B K Park

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. ncbi request reprint Metabolism of fluorine-containing drugs
    B K Park
    Department of Pharmacology and Therapeutics, New Medical Building, University of Liverpool, Liverpool, United Kingdom
    Annu Rev Pharmacol Toxicol 41:443-70. 2001
  2. ncbi request reprint Advances in molecular toxicology-towards understanding idiosyncratic drug toxicity
    B K Park
    Department of Pharmacology and Therapeutics, University of Liverpool, P O Box 147, L69 3GE, Liverpool, UK
    Toxicology 153:39-60. 2000
  3. ncbi request reprint An investigation of the formation of cytotoxic, genotoxic, protein-reactive and stable metabolites from naphthalene by human liver microsomes
    M D Tingle
    Department of Pharmacology and Therapeutics, University of Liverpool, U K
    Biochem Pharmacol 46:1529-38. 1993
  4. ncbi request reprint The role of iron in neurotoxicity: a study of novel antimalarial drugs
    S L Smith
    Department of Pharmacology, University of Liverpool, UK
    Neurotoxicology 19:557-9. 1998
  5. ncbi request reprint Kinetic parameters of lymphocyte microsomal epoxide hydrolase in carbamazepine hypersensitive patients. Assessment by radiometric HPLC
    C D Davis
    Department of Pharmacology and Therapeutics, University of Liverpool, U K
    Biochem Pharmacol 50:1361-6. 1995
  6. ncbi request reprint Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine
    D P Williams
    Department of Pharmacology and Therapeutics, The University of Liverpool, United Kingdom
    Mol Pharmacol 58:207-16. 2000
  7. ncbi request reprint Biliary metabolites of beta-artemether in rats: biotransformations of an antimalarial endoperoxide
    J L Maggs
    Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom
    Drug Metab Dispos 28:209-17. 2000
  8. pmc A comparative study of the formation of chemically reactive drug metabolites by human liver microsomes
    N R Kitteringham
    Department of Pharmacology and Therapeutics, University of Liverpool
    Br J Clin Pharmacol 26:13-21. 1988
  9. ncbi request reprint Reactive metabolites and their role in drug reactions
    D J Naisbitt
    Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK
    Curr Opin Allergy Clin Immunol 1:317-25. 2001
  10. pmc Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo
    D J Naisbitt
    Department of Pharmacology and Therapeutics, The University of Liverpool, P.O. Box 147, Liverpool L69 3BX, UK
    Br J Pharmacol 133:295-305. 2001

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Metabolism of fluorine-containing drugs
    B K Park
    Department of Pharmacology and Therapeutics, New Medical Building, University of Liverpool, Liverpool, United Kingdom
    Annu Rev Pharmacol Toxicol 41:443-70. 2001
    ..The strategic value of fluorine substitution in drug design is discussed in terms of chemical structure and basic concepts in drug metabolism and drug toxicity...
  2. ncbi request reprint Advances in molecular toxicology-towards understanding idiosyncratic drug toxicity
    B K Park
    Department of Pharmacology and Therapeutics, University of Liverpool, P O Box 147, L69 3GE, Liverpool, UK
    Toxicology 153:39-60. 2000
    ..The long-term aim of such research is to provide test systems for the evaluation of drug safety and patient susceptibility to idiosyncratic drug toxicity...
  3. ncbi request reprint An investigation of the formation of cytotoxic, genotoxic, protein-reactive and stable metabolites from naphthalene by human liver microsomes
    M D Tingle
    Department of Pharmacology and Therapeutics, University of Liverpool, U K
    Biochem Pharmacol 46:1529-38. 1993
    ..This is rapidly detoxified by microsomal epoxide hydrolase, the efficiency of which can be readily determined by measurement of the ratio of the stable metabolites, naphthalene 1,2-dihydrodiol and 1-naphthol...
  4. ncbi request reprint The role of iron in neurotoxicity: a study of novel antimalarial drugs
    S L Smith
    Department of Pharmacology, University of Liverpool, UK
    Neurotoxicology 19:557-9. 1998
    ..AEM was found to be partially converted to two isomeric products, which were identified as the tetrahydrofuran acetate isomer of AEM and 3alpha-hydroxydesoxyartemether...
