David Parker

Summary

Affiliation: University of Durham
Country: UK

Publications

  1. doi request reprint Crystallographic and solution NMR structural analyses of four hexacoordinated gallium(III) complexes based on ligands derived from 6-amino-perhydro-1,4-diazepine
    David Parker
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    Dalton Trans 42:8001-8. 2013
  2. doi request reprint Conformational analysis and synthetic approaches to polydentate perhydro-diazepine ligands for the complexation of gallium(III)
    David Parker
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    Org Biomol Chem 11:2827-38. 2013
  3. ncbi request reprint Excitement in f block: structure, dynamics and function of nine-coordinate chiral lanthanide complexes in aqueous media
    David Parker
    Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK
    Chem Soc Rev 33:156-65. 2004
  4. doi request reprint Cell-penetrating metal complex optical probes: targeted and responsive systems based on lanthanide luminescence
    Craig P Montgomery
    Department of Chemistry, Durham University, Durham DH1 3LE, U K
    Acc Chem Res 42:925-37. 2009
  5. doi request reprint Measuring equilibrium bicarbonate concentrations directly in cellular mitochondria and in human serum using europium/terbium emission intensity ratios
    David G Smith
    Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK
    Chemistry 18:11604-13. 2012
  6. doi request reprint Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes
    David G Smith
    Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK
    Chem Commun (Camb) 48:8520-2. 2012
  7. ncbi request reprint Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes
    Rachel S Dickins
    Department of Chemistry, University of Durham, South Road, UK
    J Am Chem Soc 124:12697-705. 2002
  8. doi request reprint Very bright europium complexes that stain cellular mitochondria
    James W Walton
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    Chem Commun (Camb) 49:1600-2. 2013
  9. ncbi request reprint Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage "in cellulo"
    Robert A Poole
    Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK
    Org Biomol Chem 3:1013-24. 2005
  10. ncbi request reprint Enantiopure lanthanide complexes incorporating a tetraazatriphenylene sensitiser and three naphthyl groups: exciton coupling, intramolecular energy transfer, efficient singlet oxygen formation and perturbation by DNA binding
    Gabriella Bobba
    Department of Chemistry, University of Durham, South Road, Durham, UK DH1 3LE
    Org Biomol Chem 1:1870-2. 2003

Collaborators

Detail Information

Publications51

  1. doi request reprint Crystallographic and solution NMR structural analyses of four hexacoordinated gallium(III) complexes based on ligands derived from 6-amino-perhydro-1,4-diazepine
    David Parker
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    Dalton Trans 42:8001-8. 2013
    ..Pulsed NMR experiments allow solution NMR structures to be assessed, revealing good agreement with the solid-state structures...
  2. doi request reprint Conformational analysis and synthetic approaches to polydentate perhydro-diazepine ligands for the complexation of gallium(III)
    David Parker
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    Org Biomol Chem 11:2827-38. 2013
    ....
  3. ncbi request reprint Excitement in f block: structure, dynamics and function of nine-coordinate chiral lanthanide complexes in aqueous media
    David Parker
    Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK
    Chem Soc Rev 33:156-65. 2004
    ..Such issues are aiding the development of responsive probes, ranging from simple sensors to more complex studies defining water structure and exchange dynamics...
  4. doi request reprint Cell-penetrating metal complex optical probes: targeted and responsive systems based on lanthanide luminescence
    Craig P Montgomery
    Department of Chemistry, Durham University, Durham DH1 3LE, U K
    Acc Chem Res 42:925-37. 2009
    ....
  5. doi request reprint Measuring equilibrium bicarbonate concentrations directly in cellular mitochondria and in human serum using europium/terbium emission intensity ratios
    David G Smith
    Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK
    Chemistry 18:11604-13. 2012
    ..These methods have been adapted for the determination of bicarbonate in human serum and used for the assessment of mitochondrial levels of bicarbonate in several different cell types with confocal microscopy...
  6. doi request reprint Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes
    David G Smith
    Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK
    Chem Commun (Camb) 48:8520-2. 2012
    ....
