Lena Palaniyappan

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. pmc Diagnostic discontinuity in psychosis: a combined study of cortical gyrification and functional connectivity
    Lena Palaniyappan
    To whom correspondence should be addressed Room 09, C Floor, Institute of Mental Health Building, Triumph Road, Nottingham, NG7 2TU, England, UK tel 44 115 823 0407, fax 44 115 823 0433, E mail
    Schizophr Bull 40:675-84. 2014
  2. pmc Combined white matter imaging suggests myelination defects in visual processing regions in schizophrenia
    Lena Palaniyappan
    Division of Psychiatry, Institute of Mental Health, University of Nottingham, Nottingham, UK
    Neuropsychopharmacology 38:1808-15. 2013
  3. pmc Neural primacy of the salience processing system in schizophrenia
    Lena Palaniyappan
    Centre for Translational Neuroimaging in Mental Health, Division of Psychiatry, University of Nottingham, Nottingham NG7 2TU, UK
    Neuron 79:814-28. 2013
  4. ncbi request reprint Gyrification of Broca's region is anomalously lateralized at onset of schizophrenia in adolescence and regresses at 2 year follow-up
    L Palaniyappan
    Division of Psychiatry, Institute of Mental Health, University of Nottingham, Nottingham NG7 2TU, UK
    Schizophr Res 147:39-45. 2013
  5. ncbi request reprint The concept of salience network dysfunction in schizophrenia: from neuroimaging observations to therapeutic opportunities
    L Palaniyappan
    Division of Psychiatry, Institute of Mental Health, University of Nottingham, Nottingham, UK
    Curr Top Med Chem 12:2324-38. 2012
  6. pmc Aberrant cortical gyrification in schizophrenia: a surface-based morphometry study
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, South Block, Queen s Medical Centre, Nottingham, United Kingdom
    J Psychiatry Neurosci 37:399-406. 2012
  7. ncbi request reprint The neuroanatomy of psychotic diathesis: a meta-analytic review
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    J Psychiatr Res 46:1249-56. 2012
  8. ncbi request reprint Dissociable morphometric differences of the inferior parietal lobule in schizophrenia
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, Queen s Medical Centre, UK
    Eur Arch Psychiatry Clin Neurosci 262:579-87. 2012
  9. ncbi request reprint Structural correlates of auditory hallucinations in schizophrenia: a meta-analysis
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Schizophr Res 137:169-73. 2012
  10. ncbi request reprint Differential effects of surface area, gyrification and cortical thickness on voxel based morphometric deficits in schizophrenia
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Neuroimage 60:693-9. 2012

