Linhua Pang

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint Protein kinase C-epsilon mediates bradykinin-induced cyclooxygenase-2 expression in human airway smooth muscle cells
    Linhua Pang
    Division of Respiratory Medicine, City Hospital, University of Nottingham, Nottingham NG5 1PB, UK
    FASEB J 16:1435-7. 2002
  2. ncbi request reprint Mast cell beta-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities
    Linhua Pang
    Division of Respiratory Medicine, City Hospital, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, United Kingdom
    J Immunol 176:3788-95. 2006
  3. ncbi request reprint Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors
    Linhua Pang
    Division of Respiratory Medicine, City Hospital, University of Nottingham, United Kingdom
    J Immunol 170:1043-51. 2003
  4. ncbi request reprint beta2-Adrenoceptor agonists, like glucocorticoids, repress eotaxin gene transcription by selective inhibition of histone H4 acetylation
    Mei Nie
    Division of Respiratory Medicine, City Hospital, University of Nottingham, Nottingham, United Kingdom
    J Immunol 175:478-86. 2005
  5. pmc Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter
    Alison E John
    Centre for Respiratory Research and Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham, United Kingdom
    J Immunol 183:4682-92. 2009
  6. ncbi request reprint Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists
    Mei Nie
    Division of Respiratory Medicine, City Hospital, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 280:2550-61. 2005
  7. pmc Transcriptional regulation of cyclooxygenase 2 by bradykinin and interleukin-1beta in human airway smooth muscle cells: involvement of different promoter elements, transcription factors, and histone h4 acetylation
    Mei Nie
    Division of Respiratory Medicine, City Hospital, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, United Kingdom
    Mol Cell Biol 23:9233-44. 2003
  8. ncbi request reprint Cytokines upregulate vascular endothelial growth factor secretion by human airway smooth muscle cells: Role of endogenous prostanoids
    Joanne Stocks
    Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, Nottingham, UK
    FEBS Lett 579:2551-6. 2005
  9. pmc TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein
    Deborah L Clarke
    Nottingham Respiratory Biomedical Research Unit, City Hospital, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 285:29101-10. 2010
  10. ncbi request reprint Transcriptional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid-dependent activation of AP-1 and nuclear factor (NF)-IL-6 and prostanoid-independent activation of NF-kappaB
    Yong M Zhu
    Division of Respiratory Medicine, School of Medical and Surgical Sciences, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 278:29366-75. 2003

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Protein kinase C-epsilon mediates bradykinin-induced cyclooxygenase-2 expression in human airway smooth muscle cells
    Linhua Pang
    Division of Respiratory Medicine, City Hospital, University of Nottingham, Nottingham NG5 1PB, UK
    FASEB J 16:1435-7. 2002
    ..Collectively, our results demonstrate that PKC-e mediates BK-induced COX-2 expression in HASM cells...
  2. ncbi request reprint Mast cell beta-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities
    Linhua Pang
    Division of Respiratory Medicine, City Hospital, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, United Kingdom
    J Immunol 176:3788-95. 2006
    ..These findings suggest that mast cell beta-tryptase selectively cleaves ASM-derived eotaxin and RANTES and abrogates their chemotactic activities, thus providing an explanation for the eosinophil paucity in asthmatic ASM bundles...
  3. ncbi request reprint Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors
    Linhua Pang
    Division of Respiratory Medicine, City Hospital, University of Nottingham, United Kingdom
    J Immunol 170:1043-51. 2003
    ....
  4. ncbi request reprint beta2-Adrenoceptor agonists, like glucocorticoids, repress eotaxin gene transcription by selective inhibition of histone H4 acetylation
    Mei Nie
    Division of Respiratory Medicine, City Hospital, University of Nottingham, Nottingham, United Kingdom
    J Immunol 175:478-86. 2005
    ..This provides one explanation for the benefits that result when these agents are combined to treat asthma, and may have important implications in a wide range of inflammatory diseases...
  5. pmc Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter
    Alison E John
    Centre for Respiratory Research and Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham, United Kingdom
    J Immunol 183:4682-92. 2009
    ..This is the first description of an abnormality in transcription factor binding altering chemokine expression in airway structural cells in asthma...
  6. ncbi request reprint Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists
    Mei Nie
    Division of Respiratory Medicine, City Hospital, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 280:2550-61. 2005
    ..The interaction may have wide applications and may provide a potential target for pharmacological and molecular intervention...
