L Partridge

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Feeding, fecundity and lifespan in female Drosophila melanogaster
    Andrew I Barnes
    Research Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Proc Biol Sci 275:1675-83. 2008
  2. pmc Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease
    F Kerr
    Institute of Healthy Ageing, and GEE Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK
    Neurobiol Aging 32:1977-89. 2011
  3. pmc Molecular evolution and functional characterization of Drosophila insulin-like peptides
    Sebastian Gronke
    Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000857. 2010
  4. pmc The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila
    Tomoatsu Ikeya
    UCL Institute of Healthy Ageing and GEE, University College London, Darwin Building, Gower Street, London, UK
    Proc Biol Sci 276:3799-807. 2009
  5. pmc Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster
    Richard C Grandison
    UCL Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK
    PLoS ONE 4:e4067. 2009
  6. pmc Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs
    Susan Broughton
    UCL Institute of Healthy Ageing, GEE, University College London, London, UK
    PLoS ONE 3:e3721. 2008
  7. pmc Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk
    Cathy Slack
    Institute of Healthy Ageing, Department of Genes, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000881. 2010
  8. pmc Genome-wide transcription analysis of clinal genetic variation in Drosophila
    Ying Chen
    Department of Genetics, Evolution and Environment, University College London, London, United Kingdom
    PLoS ONE 7:e34620. 2012
  9. pmc Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling
    Nazif Alic
    Institute of Healthy Ageing, and GEE, University College London, London, UK
    Mol Syst Biol 7:502. 2011
  10. pmc Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor
    Nazif Alic
    Institute of Healthy Ageing, and GEE, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Aging Cell 10:137-47. 2011

Detail Information

Publications114 found, 100 shown here

  1. pmc Feeding, fecundity and lifespan in female Drosophila melanogaster
    Andrew I Barnes
    Research Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Proc Biol Sci 275:1675-83. 2008
    ..We conclude that female mating costs are not the result of over-feeding, but may be due to other, potentially more direct, effects of ejaculate molecules...
  2. pmc Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease
    F Kerr
    Institute of Healthy Ageing, and GEE Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK
    Neurobiol Aging 32:1977-89. 2011
    ....
  3. pmc Molecular evolution and functional characterization of Drosophila insulin-like peptides
    Sebastian Gronke
    Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000857. 2010
    ..Evolutionary conservation has thus been accompanied by synergy, redundancy, and functional differentiation between DILPs, and these features may themselves be of evolutionary advantage...
  4. pmc The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila
    Tomoatsu Ikeya
    UCL Institute of Healthy Ageing and GEE, University College London, Darwin Building, Gower Street, London, UK
    Proc Biol Sci 276:3799-807. 2009
    ..This effect of Wolbachia infection on IIS could have an evolutionary explanation, and has some implications for studies of IIS in Drosophila and other organisms that harbour endosymbionts...
  5. pmc Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster
    Richard C Grandison
    UCL Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK
    PLoS ONE 4:e4067. 2009
    ..Outcomes of lifespan studies in model organisms are particularly susceptible to variations in technical procedures. This is especially true of dietary restriction, which is implemented in many different ways among laboratories...
  6. pmc Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs
    Susan Broughton
    UCL Institute of Healthy Ageing, GEE, University College London, London, UK
    PLoS ONE 3:e3721. 2008
    ..To understand the normal regulation of expression of the dilps and any functional diversification between them will require independent control of the expression of different dilps...
  7. pmc Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk
    Cathy Slack
    Institute of Healthy Ageing, Department of Genes, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000881. 2010
    ..Our findings suggest that IIS signaling in Drosophila may require the activity of a second intracellular adaptor, thereby yielding fundamental new insights into the functioning and role of the IIS pathway in ageing and metabolism...
  8. pmc Genome-wide transcription analysis of clinal genetic variation in Drosophila
    Ying Chen
    Department of Genetics, Evolution and Environment, University College London, London, United Kingdom
    PLoS ONE 7:e34620. 2012
    ..This study identified a handful of genes that contributed to clinal phenotypic variation through altered gene expression level, yet misexpression of individual gene led to modest body size change...
  9. pmc Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling
    Nazif Alic
    Institute of Healthy Ageing, and GEE, University College London, London, UK
    Mol Syst Biol 7:502. 2011
    ..We demonstrate genome-wide evolutionary conservation of dFOXO targets between the fly and the worm Caenorhabditis elegans, enriched for a second tier of regulators including the dHR96/daf-12 nuclear hormone receptor...
