A M Owen

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi The role of learned irrelevance in attentional set-shifting impairments in Parkinson's disease
    Aleksandra Slabosz
    MRC Cognition and Brain Sciences Unit, Cambridge, England
    Neuropsychology 20:578-88. 2006
  2. ncbi Cognitive dysfunction in Parkinson's disease: the role of frontostriatal circuitry
    Adrian M Owen
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    Neuroscientist 10:525-37. 2004
  3. ncbi Working memory: imaging the magic number four
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, 15, Chaucer Road, Cambridge CB2 2EF, UK
    Curr Biol 14:R573-4. 2004
  4. ncbi Residual auditory function in persistent vegetative state: a combined PET and fMRI study
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Neuropsychol Rehabil 15:290-306. 2005
  5. ncbi Detecting awareness in the vegetative state
    Adrian M Owen
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 2EF, UK
    Science 313:1402. 2006
  6. ncbi Using functional magnetic resonance imaging to detect covert awareness in the vegetative state
    Adrian M Owen
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, England
    Arch Neurol 64:1098-102. 2007
  7. ncbi Functional MRI in disorders of consciousness: advantages and limitations
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Curr Opin Neurol 20:632-7. 2007
  8. ncbi Functional neuroimaging of the vegetative state
    Adrian M Owen
    Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 7EF, UK
    Nat Rev Neurosci 9:235-43. 2008
  9. ncbi Disorders of consciousness
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, Cambridge, CB2 7EF, UK
    Ann N Y Acad Sci 1124:225-38. 2008
  10. doi Detecting awareness in the vegetative state
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK
    Ann N Y Acad Sci 1129:130-8. 2008

Collaborators

Detail Information

Publications94

  1. ncbi The role of learned irrelevance in attentional set-shifting impairments in Parkinson's disease
    Aleksandra Slabosz
    MRC Cognition and Brain Sciences Unit, Cambridge, England
    Neuropsychology 20:578-88. 2006
    ....
  2. ncbi Cognitive dysfunction in Parkinson's disease: the role of frontostriatal circuitry
    Adrian M Owen
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    Neuroscientist 10:525-37. 2004
    ..As a direct result, it has been possible to redefine impairments of executive function in Parkinson's disease more precisely in terms of the specific neuropsychological, neuroanatomical, and psychopharmacological mechanisms involved...
  3. ncbi Working memory: imaging the magic number four
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, 15, Chaucer Road, Cambridge CB2 2EF, UK
    Curr Biol 14:R573-4. 2004
    ..Recent studies show that activity in the posterior parietal cortex increases with working memory load, implicating this region in the storage of representations in visual memory...
  4. ncbi Residual auditory function in persistent vegetative state: a combined PET and fMRI study
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Neuropsychol Rehabil 15:290-306. 2005
    ....
  5. ncbi Detecting awareness in the vegetative state
    Adrian M Owen
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 2EF, UK
    Science 313:1402. 2006
    ..When asked to imagine playing tennis or moving around her home, the patient activated predicted cortical areas in a manner indistinguishable from that of healthy volunteers...
  6. ncbi Using functional magnetic resonance imaging to detect covert awareness in the vegetative state
    Adrian M Owen
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, England
    Arch Neurol 64:1098-102. 2007
    ....
  7. ncbi Functional MRI in disorders of consciousness: advantages and limitations
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Curr Opin Neurol 20:632-7. 2007
    ..We discuss recent developments in the use of neuroimaging and, in particular, functional MRI, in the assessment of patients diagnosed as vegetative state or minimally conscious state...
  8. ncbi Functional neuroimaging of the vegetative state
    Adrian M Owen
    Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 7EF, UK
    Nat Rev Neurosci 9:235-43. 2008
    ....
  9. ncbi Disorders of consciousness
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, Cambridge, CB2 7EF, UK
    Ann N Y Acad Sci 1124:225-38. 2008
    ..In this article, I review these data, focusing primarily on the vegetative and minimally conscious states...
  10. doi Detecting awareness in the vegetative state
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK
    Ann N Y Acad Sci 1129:130-8. 2008
    ....