  5. ncbi request reprint Kinetic parameters of lymphocyte microsomal epoxide hydrolase in carbamazepine hypersensitive patients. Assessment by radiometric HPLC
    C D Davis
    Department of Pharmacology and Therapeutics, University of Liverpool, U K
    Biochem Pharmacol 50:1361-6. 1995
    ..This did not affect the kinetic parameters of lymphocyte microsomal epoxide hydrolase. Our results suggest that there is normal HYL1 activity in lymphocytes of hypersensitive patients using cis-stilbene oxide as a substrate...
  6. ncbi request reprint Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine
    D P Williams
    Department of Pharmacology and Therapeutics, The University of Liverpool, United Kingdom
    Mol Pharmacol 58:207-16. 2000
    ..In conclusion, the findings of the study expand on potential mechanisms of clozapine-induced cytotoxicity, which may be of relevance to the major forms of toxicity encountered in patients taking this drug...
  7. ncbi request reprint Biliary metabolites of beta-artemether in rats: biotransformations of an antimalarial endoperoxide
    J L Maggs
    Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom
    Drug Metab Dispos 28:209-17. 2000
    ..O-methyl substitution of DHA favors ring hydroxylation in vivo. However, the principal hydroxylated metabolite, 9alpha-hydroxyAM, is unlikely to possess significant antimalarial activity...
  8. pmc A comparative study of the formation of chemically reactive drug metabolites by human liver microsomes
    N R Kitteringham
    Department of Pharmacology and Therapeutics, University of Liverpool
    Br J Clin Pharmacol 26:13-21. 1988
    ..76 and 0.78 respectively). E binding also correlated with the binding of M (r = 0.79) and Pa (r = 0.81) but not with cytochrome P-450. Binding of Ph and S did not correlate with any of the other measured metabolic parameters...
  9. ncbi request reprint Reactive metabolites and their role in drug reactions
    D J Naisbitt
    Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK
    Curr Opin Allergy Clin Immunol 1:317-25. 2001
    ....
  10. pmc Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo
    D J Naisbitt
    Department of Pharmacology and Therapeutics, The University of Liverpool, P.O. Box 147, Liverpool L69 3BX, UK
    Br J Pharmacol 133:295-305. 2001
    ..These studies demonstrate the antigenicity of nitroso sulphamethoxazole in vivo and provide evidence for the role of drug metabolism and cell surface haptenation in the induction of a cellular immune response in the rat...
  11. ncbi request reprint Metabolic activation in drug allergies
    B K Park
    Department of Pharmacology and Therapeutics, University of Liverpool, PO Box 147, L69 3GE, Liverpool
    Toxicology 158:11-23. 2001
    ..The purpose of this review is to assess critically the evidence to support the hapten mechanism, and also to consider alternative mechanisms by which drugs cause idiosyncratic toxicity...
  12. ncbi request reprint Toxicogenetics in drug development
    B K Park
    Department of Pharmacology and Therapeutics, The University of Liverpool, P O Box 147, Ashton Street, L69 3GE, Liverpool, UK
    Toxicol Lett 120:281-91. 2001
    ....
  13. pmc "Danger" conditions increase sulfamethoxazole-protein adduct formation in human antigen-presenting cells
    S N Lavergne
    Department of Pharmacology, Centre for Drug Safety Science, The University of Liverpool, Liverpool, UK
    J Pharmacol Exp Ther 331:372-81. 2009
    ..These results illustrate that danger signals enhance the formation of intracellular SMX-protein adducts in human APC. These findings might be relevant to the increased frequency of drug allergy in certain disease states...
  14. doi request reprint Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity
    B K Park
    MRC Centre for Drug Safety Science, Institute of Translational Medicine, Department of Molecular and Clinical Pharmacology, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L69 3GE, UK
    Chem Biol Interact 192:30-6. 2011
    ....
  15. pmc Carbamazepine is not a substrate for P-glycoprotein
    A Owen
    Department of Pharmacology and Therapeutics, The University of Liverpool, L69 3GE, UK
    Br J Clin Pharmacol 51:345-9. 2001
    ..Its efficacy is unlikely to be affected by Pgp over-expression in the brain. Furthermore, the interaction of CBZ with drugs that modulate both CYP3A4 and Pgp function such as verapamil is probably due to inhibition of CYP3A4 and not Pgp...
