Research Topics
| R W ParksSummaryAffiliation: University of Edinburgh Country: UK Publications
| Collaborators
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Detail Information
Publications
Early career choices and successful career progression in surgery in the UK: prospective cohort studiesMichael J Goldacre
UK Medical Careers Research Group, Department of Public Health, Oxford University, Oxford, UK
BMC Surg 10:32. 2010..We studied trends in career choices for surgery, and the eventual career destinations, of UK graduates who declared an early preference for surgery...- Management of pancreatic pseudocystsR W Parks
Surgical Unit, Mater Hospital, Belfast, UK
Ann R Coll Surg Engl 82:383-7. 2000..This review analyses the outcome for patients with acute and chronic pancreatic pseudocysts managed in two major referral centres... 
Changes in gastrointestinal morphology associated with obstructive jaundiceR W Parks
Department of Surgery, The Queen s University of Belfast, Northern Ireland, UK
J Pathol 192:526-32. 2000..Significant bacterial translocation occurs following bile duct ligation and this supports the hypothesis of gut barrier dysfunction with obstructive jaundice...- Host immune responses and intestinal permeability in patients with jaundiceR W Parks
Department of Surgery, Queen s University of Belfast, Northern Ireland, UK
Br J Surg 90:239-45. 2003..The aims of these studies were to assess the systemic immune response to intervention in patients with jaundice and to compare the effects of surgical and non-surgical biliary drainage on host immune function and gut barrier function... - Benefits of specialisation in the management of pancreatic cancer: results of a Scottish population-based studyR W Parks
Department of Clinical and Surgical Sciences, The University of Edinburgh, Royal Infirmary, 51 Little France Crescent, Edinburgh EH16 4SA, UK
Br J Cancer 91:459-65. 2004..Specialisation and concentration of cancer care has major implications for the delivery of health services... - Prognostic factors in the palliation of pancreatic cancerF J F Engelken
Department of Clinical and Surgical Sciences Surgery, The University of Edinburgh, Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh, EH3 9YW, UK
Eur J Surg Oncol 29:368-73. 2003..The aim is to evaluate the prognostic significance of clinical and laboratory variables in patients with unresectable pancreatic cancer... - Palliation for suspected unresectable hilar cholangiocarcinomaS Connor
Department of Clinical and Surgical Sciences Surgery, University of Edinburgh, Royal Infirmary, Edinburgh EH16 4SA, UK
Eur J Surg Oncol 33:341-5. 2007..The aim of this study was to evaluate the outcome of different techniques of palliation for patients with hilar cholangiocarcinoma... - Glutamine improves intestinal barrier function in experimental biliary obstructionJ S White
Department of Surgery, School of Medicine, Queen s University of Belfast, Belfast, UK
Eur Surg Res 37:342-7. 2005..To determine the effects of enteral administration of glutamine on intestinal barrier function in experimental biliary obstruction... - The probiotic bacterium Lactobacillus plantarum species 299 reduces intestinal permeability in experimental biliary obstructionJ S White
Department of Surgery, School of Medicine, Queen s University of Belfast, Belfast, UK
Lett Appl Microbiol 42:19-23. 2006..Significance and Impact of the Study: This study provides insight to direct further work into the modulation of intestinal barrier function by probiotic bacteria... - Liver resection and transplantation in the management of iatrogenic biliary injuryB N J Thomson
Department of Clinical and Surgical Sciences Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK
World J Surg 31:2363-9. 2007..Biliary injury during cholecystectomy can be managed successfully by biliary reconstruction in the majority of patients; however, a proportion of patients may require hepatic resection or even liver transplantation... 