  11. pmc Putting brain training to the test
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK
    Nature 465:775-8. 2010
    ..Although improvements were observed in every one of the cognitive tasks that were trained, no evidence was found for transfer effects to untrained tasks, even when those tasks were cognitively closely related...
  12. ncbi A new era of coma and consciousness science
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit Impaired Consciousness Research Group, Wolfson Brain Imaging Center, University of Cambridge, UK
    Prog Brain Res 177:399-411. 2009
    ....
  13. ncbi Redefining the functional organization of working memory processes within human lateral prefrontal cortex
    A M Owen
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Eur J Neurosci 11:567-74. 1999
    ....
  14. ncbi Asymmetric frontal activation during episodic memory: the effects of stimulus type on encoding and retrieval
    A C Lee
    Department of Experimental Psychology, Cambridge, UK
    Neuropsychologia 38:677-92. 2000
    ..These results suggest that encoding and retrieval may actually involve similar regions of the lateral prefrontal cortex when all factors relating to the type of stimulus material (i.e. modality), are appropriately controlled...
  15. ncbi The engagement of mid-ventrolateral prefrontal cortex and posterior brain regions in intentional cognitive activity
    Anja Dove
    Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK
    Hum Brain Mapp 29:107-19. 2008
    ..These findings help to clarify the complimentary role that the mid-VLPFC and posterior higher visual areas play in controlled and relatively automatic memory processing...
  16. pmc Putative cortical dopamine levels affect cortical recruitment during planning
    S J Fallon
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, CB2 7EF, United Kingdom Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands Electronic address
    Neuropsychologia 51:2194-201. 2013
    ..The implications of this result for our understanding of COMT's effect on cognition in health and disease are discussed. ..
  17. ncbi A multimodal approach to the assessment of patients with disorders of consciousness
    M R Coleman
    Impaired Consciousness Research Group, Wolfson Brain Imaging Centre, University of Cambridge, UK
    Prog Brain Res 177:231-48. 2009
    ....
  18. doi Prefrontal dopamine levels determine the balance between cognitive stability and flexibility
    S J Fallon
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 2EF, UK
    Cereb Cortex 23:361-9. 2013
    ....
  19. ncbi An investigation into food preferences and the neural basis of food-related incentive motivation in Prader-Willi syndrome
    E C Hinton
    Section of Developmental Psychiatry, Department of Psychiatry, University of Cambridge, UK
    J Intellect Disabil Res 50:633-42. 2006
    ..The aim of this study was to examine the role of the reward system in such eating behaviour, in terms of both the pattern of food preferences and the neural substrates of incentive in the amygdala and orbitofrontal cortex (OFC)...
  20. ncbi Spatial and non-spatial working memory at different stages of Parkinson's disease
    A M Owen
    Department of Psychiatry, University of Cambridge, UK
    Neuropsychologia 35:519-32. 1997
    ....
  21. ncbi The role of spatial configuration in tests of working memory explored with functional neuroimaging
    D Bor
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Scand J Psychol 42:217-24. 2001
    ....
  22. pmc The val158met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease
    J B Rowe
    University of Cambridge, Department of Clinical Neurosciences, Cambridge, UK
    Neurobiol Aging 31:1064-8. 2010
    ....
  23. pmc Parkinson's disease and dopaminergic therapy--differential effects on movement, reward and cognition
    J B Rowe
    University of Cambridge Department of Clinical Neurosciences, Cambridge, CB2 7EF, UK
    Brain 131:2094-105. 2008
    ..We discuss the implications for investigation and optimal treatment of this common condition at different stages of disease...
  24. ncbi Preference judgements involve a network of structures within frontal, cingulate and insula cortices
    Amir M Chaudhry
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB23DY, UK
    Eur J Neurosci 29:1047-55. 2009
    ....
  25. ncbi Perceptual and semantic components of memory for objects and faces: a pet study
    J S Simons
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    J Cogn Neurosci 13:430-43. 2001
    ..These results have implications for our understanding of the neural correlates of perceptual and semantic contributions to recognition memory...
