Research Topics
| Richard PassinghamSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
Specialisation within the prefrontal cortex: the ventral prefrontal cortex and associative learningR E Passingham
Department of Experimental Psychology, University of Oxford, UK
Exp Brain Res 133:103-13. 2000..On the basis of the existing anatomical and electrophysiological data, it is argued that the prefrontal cortex is the only area that can represent cues, responses and outcomes...- Commentary on Devlin and PoldrackRichard E Passingham
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
Neuroimage 37:1055-6; discussion 1066-8. 2007 - The anatomical basis of functional localization in the cortexRichard E Passingham
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
Nat Rev Neurosci 3:606-16. 2002 - The prefrontal cortex and working memory: physiology and brain imagingDick Passingham
Department of Experimental Psychology, University of Oxford, United Kingdom
Curr Opin Neurobiol 14:163-8. 2004..We suggest that the key to prefrontal cortex lies not in the maintenance of sensory information but in the prospective use of that information for behaviour... 
How good is the macaque monkey model of the human brain?Richard Passingham
Department of Experimental Psychology, University of Oxford University, Oxford, United Kingdom
Curr Opin Neurobiol 19:6-11. 2009..Where the results are the same, we can then use information from single unit recording in those areas to suggest the mechanisms by which those areas perform their functions in the human brain...- Medial frontal cortex: from self-generated action to reflection on one's own performanceRichard E Passingham
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, UK, OX1 3UD
Trends Cogn Sci 14:16-21. 2010..Finally, we suggest that the pattern of anatomical connections is consistent with the proposal that the medial frontal cortex is crucially involved in self-generated action and self-reflection... - Contrasting the dorsal and ventral visual systems: guidance of movement versus decision makingR E Passingham
Department of Experimental Psychology, University of Oxford, Oxford, OX1 3DU, United Kingdom
Neuroimage 14:S125-31. 2001..It is suggested that, when subjects must consciously identify the context and decide on the appropriate action, ventral pathways are involved... - Cerebral dominance for action in the human brain: the selection of actionsN D Schluter
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
Neuropsychologia 39:105-13. 2001..It is argued that the results suggest that the left hemisphere is dominant not only for speech but also for action in general... - Interference with performance of a response selection task that has no working memory component: an rTMS comparison of the dorsolateral prefrontal and medial frontal cortexK A Hadland
Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK
J Cogn Neurosci 13:1097-108. 2001..The difference appears to be that the DLPFC is important when selecting between competing responses or when concentrating if there is a high attentional demand, but that the MFC is only important during the response selection task... - The inferior frontal gyrus and phonological processing: an investigation using rTMSPhilip Nixon
Department of Experimental Psychology, University of Oxford, UK
J Cogn Neurosci 16:289-300. 2004..Furthermore, this study shows that rTMS can shed further light on the precise role of cortical language areas in humans... - The striatum and self-paced movementsP D Nixon
Department of Experimental Psychology, University of Oxford, United Kingdom
Behav Neurosci 112:719-24. 1998..The results complement similar findings for monkeys with supplementary motor cortex (SMA) lesions; the putamen is interconnected with the SMA in a cortico-striatal-thalamocortical loop... - The anterior cingulate and reward-guided selection of actionsK A Hadland
Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, United Kingdom
J Neurophysiol 89:1161-4. 2003.... - Components of switching intentional setMatthew F S Rushworth
Department of Experimental Psychology, University of Oxford, UK
J Cogn Neurosci 14:1139-50. 2002..Set initiation started with modulation of medial frontal ERPs and was followed by modulation over parietal electrodes. Implementation of intentional set was associated with modulation of response-related ERPs... - The effect of cingulate lesions on social behaviour and emotionK A Hadland
Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, UK
Neuropsychologia 41:919-31. 2003..The results are consistent with a cingulate role in social behaviour and emotion... - The effect of cingulate cortex lesions on task switching and working memoryM F S Rushworth
University of Oxford, UK
J Cogn Neurosci 15:338-53. 2003.... - Willed action and attention to the selection of actionH C Lau
Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, UK
Neuroimage 21:1407-15. 2004..However, the presupplementary motor area (pre-SMA) may subserve this function as activity in this region was found to be tightly associated with the free selection of responses... - Components of attentional set-switchingM F S Rushworth
Department of Experimental Psychology, University of Oxford, England
