Andrew C Parrott

Summary

Affiliation: University of Wales
Country: UK

Publications

  1. ncbi request reprint MDMA (3,4-methylenedioxymethamphetamine) or ecstasy: the contemporary human and animal research perspective
    Andy C Parrott
    J Psychopharmacol 20:143-6. 2006
  2. doi request reprint Increased cortisol levels in hair of recent Ecstasy/MDMA users
    A C Parrott
    Department of Psychology, Swansea University, Swansea SA2 8PP, Wales, UK Centre for Human Psychopharmacology CHP, Swinburne University, Australia Electronic address
    Eur Neuropsychopharmacol 24:369-74. 2014
  3. ncbi request reprint MDMA, serotonergic neurotoxicity, and the diverse functional deficits of recreational 'Ecstasy' users
    Andrew C Parrott
    Department of Psychology, Swansea University, Swansea, SA2 8PP, South Wales, United Kingdom Centre for Human Psychopharmacology, Swinburne University, Melbourne, Australia Electronic address
    Neurosci Biobehav Rev 37:1466-84. 2013
  4. doi request reprint Human psychobiology of MDMA or 'Ecstasy': an overview of 25 years of empirical research
    Andrew C Parrott
    Department of Psychology, Swansea University, Swansea, South Wales, UK
    Hum Psychopharmacol 28:289-307. 2013
  5. pmc MDMA and 5-HT neurotoxicity: the empirical evidence for its adverse effects in humans - no need for translation
    Andrew C Parrott
    Department of Psychology, Swansea University, UK
    Br J Pharmacol 166:1518-20; discussion 1521-2. 2012
  6. doi request reprint Adult attention deficit hyperactivity disorder and other psychiatric symptoms in recreational polydrug users
    Andrew C Parrott
    Department of Psychology, Swansea University, UK
    Hum Psychopharmacol 27:209-16. 2012
  7. doi request reprint MDMA and temperature: a review of the thermal effects of 'Ecstasy' in humans
    A C Parrott
    Department of Psychology, Swansea University, Swansea SA2 8PP, United Kingdom
    Drug Alcohol Depend 121:1-9. 2012
  8. ncbi request reprint Dancing hot on Ecstasy: physical activity and thermal comfort ratings are associated with the memory and other psychobiological problems reported by recreational MDMA users
    A C Parrott
    University of Wales Swansea, Swansea, Wales, UK
    Hum Psychopharmacol 21:285-98. 2006
  9. ncbi request reprint Chronic tolerance to recreational MDMA (3,4-methylenedioxymethamphetamine) or Ecstasy
    A C Parrott
    Department of Psychology, University of Wales, Swansea, UK
    J Psychopharmacol 19:71-83. 2005
  10. ncbi request reprint Ecstasy/MDMA and cannabis: the complexities of their interactive neuropsychobiological effects
    A C Parrott
    University of Wales, Swansea SA2 8PP, UK
    J Psychopharmacol 18:572-5. 2004