The selective use of magnetic resonance cholangiopancreatography in the imaging of the axial biliary tree in patients with acute gallstone pancreatitisR Mofidi
Department of Clinical and Surgical Sciences Surgery, University of Edinburgh, Edinburgh, UK
Pancreatology 8:55-60. 2008..The aim of this study was to assess the impact following the introduction of MRCP in the management of AGP in a tertiary referral unit...- Follow-up and outcomes for resection of colorectal liver metastases in EdinburghS Connor
Division of Clinical and Surgical Sciences Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, United Kingdom
Eur J Surg Oncol 33:55-60. 2007..The aim of this study was to assess the value of a defined follow-up protocol for patients undergoing potentially curative hepatic resection for colorectal hepatic metastases... - Risk assessment in acute pancreatitisR Mofidi
Department of Clinical and Surgical Sciences Surgery, University of Edinburgh, Edinburgh, UK
Br J Surg 96:137-50. 2009..Acute pancreatitis has a variable natural history and in a proportion of patients is associated with severe complications and a significant risk of death. The various tools available for risk assessment in acute pancreatitis are reviewed... - Predicting survival in patients with liver cancer considered for transarterial chemoembolizationS J Wigmore
Department of Clinical and Surgical Science, University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, EH16 4SA Edinburgh, UK
Eur J Surg Oncol 30:41-5. 2004..This study attempts to identify patients with liver cancer most likely to benefit from this type of treatment... - Predicting survival in patients with hepatocellular carcinoma: a UK perspectiveJ W C Kung
Department of Clinical and Surgical Sciences Surgery, Royal Infirmary of Edinburgh, University of Edinburgh, Ward 106 Room F3307, 51 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SA, UK
Eur J Surg Oncol 33:188-94. 2007..The aim of this study was to compare the Okuda, Cancer of the Liver Italian Program (CLIP), and Barcelona Clinic Liver Cancer (BCLC) classifications as predictors of survival in UK patients with HCC... - Prognostic factors in patients undergoing surgery for severe necrotizing pancreatitisR Mofidi
Department of Clinical and Surgical Sciences, University of Edinburgh, Royal Infirmary of Edinburgh, Old Dalkeith Road, Edinburgh, UK
World J Surg 31:2002-7. 2007..Necrosectomy is associated with poorer outcome when performed within 2 weeks of presentation... - The relationship between hospital volume and post-operative mortality rates for upper gastrointestinal cancer resections: Scotland 1982-2003R J E Skipworth
Clinical and Surgical Sciences Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, UK
Eur J Surg Oncol 36:141-7. 2010..Centralisation of surgical treatment of cancer has resulted in improved outcomes. We aimed to determine evidence of benefit for specialised management of upper gastrointestinal cancer in high-volume centres in Scotland... - Refining the role of laparoscopy and laparoscopic ultrasound in the staging of presumed pancreatic head and ampullary tumoursB N J Thomson
Department of Clinical and Surgical Sciences Surgery, 51 Little France Crescent, Edinburgh, EH16 4SA, UK
Br J Cancer 94:213-7. 2006..The remaining patient was deemed unfit for resection. Selective use of laparoscopic ultrasound is indicated in the staging of periampullary tumours with CT grades A to D... - Association between early systemic inflammatory response, severity of multiorgan dysfunction and death in acute pancreatitisR Mofidi
Department of Clinical and Surgical Sciences, University of Edinburgh, Royal Infirmary of Edinburgh, Old Dalkeith Road, Edinburgh EH16 4SA, UK
Br J Surg 93:738-44. 2006..001). CONCLUSION: Persistent SIRS is associated with MODS and death in patients with acute pancreatitis and is an early indicator of the likely severity of acute pancreatitis... - The extent of resection influences outcome following hepatectomy for colorectal liver metastasesG D Stewart
Department of Clinical and Surgical Sciences (Surgery, Royal Infirmary of Edinburgh, University of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SA, UK