Exp Psychol 52:83-98. 2005.... - Changes in the human brain during rhythm learningN Ramnani
University College London, UK
J Cogn Neurosci 13:952-66. 2001..There were no learning-related increases in the basal ganglia. It is suggested that it is the neocortical-cerebellar loop that is involved in the timing and coordination of responses... - The attentional role of the left parietal cortex: the distinct lateralization and localization of motor attention in the human brainM F Rushworth
Wellcome Institute of Cognitive Neurology, London, UK
J Cogn Neurosci 13:698-710. 2001..The results also provide evidence concerning the importance of ventral premotor (PMv) and Broca's area in motor attention and language processes... - Predicting sensory events. The role of the cerebellum in motor learningP D Nixon
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
Exp Brain Res 138:251-7. 2001..The function of the cerebellum in motor sequence learning may therefore be part of a more general operation in learning to prepare responses to predictable sensory events... - The left parietal cortex and motor attentionM F Rushworth
Department of Experimental Psychology, University of Oxford, U K
Neuropsychologia 35:1261-73. 1997..We suggest that the well documented left hemisphere and apraxic impairment in movement sequencing is the consequence of a difficulty in shifting the focus of motor attention from one movement in a sequence to the next... - Parietal cortex and movement. I. Movement selection and reachingM F Rushworth
Department of Experimental Psychology, University of Oxford, UK
Exp Brain Res 117:292-310. 1997..Neither part of the parietal lobe appears to be important for the non-standard, non-spatial transformations of response selection... - Parietal cortex and movement. II. Spatial representationM F Rushworth
Department of Experimental Psychology, University of Oxford, UK
Exp Brain Res 117:311-23. 1997..This suggests that 5/7b/MIP does not represent the limb in simple sensory or motor coordinates but in terms of its spatial position... - The left hemisphere and the selection of learned actionsM F Rushworth
Department of Experimental Psychology, University of Oxford, UK
Neuropsychologia 36:11-24. 1998..The lesions of the impaired LH group were widespread but always included the distributed systems known to be important for response selection-the dorsolateral frontal and parietal cortices, striatum, thalamus and white matter fascicles... - Microstimulation of movements from cerebellar-receiving, but not pallidal-receiving areas of the macaque thalamus under ketamine anaesthesiaR C Miall
University Laboratory of Physiology, Oxford, UK
Exp Brain Res 123:387-96. 1998.... - The cerebellum and cognition: cerebellar lesions do not impair spatial working memory or visual associative learning in monkeysP D Nixon
University of Oxford, Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, UK
Eur J Neurosci 11:4070-80. 1999.... - The cerebellum and cognition: cerebellar lesions impair sequence learning but not conditional visuomotor learning in monkeysP D Nixon
Department of Experimental Psychology, University of Oxford, UK
Neuropsychologia 38:1054-72. 2000..We conclude that the cerebellum is not essential for the learning or recall of stimulus-response associations but that it is crucially involved in the process by which motor sequences become automatic with extended practice... - Learning- and expectation-related changes in the human brain during motor learningN Ramnani
Wellcome Department of Cognitive Neurology, Institute of Neurology, London WC1N 3BG, United Kingdom
J Neurophysiol 84:3026-35. 2000..The changes seen in the ipsilateral cerebellar cortex may be due either to the violations of sensory predictions, or to learning-related increases in the excitability of cerebellar neurons to presentations of the CS+... - Signal-, set- and movement-related activity in the human brain: an event-related fMRI studyI Toni
Wellcome Department of Cognitive Neurology, Institute of Neurology, University of Oxford, UK
Cereb Cortex 9:35-49. 1999..Rather, these processes seem to rely on the ventral visual stream, the ventral prefrontal cortex and the anterior part of the dorsal premotor cortex... - Oral dyspraxia in inherited speech and language impairment and acquired dysphasiaK J Alcock
Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
Brain Lang 75:17-33. 2000..It is concluded that affected members of the KE family resemble patients with acquired dysphasia in having difficulties with oral praxis and that speech and language problems of affected family members arise from a lower level disorder... - Pitch and timing abilities in inherited speech and language impairmentK J Alcock
Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
Brain Lang 75:34-46. 2000..Neither their linguistic nor oral praxic deficits can be at the root of their impairment in timing; rather, the reverse may be true... - The nucleus accumbens in monkeys (Macaca fascicularis): II. Emotion and motivationC E Stern
Department of Experimental Psychology, University of Oxford, UK