  26. ncbi Towards the routine use of brain imaging to aid the clinical diagnosis of disorders of consciousness
    M R Coleman
    Impaired Consciousness Study Group, Wolfson Brain Imaging Centre, Addenbrookes Hospital, University of Cambridge, Cambridge, UK
    Brain 132:2541-52. 2009
    ....
  27. ncbi Episodic memory meets working memory in the frontal lobe: functional neuroimaging studies of encoding and retrieval
    A C Lee
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Crit Rev Neurobiol 14:165-97. 2000
    ..e., modality), are appropriately controlled...
  28. ncbi "Pray or Prey?" dissociation of semantic memory retrieval from episodic memory processes using positron emission tomography and a novel homophone task
    A C H Lee
    MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    Neuroimage 16:724-35. 2002
    ..The present results clarify and extend recent attempts to understand the neural basis of semantic memory retrieval, by actively controlling for the confounding effects of episodic memory encoding and retrieval processes...
  29. ncbi Dissociable contributions of the mid-ventrolateral frontal cortex and the medial temporal lobe system to human memory
    Anja Dove
    Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Neuroimage 31:1790-801. 2006
    ....
  30. ncbi Dissociable contributions of the human amygdala and orbitofrontal cortex to incentive motivation and goal selection
    F Sergio Arana
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    J Neurosci 23:9632-8. 2003
    ....
  31. ncbi Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 22:4563-7. 2002
    ..Overall, these data concur with findings in rodents and nonhuman primates of reversal-learning deficits after damage to ventral frontostriatal circuitry, and also support recent clinical findings using this task...
  32. pmc Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach
    S J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, Cambridge, CB2 2PY, UK
    J Neurol Neurosurg Psychiatry 76:343-8. 2005
    ..To investigate the heterogeneity of idiopathic Parkinson's disease (PD) in a data driven manner among a cohort of patients in the early clinical stages of the disease meeting established diagnostic criteria...
  33. pmc Rule-selection and action-selection have a shared neuroanatomical basis in the human prefrontal and parietal cortex
    J Rowe
    Department of Clinical Neurosciences, Cambridge University, Cambridge CB2 2QQ, UK
    Cereb Cortex 18:2275-85. 2008
    ..These tasks include the choices we make about our behavior...
  34. ncbi A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers: implications for theories of executive functioning and cognitive aging. Cambridge Neuropsychological Test Automated Batte
    T W Robbins
    Department of Experimental Psychology, University of Cambridge, U K
    J Int Neuropsychol Soc 4:474-90. 1998
    ..Finally, only limited support was found for the hypothesis that cognitive aging depends on slowed information processing...
  35. pmc Dynamic causal modelling of effective connectivity from fMRI: are results reproducible and sensitive to Parkinson's disease and its treatment?
    J B Rowe
    University of Cambridge Department of Clinical Neurosciences, CB2 2QQ, UK
    Neuroimage 52:1015-26. 2010
    ..However, caution is required when comparing groups or drug effects in terms of the connectivity parameter estimates, if there are significant posterior covariances among parameters...
  36. pmc The role of the right inferior frontal gyrus: inhibition and attentional control
    Adam Hampshire
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK
    Neuroimage 50:1313-9. 2010
    ..Our results reveal that the RIFG is recruited when important cues are detected, regardless of whether that detection is followed by the inhibition of a motor response, the generation of a motor response, or no external response at all...
  37. pmc How does reward expectation influence cognition in the human brain?
    James B Rowe
    Neurology Unit, Cambridge University, Addenbrookes Hospital, Cambridge, UK
    J Cogn Neurosci 20:1980-92. 2008
    ..These distributed changes in task-related cortical networks arise from subjects' representations of future events and likelihood of reward...
  38. ncbi Detecting residual cognitive function in persistent vegetative state
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Neurocase 8:394-403. 2002
    ....
  39. pmc Inefficiency in self-organized attentional switching in the normal aging population is associated with decreased activity in the ventrolateral prefrontal cortex
    Adam Hampshire
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    J Cogn Neurosci 20:1670-86. 2008
    ..The dorsolateral prefrontal cortex is also affected during problem solving, but age-related decline within this region appears to occur at a later stage...
