L Partridge

Summary

Affiliation: University College London
Country: UK

Publications

  1. Catterson J, Khericha M, Dyson M, Vincent A, Callard R, Haveron S, et al. Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension. Curr Biol. 2018;: pubmed publisher
    ..We conclude that short-term IF during early life can induce long-lasting beneficial effects, with robust increase in lifespan in a TOR-independent manner, probably at least in part by preserving gut health. ..
  2. Woodling N, Partridge L. Parkinson's Disease: Mitochondria Parked at the ER Hit the Snooze Button. Neuron. 2018;98:1059-1061 pubmed publisher
    ..In this issue of Neuron, Valadas et al. (2018) report that the disease genes pink1 and parkin exert novel, cell-type-specific effects to modulate ER-mitochondria contacts, neuropeptidergic transmission, and sleep patterns. ..
  3. Alic N, Partridge L. Myc mouse and anti-ageing therapy. Trends Endocrinol Metab. 2015;26:163-4 pubmed publisher
    ..Is this new anti-ageing intervention pointing a way towards new treatments for age-related diseases? ..
  4. Partridge L. Some highlights of research on aging with invertebrates, 2008. Aging Cell. 2008;7:605-8 pubmed publisher
    ..elegans, removal of the germ line in Drosophila turns out to extend lifespan. Aging research has suffered the loss of a great scientific leader, Seymour Benzer, and his trail-blazing work on aging and neurodegeneration is highlighted. ..
  5. Partridge L. Some highlights of research on aging with invertebrates, 2009. Aging Cell. 2009;8:509-13 pubmed publisher
    ..elegans support the idea that damage from superoxide plays little or no role in aging in this organism, and have prompted discussion of other kinds of damage and other kinds of mechanisms for producing aging-related decline in function. ..
  6. Partridge L. The new biology of ageing. Philos Trans R Soc Lond B Biol Sci. 2010;365:147-54 pubmed publisher
    ..Translating these discoveries into medical treatments poses new challenges, including changing clinical thinking towards broad-spectrum, preventative medicine and finding novel routes to drug development. ..
  7. Moens T, Mizielinska S, Niccoli T, Mitchell J, Thoeng A, Ridler C, et al. Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD. Acta Neuropathol. 2018;135:445-457 pubmed publisher
    ..We find that neither cytoplasmic nor nuclear sense or antisense RNA are toxic when expressed in adult Drosophila neurons, suggesting they have a limited role in disease pathogenesis. ..
  8. Sofola Adesakin O, Khericha M, Snoeren I, Tsuda L, Partridge L. pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicity. Acta Neuropathol Commun. 2016;4:109 pubmed
    ..Our findings implicate AβpE3-42 as an important source of toxicity in AD, and suggest that its specific degradation could be therapeutic. ..
  9. Slack C, Alic N, Foley A, Cabecinha M, Hoddinott M, Partridge L. The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity. Cell. 2015;162:72-83 pubmed publisher

More Information

Publications15

  1. Castillo Quan J, Li L, Kinghorn K, Ivanov D, Tain L, Slack C, et al. Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis. Cell Rep. 2016;15:638-650 pubmed publisher
    ..The discovery of GSK-3 as a therapeutic target for aging will likely lead to more effective treatments that can modulate mammalian aging and further improve health in later life. ..
  2. request reprint
    Partridge L, Gems D, Withers D. Sex and death: what is the connection?. Cell. 2005;120:461-72 pubmed
    ..Understanding the molecular basis of the cost of reproduction will be informed by elucidation of the mechanisms by which DR and IIS affect these two traits. ..
  3. Partridge L, Alic N, Bjedov I, Piper M. Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network. Exp Gerontol. 2011;46:376-81 pubmed publisher
    ..Reduced IIS can act acutely to lower death rate, implying that it may ameliorate the effects of ageing-related damage, rather than preventing it. ..
  4. Partridge L. Some highlights of research on aging with invertebrates, 2010. Aging Cell. 2011;10:5-9 pubmed publisher
    ..The invertebrates continue to be a power house of discovery for future work in mammals. ..
  5. Alic N, Tullet J, Niccoli T, Broughton S, Hoddinott M, Slack C, et al. Cell-nonautonomous effects of dFOXO/DAF-16 in aging. Cell Rep. 2014;6:608-16 pubmed publisher
    ..Whereas FoxO-to-FoxO signaling appears to be required for metabolic homeostasis, our results pinpoint FoxO-to-other signaling as an important mechanism through which localized FoxO activity ameliorates aging. ..
  6. Bolukbasi E, Khericha M, Regan J, Ivanov D, Adcott J, Dyson M, et al. Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity. Cell Rep. 2017;21:641-653 pubmed publisher
    ..Malnutrition caused by poor intestinal absorption is a major problem in the elderly, and a better understanding of the mechanisms involved will have important therapeutic implications for human aging. ..