Detail Information

Publications18

  1. pmc Diagnostic discontinuity in psychosis: a combined study of cortical gyrification and functional connectivity
    Lena Palaniyappan
    To whom correspondence should be addressed Room 09, C Floor, Institute of Mental Health Building, Triumph Road, Nottingham, NG7 2TU, England, UK tel 44 115 823 0407, fax 44 115 823 0433, E mail
    Schizophr Bull 40:675-84. 2014
    ..Further, connectivity-based neuroimaging measures appear to be better indicators of diagnostic discontinuity than the symptom-based clinical information...
  2. pmc Combined white matter imaging suggests myelination defects in visual processing regions in schizophrenia
    Lena Palaniyappan
    Division of Psychiatry, Institute of Mental Health, University of Nottingham, Nottingham, UK
    Neuropsychopharmacology 38:1808-15. 2013
    ..Combined DTI/MTI deficits in the occipito-temporal region may be an important variable when considering potential treatment targets for improving cognitive function in schizophrenia. ..
  3. pmc Neural primacy of the salience processing system in schizophrenia
    Lena Palaniyappan
    Centre for Translational Neuroimaging in Mental Health, Division of Psychiatry, University of Nottingham, Nottingham NG7 2TU, UK
    Neuron 79:814-28. 2013
    ..In addition, this offers a parsimonious explanation for the often-observed "frontal inefficiency," the failure to recruit prefrontal system when salient or novel information becomes available in patients with schizophrenia. ..
  4. ncbi request reprint Gyrification of Broca's region is anomalously lateralized at onset of schizophrenia in adolescence and regresses at 2 year follow-up
    L Palaniyappan
    Division of Psychiatry, Institute of Mental Health, University of Nottingham, Nottingham NG7 2TU, UK
    Schizophr Res 147:39-45. 2013
    ..A deviation in the lateralized development of peri-Sylvian areas for language production and comprehension appears critical to the pathophysiology of schizophrenia and may point to its species-specific origin...
  5. ncbi request reprint The concept of salience network dysfunction in schizophrenia: from neuroimaging observations to therapeutic opportunities
    L Palaniyappan
    Division of Psychiatry, Institute of Mental Health, University of Nottingham, Nottingham, UK
    Curr Top Med Chem 12:2324-38. 2012
    ..This combination approach, termed as Brain Network Modulation, could exploit neuronal plasticity to reverse a key pathophysiological deficit in schizophrenia...
  6. pmc Aberrant cortical gyrification in schizophrenia: a surface-based morphometry study
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, South Block, Queen s Medical Centre, Nottingham, United Kingdom
    J Psychiatry Neurosci 37:399-406. 2012
    ..Investigating the anatomic distribution of gyrification defects can provide important information about neurodevelopment in patients with schizophrenia...
  7. ncbi request reprint The neuroanatomy of psychotic diathesis: a meta-analytic review
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    J Psychiatr Res 46:1249-56. 2012
    ..It is unclear which of these neuroanatomical changes are associated with a predisposition or vulnerability to develop schizophrenia rather than the appearance of the clinical features of the illness...
  8. ncbi request reprint Dissociable morphometric differences of the inferior parietal lobule in schizophrenia
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, Queen s Medical Centre, UK
    Eur Arch Psychiatry Clin Neurosci 262:579-87. 2012
    ....
  9. ncbi request reprint Structural correlates of auditory hallucinations in schizophrenia: a meta-analysis
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Schizophr Res 137:169-73. 2012
    ..Despite being one of the most common symptoms of schizophrenia, determining the neural correlates of auditory hallucinations still remains elusive with various studies providing inconsistent results...
  10. ncbi request reprint Differential effects of surface area, gyrification and cortical thickness on voxel based morphometric deficits in schizophrenia
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Neuroimage 60:693-9. 2012
    ....
  11. ncbi request reprint Reality distortion is related to the structure of the salience network in schizophrenia
    L Palaniyappan
    Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham, UK
    Psychol Med 41:1701-8. 2011
    ..We investigated whether structural deficits in the salience network are associated with the reality distortion seen in schizophrenia...
  12. pmc Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    J Psychiatry Neurosci 37:17-27. 2012
    ..In this review, we bring together evidence from imaging studies to understand the role of the salience network in schizophrenia and propose a model of insular dysfunction in psychosis...
  13. ncbi request reprint Regional contraction of brain surface area involves three large-scale networks in schizophrenia
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham, NG7 2UH, United Kingdom
    Schizophr Res 129:163-8. 2011
    ..Our findings suggest that a fundamental disturbance in cortical expansion is likely in individuals who develop schizophrenia...
  14. ncbi request reprint Folding of the prefrontal cortex in schizophrenia: regional differences in gyrification
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    Biol Psychiatry 69:974-9. 2011
    ..With surface reconstructions from magnetic resonance imaging, we studied the gyrification within anatomically meaningful subdivisions of prefrontal cortex in schizophrenia...
  15. ncbi request reprint Appreciating symptoms and deficits in schizophrenia: right posterior insula and poor insight
    Lena Palaniyappan
    Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham, NG7 2UH, United Kingdom
    Prog Neuropsychopharmacol Biol Psychiatry 35:523-7. 2011
    ..Abnormalities in interoceptive awareness and self-appraisal of emotional states may contribute to the loss of insight seen in schizophrenia...
  16. ncbi request reprint Alterations in effective connectivity anchored on the insula in major depressive disorder
    Sarina J Iwabuchi
    Translational Neuroimaging, Division of Psychiatry, Institute of Mental Health, University of Nottingham, Room 09 C Floor, Triumph Road, Nottingham, NG7 2TU England, UK
    Eur Neuropsychopharmacol 24:1784-92. 2014
    ..Within limitations of inferences drawn from GCA of resting fMRI, we offer a novel framework to advance targeted network modulation approaches to treat depression. ..
  17. ncbi request reprint Cortical folding defects as markers of poor treatment response in first-episode psychosis
    Lena Palaniyappan
    Translational Neuroimaging, Division of Psychiatry, Institute of Mental Health, University of Nottingham and Nottinghamshire Healthcare National Health Service Trust, Nottingham, England
    JAMA Psychiatry 70:1031-40. 2013
    ....