C J Packard

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Non-HDL cholesterol as a measure of atherosclerotic risk
    Chris J Packard
    University Department of Pathological Biochemistry, Glasgow Royal Infirmary, Scotland, UK
    J Atheroscler Thromb 11:6-14. 2004
  2. ncbi request reprint Small dense low-density lipoprotein and its role as an independent predictor of cardiovascular disease
    Chris J Packard
    Department of Vascular Biochemistry, University of Glasgow, Scotland, UK
    Curr Opin Lipidol 17:412-7. 2006
  3. ncbi request reprint Association between apolipoprotein E4 and cognitive decline in elderly adults
    Chris J Packard
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
    J Am Geriatr Soc 55:1777-85. 2007
  4. pmc CCR2 and coronary artery disease: a woscops substudy
    David J Dow
    GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK
    BMC Res Notes 3:31. 2010
  5. ncbi request reprint Triacylglycerol-rich lipoproteins and the generation of small, dense low-density lipoprotein
    C J Packard
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Biochem Soc Trans 31:1066-9. 2003
  6. doi request reprint Lipoprotein-associated phospholipase A2 as a biomarker of coronary heart disease and a therapeutic target
    Chris J Packard
    Department of Vascular Biochemistry, Glasgow Royal Infirmary, Glasgow, Scotland, UK
    Curr Opin Cardiol 24:358-63. 2009
  7. ncbi request reprint Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group
    C J Packard
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, Scotland
    N Engl J Med 343:1148-55. 2000
  8. ncbi request reprint Optimizing lipid-lowering therapy in the prevention of coronary heart disease
    Chris J Packard
    NHS GG and C Health Board, Western Infirmary Glasgow, Tennent Blg, 38 Church Street, Glasgow, G11 6NT, UK
    Expert Rev Clin Pharmacol 3:649-61. 2010
  9. ncbi request reprint A triumvirate of targets in the prevention and treatment paradigm for cardiovascular disease
    Chris Packard
    Department of Pathological Biochemistry, Greater Glasgow Health Board, Glasgow Royal Infirmary, G31 2ER, Scotland, UK
    Atheroscler Suppl 7:21-9. 2006
  10. ncbi request reprint Plasma lipoproteins and apolipoproteins as predictors of cardiovascular risk and treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER)
    Chris J Packard
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
    Circulation 112:3058-65. 2005

Detail Information

Publications60

  1. ncbi request reprint Non-HDL cholesterol as a measure of atherosclerotic risk
    Chris J Packard
    University Department of Pathological Biochemistry, Glasgow Royal Infirmary, Scotland, UK
    J Atheroscler Thromb 11:6-14. 2004
    ..Adoption of this readily available measure to assess risk and response to treatment in patients with elevated TG would improve treatment of dyslipidemia in a substantial number at risk for CHD...
  2. ncbi request reprint Small dense low-density lipoprotein and its role as an independent predictor of cardiovascular disease
    Chris J Packard
    Department of Vascular Biochemistry, University of Glasgow, Scotland, UK
    Curr Opin Lipidol 17:412-7. 2006
    ....
  3. ncbi request reprint Association between apolipoprotein E4 and cognitive decline in elderly adults
    Chris J Packard
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
    J Am Geriatr Soc 55:1777-85. 2007
    ..To determine the influence of apolipoprotein E on cognitive decline in a cohort of elderly men and women...
  4. pmc CCR2 and coronary artery disease: a woscops substudy
    David J Dow
    GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK
    BMC Res Notes 3:31. 2010
    ..abstract:..
  5. ncbi request reprint Triacylglycerol-rich lipoproteins and the generation of small, dense low-density lipoprotein
    C J Packard
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Biochem Soc Trans 31:1066-9. 2003
    ..Statins remove VLDL particles via receptor-mediated pathways and reduce the residence time (and hence limit the potential for remodelling) of LDL in the circulation...
  6. doi request reprint Lipoprotein-associated phospholipase A2 as a biomarker of coronary heart disease and a therapeutic target
    Chris J Packard
    Department of Vascular Biochemistry, Glasgow Royal Infirmary, Glasgow, Scotland, UK
    Curr Opin Cardiol 24:358-63. 2009
    ..This study reviews evidence supporting its role as a biomarker of vascular disease and as a possible therapeutic target...