  40. ncbi Encoding strategies dissociate prefrontal activity from working memory demand
    Daniel Bor
    Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, United Kingdom
    Neuron 37:361-7. 2003
    ..The results show that, even when memory demand decreases, organization of working memory contents into higher level chunks is associated with increased prefrontal activity...
  41. doi Consciousness revealed: new insights into the vegetative and minimally conscious states
    Damian Cruse
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK
    Curr Opin Neurol 23:656-60. 2010
    ..In recent years, the results of neuroimaging studies have fundamentally changed the way we think about the vegetative and minimally conscious states...
  42. ncbi Attentional control in Parkinson's disease is dependent on COMT val 158 met genotype
    Caroline H Williams-Gray
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
    Brain 131:397-408. 2008
    ....
  43. ncbi Using executive heterogeneity to explore the nature of working memory deficits in Parkinson's disease
    Simon J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, University of Cambridge, CB2 2PY, UK
    Neuropsychologia 41:645-54. 2003
    ..The results also suggest that performance on the Tower of London task may prove to be a useful discriminant variable in defining the nature of cognitive heterogeneity in Parkinson's disease...
  44. pmc Dissociating speech perception and comprehension at reduced levels of awareness
    Matthew H Davis
    Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, United Kingdom
    Proc Natl Acad Sci U S A 104:16032-7. 2007
    ..These results have important implications for understanding the relationship between speech comprehension and awareness in the healthy brain in patients receiving sedation and in patients with disorders of consciousness...
  45. ncbi Do vegetative patients retain aspects of language comprehension? Evidence from fMRI
    Martin R Coleman
    Impaired Consciousness Study Group, Wolfson Brain Imaging Centre, University of Cambridge, UK
    Brain 130:2494-507. 2007
    ..These results provide further evidence that a subset of patients fulfilling the behavioural criteria for the vegetative state retain islands of preserved cognitive function...
  46. ncbi Cognitive impairments in early Parkinson's disease are accompanied by reductions in activity in frontostriatal neural circuitry
    Simon J G Lewis
    Cambridge Centre for Brain Repair and Department of Neurology, University of Cambridge, Cambridge, United Kingdom CB2 2EF
    J Neurosci 23:6351-6. 2003
    ..Furthermore, they suggest that fMRI may provide a valuable tool for identifying patients who may benefit from targeted therapeutic strategies...
  47. pmc The target selective neural response--similarity, ambiguity, and learning effects
    Adam Hampshire
    MRC Cognition and Brain Sciences Unit, Cambridge, Cambridgeshire, United Kingdom
    PLoS ONE 3:e2520. 2008
    ....
  48. ncbi Evidence for asymmetric frontal-lobe involvement in episodic memory from functional magnetic resonance imaging and patients with unilateral frontal-lobe excisions
    Andy C H Lee
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, CB2 2EF, Cambridge, UK
    Neuropsychologia 40:2420-37. 2002
    ..This result suggests that the memory-related asymmetries observed during functional neuroimaging studies may not be critical for task performance...
  49. ncbi Executive functions in the absence of behavior: functional imaging of the minimally conscious state
    Martin M Monti
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Prog Brain Res 177:249-60. 2009
    ..This paradigm thus exemplifies the potential for fMRI to explore high-level cognitive functions, and awareness, in the absence of any behavioral response...
  50. ncbi Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PET
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Brain 125:584-94. 2002
    ..These data suggest that L-dopa ameliorates high-level cognitive deficits in Parkinson's disease by inducing relative blood flow changes in the right dorsolateral prefrontal cortex...
  51. ncbi A common prefrontal-parietal network for mnemonic and mathematical recoding strategies within working memory
    Daniel Bor
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 2EF, UK
    Cereb Cortex 17:778-86. 2007
    ..We conclude that a prefrontal-parietal network is involved in strategic recoding in working memory, regardless of the type of recoding process...
  52. ncbi Neuroimaging and the vegetative state: resolving the behavioral assessment dilemma?
    Martin M Monti
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Ann N Y Acad Sci 1157:81-9. 2009
    ....
  53. ncbi Reading the mind from eye gaze
    Andrew J Calder
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Neuropsychologia 40:1129-38. 2002
    ..Additional subtraction contrasts largely confirmed these patterns. Our results demonstrate a considerable degree of overlap between the medial frontal areas involved in eye gaze processing and theory of mind tasks...