  10. pmc Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor
    Nazif Alic
    Institute of Healthy Ageing, and GEE, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Aging Cell 10:137-47. 2011
    ..Our findings point to the possibility that an IGFBP or a related protein, such as IGFBP7, plays a role in mammalian aging...
  11. pmc dFOXO-independent effects of reduced insulin-like signaling in Drosophila
    Cathy Slack
    Institute of Healthy Ageing and GEE, University College London, Gower Street, London, UK
    Aging Cell 10:735-48. 2011
    ....
  12. pmc Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease
    Oyinkan Sofola
    Department of Genetics, Evolution, and Environment, Institute of Healthy Ageing and Research, University College London, London, United Kingdom
    PLoS Genet 6:e1001087. 2010
    ....
  13. pmc Ageing increases vulnerability to aβ42 toxicity in Drosophila
    Iain Rogers
    Institute of Healthy Ageing and GEE, University College London, London, United Kingdom
    PLoS ONE 7:e40569. 2012
    ..Our results suggest that reduced protein turnover, increased duration of exposure and increased vulnerability to protein toxicity at later ages in combination could explain the late age-of-onset of neurodegenerative phenotypes...
  14. pmc Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila
    Cathy Slack
    Institute of Healthy Ageing, Department of Genetics Evolution and Environment, University College London, London, United Kingdom
    PLoS ONE 7:e47699. 2012
    ..Thus, metformin appears to have evolutionarily conserved effects on metabolism but not on fecundity or lifespan...
  15. pmc Cell-nonautonomous effects of dFOXO/DAF-16 in aging
    Nazif Alic
    Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Cell Rep 6:608-16. 2014
    ..Whereas FoxO-to-FoxO signaling appears to be required for metabolic homeostasis, our results pinpoint FoxO-to-other signaling as an important mechanism through which localized FoxO activity ameliorates aging. ..
  16. pmc Calories do not explain extension of life span by dietary restriction in Drosophila
    William Mair
    Department of Biology, Centre for Research on Ageing, University College London, London, United Kingdom
    PLoS Biol 3:e223. 2005
    ..Calorie intake is therefore not the key factor in the reduction of mortality rate by DR in this species...
  17. pmc Stage debut for the elusive Drosophila insulin-like growth factor binding protein
    Nazif Alic
    Institute of Healthy Ageing, GEE, University College London, London, WC1E 6BT, UK
    J Biol 7:18. 2008
    ....
  18. pmc Antagonizing Methuselah to extend life span
    Nazif Alic
    UCL Centre for Research on Ageing, Department of Biology, Darwin Building, University College London, Gower St, London WC1E 6BT, UK
    Genome Biol 8:222. 2007
    ..A recent report describes the identification through the use of in vitro selection of a peptide that antagonizes Methuselah signaling in Drosophila in vitro and extends fly life span in vivo...
  19. pmc Estimation and correction of non-specific binding in a large-scale spike-in experiment
    Eugene F Schuster
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Cambridge CB10 1SD, UK
    Genome Biol 8:R126. 2007
    ....
  20. pmc Evolutionary conservation of regulated longevity assurance mechanisms
    Joshua J McElwee
    Department of Biology, University College London, London WC1E 6BT, UK
    Genome Biol 8:R132. 2007
    ..To address this, we have applied a novel, multi-level cross-species comparative analysis to compare gene expression changes accompanying increased longevity in mutant nematodes, fruitflies and mice with reduced IIS...
  21. pmc Genome-wide gene expression in response to parasitoid attack in Drosophila
    Bregje Wertheim
    Centre for Evolutionary Genomics, Department of Biology, University College London, London WC1E 6BT, UK
    Genome Biol 6:R94. 2005
    ..The capsule sequesters and kills the parasite. The molecular processes involved are still poorly understood, especially compared with insect humoral immunity...
  22. pmc Correcting for sequence biases in present/absent calls
    Eugene F Schuster
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Cambridge CB10 1SD, UK
    Genome Biol 8:R125. 2007
    ..Correction of non-specific binding for both perfect-match and mismatch probes using probe-sequence models can partially remove the probe-sequence bias and result in better performance of the MAS 5.0 algorithm...