  7. ncbi request reprint Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group
    C J Packard
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, Scotland
    N Engl J Med 343:1148-55. 2000
    ....
  8. ncbi request reprint Optimizing lipid-lowering therapy in the prevention of coronary heart disease
    Chris J Packard
    NHS GG and C Health Board, Western Infirmary Glasgow, Tennent Blg, 38 Church Street, Glasgow, G11 6NT, UK
    Expert Rev Clin Pharmacol 3:649-61. 2010
    ..Clinical trials on the utility of high-density lipoprotein raising on a background of statin therapy are underway...
  9. ncbi request reprint A triumvirate of targets in the prevention and treatment paradigm for cardiovascular disease
    Chris Packard
    Department of Pathological Biochemistry, Greater Glasgow Health Board, Glasgow Royal Infirmary, G31 2ER, Scotland, UK
    Atheroscler Suppl 7:21-9. 2006
    ..Furthermore, the overall safety and tolerability profile is comparable among available statins. This paper examines recent data highlighting the role that statins and other lipid-lowering agents can play in this new treatment paradigm...
  10. ncbi request reprint Plasma lipoproteins and apolipoproteins as predictors of cardiovascular risk and treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER)
    Chris J Packard
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
    Circulation 112:3058-65. 2005
    ..We assessed the role of plasma lipoproteins as predictors of risk and of treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER)...
  11. pmc Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study
    Chris J Packard
    Glasgow Clinical Research Facility, Tennent Building, 38 Church Street, Western Infirmary, Glasgow G116NT, UK
    BMC Public Health 11:42. 2011
    ..The Psychosocial and Biological Determinants of Ill-health (pSoBid) study was designed to uncover novel biomarkers of chronic disease that may help explain pathways between socioeconomic adversity and poorer physical and mental health...
  12. ncbi request reprint Patients with nephrotic-range proteinuria have apolipoprotein C and E deficient VLDL1
    C J Deighan
    Renal Unit, Glasgow Royal Infirmary and Department of Pathological Biochemistry, University of Glasgow, Glasgow Royal Infirmary, Scotland, United Kingdom
    Kidney Int 58:1238-46. 2000
    ..In nephrotic-range proteinuria, the clearance of VLDL1 is delayed. VLDL1 lipolysis is influenced by apolipoprotein CII (apoCII) and apoCIII, whereas apoE regulates receptor-mediated clearance...
  13. ncbi request reprint Lipids and lipoprotein subfractions in women with PCOS: relationship to metabolic and endocrine parameters
    I R Pirwany
    Department of Obstetrics and Gynaecology, Glasgow Royal Infirmary University NHS Trust, Glasgow, UK
    Clin Endocrinol (Oxf) 54:447-53. 2001
    ....
  14. ncbi request reprint Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease
    M J Caslake
    Department of Pathological Biochemistry, 4th Floor QEB, Glasgow Royal Infirmary University NHS Trust, Glasgow, UK
    Atherosclerosis 150:413-9. 2000
    ..We propose, therefore, that plasma Lp-PLA(2) mass should be viewed as a potential novel risk factor for CAD that provides information related to but additional to traditional lipoprotein measurements...
  15. doi request reprint Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly
    N Sattar
    Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, University Place, Glasgow G12 8TA, UK
    Diabetologia 52:235-9. 2009
    ....
  16. ncbi request reprint Lipid and lipoprotein concentrations in pregnancies complicated by intrauterine growth restriction
    N Sattar
    Department of Pathological Biochemistry, Royal Infirmary University NHS Trust, Glasgow, United Kingdom
    J Clin Endocrinol Metab 84:128-30. 1999
    ....
  17. ncbi request reprint Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS)
    A M Wallace
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, University of Glasgow, Glasgow, Scotland
    Circulation 104:3052-6. 2001
    ..18; 95% CI, 1.00 to 1.39; P=0.05) at the expense of C-reactive protein. CONCLUSIONS: We show, for the first time, in a large prospective study that leptin is a novel, independent risk factor for coronary heart disease...