  54. pmc Selective tuning of the right inferior frontal gyrus during target detection
    Adam Hampshire
    Cambridge University, Cambridge, England
    Cogn Affect Behav Neurosci 9:103-12. 2009
    ..These findings support the hypothesis that the right IFG responds selectively to those items that are of the most relevance to the currently intended task schema...
  55. ncbi The role of the basal ganglia in learning and memory: neuropsychological studies
    Jessica A Grahn
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Behav Brain Res 199:53-60. 2009
    ....
  56. ncbi The cognitive functions of the caudate nucleus
    Jessica A Grahn
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Prog Neurobiol 86:141-55. 2008
    ....
  57. pmc Parkinson's disease and healthy aging: independent and interacting effects on action selection
    Laura E Hughes
    Department of Clinical Neurosciences, University of Cambridge, CB2 2QQ, United Kingdom
    Hum Brain Mapp 31:1886-99. 2010
    ..This effect is dopamine dependant, and may in part explain the clinical observation of reduced dopamine responsiveness in older patients with PD...
  58. doi Functional neuroimaging of disorders of consciousness
    Martin R Coleman
    Cambridge Impaired Consciousness Research Group, Wolfson Brain Imaging Centre, Addenbrookes Hospital, Cambridge, UK
    Int Anesthesiol Clin 46:147-57. 2008
  59. ncbi Selective tuning of the blood oxygenation level-dependent response during simple target detection dissociates human frontoparietal subregions
    Adam Hampshire
    MRC Cognition and Brain Sciences Unit, Cambridge, Cambridgeshire CB2 7EF, United Kingdom
    J Neurosci 27:6219-23. 2007
    ..The results show different degrees of target selectivity across different regions of the frontoparietal network...
  60. ncbi Catechol O-methyltransferase Val158Met genotype influences frontoparietal activity during planning in patients with Parkinson's disease
    Caroline H Williams-Gray
    Cambridge Centre for Brain Repair and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
    J Neurosci 27:4832-8. 2007
    ....
  61. ncbi Enhancing the sensitivity of a sustained attention task to frontal damage: convergent clinical and functional imaging evidence
    Tom Manly
    MRC Cognition and Brain Sciences Unit, Addenbrooke s Hospital, Cambridge, UK
    Neurocase 9:340-9. 2003
    ..While the results are discussed in terms of a frontal system involved in the voluntary maintenance of performance under conditions of low stimulation, alternative accounts in terms of strategy application are considered...
  62. ncbi Neural contributions to the motivational control of appetite in humans
    Elanor C Hinton
    Section of Developmental Psychiatry, Department of Psychiatry, University of Cambridge, Douglas House, 18b Trumpington Road, CB2 2AH, UK
    Eur J Neurosci 20:1411-8. 2004
    ..The findings of this study have implications for research into the underlying mechanisms of eating disorders...
  63. ncbi Dopaminergic basis for deficits in working memory but not attentional set-shifting in Parkinson's disease
    Simon J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, Cambridge CB2 2PY, UK
    Neuropsychologia 43:823-32. 2005
    ..These results confirm that working memory deficits in PD are both psychologically specific and related to dopamine depletion. It is anticipated that greater understanding of these mechanisms will lead to future therapeutic improvements...
  64. ncbi Frontal lobe involvement in spatial span: converging studies of normal and impaired function
    Daniel Bor
    Medical Research Council, MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Neuropsychologia 44:229-37. 2006
    ..It is suggested, however, that the patient deficit reflects strategic or goal-based dysfunction, rather than storage limitations...
  65. ncbi Preference formation and working memory in Parkinson's disease and normal ageing
    Sylvia M L Cox
    Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, CB2 2EF, Cambridge, UK
    Neuropsychologia 40:317-26. 2002
    ..These results suggest that there is a developmental progression in the degree to which different mechanisms of 'learning to like' are important over the life span...