Behav Brain Res 75:179-93. 1996..These studies suggest that lesions of the NA or the anterior cingulate cortex result in substantial changes in emotional behavior, however, these changes do not mimic those found following lesions of the amygdala... - Pitch and timing abilities in adult left-hemisphere-dysphasic and right-hemisphere-damaged subjectsK J Alcock
Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
Brain Lang 75:47-65. 2000..It is concluded that the two hemispheres differ in their specialization for the perception and production of pitch and rhythm... - Touching a rubber hand: feeling of body ownership is associated with activity in multisensory brain areasH Henrik Ehrsson
Wellcome Department of Cognitive Neurology, Institute of Neurology, London WC1N 3BG, United Kingdom
J Neurosci 25:10564-73. 2005..We propose that this could be the mechanism for the feeling of body ownership... - Attentional selection and action selection in the ventral and orbital prefrontal cortexMatthew F S Rushworth
Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
J Neurosci 25:11628-36. 2005..A special contribution of PFv+o may be initial selection of behaviorally relevant stimuli... - Prefrontal set activity predicts rule-specific neural processing during subsequent cognitive performanceKatsuyuki Sakai
Department of Cognitive Neuroscience, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
J Neurosci 26:1211-8. 2006.... - Is the prefrontal cortex necessary for establishing cognitive sets?James B Rowe
Department of Clinical Neurosciences, Cambridge University, Cambridge CB2 2QQ, United Kingdom
J Neurosci 27:13303-10. 2007..The results suggest that the left rostral prefrontal cortex is indeed required for establishing a cognitive set but that the essential function is to support the functional connectivity among the task-related regions... - Cerebral changes during performance of overlearned arbitrary visuomotor associationsMeike J Grol
Psychonomics Division, Helmholtz Institute, University Utrecht, 3584 CS Utrecht, The Netherlands
J Neurosci 26:117-25. 2006..More generally, our findings illustrate how rich cerebral dynamics can underlie stable behavior... - Seeing or doing? Influence of visual and motor familiarity in action observationBeatriz Calvo-Merino
Institute of Cognitive Neuroscience and Department of Psychology, University College London, 17 Queen Square, WC1N 3AR London, United Kingdom
Curr Biol 16:1905-10. 2006..We understand actions not only by visual recognition, but also motorically. In addition, we confirm that the cerebellum is part of the action observation network... - Manipulating the experienced onset of intention after action executionHakwan C Lau
University College London, UK
J Cogn Neurosci 19:81-90. 2007..A model, which is based on the mechanism of cue integration under the presence of noise, is offered to explain the results. The implications for the conscious control of spontaneous actions are discussed... - Unconscious activation of the cognitive control system in the human prefrontal cortexHakwan C Lau
Wellcome Department of Imaging Neuroscience, University College London, London WC1N 3BG, United Kingdom
J Neurosci 27:5805-11. 2007..These results suggest that the cognitive control system in the prefrontal cortex is not exclusively driven by conscious information, as has been believed previously... - Reading hidden intentions in the human brainJohn Dylan Haynes
Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany
Curr Biol 17:323-8. 2007..Decoding of intentions was most robust from the medial prefrontal cortex, which is consistent with a specific role of this region when subjects reflect on their own mental states... - On measuring the perceived onsets of spontaneous actionsHakwan C Lau
Wellcome Department of Imaging Neuroscience, University College London, London WC1N 3BG, United Kingdom
J Neurosci 26:7265-71. 2006..We therefore argue that the timing method of Libet et al. (1983) is problematic, because the measuring process affects the neural representations of action and thus also the perceived onsets that the method is designed to measure... - Dissociating response selection and conflict in the medial frontal surfaceHakwan Lau
Functional Imaging Laboratory, Wellcome Department of Imaging Neuroscience, University College London, 12 Queen Square, London WC1N 3BG, UK
Neuroimage 29:446-51. 2006..The two clusters of activation do not overlap, and the peaks of them were about 30 mm apart. We conclude that the activity in the pre-SMA is related to the endogenous generation of action rather than response conflict... - Cortico-basal ganglia pathways are essential for the recall of well-established visuomotor associationsPhilip D Nixon
Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK
Eur J Neurosci 20:3165-78. 2004..We therefore suggest that when visuomotor associations have become well established through over-training, performance depends on connections between the basal ganglia and premotor cortex... - Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor imaging and fast marching tractographyGeoffrey J M Parker
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
Neuroimage 15:797-809. 2002..Analogous human anatomical connectivity is also presented for the first time using the FMT method, and the results are compared. The current limitations of the methodology and possibilities available for further studies are discussed... - Multiple movement representations in the human brain: an event-related fMRI studyIvan Toni