  7. ncbi request reprint Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes
    Rachel S Dickins
    Department of Chemistry, University of Durham, South Road, UK
    J Am Chem Soc 124:12697-705. 2002
    ..Crystal structures of the Gly and Ser adducts confirm this. In peptides and proteins (e.g. albumin) containing Glu or Asp residues, the more basic side chain carboxylate may chelate to the Ln ion, displacing both waters...
  8. doi request reprint Very bright europium complexes that stain cellular mitochondria
    James W Walton
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    Chem Commun (Camb) 49:1600-2. 2013
    ..Certain complexes enter mammalian cells by macropinocytosis and stain the mitochondria selectively, allowing observation of the Eu emission in cellulo by time-gated spectral imaging...
  9. ncbi request reprint Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage "in cellulo"
    Robert A Poole
    Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK
    Org Biomol Chem 3:1013-24. 2005
    ..g. iodide, ascorbate and urate, and a mechanistic interpretation is put forward involving an electron transfer process. The cationic lanthanide complexes are taken up by NlH/3T3 cells and tend to localise inside the cell nucleus...
  10. ncbi request reprint Enantiopure lanthanide complexes incorporating a tetraazatriphenylene sensitiser and three naphthyl groups: exciton coupling, intramolecular energy transfer, efficient singlet oxygen formation and perturbation by DNA binding
    Gabriella Bobba
    Department of Chemistry, University of Durham, South Road, Durham, UK DH1 3LE
    Org Biomol Chem 1:1870-2. 2003
    ....
  11. doi request reprint Variation of water exchange dynamics with ligand structure and stereochemistry in lanthanide complexes based on 1,4-diazepine derivatives
    Elisa M Elemento
    Department of Chemistry, Durham University, South Road, Durham, UK DH1 3LE
    Org Biomol Chem 7:1120-31. 2009
    ..The absence of a good correlation of (1)H NMR pseudo-contact shifts for Eu and Yb analogues is suggested to arise from a change in hydration state between Eu and Yb...
  12. ncbi request reprint Design, synthesis and evaluation of ratiometric probes for hydrogencarbonate based on europium emission
    Yann Bretonniere
    Department of Chemistry, University of Durham, South Road, Durham, UK DH1 3LE
    Org Biomol Chem 2:1624-32. 2004
    ..Preliminary screens reveal the complexes to be non-toxic to NIH-3T3 cells and to be taken inside the cell, encouraging further study...
  13. doi request reprint Lanthanide complexes as chiral probes exploiting circularly polarized luminescence
    Rachel Carr
    Department of Chemistry, Durham University, UK
    Chem Soc Rev 41:7673-86. 2012
    ..With complexes of enantiopure ligands, perturbation may involve either dynamic helicity inversion or a reversible change in the lanthanide coordination environment...
  14. doi request reprint Strategies to enhance signal intensity with paramagnetic fluorine-labelled lanthanide complexes as probes for 19F magnetic resonance
    Kirsten H Chalmers
    Department of Chemistry, Durham University, South Road, Durham, UK DH1 3LE
    Dalton Trans 40:904-13. 2011
    ..These lead to an enhanced sensitivity of detection in (19)F magnetic resonance experiments versus a diamagnetic Y(III) analogue, paving the way for future shift and imaging studies...
  15. doi request reprint Evidence for the optical signalling of changes in bicarbonate concentration within the mitochondrial region of living cells
    David G Smith
    Department of Chemistry, Durham University, South Road, Durham, UK DH1 3LE
    Chem Commun (Camb) 47:7347-9. 2011
    ....
  16. doi request reprint Critical evaluation of five emissive europium(III) complexes as optical probes: correlation of cytotoxicity, anion and protein affinity with complex structure, stability and intracellular localisation profile
    Benjamin S Murray
    Department of Chemistry, Durham University, South Road, Durham, UK
    Org Biomol Chem 6:2085-94. 2008
    ..Such features augur well for its future application as a responsive probe in microscopy to monitor local changes in pHCO(3)...
  17. doi request reprint A ratiometric optical imaging probe for intracellular pH based on modulation of europium emission
    Robert Pal
    Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK
    Org Biomol Chem 6:1020-33. 2008
    ..A value of 7.4 was estimated for NIH 3T3 cells in the protein rich regions of the nucleolus and ribosomes...