  18. ncbi request reprint Atherogenic lipoprotein phenotype in end-stage renal failure: origin and extent of small dense low-density lipoprotein formation
    C J Deighan
    Glasgow Royal Infirmary, UK
    Am J Kidney Dis 35:852-62. 2000
    ..Atherogenic levels of LDLIII are found in patients with triglyceride levels greater than 177 mg/dL. This is likely to represent a further cardiovascular risk factor in this population...
  19. ncbi request reprint Effects of colestipol alone and in combination with simvastatin on apolipoprotein B metabolism
    A Gaw
    Institute of Biochemistry, Glasgow Royal Infirmary, UK
    Arterioscler Thromb Vasc Biol 16:236-49. 1996
    ..Compared with baseline, combined therapy generated falls in both IDL (35%, P = .01) and LDL (37%, P < .04) apoB pools due to enhanced clearance of IDL (214%, P < .03) and reduced total input of LDL (39%, P < .003)...
  20. ncbi request reprint The atherogenic lipoprotein phenotype: small dense LDL and lipoprotein remnants in nephrotic range proteinuria
    C J Deighan
    Renal Unit, Walton Building, Glasgow Royal Infirmary, Castle St, Glasgow, G4 0SF, UK
    Atherosclerosis 157:211-20. 2001
    ..Increases in LDLIII and RLP are closely related to plasma triglyceride. The association between excess RLP and LDLIII suggests that RLP contribute to the increased atherogenicity attributed to the atherogenic lipoprotein phenotype...
  21. ncbi request reprint The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER). PROSPER Study Group. PROspective Study of Pravastatin in the Elderly at Risk
    J Shepherd
    University of Glasgow, Scotland
    Am J Cardiol 84:1192-7. 1999
    ..Finally, an assessment will be made of the effects of treatment on cognitive function, disability, hospitalization or institutionalization, vascular mortality, and all-cause mortality...
  22. ncbi request reprint Comparative effects of cerivastatin and fenofibrate on the atherogenic lipoprotein phenotype in proteinuric renal disease
    C J Deighan
    Renal Unit, Walton Building, Glasgow Royal Infirmary, Castle Street, Glasgow, G4 0SF, United Kingdom
    J Am Soc Nephrol 12:341-8. 2001
    ..Fenofibrate but not cerivastatin reduces remnant lipoproteins. The two treatments seem to reduce LDLIII by different mechanisms, suggesting a potential role for combination therapy to optimize lowering of LDLIII and RLP...
  23. ncbi request reprint Lipoprotein metabolism in hepatic lipase deficiency: studies on the turnover of apolipoprotein B and on the effect of hepatic lipase on high density lipoprotein
    T Demant
    University Department of Biochemistry, Royal Infirmary, Glasgow, UK
    J Lipid Res 29:1603-11. 1988
    ..The pathways of direct plasma catabolism of these species were not affected by the enzyme defect. In vitro studies were performed by adding purified hepatic lipase to the patient's plasma.(ABSTRACT TRUNCATED AT 250 WORDS)..
  24. ncbi request reprint Lipoprotein (a), cholesterol and triglycerides in women with venous thromboembolism
    M D McColl
    Department of Haematology, Royal Infirmary, Glasgow, UK
    Blood Coagul Fibrinolysis 11:225-9. 2000
    ....
  25. ncbi request reprint Insulin resistance in the St. Thomas' mixed hyperlipidaemic (SMHL) rabbit, a model for familial combined hyperlipidaemia
    B de Roos
    Department of Pathological Biochemistry, 4th Floor, Queen Elizabeth Building, Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Atherosclerosis 156:249-54. 2001
    ..Therefore, the SMHL rabbit offers a valuable animal model in which to study the relation between hypertriglyceridaemia and insulin resistance...
  26. ncbi request reprint Serial metabolic measurements and conversion to type 2 diabetes in the west of Scotland coronary prevention study: specific elevations in alanine aminotransferase and triglycerides suggest hepatic fat accumulation as a potential contributing factor
    Naveed Sattar
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
    Diabetes 56:984-91. 2007
    ....