  66. ncbi Prefrontal cortical involvement in verbal encoding strategies
    Daniel Bor
    Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 2EF, UK
    Eur J Neurosci 19:3365-70. 2004
    ..Thus, the lateral prefrontal cortex appears to play a general role in strategically recoding information from memory, in order to optimize performance...
  67. ncbi Fractionating attentional control using event-related fMRI
    Adam Hampshire
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK
    Cereb Cortex 16:1679-89. 2006
    ....
  68. ncbi Striatal contributions to working memory: a functional magnetic resonance imaging study in humans
    Simon J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, Cambridge, CB2 2PY, UK
    Eur J Neurosci 19:755-60. 2004
    ..These results suggest an essential and specific role for the caudate nucleus in executive function, which may underlie the cognitive disturbances observed in frontostriatal neurodegenerative disorders such as Parkinson's disease...
  69. ncbi Cognitive training: neural correlates of expert skills
    Daniel Bor
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK
    Curr Biol 17:R95-7. 2007
    ..Recent evidence from functional magnetic imaging studies suggests that a network of frontal and parietal regions plays a crucial role...
  70. ncbi Frontoparietal activity with minimal decision and control
    Nicholas Hon
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 2EF, United Kingdom
    J Neurosci 26:9805-9. 2006
    ..Even without behavior to control, these classical "control" regions are active in simple update of attended information...
  71. ncbi The problem of functional localization in the human brain
    Matthew Brett
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Nat Rev Neurosci 3:243-9. 2002
    ..These problems cause uncertainty in localization, which limits the effective resolution of functional imaging, especially for brain areas involved in higher cognitive function...
  72. pmc Functional organization of spatial and nonspatial working memory processing within the human lateral frontal cortex
    A M Owen
    Medical Research Council Applied Psychology Unit, 15 Chaucer Road, Cambridge, CB2 2EF, United Kingdom
    Proc Natl Acad Sci U S A 95:7721-6. 1998
    ....
  73. ncbi Memory: obstacle avoidance without visual cues
    Jessica A Grahn
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Curr Biol 16:R247-9. 2006
    ..Recent evidence from behavioural studies in cats suggests that working memory may be crucial...
  74. ncbi N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    Hum Brain Mapp 25:46-59. 2005
    ....
  75. ncbi Using neuroimaging to detect awareness in disorders of consciousness
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Funct Neurol 23:189-94. 2008
    ....
  76. ncbi Working memory: linking capacity with selectivity
    Daniel Bor
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Curr Biol 16:R136-8. 2006
    ..Recent evidence from electroencephalogram recordings suggests that one crucial component of this variation is our ability to exclude irrelevant information...
  77. ncbi Regional brain activations differ for semantic features but not categories
    Andy C H Lee
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 2EF
    Neuroreport 13:1497-501. 2002
    ..These findings support a primarily attribute-based neural organisation of semantic knowledge...
  78. ncbi Using a hierarchical approach to investigate residual auditory cognition in persistent vegetative state
    Adrian M Owen
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK
    Prog Brain Res 150:457-71. 2005
    ..Preliminary results in a small series of patients provide a strong basis for the systematic study of possible residual cognitive function in persistent vegetative state...
  79. ncbi Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Box 189, Cambridge CB2 0QQ, UK
    Science 321:421-2. 2008
    ....
  80. ncbi Neural representations of hunger and satiety in Prader-Willi syndrome
    E C Hinton
    Section of Developmental Psychiatry, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Int J Obes (Lond) 30:313-21. 2006
    ..To investigate the neural basis of the abnormal eating behaviour in Prader-Willi syndrome (PWS), using brain imaging. We predicted that the satiety response in those with PWS would be delayed and insensitive to food intake...
  81. ncbi Impaired preference conditioning after anterior temporal lobe resection in humans
    I S Johnsrude
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, CB2 2EF United Kingdom
    J Neurosci 20:2649-56. 2000
    ..This double dissociation provides clear evidence that, in humans as in other animals, reward-related learning (conditioned reward) critically depends on a circuit involving inferotemporal cortex and the ANC...
  82. ncbi Willful modulation of brain activity in disorders of consciousness
    Martin M Monti
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom
    N Engl J Med 362:579-89. 2010
    ..The rate of misdiagnosis is approximately 40%, and new methods are required to complement bedside testing, particularly if the patient's capacity to show behavioral signs of awareness is diminished...