  16. ncbi request reprint The metabolism of 2,4-dibromo-17 alpha-ethynyl[6,7-3H]oestradiol in the rat
    J L Maggs
    Department of Pharmacology and Therapeutics, University of Liverpool, U K
    Xenobiotica 20:45-54. 1990
    ..The inertness of 2,4-DBEE2 to ring-A hydroxylation in male rats conforms with the insignificant debromination of 2,4-dibromoestradiol by hepatic microsomes...
  17. ncbi request reprint Assessment of the effects of metabolism on the estrogenic activity of xenoestrogens: a two-stage approach coupling human liver microsomes and a yeast estrogenicity assay
    R Elsby
    Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom
    J Pharmacol Exp Ther 296:329-37. 2001
    ....
  18. ncbi request reprint Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment
    D J Naisbitt
    Department of Pharmacology and Therapeutics, University of Liverpool, Merseyside, England
    Drug Saf 23:483-507. 2000
    ..A greater understanding of the mechanism(s) of hypersensitivity may identify novel therapeutic strategies and help to combat one of the more severe forms of adverse reactions to drugs...
  19. doi request reprint Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study
    R P Jones
    School of Cancer Studies, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
    Cancer Chemother Pharmacol 72:359-68. 2013
    ..Attempts to correlate tumour metabolism with response have been mixed. This study investigated the hepatic metabolism of irinotecan as a potential predictor of tumour response to irinotecan-eluting beads (DEBIRI)...
  20. ncbi request reprint Formation of cytotoxic metabolites from phenytoin, imipramine, desipramine, amitriptyline and mianserin by mouse and human hepatic microsomes
    R J Riley
    Department of Pharmacology and Therapeutics, University of Liverpool, U K
    Biochem Pharmacol 39:1951-8. 1990
    ....
  21. pmc alpha(1)-Adrenoceptor antagonists prevent paracetamol-induced hepatotoxicity in mice
    L E Randle
    Department of Pharmacology and Therapeutics, The University of Liverpool, Liverpool, UK
    Br J Pharmacol 153:820-30. 2008
    ..Adrenoceptor stimulation or antagonism can modulate chemical-induced hepatotoxicity. We investigated the role of endogenous catecholamines and alpha(1)-adrenoceptors in the development of paracetamol- induced hepatotoxicity...
  22. doi request reprint Serum microRNA biomarkers for drug-induced liver injury
    P J Starkey Lewis
    MRC Center for Drug Safety Science, Department of Clinical and Molecular Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
    Clin Pharmacol Ther 92:291-3. 2012
    ....
  23. ncbi request reprint Evaluation of the generation of genotoxic and cytotoxic metabolites of benzo[a]pyrene, aflatoxin B1, naphthalene and tamoxifen using human liver microsomes and human lymphocytes
    A S Wilson
    Department of Pharmacology and Therapeutics, University of Liverpool, UK
    Hum Exp Toxicol 14:507-15. 1995
    ..This indicates that both intracellular and extracellular bioactivation of these two compounds can produce genotoxicity. In contrast, naphthalene and tamoxifen were non-genotoxic...
  24. ncbi request reprint Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis
    M Pirmohamed
    Department of Pharmacology and Therapeutics, University of Liverpool
    Br J Rheumatol 32:222-6. 1993
    ..We therefore conclude that cimetidine may be safely used in patients with RA who are being treated with sulphasalazine...
  25. ncbi request reprint Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones
    D J Naisbitt
    Department of Pharmacology, The University of Liverpool, Liverpool, United Kingdom
    Mol Pharmacol 63:732-41. 2003
    ..These studies characterize drug-specific T cells in CBZ-hypersensitive patients that are phenotypically different from T cells involved in other serious cutaneous adverse drug reactions...
  26. doi request reprint T cell responses to drugs and drug metabolites
    C J Earnshaw
    Department of Molecular and Clinical Pharmacology, Medical Research Council Centre for Drug Safety Science, University of Liverpool, Sherrington Building, Ahston Street, Liverpool, L69 3GE, UK
    EXS 104:137-63. 2014
    ....
  27. ncbi request reprint Are chemically reactive metabolites responsible for adverse reactions to drugs?