  27. doi request reprint Fasting plasma glucose in non-diabetic participants and the risk for incident cardiovascular events, diabetes, and mortality: results from WOSCOPS 15-year follow-up
    David Preiss
    Faculty of Medicine, University of Glasgow, Glasgow, UK
    Eur Heart J 31:1230-6. 2010
    ..The evidence base for fasting plasma glucose (FPG) in the non-diabetic range as a risk factor for cardiovascular disease (CVD) is inconclusive. We investigated this question in the West of Scotland Coronary Prevention Study (WOSCOPS)...
  28. doi request reprint Obesity is associated with fatal coronary heart disease independently of traditional risk factors and deprivation
    Jennifer Logue
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Heart 97:564-8. 2011
    ..However, there is now evidence of a differential effect of risk factors on fatal and non-fatal CHD events, with markers of inflammation more strongly associated with fatal than non-fatal events...
  29. ncbi request reprint Understanding coronary heart disease as a consequence of defective regulation of apolipoprotein B metabolism
    C J Packard
    Department of Pathological Biochemistry, Glasgow Royal Infirmary University NHS Trust, UK
    Curr Opin Lipidol 10:237-44. 1999
    ..Important influences are the rate and nature of lipoproteins secreted from the liver, the extent of remodelling by lipid exchange and lipolysis in the circulation and the affinity of the various particles for cell surface receptors...
  30. ncbi request reprint Remodelling of cerebrospinal fluid lipoproteins after subarachnoid hemorrhage
    A D Kay
    Department of Neurosurgery, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, UK
    Atherosclerosis 170:141-6. 2003
    ..The remodelling of CSF Lps and selective reduction of apoE containing lipoproteins may reflect an important response of the human brain to injury...
  31. pmc Exercise training has greater effects on insulin sensitivity in daughters of patients with type 2 diabetes than in women with no family history of diabetes
    N D Barwell
    Institute of Diet, Exercise and Lifestyle, Faculty of Biomedical and Life Sciences, West Medical Building, University of Glasgow, University Avenue, Glasgow, UK
    Diabetologia 51:1912-9. 2008
    ..This study aimed to determine the effects of an exercise training intervention on insulin sensitivity in both groups...
  32. ncbi request reprint Effects of short-term detraining on postprandial metabolism, endothelial function, and inflammation in endurance-trained men: dissociation between changes in triglyceride metabolism and endothelial function. j.gill@bio.gla.ac.uk
    Jason M R Gill
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow, Scotland G31 2ER, United Kingdom
    J Clin Endocrinol Metab 88:4328-35. 2003
    ..These results suggest that, although fat ingestion induces endothelial dysfunction, interventions that alter postprandial TG metabolism will not necessarily concomitantly influence endothelial function...
  33. ncbi request reprint C-reactive protein and prediction of coronary heart disease and global vascular events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)
    Naveed Sattar
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland, UK
    Circulation 115:981-9. 2007
    ..The role of C-reactive protein (CRP) in predicting vascular events and response to statin therapy remains uncertain. Additional large prospective studies are required...
  34. ncbi request reprint Long-term follow-up of the West of Scotland Coronary Prevention Study
    Ian Ford
    Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom
    N Engl J Med 357:1477-86. 2007
    ..9 to 5.5% (P<0.001) in the treatment group. Extended follow-up data were obtained for approximately 10 years after completion of the trial...
  35. ncbi request reprint Factors affecting low-density lipoprotein and high-density lipoprotein cholesterol response to pravastatin in the West Of Scotland Coronary Prevention Study (WOSCOPS)
    Leanne Streja
    Robertson Centre for Biostatistics, Glasgow University, Glasgow, Scotland, UK
    Am J Cardiol 90:731-6. 2002
    ..The absolute increment in HDL cholesterol is relatively constant across a range of baseline values, hence the percent change is largely a function of the starting value...
  36. pmc Psychological, social and biological determinants of ill health (pSoBid): study protocol of a population-based study
    Yoga N Velupillai
    Glasgow Centre for Population Health, Level 6, 39 St Vincent Place, Glasgow, G1 2ER, UK
    BMC Public Health 8:126. 2008
    ....
  37. doi request reprint Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies
    Naveed Sattar
    Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Lancet 371:1927-35. 2008
    ..We investigated to what extent metabolic syndrome and its individual components were related to risk for these two diseases in elderly populations...