  83. ncbi Acquiring a cognitive skill with a new repeating version of the Tower of London task
    Marie Christine Ouellet
    Ecole de Psychologie, Universite Laval
    Can J Exp Psychol 58:272-88. 2004
    ....
  84. ncbi Anterior prefrontal cortex: insights into function from anatomy and neuroimaging
    Narender Ramnani
    Centre for fMRI of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    Nat Rev Neurosci 5:184-94. 2004
  85. ncbi Planning and problem solving: from neuropsychology to functional neuroimaging
    Josef M Unterrainer
    Neuropsychology, Department of Psychology, University of Freiburg, Germany
    J Physiol Paris 99:308-17. 2006
    ..Finally, we turn to a number of new directions and recent studies exploring different aspects of planning and problem solving and their association to related cognitive dimensions...
  86. pmc How should functional imaging of patients with disorders of consciousness contribute to their clinical rehabilitation needs?
    Steven Laureys
    Cyclotron Research Center and Neurology Department, University of Liege, Liege, Belgium
    Curr Opin Neurol 19:520-7. 2006
    ..We discuss the problems of evidence-based neurorehabilitation in disorders of consciousness, and recent functional neuroimaging data obtained in the vegetative state and minimally conscious state...
  87. pmc Distinct roles for lateral and medial anterior prefrontal cortex in contextual recollection
    Jon S Simons
    Institute of Cognitive Neuroscience and Department of Pyschology, University College London, United Kingdom
    J Neurophysiol 94:813-20. 2005
    ..Lateral regions seem to be more involved in the early retrieval specification stages of recollection, with medial regions contributing to later stages (e.g., monitoring and verification)...
  88. ncbi Improving reverse neuroimaging inference: cognitive domain versus cognitive complexity
    Kalina Christoff
    Trends Cogn Sci 10:352-3. 2006
  89. ncbi Anterior prefrontal cortex and the recollection of contextual information
    Jon S Simons
    Institute of Cognitive Neuroscience, Department of Psychology, University College London, 17 Queen Square, London WC1N 3AR, UK
    Neuropsychologia 43:1774-83. 2005
    ..These results suggest different roles for lateral and medial anterior prefrontal cortex in recollection...
  90. ncbi Task-induced deactivations during successful paired associates learning: an effect of age but not Alzheimer's disease
    Rebecca L Gould
    King s College London, MRC Centre for Neurodegeneration Research, Section of Old Age Psychiatry, Box P070, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Neuroimage 31:818-31. 2006
    ....
  91. ncbi Functional neuroanatomy of successful paired associate learning in Alzheimer's disease
    Rebecca L Gould
    Section of Old Age Psychiatry, Box P070, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Am J Psychiatry 162:2049-60. 2005
    ..The purpose of the study was to develop a strategy for functional imaging of neurodegenerative disorders that overcomes confounds associated with differential performance between patient and comparison groups...
  92. ncbi Reduced activation to implicit affect induction in euthymic bipolar patients: an fMRI study
    Gin S Malhi
    School of Psychiatry, University of New South Wales, Sydney, Australia
    J Affect Disord 97:109-22. 2007
    ..To examine whether euthymic bipolar patients engage similar or contrasting brain regions as healthy subjects when responding to implicit affect induction...
  93. ncbi Cognitive tasks for driving a brain-computer interfacing system: a pilot study
    Eleanor Curran
    Department of Law, University of Keele, ST5 5BG Keele, UK
    IEEE Trans Neural Syst Rehabil Eng 12:48-54. 2004
    ..These findings have implications for establishing appropriate methods to operate BCI systems, particularly for disabled people who may experience difficulty with motor tasks, even motor imagery...
  94. ncbi Brain function in coma, vegetative state, and related disorders
    Steven Laureys
    Belgian National Funds for Scientific Research Cyclotron Research Center and Department of Neurology, University of Liege, Belgium
    Lancet Neurol 3:537-46. 2004
    ..Neuroimaging techniques remain important tools for clinical research that will extend our understanding of the underlying mechanisms of these disorders...