Detail Information
Publications
Endothelin-1 is elevated in Alzheimer's disease and upregulated by amyloid-βJennifer C Palmer
Dementia ResearchGroup, School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol, UK
J Alzheimers Dis 29:853-61. 2012..024). These findings provide evidence of overactivity of the endothelin system in AD, further supporting the suggestion that endothelin receptor antagonists may be of value for the treatment of this disease...
Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by AbetaJennifer C Palmer
Dementia Research Group, Frenchay Hospital, Bristol, United Kingdom
Am J Pathol 175:262-70. 2009..Our findings suggest that endothelin-1 receptor antagonists, already licensed for treating other diseases, could be of benefit in AD therapies...
Endothelin-converting enzyme-1 in Alzheimer's disease and vascular dementiaJ C Palmer
Clinical Science at North Bristol, University of Bristol, Dementia Research Group, Frenchay Hospital, Bristol, UK
Neuropathol Appl Neurobiol 36:487-97. 2010..In vitro, expression of ECE-2 was upregulated by Aβ. Our aims for this study were to examine expression of ECE-1 (which has 57% homology with ECE-2) in temporal cortex from patients with AD, vascular dementia (VaD) and controls...
Endothelin receptor antagonists: potential in Alzheimer's diseaseJennifer Palmer
Dementia Research Group, Institute of Clinical Neurosciences, School of Clinical Sciences, University of Bristol, Frenchay Hospital, Bristol BS16 1LE, United Kingdom
Pharmacol Res 63:525-31. 2011....
