Karen Page

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Mathematical models of cancer dormancy
    Karen Page
    Bioinformatics Unit, Department of Computer Science, University College London, UK
    Leuk Lymphoma 46:313-27. 2005
  2. ncbi What can we learn from the population incidence of cancer? Armitage and Doll revisited
    Chris Hornsby
    Department of Computer Science, University College London, London, UK
    Lancet Oncol 8:1030-8. 2007
  3. doi Breast cancer dormancy can be maintained by small numbers of micrometastases
    Lisa Willis
    CoMPLEX, University College London, London, United Kingdom
    Cancer Res 70:4310-7. 2010
  4. ncbi Empathy leads to fairness
    Karen M Page
    Bioinformatics Unit, Department of Computer Science, University College London, Gower Street, London WC1E 6BT, U K
    Bull Math Biol 64:1101-16. 2002
  5. ncbi Language learning: how much evidence does a child need in order to learn to speak grammatically?
    Karen M Page
    Department of Computer Science, Bioinformatics Unit, University College London, Gower Street, WC1E 6BT London, UK
    Bull Math Biol 66:651-62. 2004
  6. pmc The in vivo rate of somatic adenomatous polyposis coli mutation
    Chris Hornsby
    Department of Computer Science, University College London, London, U K
    Am J Pathol 172:1062-8. 2008
  7. ncbi Speed of reaction diffusion in embryogenesis
    Karen M Page
    Department of Mathematics, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Phys Rev E Stat Nonlin Soft Matter Phys 76:011902. 2007
  8. pmc Stochastic models of receptor oligomerization by bivalent ligand
    Tomás Alarcón
    Bioinformatics Unit, Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK
    J R Soc Interface 3:545-59. 2006
  9. ncbi Mathematical models of the fate of lymphoma B cells after antigen receptor ligation with specific antibodies
    Tomás Alarcón
    Bioinformatics Unit, Department of Computer Science, University College London, London WC1E 6BT, UK
    J Theor Biol 240:54-71. 2006
  10. ncbi The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2 delta-2 protein with abnormal function
    Jens Brodbeck
    Department of Pharmacology, University College London, Gower Street, London WC1E, United Kingdom
    J Biol Chem 277:7684-93. 2002

Collaborators

Detail Information

Publications14

  1. ncbi Mathematical models of cancer dormancy
    Karen Page
    Bioinformatics Unit, Department of Computer Science, University College London, UK
    Leuk Lymphoma 46:313-27. 2005
    ..We determine parameters that control the size of the dormant tumors, and the fraction of proliferating cells. Finally, we discuss the implications for tumor immunotherapy...
  2. ncbi What can we learn from the population incidence of cancer? Armitage and Doll revisited
    Chris Hornsby
    Department of Computer Science, University College London, London, UK
    Lancet Oncol 8:1030-8. 2007
    ..Why have we been unable to elucidate the quantitative dependence of cancer incidence on the molecular processes that feature in its aetiology? In this review we aim to provide answers for this question...
  3. doi Breast cancer dormancy can be maintained by small numbers of micrometastases
    Lisa Willis
    CoMPLEX, University College London, London, United Kingdom
    Cancer Res 70:4310-7. 2010
    ..In summary, breast cancer dormancy seems to be maintained by small numbers of sizeable micrometastases that escape from growth restriction with a half-life exceeding 12 years...
  4. ncbi Empathy leads to fairness
    Karen M Page
    Bioinformatics Unit, Department of Computer Science, University College London, Gower Street, London WC1E 6BT, U K
    Bull Math Biol 64:1101-16. 2002
    ..Here we study the Ultimatum Game in an evolutionary context and show that empathy can lead to the evolution of fairness. Empathy means that individuals make offers which they themselves would be prepared to accept...
  5. ncbi Language learning: how much evidence does a child need in order to learn to speak grammatically?
    Karen M Page
    Department of Computer Science, Bioinformatics Unit, University College London, Gower Street, WC1E 6BT London, UK
    Bull Math Biol 66:651-62. 2004
    ..We reformulate this algorithm in the context of Chomsky's 'principles and parameters' and show that it is possible to bound the amount of evidence required to almost certainly speak almost grammatically...
  6. pmc The in vivo rate of somatic adenomatous polyposis coli mutation
    Chris Hornsby
    Department of Computer Science, University College London, London, U K
    Am J Pathol 172:1062-8. 2008
    ..The quality of fit provided by this method supports the theory that FAP and sporadic bowel cancer follow the same genetic pathway and are separated by only one mutation...
  7. ncbi Speed of reaction diffusion in embryogenesis
    Karen M Page
    Department of Mathematics, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Phys Rev E Stat Nonlin Soft Matter Phys 76:011902. 2007
    ..In this paper, we investigate this issue in specific reaction diffusion models and address the question of whether patterning via reaction diffusion is fast enough to be applicable to morphogenesis...
  8. pmc Stochastic models of receptor oligomerization by bivalent ligand
    Tomás Alarcón
    Bioinformatics Unit, Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK
    J R Soc Interface 3:545-59. 2006
    ....
  9. ncbi Mathematical models of the fate of lymphoma B cells after antigen receptor ligation with specific antibodies
    Tomás Alarcón
    Bioinformatics Unit, Department of Computer Science, University College London, London WC1E 6BT, UK
    J Theor Biol 240:54-71. 2006
    ..We use bifurcation analysis and objective sensitivity analysis to assess the robustness of our results. Importantly, this analysis yields experimentally testable predictions on the role of Myc, which could have therapeutic implications...
  10. ncbi The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2 delta-2 protein with abnormal function
    Jens Brodbeck
    Department of Pharmacology, University College London, Gower Street, London WC1E, United Kingdom
    J Biol Chem 277:7684-93. 2002
    ..1/beta(4) channel combination when co-expressed in vitro, co-expression with the truncated mutant alpha 2 delta-2 protein reduced current density, indicating that it may contribute to the du phenotype...
  11. pmc Mathematical models of the VEGF receptor and its role in cancer therapy
    Tomás Alarcón
    Bioinformatics Unit, Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK
    J R Soc Interface 4:283-304. 2007
    ....
  12. ncbi Generalized, switch-like competitive heterodimerization networks
    Olivier Cinquin
    CoMPLEX, UCL University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Bull Math Biol 69:483-94. 2007
    ..Here, we derive a generalized rule. This in turns allows one to study more ways in which these networks could be regulated, linking intrinsic cellular differentiation determinants to extracellular cues...
  13. ncbi Unifying evolutionary dynamics
    Karen M Page
    Institute for Advanced Study, Einstein Drive, Princeton, NJ, 08540, U S A
    J Theor Biol 219:93-8. 2002
    ..From these equations, we obtain as special cases adaptive dynamics, evolutionary game dynamics, the Lotka-Volterra equation of ecology and the quasispecies equation of molecular evolution...
  14. ncbi Module dynamics of the GnRH signal transduction network
    David C Krakauer
    Santa Fe Institute, NM 87501, USA
    J Theor Biol 218:457-70. 2002
    ..We propose that the cell computes by exploiting variation in the time scales of protein activation (phosphorylation) and gene expression...