    D P Williams
    Department of Pharmacology and Therapeutics, The University of Liverpool, Liverpool, UK
    Curr Drug Metab 3:351-66. 2002
    ..We have therefore examined the evidence for the role of reactive metabolites in the three most common drug-induced toxicities: hepatotoxicity, skin reactions and blood dyscrasias...
  28. ncbi request reprint Time course toxicogenomic profiles in CD-1 mice after nontoxic and nonlethal hepatotoxic paracetamol administration
    D P Williams
    Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Building, Ashton Street, P O Box 147, Liverpool, Merseyside L69 3GE, United Kingdom
    Chem Res Toxicol 17:1551-61. 2004
    ..The complete data set can be viewed at http://www.ebi.ac.uk/arrayexpress/. The accession number is E-MEXP-82...
  29. ncbi request reprint HIV and drug allergy
    M Pirmohamed
    Department of Pharmacology and Therapeutics, The University of Liverpool, Liverpool, UK
    Curr Opin Allergy Clin Immunol 1:311-6. 2001
    ....
  30. doi request reprint Mechanism-based bioanalysis and biomarkers for hepatic chemical stress
    D J Antoine
    Department of Pharmacology and Therapeutics, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK
    Xenobiotica 39:565-77. 2009
    ..These biomarkers can provide both the means to inform the pharmacologist and chemist with respect to safe drug design, and provide clinicians with valuable tools for patient monitoring...
  31. ncbi request reprint Genetic susceptibility to adverse drug reactions
    M Pirmohamed
    Department of Pharmacology and Therapeutics, The University of Liverpool, Ashton Street, Liverpool, UK L69 3GE
    Trends Pharmacol Sci 22:298-305. 2001
    ..The overall clinical utility of genotyping in preventing ADRs needs to be proven by the use of prospective randomized controlled clinical trials...
  32. ncbi request reprint Human pluripotent stem cells for modeling toxicity
    R L C Sison-Young
    MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom
    Adv Pharmacol 63:207-56. 2012
    ..This article will review the advances and challenges of using human pluripotent stem cells for modeling metabolism and toxicity, and offer some perspectives as to where its future may lie...
  33. ncbi request reprint The role of glutathione in the neurotoxicity of artemisinin derivatives in vitro
    S L Smith
    Department of Pharmacology and Therapeutics, University of Liverpool, L69 3GE, Liverpool, UK
    Biochem Pharmacol 61:409-16. 2001
    ..This is consistent with their mechanisms of toxicity being free radical-mediated damage to redox-sensitive proteins essential for neurite outgrowth, or alteration of a redox-sensitive signalling system which regulates neurite outgrowth...
  34. ncbi request reprint The burden of alcohol misuse on an inner-city general hospital
    M Pirmohamed
    Department of Pharmacology and Therapeutics, University of Liverpool, UK
    QJM 93:291-5. 2000
    ..The implementation of education, screening and intervention strategies in A&E departments, and employment of key trained personnel, should be considered, to optimize the clinical management of these patients...
  35. doi request reprint Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer
    V E Shaw
    Liverpool CR UK Centre, NIHR Pancreas Biomedical Research Unit, Liverpool Experimental Cancer Medicine Centre, School of Cancer Studies, The Duncan Building, Daulby Street, Liverpool, L69 3GA, UK
    Expert Rev Vaccines 9:1007-16. 2010
    ..It places GV1001 in the context of other immunotherapeutic approaches targeting telomerase and assesses the chances of the vaccine becoming a future standard of care in the treatment of cancer...
  36. ncbi request reprint LC determination of carbamazepine in murine brain
    A Owen
    Department of Pharmacology and Therapeutics, Ashton Street Medical School, The University of Liverpool, Liverpool L69 3GE, UK
    J Pharm Biomed Anal 26:573-7. 2001
    ..0) with UV detection at 285 nm. The method is selective, reproducible and precise with a limit detection of 45 ng/ml and is suitable for the determination of CBZ in murine brain after intra-peritoneal administration...
  37. ncbi request reprint Comparison of the modulatory effects of human and rat liver microsomal metabolism on the estrogenicity of bisphenol A: implications for extrapolation to humans
    R Elsby
    Department of Pharmacology and Therapeutics, University of Liverpool, New Medical Building, Ashton St, Liverpool, L69 3BX UK
    J Pharmacol Exp Ther 297:103-13. 2001
    ....