Nadeene Parker

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria
    Nadeene Parker
    MRC Mitochondrial Biology Unit, Wellcome Trust MRC Building, Hills Road, Cambridge, CB2 0XY, UK
    J Bioenerg Biomembr 41:335-42. 2009
  2. pmc Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2
    Nadeene Parker
    MRC Mitochondrial Biology Unit, Cambridge CB2 0XY, UK
    Biochim Biophys Acta 1787:1451-7. 2009
  3. pmc Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential
    Nadeene Parker
    MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Biosci Rep 28:83-8. 2008
  4. pmc Not all mitochondrial carrier proteins support permeability transition pore formation: no involvement of uncoupling protein 1
    Paul G Crichton
    MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
    Biosci Rep 30:187-92. 2010
  5. pmc Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria
    Nadeene Parker
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 0XY, UK
    Biochem J 412:131-9. 2008
  6. pmc High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation
    Vian Azzu
    MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge, CB2 0XY, UK
    Biochem J 413:323-32. 2008
  7. pmc Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells
    Vian Azzu
    MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Cambridge, UK
    Biochim Biophys Acta 1777:1378-83. 2008
  8. pmc Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria
    Telma C Esteves
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Biochem J 395:619-28. 2006
  9. ncbi Novel uncoupling proteins
    Charles Affourtit
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Novartis Found Symp 287:70-80; discussion 80-91. 2007
  10. pmc Multiphoton imaging reveals differences in mitochondrial function between nephron segments
    Andrew M Hall
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    J Am Soc Nephrol 20:1293-302. 2009

Detail Information

Publications10

  1. doi Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria
    Nadeene Parker
    MRC Mitochondrial Biology Unit, Wellcome Trust MRC Building, Hills Road, Cambridge, CB2 0XY, UK
    J Bioenerg Biomembr 41:335-42. 2009
    ....
  2. pmc Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2
    Nadeene Parker
    MRC Mitochondrial Biology Unit, Cambridge CB2 0XY, UK
    Biochim Biophys Acta 1787:1451-7. 2009
    ..We conclude that the decreased glucose tolerance in Nnt knockout mice observed in our experiments does not require UCP2...
  3. pmc Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential
    Nadeene Parker
    MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Biosci Rep 28:83-8. 2008
    ..These results suggest that both endogenous HNE production and high membrane potential are required before mild uncoupling will be triggered to attenuate mitochondrial ROS production...
  4. pmc Not all mitochondrial carrier proteins support permeability transition pore formation: no involvement of uncoupling protein 1
    Paul G Crichton
    MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
    Biosci Rep 30:187-92. 2010
    ....
  5. pmc Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria
    Nadeene Parker
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 0XY, UK
    Biochem J 412:131-9. 2008
    ....
  6. pmc High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation
    Vian Azzu
    MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge, CB2 0XY, UK
    Biochem J 413:323-32. 2008
    ..We propose a model to relate adenine nucleotide translocase conformation to proton conductance in the presence or absence of 4-hydroxynonenal and/or carboxyatractylate...
  7. pmc Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells
    Vian Azzu
    MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Cambridge, UK
    Biochim Biophys Acta 1777:1378-83. 2008
    ..0-4.4 ng/million cells (2.7-14.5 ng/mg mitochondrial protein). This dynamic response to nutrients was achieved by varied expression rates against a background of a very short UCP2 protein half-life of about 1 h...
  8. pmc Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria
    Telma C Esteves
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Biochem J 395:619-28. 2006
    ..These results show that reactive alkenals activate the proton conductance of UCP1 more strongly when fatty acids are also added, with implications for both mechanistic and physiological models of UCP1 activation...
  9. ncbi Novel uncoupling proteins
    Charles Affourtit
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Novartis Found Symp 287:70-80; discussion 80-91. 2007
    ..3) UCP3 may catalyse fatty acid transport. (4) UCP2 has a signalling role in pancreatic beta cells, where it attenuates insulin secretion. Other roles remain to be discovered...
  10. pmc Multiphoton imaging reveals differences in mitochondrial function between nephron segments
    Andrew M Hall
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    J Am Soc Nephrol 20:1293-302. 2009
    ..In summary, there are axial differences in mitochondrial function along the nephron, which may contribute to the pattern and pathophysiology of some forms of renal injury...