  38. ncbi request reprint A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study
    Dilys J Freeman
    Department of Biological Sciences, University of Durham, Durham, UK
    Eur Heart J 24:1833-42. 2003
    ..Gene-smoking and gene-treatment interactions were investigated...
  39. ncbi request reprint Regulation of small dense LDL concentration in Korean and Scottish men and women
    Hong Keun Cho
    Department of Internal Medicine, Medical College, Ewha Women s University, Seoul, Republic of Korea
    Atherosclerosis 164:187-93. 2002
    ....
  40. ncbi request reprint Influence of atorvastatin and simvastatin on apolipoprotein B metabolism in moderate combined hyperlipidemic subjects with low VLDL and LDL fractional clearance rates
    Lorne F Forster
    Department of Pathological Biochemistry, Glasgow Royal Infirmary University NHS Trust, 4th Floor, Queen Elizabeth Building 10 Alexandra Parade, Glasgow, G31 2ER, Scotland, UK
    Atherosclerosis 164:129-45. 2002
    ..This leads to a substantial, and approximately equivalent, percentage reduction in plasma triglyceride and LDL cholesterol...
  41. ncbi request reprint UK Food Standards Agency cis-monounsaturated fatty acid workshop report
    Peter Sanderson
    Nutrition Division, Food Standards Agency, Aviation House, 125 Kingsway, London, WC2 6NH, UK
    Br J Nutr 88:99-104. 2002
    ..Recommendations for studies investigating the mechanistic effects of MUFA were also made. Methods of manipulating the food chain to increase MUFA at the expense of saturated fatty acids were also discussed...
  42. ncbi request reprint Influence of an asparagine to lysine mutation at amino acid 3516 of apolipoprotein B on low-density lipoprotein receptor binding
    Dairena Gaffney
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, North Glasgow Hospital University NHS Trust, Fourth Floor, Queen Elizabeth Building, Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    Clin Chim Acta 321:113-21. 2002
    ..Previously, undescribed mutations were sought...
  43. ncbi request reprint C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study
    Dilys J Freeman
    Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow, UK
    Diabetes 51:1596-600. 2002
    ..They also add to the notion that low-grade inflammation is important in the pathogenesis of type 2 diabetes...
  44. ncbi request reprint Comparison of apolipoprotein B metabolism in familial defective apolipoprotein B and heterogeneous familial hypercholesterolemia
    Dairena Gaffney
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, North Glasgow Hospitals University NHS Trust, 4th Floor, Queen Elizabeth Building, Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    Atherosclerosis 162:33-43. 2002
    ..We conclude that disturbances in IDL metabolism provide the basis for understanding why FDB is less severe than FH. Our findings suggest that an apoB-LDL receptor interaction is important in the IDL to LDL conversion...
  45. ncbi request reprint Effects of dietary monounsaturated fatty acids on lipoprotein concentrations, compositions, and subfraction distributions and on VLDL apolipoprotein B kinetics: dose-dependent effects on LDL
    Jason M R Gill
    Department of Pathological Biochemistry, University of Glasgow, Glasgow, United Kingdom
    Am J Clin Nutr 78:47-56. 2003
    ..Replacing dietary saturated fatty acids (SFAs) with monounsaturated fatty acids (MUFAs) lowers LDL cholesterol, but the underlying mechanisms remain unclear...
  46. ncbi request reprint Effect of prior moderate exercise on postprandial metabolism in men with type 2 diabetes: heterogeneity of responses
    Jason M R Gill
    Department of Vascular Biochemistry, University of Glasgow, United Kingdom
    Atherosclerosis 194:134-43. 2007
    ....
  47. ncbi request reprint Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study
    Naveed Sattar
    University Department of Pathological Biochemistry, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    Circulation 108:414-9. 2003
    ..Information on the prospective association of this definition for coronary heart disease (CHD) and type 2 diabetes is currently limited...
  48. ncbi request reprint Phenotype-dependent and -independent actions of rosuvastatin on atherogenic lipoprotein subfractions in hyperlipidaemia
    Muriel J Caslake
    Department of Pathological Biochemistry, Glasgow Royal Infirmary University NHS Trust, 4th Floor Queen Elizabeth Building, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Atherosclerosis 171:245-53. 2003
    ..Rosuvastatin therefore, in addition to lowering LDL and apoB-concentrations, largely corrected the TG and LDL abnormalities in subjects who had the propensity to develop the atherogenic lipoprotein phenotype...