  18. doi request reprint Design principles and theory of paramagnetic fluorine-labelled lanthanide complexes as probes for (19)F magnetic resonance: a proof-of-concept study
    Kirsten H Chalmers
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    Chemistry 16:134-48. 2010
    ..The sensitivity benefits of using such paramagnetic fluorinated probes in (19)F NMR spectroscopic studies are quantified in preliminary spectroscopic and imaging experiments with respect to a diamagnetic yttrium(III) analogue...
  19. doi request reprint The nature of the sensitiser substituent determines quenching sensitivity and protein affinity and influences the design of emissive lanthanide complexes as optical probes for intracellular use
    Filip Kielar
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    Org Biomol Chem 6:2256-8. 2008
    ....
  20. ncbi request reprint A europium complex that selectively stains nucleoli of cells
    Junhua Yu
    Department of Chemistry, School of Biological and Biomedical Sciences, Durham University, South Road, Durham DH1 3LE, United Kingdom
    J Am Chem Soc 128:2294-9. 2006
    ..The intracellular speciation of the complex has been examined by circularly polarized emission spectroscopy and is consistent with the presence of more than one europium species, possibly protein bound...
  21. doi request reprint Observation of the selective staining of chromosomal DNA in dividing cells using a luminescent terbium(III) complex
    Ga Lai Law
    Department of Chemistry, Durham University, South Road, Durham, UK DH1 3LE
    Chem Commun (Camb) 46:2391-3. 2010
    ..The emission intensity of a monocationic Tb or Eu(III) complex of a bis(1-azaxanthone) ligand is enhanced in the presence of serum albumin; the lanthanide complex stains dividing cells, allowing visualisation of mitotic chromosomes...
  22. pmc A europium luminescence assay of lactate and citrate in biological fluids
    Robert Pal
    Department of Chemistry, Durham University, South Road, Durham, UK DH1 3LE
    Org Biomol Chem 7:1525-8. 2009
    ....
  23. doi request reprint Complete stereocontrol in the synthesis of macrocyclic lanthanide complexes: direct formation of enantiopure systems for circularly polarised luminescence applications
    Nicholas H Evans
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    Dalton Trans 42:15610-6. 2013
    ..The absolute configuration of each complex is determined by the stereogenicity of the C-substituent, revealed by comparison of the sign and sequence of CPL transitions for a series of complexes...
  24. doi request reprint A chiral probe for the acute phase proteins alpha-1-acid glycoprotein and alpha-1-antitrypsin based on europium luminescence
    Rachel Carr
    Department of Chemistry, Durham University, Durham, UK
    Dalton Trans 41:13154-8. 2012
    ..A direct determination of elevated α(1)-AGP levels in human serum was achieved by monitoring changes in the intensity ratio of Eu emission bands...
  25. ncbi request reprint Isostructural series of nine-coordinate chiral lanthanide complexes based on triazacyclononane
    James W Walton
    Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK
    Inorg Chem 51:8042-56. 2012
    ..The values of 〈β(HLS)〉 reach a maximum around the center of the series and are not simply dependent on the number of f electrons, suggesting a dominant contribution from the octupolar rather than the dipolar term...
  26. doi request reprint 19F-lanthanide complexes with increased sensitivity for 19F-MRI: optimization of the MR acquisition
    Kirsten H Chalmers
    Department of Chemistry, Durham University, Durham, United Kingdom
    Magn Reson Med 66:931-6. 2011
    ..Phantom experiments at 7 T indicate a lower limit for detection by imaging of 20 μM...
  27. doi request reprint Electron-capture dissociation and collision-induced dissociation of lanthanide metal-ligand complexes and lanthanide metal-ligand complexes bound to phosphopeptides
    Jackie A Mosely
    Departm ent of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    Eur J Mass Spectrom (Chichester, Eng) 15:145-55. 2009
    ..ECD analysis of the triflate salts of the terbium complexes is most informative in developing a method to optimise structural information that can be gained from this group of molecules by mass spectrometry...
  28. doi request reprint The mechanism of cell uptake for luminescent lanthanide optical probes: the role of macropinocytosis and the effect of enhanced membrane permeability on compartmentalisation
    Elizabeth J New
    Department of Chemistry, Durham University, South Road, Durham DH13LE, UK
    Org Biomol Chem 7:851-5. 2009
    ..Inhibition studies and co-localisation experiments with several emissive lanthanide complexes reveal cell uptake by macropinocytosis...