  23. pmc Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan
    Dickon M Humphrey
    MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Exp Gerontol 44:316-27. 2009
    ..These data suggest that lowering mitochondrial coupling by high expression of hUCP3 alters mNSC function in a way that appears to increase DILP-levels in fly heads and lead to a concomitant decrease in lifespan...
  24. pmc Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
    Ivana Bjedov
    Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, UK
    Cell Metab 11:35-46. 2010
    ..Rapamycin could increase life span of weak insulin/Igf signaling (IIS) pathway mutants and of flies with life span maximized by dietary restriction, indicating additional mechanisms...
  25. ncbi request reprint Dietary restriction, mortality trajectories, risk and damage
    Linda Partridge
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Mech Ageing Dev 126:35-41. 2005
    ..In rodents, some phenotypes associated with DR, including microarray profiles, show rapid switching with changed nutritional regime, pointing to potentially acute effects of DR in mammals...
  26. pmc Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network
    Linda Partridge
    Institute of Healthy Ageing, London, WC1E 6BT, UK
    Exp Gerontol 46:376-81. 2011
    ..Reduced IIS can act acutely to lower death rate, implying that it may ameliorate the effects of ageing-related damage, rather than preventing it...
  27. pmc Some highlights of research on aging with invertebrates, 2010
    Linda Partridge
    Max Planck Institute for Biology of Ageing, Gleueler Strasse 55a, 50931 Koln, Germany
    Aging Cell 10:5-9. 2011
    ..The invertebrates continue to be a power house of discovery for future work in mammals...
  28. ncbi request reprint Dietary restriction in Drosophila
    Linda Partridge
    UCL Centre for Research on Ageing, Department of Biology, University College London, London WC1E 6BT, UK
    Mech Ageing Dev 126:938-50. 2005
    ..This rapid mortality rate recovery provides a powerful framework within which to further investigate the mechanisms by which DR extends lifespan...
  29. ncbi request reprint Sex and death: what is the connection?
    Linda Partridge
    UCL Centre for Research on Ageing, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom
    Cell 120:461-72. 2005
    ..Understanding the molecular basis of the cost of reproduction will be informed by elucidation of the mechanisms by which DR and IIS affect these two traits...
  30. doi request reprint Some highlights of research on aging with invertebrates, 2008
    Linda Partridge
    Institute of Healthy Ageing and GEE, UCL, London, UK
    Aging Cell 7:605-8. 2008
    ..elegans, removal of the germ line in Drosophila turns out to extend lifespan. Aging research has suffered the loss of a great scientific leader, Seymour Benzer, and his trail-blazing work on aging and neurodegeneration is highlighted...
  31. ncbi request reprint Evolutionary theories of ageing applied to long-lived organisms
    L Partridge
    Department of Biology, University College London, Wolfson House, 4 Stephenson Way, NW1 2HE, London, UK
    Exp Gerontol 36:641-50. 2001
    ..Evidence for the roles of these two processes in the evolution of long-livedness can be derived from the response to selection, comparative studies of life history traits and testing for potential trade-offs at the mechanistic level...
  32. pmc The new biology of ageing
    Linda Partridge
    Institute of Healthy Ageing and GEE, UCL, London, UK
    Philos Trans R Soc Lond B Biol Sci 365:147-54. 2010
    ..Translating these discoveries into medical treatments poses new challenges, including changing clinical thinking towards broad-spectrum, preventative medicine and finding novel routes to drug development...
  33. ncbi request reprint Beyond the evolutionary theory of ageing, from functional genomics to evo-gero
    Linda Partridge
    Centre for Research on Ageing, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Trends Ecol Evol 21:334-40. 2006
    ....
  34. doi request reprint Forkhead transcription factors and ageing
    L Partridge
    Institute of Healthy Ageing, GEE, London, UK
    Oncogene 27:2351-63. 2008
    ....
  35. doi request reprint Some highlights of research on aging with invertebrates, 2009
    Linda Partridge
    Institute of Healthy Aging and GEE, UCL, Darwin Building, Gower St, London WC1E 6BT, UK
    Aging Cell 8:509-13. 2009
    ..elegans support the idea that damage from superoxide plays little or no role in aging in this organism, and have prompted discussion of other kinds of damage and other kinds of mechanisms for producing aging-related decline in function...