Eur J Surg Oncol 30:370-6. 2004..Extended liver resections have a role for selected patients with bilobar colorectal metastases or large solitary deposits close to the hepatic vein confluence... - Early specialist repair of biliary injuryB N J Thomson
Department of Clinical and Surgical Sciences (Surgery, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK
Br J Surg 93:216-20. 2006..In selected patients, early repair within the first 2 weeks resulted in a similar outcome to that of delayed repair... - Randomized clinical trial of laxatives and oral nutritional supplements within an enhanced recovery after surgery protocol following liver resectionP O Hendry
Clinical and Surgical Sciences Surgery, Royal Infirmary, Edinburgh, UK
Br J Surg 97:1198-206. 2010..Combined with carbohydrate loading and oral nutritional supplements (ONS), it may further enhance recovery of gastrointestinal function and promote earlier overall recovery... - Guidelines for resection of colorectal cancer liver metastasesO J Garden
Clinical and Surgical Sciences (Surgery, University of Edinburgh, Royal Infirmary, 51 Little France Crescent, Edinburgh EH16 4SA, UK
Gut 55:iii1-8. 2006 - Palliation of pancreatic neoplasmsB N J Thomson
Department of Clinical and Surgical Sciences (Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK
Minerva Chir 59:113-22. 2004..Prognostic factors such as histopathology, presence of metastatic disease and C reactive protein levels may allow better prediction of survival, therefore aiding selection of the most appropriate palliative techniques... - Patterns of bacterial translocation in experimental biliary obstructionJ S White
Department of Surgery, School of Medicine, Queen s University of Belfast, Belfast, United Kingdom
J Surg Res 132:80-4. 2006..The aim of this study was to estimate the extent and pattern of bacterial translocation in experimental biliary obstruction... - Intraoperative cholangiography in modern surgical practiceDeepika Akolekar
Department of Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK
Dig Surg 26:130-4. 2009..The aim of this study was to assess the practice of performing intraoperative cholangiography (IOC) during laparoscopic cholecystectomy in a busy teaching hospital... - Postchemoembolisation syndrome--tumour necrosis or hepatocyte injury?S J Wigmore
Department of Clinical and Surgical Sciences Surgery, University of Edinburgh, Royal Infirmary, SI Little France Crescent, Edinburgh EH16 4SA, UK
Br J Cancer 89:1423-7. 2003..There is no evidence that either a postchemoembolisation fever or cytolysis is associated with an enhanced tumour response or improved long-term survival in patients with primary or secondary liver cancer... - Open cholecystectomy in the laparoscopic eraP J Jenkins
Clinical and Surgical Sciences Surgery, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK
Br J Surg 94:1382-5. 2007..As techniques in laparoscopic cholecystectomy have improved, surgeon experience of open cholecystectomy may be limited. This study examined the current indications for and techniques used in primary open cholecystectomy... - What proportion of basic surgical trainees continue in a surgical career? A survey of the factors which are important in influencing career decisionsJ M J Richards
Department of Clinical and Surgical Sciences Surgery, University of Edinburgh, Little France Crescent
Surgeon 7:270-5. 2009..There is little information available on the factors involved in career choices amongst surgical trainees and this study aimed to address this issue... - Prognostic models for predicting death after hepatectomy in individuals with hepatic metastases from colorectal cancerM D Smith
Department of Clinical and Surgical Sciences (Surgery, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, EH16 4SA, UK
World J Surg 32:1108-9. 2008 - Outcomes following a dedicated period of research during surgical trainingB M Stutchfield
Clinical and Surgical Sciences Surgery, University of Edinburgh, Edinburgh, Scotland, UK
Scott Med J 56:206-9. 2011..A period of dedicated research was thought necessary for career progression, but few thought dedicated research should be integral to surgical training... - The administration of an oral carbohydrate-containing fluid prior to major elective upper-gastrointestinal surgery preserves skeletal muscle mass postoperatively--a randomised clinical trialK A Yuill
Department of Clinical and Surgical Sciences, Royal Infirmary of Edinburgh, Edinburgh, UK