  29. doi request reprint Analysis of citrate in low-volume seminal fluid samples using a time-gated measurement of europium luminescence
    Robert Pal
    Department of Chemistry, Durham University, South Road, Durham DH13LE, UK
    J Pharm Biomed Anal 56:352-8. 2011
    ..Citrate concentrations were not statistically different between age groups and averaged 35.0(±14.6) mM for the 40-43 group, and 28.2(±12.7) mM for the 50-53 cohort; in each case a polymodal distribution was observed...
  30. doi request reprint A bright and responsive europium probe for determination of pH change within the endoplasmic reticulum of living cells
    Brian K McMahon
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    Chem Commun (Camb) 49:5363-5. 2013
    ..Careful calibration, using a time-gated spectral imaging microscope, allows the intensity ratio of emission bands and the variation of excited state lifetime to be used for pH determination, with a pKa of 7.15...
  31. doi request reprint Bright mono-aqua europium complexes based on triazacyclononane that bind anions reversibly and permeate cells efficiently
    Stephen J Butler
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    Chemistry 19:9511-7. 2013
    ....
  32. ncbi request reprint Identification of emissive lanthanide complexes suitable for cellular imaging that resist quenching by endogenous anti-oxidants
    Robert A Poole
    Department of Chemistry, Durham University, South Road, Durham, UK DH1 3LE
    Org Biomol Chem 5:2055-62. 2007
    ..1](3+), consistent with its ease of visualisation by luminescence microscopy...
  33. doi request reprint Critical in vitro evaluation of responsive MRI contrast agents for calcium and zinc
    Anurag Mishra
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE UK
    Chemistry 17:1529-37. 2011
    ..Such systems may, therefore, be considered for use as magnetic resonance imaging (MRI) contrast agents to track the restoration of changes in metal-ion concentration in the cerebrospinal fluid of the brain, following neural stimulation...
  34. doi request reprint Experimental measurement and theoretical assessment of fast lanthanide electronic relaxation in solution with four series of isostructural complexes
    Alexander M Funk
    Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U K
    J Phys Chem A 117:905-17. 2013
    ..Both experiment and theory indicate that complexes of terbium and dysprosium should most efficiently promote paramagnetic enhancement of the rate of nuclear relaxation...
  35. doi request reprint Paramagnetic 19F chemical shift probes that respond selectively to calcium or citrate levels and signal ester hydrolysis
    Peter Harvey
    Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK
    Chemistry 18:8748-57. 2012
    ..4 Å found for a thulium complex, in an X-ray structure of the metal complex aqua adduct. The enhanced rate of longitudinal relaxation of the (19)F nucleus allows faster data acquisition...
  36. doi request reprint Development of responsive lanthanide probes for cellular applications
    Elizabeth J New
    Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK
    Curr Opin Chem Biol 14:238-46. 2010
    ....
  37. ncbi request reprint Survey of factors determining the circularly polarised luminescence of macrocyclic lanthanide complexes in solution
    James I Bruce
    Department of Chemistry, University of Durham, Durham, UK
    Chirality 14:562-7. 2002
    ..In particular, the polarisability of the ligand donor atoms, especially for any axial donor, is very important. Examples of each case are discussed for structurally related cationic Eu(III) complexes...
  38. doi request reprint Direct and selective tagging of cysteine residues in peptides and proteins with 4-nitropyridyl lanthanide complexes
    Kathryn L Gempf
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    Chem Commun (Camb) 49:9104-6. 2013
    ..The conjugation reaction creates a short link between the tag and peptide, holding the peptide closer to the Ln(3+) ion and with reduced flexibility compared to existing methods. ..
  39. ncbi request reprint Structure, resolution and chiroptical analysis of stable lanthanide complexes of a pyridylphenylphosphinate triazacyclononane ligand
    James W Walton
    Department of Chemistry, Durham University, Durham, DH1 3LE, UK
    Chem Commun (Camb) 47:12289-91. 2011
    ..The C(3)-symmetric Δ and Λ complexes of Eu and Tb are strongly emissive and can be resolved by chiral HPLC; the absolute configuration of each complex has been assigned using CD and CPL measurements...