  49. ncbi request reprint Metabolic syndrome and diabetes mellitus
    W E Feeman
    Circulation 109:E23. 2004
  50. ncbi request reprint Phenotypes, genotypes and response to statin therapy
    Muriel J Caslake
    Department of Vascular Biochemistry, Glasgow Royal Infirmary, Glasgow, Scotland, UK
    Curr Opin Lipidol 15:387-92. 2004
    ..The aim of this review is to describe what is known about factors that determine a patient's response, and to offer a mechanism to explain how plasma triglyceride influences the nature and magnitude of lipid lowering on statin therapy...
  51. ncbi request reprint Hepatic production of VLDL1 but not VLDL2 is related to insulin resistance in normoglycaemic middle-aged subjects
    Jason M R Gill
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, UK
    Atherosclerosis 176:49-56. 2004
    ..These results suggest a role for insulin resistance in the determination of hepatic VLDL1 production and highlight the independent regulation of VLDL1 and VLDL2 metabolism...
  52. ncbi request reprint Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention study
    Naveed Sattar
    Division of Cardiovascular and Medical Sciences, Universityof Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Diabetes 53:2855-60. 2004
    ..The simplicity of ALT measurement and its availability in routine clinical practice suggest that this enzyme activity could be included in future diabetes prediction algorithms...
  53. ncbi request reprint Effects of prior moderate exercise on postprandial metabolism and vascular function in lean and centrally obese men
    Jason M R Gill
    Department of Vascular Biochemistry, University of Glasgow, Glasgow Royal Infirmary, Glasgow G12 8QQ, Scotland, UK
    J Am Coll Cardiol 44:2375-82. 2004
    ..We investigated whether a session of prior exercise could ameliorate postprandial endothelial dysfunction...
  54. ncbi request reprint Characterisation of the lipoprotein structure in the St. Thomas' Mixed Hyperlipidaemic (SMHL) rabbit
    Baukje de Roos
    Department of Vascular Biochemistry, Division of Cardiovascular and Medical Sciences, Glasgow, UK
    Atherosclerosis 181:63-8. 2005
    ....
  55. ncbi request reprint Effects of a moderate exercise session on postprandial lipoproteins, apolipoproteins and lipoprotein remnants in middle-aged men
    Jason M R Gill
    Department of Vascular Biochemistry, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK
    Atherosclerosis 185:87-96. 2006
    ....
  56. ncbi request reprint Lipoprotein-associated phospholipase A2 as a biomarker for coronary disease and stroke
    Muriel J Caslake
    Department of Vascular Biochemistry at Glasgow University, UK
    Nat Clin Pract Cardiovasc Med 2:529-35. 2005
    ....
  57. ncbi request reprint Remodeling of cerebrospinal fluid lipoprotein particles after human traumatic brain injury
    Andrew D Kay
    Department of Neurosurgery, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom
    J Neurotrauma 20:717-23. 2003
    ..Treatment strategies targeting CNS lipid transport, required for neuronal sprouting and synaptogenesis, may be applicable to traumatic brain injury...
  58. ncbi request reprint Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease
    Muriel J Caslake
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow, UK
    Curr Opin Lipidol 14:347-52. 2003
    ..This review addresses the molecular properties of Lp-PLA(2), the controversy surrounding its role in atherosclerosis and the regulation of its plasma levels in humans...
  59. ncbi request reprint Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study
    Scott W Brouilette
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Lancet 369:107-14. 2007
    ..Inter-individual differences in biological ageing could affect susceptibility to coronary heart disease. Our aim was to determine whether mean leucocyte telomere length is a predictor of the development of coronary heart disease...
  60. ncbi request reprint Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial
    James Shepherd
    University Department of Pathological Biochemistry, University of Glasgow, Royal Infirmary, Scotland, Glasgow, UK
    Lancet 360:1623-30. 2002
    ..Our aim was to test the benefits of pravastatin treatment in an elderly cohort of men and women with, or at high risk of developing, cardiovascular disease and stroke...