Clin Nutr 24:32-7. 2005..The aims of this study were to assess the tolerance of preoperative carbohydrate fluid administration and to determine its effect on postoperative metabolic and clinical responses... - Glutathione supplementation to University of Wisconsin solution causes endothelial dysfunctionA L Tambyraja
Clinical and Surgical Sciences Surgery, Royal Infirmary of Edinburgh, 51 Little France Crescent, University of Edinburgh, Edinburgh, EH16 4SA, UK
Transpl Immunol 18:146-50. 2007..This study assesses the effect of GSH-supplementation on endothelial function in tissues subjected to cold ischaemia and compares its effects to a mono-ethyl ester equivalent (GSH-MEE) and S-nitrosated GSH (GSNO)... - Cholangiocarcinoma arising after biliary-enteric drainage procedures for benign diseaseV Bettschart
Department of Clinical and Surgical Sciences (Surgery, University of Edinburgh and Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, UK
Gut 51:128-9. 2002 - Interstitial ablative techniques for hepatic tumoursC Erce
Department of Clinical and Surgical Sciences (Surgery, University of Edinburgh, Edinburgh, UK
Br J Surg 90:272-89. 2003.... - Traumatic injury to the colon and rectum in Scotland: demographics and outcomeR R Brady
Department of Surgery, Queen Margaret Hospital, NHS Fife, Scotland, UK
Colorectal Dis 14:e16-22. 2012..An analysis of a multi-centred database of trauma patients was performed... - Treatment of hepatic metastases of neuroendocrine malignancies: a 10-year experienceC H C Dejong
Department of Clinical and Surgical Sciences, Royal Infirmary, Edinburgh, Scotland
J R Coll Surg Edinb 47:495-9. 2002..Both chemoembolisation and somatostatin-analogues offer useful symptomatic control for these patients with good survival prospects... - A population-based study of pancreatic trauma in ScotlandJohn M Scollay
Department of Clinical and Surgical Sciences Surgery, University of Edinburgh, Scotland, UK
World J Surg 30:2136-41. 2006..The aim of this population-based study was to assess the incidence, mechanisms, management and outcome of patients who sustained pancreatic trauma in Scotland over the period 1992-2002... - Incidence of benign pathology in patients undergoing hepatic resection for suspected malignancyR A E Clayton
Department of Clinical and Surgical Sciences (Surgery) Royal Infirmary of Edinburgh
Surgeon 1:32-8. 2003..Despite appropriate investigation a subset of patients with benign disease will still be subjected to major hepatic resection which should be undertaken in a specialist unit... - Presentation, treatment and outcome in patients with ampullary tumoursV Bettschart
Department of Surgery, Sherbrooke University, Sherbrooke, Quebec, Canada
Br J Surg 91:1600-7. 2004..CONCLUSION: An aggressive surgical approach to ampullary tumours is justified by the low proportion of benign lesions, the absence of postoperative mortality and improved long-term survival... - Pre-operative high sensitivity C-reactive protein and postoperative outcome in patients undergoing elective orthopaedic surgeryG L Ackland
Anaesthesia and Critical Care Medicine, Centre for Anaesthesia, Critical Care and Pain Management, University College London, London, UK
Anaesthesia 62:888-94. 2007..5-6.5; p = 0.03; log rank test). In 21 patients with > 8 days length of stay, high pre-operative hsCRP patients were over-represented (p = 0.04). Pre-operative hsCRP is related to length of stay and delayed postoperative complications... - Impairment of Gag-specific CD8(+) T-cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251- and simian-human immunodeficiency virus KU2-infected macaquesZ Hel
Basic Research Laboratory, Bethesda, Maryland 20892, USA
J Virol 75:11483-95. 2001..The data obtained in this pilot study lead to the hypothesis that disease progression may be associated with loss of virus-specific CD8(+) T-cell function... - An audit of the management of patients with acute pancreatitis against national standards of practiceR Mofidi
Department of Clinical and Surgical Sciences, University of Edinburgh, Edinburgh UK
Br J Surg 94:844-8. 2007..The aim of this study was to audit the management of patients with acute pancreatitis against the standards of practice in the British Society of Gastroenterology guidelines...