  36. ncbi request reprint Optimization of dietary restriction protocols in Drosophila
    Timothy M Bass
    UCL Centre for Research on Ageing, Department of Biology, University College London, Gower St, London, WC1E 6BT, UK
    J Gerontol A Biol Sci Med Sci 62:1071-81. 2007
    ..We propose procedures to ensure that diets are suitable for the study of DR in Drosophila...
  37. ncbi request reprint Mechanisms of ageing: public or private?
    Linda Partridge
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Genet 3:165-75. 2002
    ..As we discuss in this review, this conservation might stem from mechanisms that match reproductive rate to nutrient supply...
  38. ncbi request reprint Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    D J Clancy
    Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Science 292:104-6. 2001
    ..The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved...
  39. pmc The Acp26Aa seminal fluid protein is a modulator of early egg hatchability in Drosophila melanogaster
    T Chapman
    The Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Proc Biol Sci 268:1647-54. 2001
    ..The results show that subtle processes coordinate the stimulation of egg production and sperm storage in mating pairs...
  40. doi request reprint Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?
    M D W Piper
    Centre for Research on Ageing, Department of Biology, University College London, London, UK
    J Intern Med 263:179-91. 2008
    ....
  41. doi request reprint Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
    Colin Selman
    Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK
    Science 326:140-4. 2009
    ..Our results demonstrate that S6K1 influences healthy mammalian life-span and suggest that therapeutic manipulation of S6K1 and AMPK might mimic CR and could provide broad protection against diseases of aging...
  42. ncbi request reprint Cellular basis of wing size variation in Drosophila melanogaster: a comparison of latitudinal clines on two continents
    B J Zwaan
    Department of Biology, Galton Laboratory, University College, London, U K
    Heredity (Edinb) 84:338-47. 2000
    ..Our findings are discussed in relation to the cellular basis of evolutionary change in laboratory thermal selection lines and natural populations along latitudinal clines...
  43. ncbi request reprint The genetic bases of divergence in desiccation and starvation resistance among tropical and temperate populations of Drosophila melanogaster
    W J Kennington
    Department of Biology, Galton Laboratory, University College London, 4 Stephenson Way, London, NW1 2HE, UK
    Heredity (Edinb) 87:363-72. 2001
    ..More line-cross analysis studies of naturally diverged populations that take into account maternal effects will shed further light on the true incidence of epistasis and its importance in the evolutionary process...
  44. doi request reprint Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response
    Maria E Giannakou
    Centre for Research on Aging, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Aging Cell 7:187-98. 2008
    ....
  45. pmc Sex peptide of Drosophila melanogaster males is a global regulator of reproductive processes in females
    A Gioti
    Department of Genetics, Evolution and Environment, University College London, Gower Street, London, UK
    Proc Biol Sci 279:4423-32. 2012
    ..The expression of many genes in one sex can therefore be under the influence of a regulator expressed in the other. This could influence the extent of sexual conflict both within and between loci...
  46. ncbi request reprint Selection on age at reproduction in Drosophila melanogaster: female mating frequency as a correlated response
    C M Sgrò
    Department of Biology, University College London, United Kingdom
    Evolution 54:2152-5. 2000
    ..These results indicate that the response to selection on age at reproduction has involved changes in the scheduling of female reproductive behavior...
  47. ncbi request reprint Insulin/IGF signalling and ageing: seeing the bigger picture
    D Gems
    Department of Biology, University College London, 4 Stephenson Way, NW1 2HE, London, UK
    Curr Opin Genet Dev 11:287-92. 2001
    ..The focus now is on how this pathway is regulated, how it controls nematode ageing, and how this relates to the ageing process in higher animals...
  48. pmc A comparison of the genetic basis of wing size divergence in three parallel body size clines of Drosophila melanogaster
    A S Gilchrist
    Department of Biology, Galton Laboratory, University College London, London NW1 2HE, United Kingdom
    Genetics 153:1775-87. 1999
    ..The diversity in genetic architecture of the clines suggests that natural selection has produced similar phenotypic divergence by different combinations of gene action and interaction...
  49. ncbi request reprint Dietary restriction in long-lived dwarf flies
    David J Clancy
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 296:319. 2002
  50. ncbi request reprint The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster
    Tapiwanashe Magwere
    Centre for Research on Ageing, University College London, Department of Biology, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom
    Mech Ageing Dev 127:356-70. 2006
    ..These findings place significant constraints on the role of oxidative stress in normal ageing...