  7. pmc Transcriptional regulation of cyclooxygenase 2 by bradykinin and interleukin-1beta in human airway smooth muscle cells: involvement of different promoter elements, transcription factors, and histone h4 acetylation
    Mei Nie
    Division of Respiratory Medicine, City Hospital, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, United Kingdom
    Mol Cell Biol 23:9233-44. 2003
    ....
  8. ncbi request reprint Cytokines upregulate vascular endothelial growth factor secretion by human airway smooth muscle cells: Role of endogenous prostanoids
    Joanne Stocks
    Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, Nottingham, UK
    FEBS Lett 579:2551-6. 2005
    ..Furthermore, the effect of the COX inhibitors was overcome by adding exogenous PGE(2). In conclusion, IL-1beta increases VEGF-A secretion by COX-2 derived PGE(2) production whereas TGFbeta uses COX-independent pathways...
  9. pmc TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein
    Deborah L Clarke
    Nottingham Respiratory Biomedical Research Unit, City Hospital, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 285:29101-10. 2010
    ....
  10. ncbi request reprint Transcriptional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid-dependent activation of AP-1 and nuclear factor (NF)-IL-6 and prostanoid-independent activation of NF-kappaB
    Yong M Zhu
    Division of Respiratory Medicine, School of Medical and Surgical Sciences, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 278:29366-75. 2003
    ..Endogenous prostanoid generation in response to GPCR ligands such as BK may be an important mechanism whereby GPCRs signal to the nucleus to maximize the transcription of inflammatory response genes...
  11. pmc Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis
    William R Coward
    Division of Respiratory Medicine, City Hospital, University of Nottingham, Hucknall Road, Nottingham, United Kingdom
    Mol Cell Biol 29:4325-39. 2009
    ..The results demonstrate that epigenetic abnormality in the form of histone hypoacetylation is responsible for diminished COX-2 expression in IPF...
  12. pmc Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma
    Amanda L Tatler
    Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Immunol 187:6094-107. 2011
    ..These data highlight a mechanism of TGF-β activation in asthma and support the hypothesis that bronchoconstriction promotes airway remodeling via integrin mediated TGF-β activation...
  13. ncbi request reprint Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways
    José A Sánchez-Alcázar
    Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham, NG5 1PB, UK
    Lung Cancer 40:33-44. 2003
    ..These observations suggest that COX inhibitors induce apoptosis in non-small lung cancer cells through cytochrome c and AIF release, and subsequent caspase activation, independently of COX-2 expression and prostaglandin production...
  14. pmc Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis
    William R Coward
    Division of Respiratory Medicine, Centre for Respiratory Research and Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, United Kingdom
    Mol Cell Biol 30:2874-86. 2010
    ....
  15. ncbi request reprint Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids
    Helen C Rodgers
    Division of Respiratory Medicine, City Hospital, Nottingham NG5 1PB, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 283:L612-8. 2002
    ....
  16. pmc Beta-tryptase regulates IL-8 expression in airway smooth muscle cells by a PAR-2-independent mechanism
    Charlotte S Mullan
    Division of Respiratory Medicine, Clinical Sciences Building, City Hospital, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK
    Am J Respir Cell Mol Biol 38:600-8. 2008
    ....
  17. doi request reprint Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis
    Amanda L Tatler
    Centre for Respiratory Research, Clinical Sciences Building, City Hospital, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK
    Biochem Biophys Res Commun 370:239-42. 2008
    ..The results indicate that tryptase activates TGFbeta via a PAR2-independent proteolytic mechanism in human ASM cells and may help understanding the role of tryptase in asthma...
  18. ncbi request reprint Interleukin-1beta differentially regulates beta2 adrenoreceptor and prostaglandin E2-mediated cAMP accumulation and chloride efflux from Calu-3 bronchial epithelial cells. Role of receptor changes, adenylyl cyclase, cyclo-oxygenase 2, and protein kinase A
    Andrew Clayton
    Division of Respiratory Medicine, University of Nottingham, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 280:23451-63. 2005
    ..These findings have important implications for diseases involving inflammation and abnormal ion flux such as cystic fibrosis...
  19. ncbi request reprint Glucocorticoid and beta-adrenoceptor agonist interactions in asthma
    Alan J Knox
    Division of Respiratory Medicine, Clinical Sciences Building, Nottingham City Hospital, Hucknall Road, Nottingham, UK
    Lancet 360:1265-6. 2002