  40. doi request reprint Structure and stability of hexadentate complexes of ligands based on AAZTA for efficient PET labelling with gallium-68
    Bradley P Waldron
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    Chem Commun (Camb) 49:579-81. 2013
    ..Pre-organised tricarboxylate ligands based on 6-amino-perhydro-1,4-diazepine bind (68)Ga rapidly and selectively in acetate buffer at pH 4 to 7, forming kinetically stable complexes suitable for use in PET imaging...
  41. ncbi request reprint Luminescent nonacoordinate cationic lanthanide complexes as potential cellular imaging and reactive probes
    Juan C Frias
    Department of Chemistry, University of Durham, South Road, Durham, UK DH1 3LE
    Org Biomol Chem 1:905-7. 2003
    ..The uptake of these complexes by the cells was assessed by fluorescence microscopy. Complex-induced DNA damage was studied by gel electrophoresis and shown to be a function of complex chirality...
  42. ncbi request reprint Responsive luminescent lanthanide complexes
    David Parker
    Department of Chemistry, University of Durham, South Road, Durham, DH1 3LE, U K
    Met Ions Biol Syst 40:233-80. 2003
  43. ncbi request reprint Synthesis and comparative anion binding profiles of two di-aqua Eu(III) complexes
    Daniela Imperio
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    Dalton Trans 39:9897-903. 2010
    ..65 (295 k, 0.1 m nacl)...
  44. ncbi request reprint A cationic lanthanide complex binds selectively to phosphorylated tyrosine sites, aiding NMR analysis of the phosphorylated insulin receptor peptide fragment
    Paul Atkinson
    Department of Chemistry, Durham University, South Road, Durham, UK
    Org Biomol Chem 4:3166-71. 2006
    ....
  45. doi request reprint Anion binding in water at lanthanide centres: from structure and selectivity to signalling and sensing
    Stephen J Butler
    Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK
    Chem Soc Rev 42:1652-66. 2013
    ....
  46. doi request reprint Using electron induced dissociation (EID) on an LC time-scale to characterize a mixture of analogous small organic molecules
    Aruna S Prakash
    Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK
    J Am Soc Mass Spectrom 23:850-7. 2012
    ....
  47. ncbi request reprint Ternary complexes between cationic GdIII chelates and anionic metabolites in aqueous solution: an NMR relaxometric study
    Mauro Botta
    Dipartimento di Scienze e Tecnologie Avanzate, Universita del Piemonte Orientale Amedeo Avogadro, Corso Borsalino 54, 15100 Alessandria, Italy
    Chemistry 9:2102-9. 2003
    ....
  48. ncbi request reprint Synthesis and physicochemical characterization of 1,4,7,10-tetra (2-glutaryl)-1,4,7,10 tetraazacyclododecane lanthanide complexes
    Marc Port
    Guerbet Research, Aulnay sous Bois, France
    Acad Radiol 9:S300-3. 2002
  49. ncbi request reprint Aqueous solutions of uranium(VI) as studied by time-resolved emission spectroscopy: a round-robin test
    Isabelle Billard
    Institut de Recherches Subatomiques, Chimie Nucléaire, CNRS IN2P3 and University L Pasteur, B P 28, 67037, Strasbourg Cedex 2, France
    Appl Spectrosc 57:1027-38. 2003
    ..The successes and limitations of TRES in uranyl analysis and speciation in aqueous solutions are discussed...
  50. pmc Extending the absorbing boundary method to fit dwell-time distributions of molecular motors with complex kinetic pathways
    Jung Chi Liao
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:3171-6. 2007
    ....
  51. pmc Antibody detection and kinetics of antibody production during early stages of immunization with hepatitis B virus vaccine
    Odd Odinsen
    PlasmAcute AS, High Technology Center, Thormøhlensgate 55, 5008 Bergen, Norway
    Clin Vaccine Immunol 14:1623-8. 2007
    ..Thus, primary immunization with the HBV vaccine appears to transiently elicit low-affinity anti-HBs in B-cell lysates into plasma...