were accompanied by analogous changes in diastolic blood pressure, pulse pressure, maximum dP/dt but not in the time interval between each R wave on the electrocardiogram...
- Identification of neurocircuitry controlling cardiovascular function in humans using functional neurosurgery: implications for exercise controlAlexander L Green
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
Exp Physiol 93:1022-8. 2008..The role of the PAG in cardiovascular control in humans, with reference to electrical stimulation experiments, is also described...
- Cardiac neurobiology of nitric oxide synthasesEdward J Danson
University Laboratory of Physiology, University of Oxford, Parks Road, Oxford OX1 3PT, UK
Ann N Y Acad Sci 1047:183-96. 2005..The present idea, that divergent NO-signaling pathways from multiple sources within the heart and nervous system converge to modulate cardiac excitability and impact on morbidity and mortality in health and disease, is discussed...
- Identifying cardiorespiratory neurocircuitry involved in central command during exercise in humansAlexander L Green
Department of Neurosurgery, Radcliffe Infirmary, Oxford OX2 6HE, UK
J Physiol 578:605-12. 2007....
- Stimulating the human midbrain to reveal the link between pain and blood pressureAlexander L Green
Department of Neurosurgery, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, United Kingdom
Pain 124:349-59. 2006..Thus stimulation of the PAG may partly control pain by reducing sympathetic activity as predicted by William James over a century ago...
- Controlling the heart via the brain: a potential new therapy for orthostatic hypotensionAlexander L Green
Department of Neurosurgery, Radcliffe Infirmary, Oxford, England
Neurosurgery 58:1176-83; discussion 1176-83. 2006..Our aim was to assess whether orthostatic hypotension can be successfully treated with deep brain stimulation of the periventricular/periaqueductal gray areas in humans...
- Depiction of the neuroscientific principles of human motion 2 millennia ago by LucretiusJonathan A Hyam
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Neurology 77:1000-4. 2011..Lucretius was the first commentator to introduce into Epicurean poetry the concept of such a mechanism consisting of a logical order of processes which are still consistent with modern concepts...
- Intra-operative deep brain stimulation of the periaqueductal grey matter modulates blood pressure and heart rate variability in humansAlexander L Green
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK Department of Neurosurgery, John Radcliffe Hospital, Oxford, UK and Department of Anaesthesia, John Radcliffe Hospital, Oxford, UK
Neuromodulation 13:174-81. 2010..Understanding of the mechanisms by which this therapy causes cardiovascular modulation will inform future innovation in this field with the aim of improving the efficacy and safety of patient treatment options...
- Reactive oxygen species and autonomic regulation of cardiac excitabilityEdward J F Danson
Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK
J Cardiovasc Electrophysiol 17:S104-S112. 2006..This article reviews the roles of ROS in autonomic dysfunction and arrhythmia. In addition, novel research directed toward finding targets for modulating sympathovagal balance in cardiac disease is discussed...
- Nitric oxide and autonomic control of heart rate: a question of specificityJulian F R Paton
Dept of Physiology, School of Medical Sciences, University of Bristol, UK
Trends Neurosci 25:626-31. 2002....
- Cardiac nitric oxide: emerging role for nNOS in regulating physiological functionEdward J Danson
University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
Pharmacol Ther 106:57-74. 2005..Functionally, alteration in nNOS-NO signalling in the heart may correlate with different cardiac regulatory states. The idea of this being associated with exercise-trained states and myocardial disease is discussed...
- Neuronal nitric oxide synthase gene transfer decreases [Ca2+]i in cardiac sympathetic neuronsLijun Wang
Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford, UK
J Mol Cell Cardiol 43:717-25. 2007..Therefore, we propose this as a possible key step involved in NO decreasing cardiac sympathetic neurotransmission...
- Noradrenergic cell specific gene transfer with neuronal nitric oxide synthase reduces cardiac sympathetic neurotransmission in hypertensive ratsDan Li
Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, UK
Hypertension 50:69-74. 2007..We conclude that artificial upregulation of sympathetic nNOS via gene transfer with a noradrenergic promoter may provide a novel approach for correcting peripheral sympathetic hyperactivity in hypertension...
- Identifying cardiovascular neurocircuitry involved in the exercise pressor reflex in humans using functional neurosurgeryShanika D Basnayake
Dept of Physiology, Anatomy and Genetics, Univ of Oxford, Oxford OX1 3PT, UK
J Appl Physiol 110:881-91. 2011..No significant changes were seen in the activity of other nuclei during occlusion. These electrophysiological data provide direct evidence for a role of the PAG in the integrating neurocircuitry of the exercise pressor reflex in humans...
- Cholinergic control of heart rate by nitric oxide is site specificNeil Herring
University Laboratory of Physiology, Oxford University, Oxford OX1 3PT, UK
News Physiol Sci 17:202-6. 2002..Endogenous nitric oxide can potentially regulate all of these processes; however, recent work suggests that the main functional role of nitric oxide lies in the modulation of acetylcholine release...
- Neuromodulators of peripheral cardiac sympatho-vagal balanceNeil Herring
Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Parks Road, Oxford OX1 3PT, UK
Exp Physiol 94:46-53. 2009..This review will focus on recent evidence that nitric oxide, natriuretic peptides and neuropeptide Y act by converging on neuronal cyclic nucleotide-dependent pathways to alter the autonomic phenotype in both health and disease...
- Long-term effect of neuronal nitric oxide synthase over-expression on cardiac neurotransmission mediated by a lentiviral vectorLijun Wang
Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford Parks Road, Oxford, UK
J Physiol 587:3629-37. 2009..This approach may provide a new tool to target impaired cardiac autonomic phenotypes that are disrupted by several cardiovascular pathologies...
- Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathwayNeil Herring
Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Parks Road, Oxford University OX1 3PT, UK
J Mol Cell Cardiol 44:477-85. 2008..These results show that NPY attenuates vagal bradycardia via a pre-synaptic decrease in acetylcholine release that appears to be mediated by a Y2 receptor pathway involving modulation of PKC...