Centre for Cognitive Neuroimaging, University of Nijmegen, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
J Cogn Neurosci 14:769-84. 2002..We suggest that goal-directed preparatory activity relies on both visuomotor and visuoperceptual areas. These findings point to a functional-anatomical basis for the integration of perceptual and executive processes... - Changes of cortico-striatal effective connectivity during visuomotor learningIvan Toni
F C Donders Centre for Cognitive Neuroimaging, University of Nijmegen, NL 6500 HB Nijmegen, The Netherlands
Cereb Cortex 12:1040-7. 2002..We infer that novel visuomotor associations are established through the enhancement of specific cortico-striatal circuits, rather than through the alteration of direct temporo-frontal or parieto-frontal connectivity... - Prefrontal interactions reflect future task operationsKatsuyuki Sakai
Wellcome Department of Cognitive Neurology, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
Nat Neurosci 6:75-81. 2003..Thus we have identified inter-regional interactions that reflect preparation for task performance... - Parahippocampal reactivation signal at retrieval after interruption of rehearsalKatsuyuki Sakai
Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom
J Neurosci 22:6315-20. 2002..The primary role of the PHC in retrieval may be to trigger the reactivation of these cortical areas that had maintained the remembered items, thereby reactivating the information that is no longer maintained on-line... - That's my hand! Activity in premotor cortex reflects feeling of ownership of a limbH Henrik Ehrsson
Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
Science 305:875-7. 2004..The neural activity in the premotor cortex reflected the feeling of ownership of the hand. This suggests that multisensory integration in the premotor cortex provides a mechanism for bodily self-attribution... - Attention to intentionHakwan C Lau
Department of Experimental Psychology, University of Oxford, Oxford, UK
Science 303:1208-10. 2004..Prefrontal activity, but not parietal activity, was more strongly coupled with activity in the pre-SMA. We conclude that activity in the pre-SMA reflects the representation of intention... - Prefrontal selection and medial temporal lobe reactivation in retrieval of short-term verbal informationKatsuyuki Sakai
Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
Cereb Cortex 14:914-21. 2004..By contrast, the activity in the middle frontal gyrus did not differ between the two conditions. Taking these results together, we have shown the double dissociation between the PFC and MTL in memory retrieval... - The prefrontal cortex shows context-specific changes in effective connectivity to motor or visual cortex during the selection of action or colourJames B Rowe
Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, UK
Cereb Cortex 15:85-95. 2005.... - The frontal cortex: does size matter?Richard E Passingham
Nat Neurosci 5:190-2. 2002 - Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblingsRobyn A Honea
Genes, Cognition and Psychosis Program, National Institute of Mental Health, Division of Intramural Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1364, USA
Biol Psychiatry 63:465-74. 2008..We sought to discover previously unidentified gray matter volume differences in patients with schizophrenia and their siblings with optimized voxel-based morphometry... - Knowing when to stop: the brain mechanisms of chasing lossesDaniel K Campbell-Meiklejohn
Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom
Biol Psychiatry 63:293-300. 2008..Continued gambling to recover previous losses ("loss-chasing") is central to pathological gambling. However, very little is known about the neural mechanisms that mediate this behavior... - Relative blindsight in normal observers and the neural correlate of visual consciousnessHakwan C Lau
Wellcome Department of Imaging Neuroscience, University College London, London WC1N 3BG, United Kingdom
Proc Natl Acad Sci U S A 103:18763-8. 2006..Our results suggest that the prefrontal cortex is important for the essentially subjective aspects of conscious perception... - Brain mechanisms for inferring deceit in the actions of othersJulie Grezes
Laboratoire de Physiologie de la Perception et de l Action, Centre National de la Recherche Scientifique College de France, 75005 Paris, France
J Neurosci 24:5500-5. 2004..We suggest that these activations reflect the observers' judgements of social intentions toward themselves and might reflect an emotional response to being deceived... - Learning of sequences of finger movements and timing: frontal lobe and action-oriented representationKatsuyuki Sakai
Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom
J Neurophysiol 88:2035-46. 2002.... - Threatening a rubber hand that you feel is yours elicits a cortical anxiety responseH Henrik Ehrsson
Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, United Kingdom
Proc Natl Acad Sci U S A 104:9828-33. 2007..These findings are of fundamental importance because they suggest that the feeling of body ownership is associated with changes in the interoceptive systems...