Detail Information

Publications40

  1. ncbi request reprint MDMA (3,4-methylenedioxymethamphetamine) or ecstasy: the contemporary human and animal research perspective
    Andy C Parrott
    J Psychopharmacol 20:143-6. 2006
  2. doi request reprint Increased cortisol levels in hair of recent Ecstasy/MDMA users
    A C Parrott
    Department of Psychology, Swansea University, Swansea SA2 8PP, Wales, UK Centre for Human Psychopharmacology CHP, Swinburne University, Australia Electronic address
    Eur Neuropsychopharmacol 24:369-74. 2014
    ..Future study design and directions for research concerning the psychoneuroendocrinological impact of MDMA are also discussed...
  3. ncbi request reprint MDMA, serotonergic neurotoxicity, and the diverse functional deficits of recreational 'Ecstasy' users
    Andrew C Parrott
    Department of Psychology, Swansea University, Swansea, SA2 8PP, South Wales, United Kingdom Centre for Human Psychopharmacology, Swinburne University, Melbourne, Australia Electronic address
    Neurosci Biobehav Rev 37:1466-84. 2013
    ..In summary, abstinent Ecstasy/MDMA users can show deficits in a wide range of biobehavioral functions with a serotonergic component. ..
  4. doi request reprint Human psychobiology of MDMA or 'Ecstasy': an overview of 25 years of empirical research
    Andrew C Parrott
    Department of Psychology, Swansea University, Swansea, South Wales, UK
    Hum Psychopharmacol 28:289-307. 2013
    ..This paper aimed to review how scientific knowledge about the human psychobiology of MDMA has developed over time...
  5. pmc MDMA and 5-HT neurotoxicity: the empirical evidence for its adverse effects in humans - no need for translation
    Andrew C Parrott
    Department of Psychology, Swansea University, UK
    Br J Pharmacol 166:1518-20; discussion 1521-2. 2012
    ..Hence, MDMA is clearly damaging to humans, with extensive empirical data for both structural and functional deficits...
  6. doi request reprint Adult attention deficit hyperactivity disorder and other psychiatric symptoms in recreational polydrug users
    Andrew C Parrott
    Department of Psychology, Swansea University, UK
    Hum Psychopharmacol 27:209-16. 2012
    ..This study investigated whether symptoms of adult attention deficit hyperactivity disorder (ADHD) were also raised in polydrug users...
  7. doi request reprint MDMA and temperature: a review of the thermal effects of 'Ecstasy' in humans
    A C Parrott
    Department of Psychology, Swansea University, Swansea SA2 8PP, United Kingdom
    Drug Alcohol Depend 121:1-9. 2012
    ..To review the thermal effects of MDMA in humans, and discuss the practical implications...
  8. ncbi request reprint Dancing hot on Ecstasy: physical activity and thermal comfort ratings are associated with the memory and other psychobiological problems reported by recreational MDMA users
    A C Parrott
    University of Wales Swansea, Swansea, Wales, UK
    Hum Psychopharmacol 21:285-98. 2006
    ..We assessed whether dancing and feeling hot on Ecstasy would be associated with more psychobiological problems in recreational users...
  9. ncbi request reprint Chronic tolerance to recreational MDMA (3,4-methylenedioxymethamphetamine) or Ecstasy
    A C Parrott
    Department of Psychology, University of Wales, Swansea, UK
    J Psychopharmacol 19:71-83. 2005
    ..Several traditional processes are probably involved, but one of the possible causes is a novel mechanism largely unique to the ring substituted amphetamine derivatives, namely serotonergic neurotoxicity...
  10. ncbi request reprint Ecstasy/MDMA and cannabis: the complexities of their interactive neuropsychobiological effects
    A C Parrott
    University of Wales, Swansea SA2 8PP, UK
    J Psychopharmacol 18:572-5. 2004
  11. ncbi request reprint Alcohol, ecstasy, Aldous Huxley's 'soma'
    A C Parrott
    Department of Psychology, Swansea University, Swansea SA2 8PP, UK
    J Psychopharmacol 21:8-9. 2007
  12. ncbi request reprint The psychotherapeutic potential of MDMA (3,4-methylenedioxymethamphetamine): an evidence-based review
    A C Parrott
    Department of Psychology, University of Wales Swansea, Swansea, SA2 8PP, Wales, UK
    Psychopharmacology (Berl) 191:181-93. 2007
    ..AIMS AND RATIONALE: The purpose of this study was to review whether methylenedioxymethamphetamine (MDMA) has the appropriate pharmacodynamic profile to be a therapeutic agent...
  13. ncbi request reprint Cannabis and Ecstasy/MDMA (3,4-methylenedioxymethamphetamine): an analysis of their neuropsychobiological interactions in recreational users
    A C Parrott
    Swansea University, Swansea, Wales, UK
    J Neural Transm 114:959-68. 2007
    ..In order to investigate these potential complexities, future research will need better empirical data on the exact patterns of co-drug usage...
  14. ncbi request reprint Is ecstasy MDMA? A review of the proportion of ecstasy tablets containing MDMA, their dosage levels, and the changing perceptions of purity
    A C Parrott
    Department of Psychology, University of Wales Swansea, Swansea, SAZ 8PP, United Kingdom
    Psychopharmacology (Berl) 173:234-41. 2004
    ..The historical origins and evolution of this mismatch will be reviewed, in order to estimate the proportions of ecstasy tablets containing MDMA at different periods over the past 30 years...