  51. ncbi request reprint Counting the calories: the role of specific nutrients in extension of life span by food restriction
    Matthew D W Piper
    Department of Biology, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK
    J Gerontol A Biol Sci Med Sci 60:549-55. 2005
    ..Delineation of the nutritional components that are critical for life-span extension will help to reveal the mechanisms by which it operates...
  52. pmc Genetic and environmental responses to temperature of Drosophila melanogaster from a latitudinal cline
    A C James
    Department of Biology, Galton Laboratory, University College London, United Kingdom
    Genetics 146:881-90. 1997
    ..Neither thorax length nor wing size and its cellular components showed significant latitudinal variation in plasticity...
  53. pmc Influence of female reproductive anatomy on the outcome of sperm competition in Drosophila melanogaster
    J Bangham
    Department of Biology, Darwin Building, University College London, Gower Street, London WC1E 6BT, UK
    Proc Biol Sci 270:523-30. 2003
    ..The results indicate that temporal patterns of sperm use as well as P(2) should be taken into account when measuring the outcome of sperm competition...
  54. ncbi request reprint Adaptation and constraint in the evolution of Drosophila melanogaster wing shape
    A S Gilchrist
    Department of Biology, University College London, UK
    Evol Dev 2:114-24. 2000
    ..The overall range of wing shape variation, across a large range of wing size, is extremely small, and the possibility that wing shape is subject to stabilizing selection (or canalization) is discussed...
  55. ncbi request reprint Quantitative genetic analysis of natural variation in body size in Drosophila melanogaster
    J Gockel
    Department of Biology, University College London, London, UK
    Heredity (Edinb) 89:145-53. 2002
    ..Future studies using higher resolution QTL maps should reveal whether the degree of clinality in microsatellite allele frequencies can be used to identify QTL in traits that vary along an environmental gradient...
  56. pmc Dietary restriction in Drosophila: delayed aging or experimental artefact?
    Matthew D W Piper
    University College London Centre for Research on Ageing, Department of Biology, University College London, London, United Kingdom
    PLoS Genet 3:e57. 2007
    ..We also indicate some experiments that could be performed to determine if DR in Drosophila operates through similar mechanisms to the process in rodents...
  57. ncbi request reprint Dynamics of the action of dFOXO on adult mortality in Drosophila
    Maria E Giannakou
    Centre for Research on Ageing, Department of Biology, University College London, London, UK
    Aging Cell 6:429-38. 2007
    ..The decreased mortality and increased lifespan of dFOXO overexpressing flies was uncoupled from any effect on female fecundity and from expression levels of Drosophila insulin-like peptides in the brain...
  58. pmc Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
    Susan J Broughton
    Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:3105-10. 2005
    ..However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation...
  59. ncbi request reprint Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity
    William Mair
    Department of Biology, University College London, Darwin Building, Gower Street, WC1E 6BT, UK
    Exp Gerontol 39:1011-9. 2004
    ....
  60. ncbi request reprint Diet, metabolism and lifespan in Drosophila
    Matthew D W Piper
    UCL Centre for Research on Ageing, Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Exp Gerontol 40:857-62. 2005
    ..Current data indicate lifespan-extension by DR is likely to involve both enhancement of various defense and detoxification mechanisms and a complex range of metabolic alterations that make energy available for these processes...
  61. ncbi request reprint A lethal side-effect
    Linda Partridge
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Nature 418:921. 2002
  62. ncbi request reprint Demography of dietary restriction and death in Drosophila
    William Mair
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Science 301:1731-3. 2003
    ..DR of mammals may also reduce short-term risk of death, and hence DR instigated at any age could generate a full reversal of mortality...
  63. pmc The role of male accessory gland protein Acp36DE in sperm competition in Drosophila melanogaster
    T Chapman
    Department of Biology, University College London, UK
    Proc Biol Sci 267:1097-105. 2000
    ..Our results indicate that mutations in genes that affect sperm storage can drastically affect the outcome of sperm competition...
