Sean S O'Sullivan

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi ALS in a patient with hereditary neuropathy with liability to pressure palsy
    S S O'Sullivan
    Neurology Neurophysiology Department, Cork University Hospital, Wilton, Cork, Ireland
    Neurology 67:2260. 2006
  2. ncbi Excessive hoarding in Parkinson's disease
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom
    Mov Disord 25:1026-33. 2010
  3. ncbi Detection rates of sexual dysfunction amongst patients with multiple sclerosis in an outpatient setting--can this be improved?
    S S O'Sullivan
    Department of Neurology, Beaumont Hospital, Dublin
    Ir Med J 99:304-6. 2006
  4. doi Aetiology and prognosis of encephalopathic patterns on electroencephalogram in a general hospital
    S S O'Sullivan
    Department of Neurology, Cork University Hospital, Cork, Ireland
    J Clin Neurosci 15:637-42. 2008
  5. doi The effect of drug treatment on neurogenesis in Parkinson's disease
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, University College London, London, United Kingdom
    Mov Disord 26:45-50. 2011
  6. ncbi Clinical characteristics and outcome of patients diagnosed with psychogenic nonepileptic seizures: a 5-year review
    Sean S O'Sullivan
    Department of Neurology, Cork University Hospital, Wilton, Cork, Ireland
    Epilepsy Behav 11:77-84. 2007
  7. doi Cue-induced striatal dopamine release in Parkinson's disease-associated impulsive-compulsive behaviours
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, University College London, London WC1N 1PJ, UK
    Brain 134:969-78. 2011
  8. ncbi Acquired generalised neuromyotonia, cutaneous lupus erythematosus and alopecia areata in a patient with myasthenia gravis
    Sean S O'Sullivan
    Department of Neurology and Neurophysiology, Cork University Hospital, Wilton, Cork, Ireland
    Clin Neurol Neurosurg 109:374-5. 2007
  9. ncbi Dopamine agonists rather than deep brain stimulation cause reflection impulsivity in Parkinson's disease
    Atbin Djamshidian
    Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, UK
    J Parkinsons Dis 3:139-44. 2013
  10. doi The midbrain to pons ratio: a simple and specific MRI sign of progressive supranuclear palsy
    Luke A Massey
    Sara Koe PSP Research Centre, Rita Lila Weston Institute for Neurology Studies and Queen Square Brain Bank, Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK
    Neurology 80:1856-61. 2013

Detail Information

Publications56

  1. ncbi ALS in a patient with hereditary neuropathy with liability to pressure palsy
    S S O'Sullivan
    Neurology Neurophysiology Department, Cork University Hospital, Wilton, Cork, Ireland
    Neurology 67:2260. 2006
  2. ncbi Excessive hoarding in Parkinson's disease
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, University College London, United Kingdom
    Mov Disord 25:1026-33. 2010
    ..The association of hoarding with other ICBs and low trait impulse control suggests that excessive hoarding is related to the spectrum of impulsive behaviors in PD...
  3. ncbi Detection rates of sexual dysfunction amongst patients with multiple sclerosis in an outpatient setting--can this be improved?
    S S O'Sullivan
    Department of Neurology, Beaumont Hospital, Dublin
    Ir Med J 99:304-6. 2006
    ..Sexual dysfunction is an important, yet under-reported symptom in multiple sclerosis (MS)...
  4. doi Aetiology and prognosis of encephalopathic patterns on electroencephalogram in a general hospital
    S S O'Sullivan
    Department of Neurology, Cork University Hospital, Cork, Ireland
    J Clin Neurosci 15:637-42. 2008
    ..However, 21.4% of those patients with excessive theta activity only on EEG had died. This study highlights an increased mortality even in the apparently 'milder' degrees of EEG abnormalities...
  5. doi The effect of drug treatment on neurogenesis in Parkinson's disease
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, University College London, London, United Kingdom
    Mov Disord 26:45-50. 2011
    ..Our findings suggest a positive impact of chronic L-dopa use on the number of NSC in the SVZ of PD patients, which may have relevance for future studies on neuroprotection in neurodegenerative diseases...
  6. ncbi Clinical characteristics and outcome of patients diagnosed with psychogenic nonepileptic seizures: a 5-year review
    Sean S O'Sullivan
    Department of Neurology, Cork University Hospital, Wilton, Cork, Ireland
    Epilepsy Behav 11:77-84. 2007
    ..The goal of this article was to describe the clinical characteristics and outcomes of patients diagnosed with psychogenic nonepileptic seizures (PNES)...
  7. doi Cue-induced striatal dopamine release in Parkinson's disease-associated impulsive-compulsive behaviours
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, University College London, London WC1N 1PJ, UK
    Brain 134:969-78. 2011
    ....