  15. pmc Dance clubbing on MDMA and during abstinence from Ecstasy/MDMA: prospective neuroendocrine and psychobiological changes
    A C Parrott
    Department of Psychology Swansea University, Swansea, UK
    Neuropsychobiology 57:165-80. 2008
    ..The present study is the first to prospectively compare a group of recreational Ecstasy users when dance clubbing on 3,4-methylenedioxymethamphetamine (MDMA) and when clubbing during abstinence from Ecstasy/MDMA...
  16. pmc Cortisol and 3,4-methylenedioxymethamphetamine: neurohormonal aspects of bioenergetic stress in ecstasy users
    A C Parrott
    Department of Psychology, Swansea University, Swansea SA2 8PP, UK
    Neuropsychobiology 60:148-58. 2009
    ..3,4-Methylenedioxymethamphetamine (MDMA) can affect both neurotransmitter and neurohormonal activity. This review will debate the role of the metabolic activation hormone cortisol for the psychobiological effects of ecstasy/MDMA...
  17. doi request reprint MDMA and methamphetamine: some paradoxical negative and positive mood changes in an acute dose laboratory study
    Andrew C Parrott
    Brain Sciences Institute, Swinburne University, Melbourne, Vic, Australia
    Psychopharmacology (Berl) 215:527-36. 2011
    ..This study investigated the acute mood effects of oral MDMA, methamphetamine, and placebo in a double-blind laboratory study...
  18. ncbi request reprint MDMA in humans: factors which affect the neuropsychobiological profiles of recreational ecstasy users, the integrative role of bioenergetic stress
    Andy C Parrott
    Department of Psychology, University of Swansea, UK
    J Psychopharmacol 20:147-63. 2006
    ..These multiple influences are integrated within a bioenergetic stress model, where factors which heighten acute metabolic distress lead to more neuropsychobiological problems...
  19. pmc Procedural and declarative memory task performance, and the memory consolidation function of sleep, in recent and abstinent ecstasy/MDMA users
    Mark Blagrove
    Swansea University, Swansea, UK
    J Psychopharmacol 25:465-77. 2011
    ..However, ecstasy/MDMA did not affect the memory consolidation function of sleep for either the declarative or the procedural memory task...
  20. ncbi request reprint Recreational ecstasy/MDMA and other drug users from the UK and Italy: psychiatric symptoms and psychobiological problems
    A C Parrott
    Department of Psychology, University of East London, London E15 4LZ, UK
    Psychopharmacology (Berl) 159:77-82. 2001
    ..Recreational drug use is increasingly widespread amongst young people, but there are concerns that psychoactive drugs may be associated with psychiatric symptoms or psychobiological problems...
  21. ncbi request reprint MDMA (3,4-Methylenedioxymethamphetamine) or ecstasy: the neuropsychobiological implications of taking it at dances and raves
    A C Parrott
    Department of Psychology, University of Wales, Swansea, UK
    Neuropsychobiology 50:329-35. 2004
    ..Consistent with this prediction, the extent of self-reported dancing/exercise when on MDMA has recently been shown to be associated with significantly more psychobiological problems afterwards...
  22. ncbi request reprint Ecstasy (MDMA) effects upon mood and cognition: before, during and after a Saturday night dance
    A C Parrott
    Department of Psychology, University of East London, UK
    Psychopharmacology (Berl) 139:261-8. 1998
    ..The cognitive deficits in drug-free recreational ecstasy users, suggest that MDMA may also be neurotoxic in humans...
  23. ncbi request reprint Psychobiological problems in heavy 'ecstasy' (MDMA) polydrug users
    A C Parrott
    Department of Psychology, University of East London, London, UK
    Drug Alcohol Depend 60:105-10. 2000
    ..However, since repeated MDMA can cause serotonergic neurotoxicity in laboratory animals and man, these problems may reflect reduced serotonin activity induced by regular ecstasy use...
  24. ncbi request reprint Cognitive performance in recreational users of MDMA of 'ecstasy': evidence for memory deficits
    A C Parrott
    Department of Psychology, University of East London, UK
    J Psychopharmacol 12:79-83. 1998
    ..Although the design of this study was far from ideal, these data are consistent with other findings of memory decrements in recreational MDMA users, possibly caused by serotonergic neurotoxicity...
  25. ncbi request reprint Ecstasy use: cognitive deficits related to dosage rather than self-reported problematic use of the drug
    H C Fox
    Department of Psychology, University of East London, UK
    J Psychopharmacol 15:273-81. 2001
    ..Because all Ecstasy participants also consumed a range of other illicit drugs, the results are reflective of Ecstasy polydrug use in individuals who use Ecstasy as a drug of preference...
  26. ncbi request reprint Neuropsychological evidence of a relatively selective profile of temporal dysfunction in drug-free MDMA ("ecstasy") polydrug users
    H C Fox
    Department of Psychology, University of East London, Romford Road, London E15 4LZ, UK
    Psychopharmacology (Berl) 162:203-14. 2002
    ..The serotonin system predominantly innervates frontal and limbic regions of the brain and has been associated with consolidatory learning and mnemonic processes in humans...