  64. ncbi request reprint Starvation resistance and adult body composition in a latitudinal cline of Drosophila melanogaster
    S J Robinson
    Department of Biology, University College London, United Kingdom
    Evolution 54:1819-24. 2000
    ..We therefore suggest that the cline in starvation resistance in India may have evolved in response to specific climatic variation found only in India...
  65. ncbi request reprint Rapid laboratory evolution of adult wing area in Drosophila melanogaster in response to humidity
    W Jason Kennington
    Department of Biology, University College London, Darwin Building, Gower Street, London, WC1E 6BT, United Kingdom
    Evolution 57:932-6. 2003
    ..There were no evolutionary effects of temperature on wing area or cell density. This may have been due to the short duration of the selection experiment, and/or counteracting selection pressures on body size at warm temperature...
  66. ncbi request reprint Interpreting interactions between treatments that slow aging
    David Gems
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Aging Cell 1:1-9. 2002
    ..When considered in the light of these problems, the conclusions of a number of recent lifespan interaction studies appear questionable. We suggest six rules for avoiding the pitfalls that can beset interaction studies...
  67. pmc The sex peptide of Drosophila melanogaster: female post-mating responses analyzed by using RNA interference
    Tracey Chapman
    Department of Biology, Darwin Building, and Wolfson Institute for Biomedical Research, Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK
    Proc Natl Acad Sci U S A 100:9923-8. 2003
    ..The prolonged "sperm effect" on female receptivity and egg production is therefore entirely attributable to SP, but sperm are necessary for its occurrence...
  68. ncbi request reprint Endocrine regulation of aging and reproduction in Drosophila
    Janne M Toivonen
    Institute of Healthy Aging, UCL Research Department of Genetics, Environment and Evolution, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Mol Cell Endocrinol 299:39-50. 2009
    ..Here we shall review how major hormonal pathways in the fruit fly Drosophila melanogaster interact to influence reproductive capacity and aging...
  69. ncbi request reprint QTL mapping reveals a striking coincidence in the positions of genomic regions associated with adaptive variation in body size in parallel clines of Drosophila melanogaster on different continents
    Federico C F Calboli
    Department of Biology, University College London, Darwin Building, Gower Street, London, WC1E 2BT, United Kingdom
    Evolution 57:2653-8. 2003
    ....
  70. ncbi request reprint Sex differences in the effect of dietary restriction on life span and mortality rates in female and male Drosophila melanogaster
    Tapiwanashe Magwere
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom
    J Gerontol A Biol Sci Med Sci 59:3-9. 2004
    ....
  71. ncbi request reprint Long-lived Drosophila with overexpressed dFOXO in adult fat body
    Maria E Giannakou
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Science 305:361. 2004
    ..The role of FOXO transcription factors and the adipose tissue are therefore evolutionarily conserved in the regulation of aging, and reduction of IIS in the adult is sufficient to mediate its effects on life-span and fecundity...
  72. ncbi request reprint Different cell size and cell number contribution in two newly established and one ancient body size cline of Drosophila subobscura
    Federico C F Calboli
    Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Evolution 57:566-73. 2003
    ..The different cellular bases of different size clines are most likely explained either entirely by chance or by different patterns of genetic variance--or its expression--in founding populations...
  73. pmc Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
    Richard C Grandison
    Institute of Healthy Ageing, Department of Genetics Evolution and Environment, University College London, UK
    Nature 462:1061-4. 2009
    ..In other organisms, including mammals, it may be possible to obtain the benefits to lifespan of dietary restriction without incurring a reduction in fecundity, through a suitable balance of nutrients in the diet...
  74. ncbi request reprint A functioning ovary is not required for sex peptide to reduce receptivity to mating in D. melanogaster
    Andrew I Barnes
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    J Insect Physiol 53:343-8. 2007
    ..The results show that the effects of SP on receptivity are not dependent upon a fully functional ovary, and hence that egg development or laying is not causal in the SP receptivity response...
  75. ncbi request reprint Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster
    Scott D Pletcher
    Department of Biology, University College London, The Darwin Building, Gower Street, London WC1E 6BT, UK
    Curr Biol 12:712-23. 2002
    ..We used the global patterns of expression profiles to test if particular genomic regions contribute differentially to changes in transcript profiles with age and if global disregulation of gene expression occurs during aging...