  8. ncbi Acquired generalised neuromyotonia, cutaneous lupus erythematosus and alopecia areata in a patient with myasthenia gravis
    Sean S O'Sullivan
    Department of Neurology and Neurophysiology, Cork University Hospital, Wilton, Cork, Ireland
    Clin Neurol Neurosurg 109:374-5. 2007
    ..We review the current literature on autoimmune conditions associated with myasthenia gravis and thymectomy. To our knowledge, this combination of multiple autoimmune conditions has not been reported previously...
  9. ncbi Dopamine agonists rather than deep brain stimulation cause reflection impulsivity in Parkinson's disease
    Atbin Djamshidian
    Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, UK
    J Parkinsons Dis 3:139-44. 2013
    ..However, it is unclear whether bilateral deep brain stimulation of the subthalamic nucleus also causes impairment in decision making...
  10. doi The midbrain to pons ratio: a simple and specific MRI sign of progressive supranuclear palsy
    Luke A Massey
    Sara Koe PSP Research Centre, Rita Lila Weston Institute for Neurology Studies and Queen Square Brain Bank, Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK
    Neurology 80:1856-61. 2013
    ..We aimed to develop in histologically proven disease a simple measure of the midbrain and pons on sagittal MRI to identify PSP...
  11. ncbi Relationships between age and late progression of Parkinson's disease: a clinico-pathological study
    Peter A Kempster
    Reta Lila Weston Institute of Neurological Studies, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
    Brain 133:1755-62. 2010
    ..The chief effects of age on the rate of progression are seen over the early-middle part of the disease. An exponential curve for clinical progression provides the best explanation for these observations about age and the disease course...
  12. doi Sleep disturbance and impulsive-compulsive behaviours in Parkinson's disease
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, University College London, London, UK
    J Neurol Neurosurg Psychiatry 82:620-2. 2011
    ..Impulsive-compulsive behaviours (ICBs) in Parkinson's disease (PD) have been anecdotally linked with impaired sleep. The authors investigate measures of sleep in PD patients with and without ICBs, and in healthy controls...
  13. doi Increased reflection impulsivity in patients with ephedrone-induced Parkinsonism
    Atbin Djamshidian
    Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, UK
    Addiction 108:771-9. 2013
    ..Routine neuropsychological assessment has revealed no cognitive deficits, despite widespread abnormalities on brain imaging studies and severe extrapyramidal motor handicap on clinical examination...
  14. pmc Decision making, impulsivity, and addictions: do Parkinson's disease patients jump to conclusions?
    Atbin Djamshidian
    Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, United Kingdom
    Mov Disord 27:1137-45. 2012
    ..Our results also suggest that intact cortical processing and less distractibility in PD patients without ICBs may protect them from developing behavioral addictions...
  15. doi Glucocerebrosidase mutations do not cause increased Lewy body pathology in Parkinson's disease
    Laura Parkkinen
    Queen Square Brain Bank for Neurological Disorders, Institute of Neurology, University College London, UK
    Mol Genet Metab 103:410-2. 2011
    ..Our results do not support GBA carriers to have a more advanced neuropathologic disease i.e. increased density of protein aggregates...
  16. pmc Novelty seeking behaviour in Parkinson's disease
    Atbin Djamshidian
    Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, United Kingdom
    Neuropsychologia 49:2483-8. 2011
    ..Our findings suggest that attraction to novelty is a personality trait in all PD patients with ICBs which is independent of medication status...
  17. doi Testing an aetiological model of visual hallucinations in Parkinson's disease
    David A Gallagher
    Institute of Neurology, University College London, UK
    Brain 134:3299-309. 2011
    ..These clinical data are supported by the pathological study, in which higher overall cortical Lewy body counts, and in particular areas implicated in visuoperception and executive function, were associated with visual hallucinations...
  18. doi Impulsive-compulsive spectrum behaviors in pathologically confirmed progressive supranuclear palsy
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 25:638-42. 2010
    ..Pathological comparisons between these three cases and other case series of progressive supranuclear palsy are made...
  19. ncbi Punding in Parkinson's disease
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, UK
    Pract Neurol 7:397-9. 2007
  20. pmc Effects of dopamine on sensitivity to social bias in Parkinson's disease
    Atbin Djamshidian
    Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University College London, London, United Kingdom
    PLoS ONE 7:e32889. 2012
    ..PD patients with ICBs on medication also showed more learning from negative feedback and less from positive feedback, whereas off medication they showed the opposite effect...
  21. doi Concomitant progressive supranuclear palsy and multiple system atrophy: more than a simple twist of fate?
    Laura Silveira-Moriyama
    Reta Lila Weston Institute for Neurological Studies, UCL Institute of Neurology, London, UK
    Neurosci Lett 467:208-11. 2009
    ..The growing number of collective case reports, including the one reported here, might suggest an increased prevalence of concomitant PSP and MSA than what would be expected by chance...
  22. pmc Risk and learning in impulsive and nonimpulsive patients with Parkinson's disease
    Atbin Djamshidian
    Department of Molecular Neuroscience and Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London, UK
    Mov Disord 25:2203-10. 2010
    ..Thus, medication status and an impulsive behavioral diagnosis differentially affect several behaviors in PD...