  27. ncbi request reprint 'Is MDMA a human neurotoxin?': diverse views from the discussants
    J J Turner
    Department of Psychology, University of East London, London, UK
    Neuropsychobiology 42:42-8. 2000
    ..Moreover, these deficits often remained when other illicit drug use was statistically controlled. In conclusion: If MDMA neurotoxicity in humans is a myth, then it is a myth with a heavy serotonergic component...
  28. doi request reprint Explaining the stress-inducing effects of nicotine to cigarette smokers
    Andrew C Parrott
    Department of Psychology, Swansea University, UK
    Hum Psychopharmacol 27:150-5. 2012
    ..To explain how nicotine dependency causes mood fluctuation and increases daily stress...
  29. ncbi request reprint Human research on MDMA (3,4-methylene- dioxymethamphetamine) neurotoxicity: cognitive and behavioural indices of change
    A C Parrott
    Department of Psychology, University of East London, London, UK
    Neuropsychobiology 42:17-24. 2000
    ..Finally, this profile of cognitive deficits is also consistent with a hypothetical integrative construct: namely reduced cortical inhibition...
  30. ncbi request reprint Persistent neuropsychological problems after 7 years of abstinence from recreational Ecstasy (MDMA): a case study
    K Soar
    Department of Psychology, School of Psychology, University of East London, UK
    Psychol Rep 95:192-6. 2004
    ..Severe problems with sleep and sex were also reported. Further studies involving larger groups of abstinent former users are needed; adverse sequelae associated with intensive Ecstasy use may sometimes be enduring...
  31. ncbi request reprint Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity
    A C Parrott
    Department of Psychology, University of East London, E15 4LZ, London, UK
    Pharmacol Biochem Behav 71:837-44. 2002
    ..Functional deficits may remain long after drug use has ceased and are consistent with serotonergic axonal loss in higher brain regions...
  32. ncbi request reprint Self-rated everyday and prospective memory abilities of cigarette smokers and non-smokers: a web-based study
    T M Heffernan
    Human Cognitive Neuroscience Unit, Department of Psychology, Northumbria University, Newcastle upon Tyne NE1 8ST, UK
    Drug Alcohol Depend 78:235-41. 2005
    ..057). These findings suggest there are selective memory deficits associated with smoking and that long-term prospective memory deficits should be added to the growing list of problems associated with cigarette use...
  33. ncbi request reprint Daily uplifts, hassles, stresses and cognitive failures: in cigarette smokers, abstaining smokers, and non-smokers
    A C Parrott
    Department of Psychology, University of East London, UK
    Behav Pharmacol 10:639-46. 1999
    ..The repetitive use of nicotine by cigarette smokers does not seem to generate any real psychobiological gains or advantages. Instead, dependent smokers need regular hits of nicotine just to remain feeling normal...
  34. ncbi request reprint Nesbitt's Paradox resolved? Stress and arousal modulation during cigarette smoking
    A C Parrott
    Department of Psychology, University of East London, UK
    Addiction 93:27-39. 1998
    ..Nesbitt's Paradox is therefore not actually a paradox; it never was a paradox...
  35. ncbi request reprint Cannabis and Ecstasy/ MDMA: empirical measures of creativity in recreational users
    Katy A Jones
    Department of Psychology, School of Health and Behavioural Sciences, University of Wollongong, New South Wales 2522, Australia
    J Psychoactive Drugs 41:323-9. 2009
    ..Cannabis users produced significantly more "rare-creative" responses, but did not rate themselves as more creative...
  36. ncbi request reprint Gender differences in self-reported anxiety, depression, and somatization among ecstasy/MDMA polydrug users, alcohol/tobacco users, and nondrug users
    Raffaella M Milani
    School of Psychology, University of East London, Romford Road, London E15 4LZ, UK
    Addict Behav 29:965-71. 2004
    ..Interestingly, in the male sample, drug users reported higher symptom ratings than nondrug users, whereas women's scores remained constant across drug groups...
  37. ncbi request reprint Differential experiences of the psychobiological sequelae of ecstasy use: quantitative and qualitative data from an internet study
    Jacqui Rodgers
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    J Psychopharmacol 20:437-46. 2006
    ..Participants also reported a number of effects that they regarded as beneficial. Future research should also take these aspects of use into account...
  38. ncbi request reprint Cannabis, ecstasy/MDMA and memory: a commentary on Simon & Mattick's recent study
    Andy C Parrott
    Addiction 98:1003-4; author reply 1004-5. 2003
  39. ncbi request reprint International Conference on Memory (ICOM-4), University of New South Wales, Sydney, Australia, 16-21 July 2006 Ecstasy/MDMA and Memory Symposium
    Andy C Parrott
    Department of Psychology, University of Swansea, Swansea, UK
    J Psychopharmacol 21:895-7. 2007
  40. ncbi request reprint MDMA and the loss of reinforcement in Fantegrossi et al (2004)
    Andy C Parrott
    Neuropsychopharmacology 29:1940-1; author reply 1942. 2004