  76. ncbi request reprint Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice
    Colin Selman
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, London, United Kingdom
    Physiol Genomics 27:187-200. 2006
    ..Mice undergoing acute CR rapidly adopt many transcriptional and metabolic changes of long-term CR, suggesting that the beneficial effects of CR may require only a short-term reduction in caloric intake...
  77. pmc No extension of lifespan by ablation of germ line in Drosophila
    Andrew I Barnes
    Department of Biology, University College London Darwin Building, Gower Street, London WC1E 6BT, UK
    Proc Biol Sci 273:939-47. 2006
    ..In addition, we suggest that the specific roles and putative patterns of molecular signalling in the germ line and somatic tissues are not conserved between flies and worms...
  78. ncbi request reprint Stress-response hormesis and aging: "that which does not kill us makes us stronger"
    David Gems
    Institute of Healthy Ageing and Department of Genetics, Environment and Evolution, University College London, London WC1E 6BT, UK
    Cell Metab 7:200-3. 2008
    ..The principle of stress-response hormesis is increasingly finding application in studies of aging, where hormetic increases in life span have been seen in several animal models...
  79. ncbi request reprint The evolution of longevity
    Linda Partridge
    Department of Biology, University College London, Darwin Building, Gower Street, WC1E 6BT, London, UK
    Curr Biol 12:R544-6. 2002
  80. ncbi request reprint The effect of dietary restriction on mitochondrial protein density and flight muscle mitochondrial morphology in Drosophila
    Tapiwanashe Magwere
    University College London, Department of Biology, Darwin Building, Gower Street, London WC1E 6BT, UK
    J Gerontol A Biol Sci Med Sci 61:36-47. 2006
    ..If DR in Drosophila extends life span by reducing ROS production, then it does so through mechanisms that operate only in vivo...
  81. doi request reprint Invertebrate models of age-related muscle degeneration
    Hrvoje Augustin
    Institute of Healthy Ageing and GEE, University College London, London WC1E 6BT, UK
    Biochim Biophys Acta 1790:1084-94. 2009
    ..The simplicity and accessibility of these models, however, offer ample opportunities for studying age-related myopathologies as well as investigating drugs and therapies to alleviate them...
  82. ncbi request reprint Some highlights of research on aging with invertebrates, 2006-2007
    Linda Partridge
    Centre for Research on Ageing, University College London, Department of Biology, Darwin Building, Gower Street, London WC1E 6BT, UK
    Aging Cell 6:595-8. 2007
    ..In the near future, studies of invertebrate aging are likely to move away from an exclusive reliance on genetic manipulation towards a more biochemical and physiological understanding of these systems...
  83. doi request reprint A longer and healthier life with TOR down-regulation: genetics and drugs
    Ivana Bjedov
    Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Biochem Soc Trans 39:460-5. 2011
    ..The proposed underlying anti-aging mechanisms are down-regulated translation, increased autophagy, altered metabolism and increased stress resistance...
  84. ncbi request reprint The contrasting genetic architecture of wing size and shape in Drosophila melanogaster
    A S Gilchrist
    Department of Biology, Galton Laboratory, University College London, London NW1 2HE, UK
    Heredity (Edinb) 86:144-52. 2001
    ..Our results support the idea that epistatic variance may be more common in natural populations than was once suspected. Also, our results suggest substantial directional selection on wing size but not shape...
  85. doi request reprint DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition
    Susan J Broughton
    Institute of Healthy Ageing and GEE, University College London, UK
    Aging Cell 9:336-46. 2010
    ....
  86. ncbi request reprint Role of insulin-like signalling in Drosophila lifespan
    Maria E Giannakou
    Centre for Research on Ageing, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Trends Biochem Sci 32:180-8. 2007
    ....
  87. ncbi request reprint Biomarkers of aging in Drosophila
    Jake Jacobson
    Department of Genes, Evolution and Environment, University College London, London WC1E 6BT, UK
    Aging Cell 9:466-77. 2010
    ..Our approach provides a powerful method for identification of biomarkers of aging...
  88. ncbi request reprint Benchmarks for ageing studies
    Linda Partridge
    Centre for Research on Ageing, Department of Biology, University College London, The Darwin Building, Gower Street, London WC1E 6BT, UK
    Nature 450:165-7. 2007
  89. pmc No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects
    Janne M Toivonen
    Department of Biology, University College London, London, United Kingdom
    PLoS Genet 3:e95. 2007
    ..In addition, we saw no effects on lifespan of expression knockdown of the Indy orthologues nac-2 and nac-3 in the nematode Caenorhabditis elegans...
