Vincent Pasque

Summary

Publications

  1. doi Zebrafish Sox7 and Sox18 function together to control arterial-venous identity
    Helene Pendeville
    GIGA Research Unité de Biologie Moleculaire et Génie Génétique, Tour B34, Universite de Liege, B 4000 Sart Tilman, Belgium
    Dev Biol 317:405-16. 2008
  2. doi Epigenetic factors influencing resistance to nuclear reprogramming
    Vincent Pasque
    Wellcome Trust Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Trends Genet 27:516-25. 2011
  3. doi Epigenetic reprogramming: is deamination key to active DNA demethylation?
    Marta Teperek-Tkacz
    Wellcome Trust Cancer Research UK Gurdon Institute, Cambridge, CB2 1QN, UK
    Reproduction 142:621-32. 2011
  4. pmc Nuclear actin in transcriptional reprogramming by oocytes: are actin nucleators key players?
    Kei Miyamoto
    Cell Cycle 10:3040-1. 2011
  5. pmc Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process?
    Jerome Jullien
    Wellcome Trust Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nat Rev Mol Cell Biol 12:453-9. 2011
  6. pmc Histone variant macroH2A confers resistance to nuclear reprogramming
    Vincent Pasque
    Wellcome Trust Cancer Research UK Gurdon Institute, Cambridge, UK
    EMBO J 30:2373-87. 2011
  7. pmc Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes
    Kei Miyamoto
    Wellcome Trust, Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom
    Genes Dev 25:946-58. 2011
  8. doi Efficiencies and mechanisms of nuclear reprogramming
    V Pasque
    The Wellcome Trust Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Cambridge CB2 1QN, United Kingdom
    Cold Spring Harb Symp Quant Biol 75:189-200. 2010
  9. pmc Mammalian nuclear transplantation to Germinal Vesicle stage Xenopus oocytes - a method for quantitative transcriptional reprogramming
    R P Halley-Stott
    Wellcome Trust Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, UK
    Methods 51:56-65. 2010
  10. pmc Expression of zebrafish pax6b in pancreas is regulated by two enhancers containing highly conserved cis-elements bound by PDX1, PBX and PREP factors
    François M Delporte
    Unit of Molecular Biology and Genetic Engineering, University of Liege, GIGA R, B34, Avenue de l Hopital, 1, B 4000 Liege, Belgium
    BMC Dev Biol 8:53. 2008

Detail Information

Publications11

  1. doi Zebrafish Sox7 and Sox18 function together to control arterial-venous identity
    Helene Pendeville
    GIGA Research Unité de Biologie Moleculaire et Génie Génétique, Tour B34, Universite de Liege, B 4000 Sart Tilman, Belgium
    Dev Biol 317:405-16. 2008
    ..The striking similarities between the phenotype of Sox7/Sox18 morphants and Gridlock mutants strongly suggest that Sox7 and Sox18 control arterial-venous identity by regulating Gridlock expression...
  2. doi Epigenetic factors influencing resistance to nuclear reprogramming
    Vincent Pasque
    Wellcome Trust Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Trends Genet 27:516-25. 2011
    ..We see this as a step towards understanding the mechanisms by which nuclear reprogramming takes place...
  3. doi Epigenetic reprogramming: is deamination key to active DNA demethylation?
    Marta Teperek-Tkacz
    Wellcome Trust Cancer Research UK Gurdon Institute, Cambridge, CB2 1QN, UK
    Reproduction 142:621-32. 2011
    ..These findings are also considered along with alternative demethylation pathways involving hydroxymethylation...
  4. pmc Nuclear actin in transcriptional reprogramming by oocytes: are actin nucleators key players?
    Kei Miyamoto
    Cell Cycle 10:3040-1. 2011
  5. pmc Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process?
    Jerome Jullien
    Wellcome Trust Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nat Rev Mol Cell Biol 12:453-9. 2011
    ..These events occur in an ordered manner and on a defined timescale, indicating that reprogramming by nuclear transfer and by cell fusion rely on deterministic processes...
  6. pmc Histone variant macroH2A confers resistance to nuclear reprogramming
    Vincent Pasque
    Wellcome Trust Cancer Research UK Gurdon Institute, Cambridge, UK
    EMBO J 30:2373-87. 2011
    ..Our results uncover the decreased stability of the Xi in EpiSCs, and highlight the importance of combinatorial epigenetic repression involving macroH2A in restricting transcriptional reprogramming by oocytes...
  7. pmc Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes
    Kei Miyamoto
    Wellcome Trust, Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom
    Genes Dev 25:946-58. 2011
    ..This is the first report showing that naturally stored actin in an oocyte nucleus helps transcriptional reprogramming in a polymerization-dependent manner...
  8. doi Efficiencies and mechanisms of nuclear reprogramming
    V Pasque
    The Wellcome Trust Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Cambridge CB2 1QN, United Kingdom
    Cold Spring Harb Symp Quant Biol 75:189-200. 2010
    ..We comment on the mechanisms that lead to successful somatic-cell reprogramming and on those that resist in helping to maintain the differentiated state of somatic cells...
  9. pmc Mammalian nuclear transplantation to Germinal Vesicle stage Xenopus oocytes - a method for quantitative transcriptional reprogramming
    R P Halley-Stott
    Wellcome Trust Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, UK
    Methods 51:56-65. 2010
    ..We also determine the efficiency of an injected mRNA translation into protein...
  10. pmc Expression of zebrafish pax6b in pancreas is regulated by two enhancers containing highly conserved cis-elements bound by PDX1, PBX and PREP factors
    François M Delporte
    Unit of Molecular Biology and Genetic Engineering, University of Liege, GIGA R, B34, Avenue de l Hopital, 1, B 4000 Liege, Belgium
    BMC Dev Biol 8:53. 2008
    ....
  11. pmc Epigenetic stability of repressed states involving the histone variant macroH2A revealed by nuclear transfer to Xenopus oocytes
    Vincent Pasque
    Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK
    Nucleus 2:533-9. 2011
    ..We focus on developmentally regulated X chromosome inactivation and repression of autosomal pluripotency genes, where macroH2A may help maintain the long-term stability of the differentiated state of somatic cells...