  90. ncbi request reprint Why it is difficult to model sperm displacement in Drosophila melanogaster: the relation between sperm transfer and copulation duration
    A S Gilchrist
    Galton Laboratory, Department of Biology, University College London, United Kingdom
    Evolution 54:534-42. 2000
    ..Experimental interruption of first matings indicated that the extra copulation time serves to delay female remating, rather than to increase that rate at which of offspring are sired before remating...
  91. pmc Interactions of mating, egg production and death rates in females of the Mediterranean fruit fly, Ceratitis capitata
    T Chapman
    Galton Laboratory, Department of Biology, University College London, UK
    Proc Biol Sci 265:1879-94. 1998
    ..To put our results into context, we reviewed the existing literature on the effects of mating on longevity, egg production and sexual receptivity for 64 species of Diptera, and examined the pattern of mating effects that emerged...
  92. pmc Testing for asymmetrical gene flow in a Drosophila melanogaster body-size cline
    W Jason Kennington
    Department of Biology, University College London, London WC1E 2BT, United Kingdom
    Genetics 165:667-73. 2003
    ..We also show that, in contrast to the findings of a previous study, there is good evidence to suggest that the cline experiences significant levels of gene flow between populations...
  93. doi request reprint Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"
    Colin Selman
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, 5 University Street, London WC1E 6JJ, UK
    Science 320:1012; author reply 1012. 2008
    ..However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals...
  94. pmc Quantification of food intake in Drosophila
    Richard Wong
    Institute of Healthy Ageing, and GEE, University College London, London, UK
    PLoS ONE 4:e6063. 2009
    ..This approach provides a practical and reliable method for quantification of food intake in Drosophila under normal, undisturbed culture conditions...
  95. doi request reprint Insulin/IGF-like signalling, the central nervous system and aging
    Susan Broughton
    UCL Institute of Healthy Aging, GEE Genetics, Evolution and Environment, University College London, Gower St, London WC1E 6BT, UK
    Biochem J 418:1-12. 2009
    ..Tissue-specific manipulation of IIS and the cellular defence mechanisms that it regulates will better define the ways in which IIS affects neuronal and whole-organism function during aging...
  96. ncbi request reprint Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans
    Timothy M Bass
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Mech Ageing Dev 128:546-52. 2007
    ..1 mutant animals. We postulate that the effect of resveratrol upon lifespan in C. elegans could reflect induction of phase 2 drug detoxification or activation of AMP kinase...
  97. doi request reprint Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster
    Richard Wong
    Institute for Healthy Ageing, Darwin Building, University College London, Gower St, London, WC1E 6BT, UK
    Nat Methods 5:214-5; author reply 215. 2008
  98. ncbi request reprint Behavioural genetics: molecular genetics meets feeding ecology
    L Partridge
    Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK
    Curr Biol 8:R23-4. 1998
    ..This polymorphism is determined by alleles of a cyclic GMP-dependent protein kinase gene; rovers are at an advantage in crowded populations, while sitters have the edge at low population density...
  99. pmc Nonclinality of molecular variation implicates selection in maintaining a morphological cline of Drosophila melanogaster
    J Gockel
    Galton Laboratory, Department of Biology, University College, 4 Stephenson Way, London NW1 2HE, United Kingdom
    Genetics 158:319-23. 2001
    ..Explicit incorporation of the relevant environmental gradient can result in a simple and powerful test of selection. For the Australian cline, our analysis provides strong internal evidence that the cline is due to selection...
  100. ncbi request reprint Genetic variation for preadult viability in Drosophila melanogaster
    M Gardner
    Department of Biology, University College London, United Kingdom
    Evolution 55:1609-20. 2001
    ..Similarly, there was a positive correlation between heterozygous viability and mean numbers at low density, but a negative correlation at high density...
  101. ncbi request reprint Flight activity, mortality rates, and lipoxidative damage in Drosophila
    Tapiwanashe Magwere
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    J Gerontol A Biol Sci Med Sci 61:136-45. 2006
    ..The effect of flight activity on insect life span differs considerably from the beneficial effects of exercise in mammals; these differences may be caused by physiological differences between the two taxa...