  23. pmc Altruistic punishment in patients with Parkinson's disease with and without impulsive behaviour
    Atbin Djamshidian
    Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, United Kingdom
    Neuropsychologia 49:103-7. 2011
    ..These results suggest a role for dopamine in altruistic punishment decisions in PD patients with impulsive compulsive behaviour...
  24. pmc Salivary cortisol levels in Parkinson's disease and its correlation to risk behaviour
    Atbin Djamshidian
    Reta Lila Weston Institute of Neurological Studies and Queen Square Brain Bank for Neurological Diseases, University College London, London, UK
    J Neurol Neurosurg Psychiatry 82:1107-11. 2011
    ..To investigate salivary cortisol samples in patients with Parkinson's disease (PD) with and without impulsive compulsive behaviours (ICB) during a risk task...
  25. ncbi Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson's disease
    Laura Parkkinen
    Queen Square Brain Bank for Neurological Disorders, London, UK
    J Parkinsons Dis 1:277-86. 2011
    ..Our data also provides no support for a primary pathogenic role of LBs as neither their distribution nor density was associated with the severity of nigral cell loss. ..
  26. doi MM2 subtype of sporadic Creutzfeldt-Jakob disease may underlie the clinical presentation of progressive supranuclear palsy
    Igor N Petrovic
    Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, 1 Wakefield St, London, WC1N 1PJ, UK
    J Neurol 260:1031-6. 2013
    ..This case and the literature support the notion that biochemical properties of the prion protein can influence the clinical presentation of sCJD...
  27. doi Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy
    Luke A Massey
    Sara Koe PSP Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 27:1754-62. 2012
    ..However, the low sensitivity of these and macroscopic findings at autopsy suggest a need for imaging techniques sensitive to microstructural abnormalities without regional atrophy...
  28. doi Does corticobasal degeneration exist? A clinicopathological re-evaluation
    Helen Ling
    Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK
    Brain 133:2045-57. 2010
    ..Despite these diagnostic difficulties we conclude that corticobasal degeneration is a discrete clinicopathological entity but with a broader clinical spectrum than was originally proposed...
  29. pmc Stroop test performance in impulsive and non impulsive patients with Parkinson's disease
    Atbin Djamshidian
    Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, United Kingdom
    Parkinsonism Relat Disord 17:212-4. 2011
    ....
  30. doi Reckless generosity in Parkinson's disease
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 25:221-3. 2010
    ..We describe another, potentially related phenomenon putatively associated with the use of dopamine agonists in 3 patients with PD, characterized by excessive and inappropriate philanthropy...
  31. doi Clinical aspects of impulsive compulsive behaviours in Parkinson's disease
    Atbin Djamshidian
    Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London, London, UK
    J Neurol Sci 310:183-8. 2011
    ....
  32. doi Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients
    Tammaryn Lashley
    Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Acta Neuropathol 115:417-25. 2008
    ....
  33. doi Globular glial tauopathies (GGT) presenting with motor neuron disease or frontotemporal dementia: an emerging group of 4-repeat tauopathies
    Zeshan Ahmed
    Queen Square Brain Bank for Neurological Disorders, Department of Molecular Neuroscience, UCL Institute of Neurology, 1 Wakefield Street, London, WC1N 1PJ, UK
    Acta Neuropathol 122:415-28. 2011
    ..We, therefore, propose the term globular glial tauopathy as an encompassing term to classify this emerging class of 4R tauopathy...
  34. doi Dopamine dysregulation syndrome: an overview of its epidemiology, mechanisms and management
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, England
    CNS Drugs 23:157-70. 2009
    ..Further studies are also required to identify factors that can predict those patients with DDS or ICDs who will derive benefit from surgical interventions such as deep brain stimulation...
  35. ncbi Nonmotor symptoms as presenting complaints in Parkinson's disease: a clinicopathological study
    Sean S O'Sullivan
    Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 23:101-6. 2008
    ..Presenting with NMS does not affect the motor response to medication, but is associated with shorter disease duration (chi(2) P = 0.016)...
  36. doi Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?
    Yaroslau Compta
    Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 134:1493-505. 2011
    ..Cortical amyloid-β and age at disease onset seem to determine the rate to dementia...
  37. pmc Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
    Daniel G Healy
    Department of Clinical Neurosciences, Institute of Neurology, University College London, London, UK
    Lancet Neurol 7:583-90. 2008
    ..LRRK2-associated PD be distinguished from idiopathic PD; which mutations in LRRK2 are pathogenic; and what is the age-specific cumulative risk of PD for individuals who inherit or are at risk of inheriting a deleterious mutation in LRRK2?..
  38. pmc Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease
    Juliane Neumann
    Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK
    Brain 132:1783-94. 2009
    ....
  39. doi Progressive supranuclear palsy syndrome presenting as progressive nonfluent aphasia: a neuropsychological and neuroimaging analysis
    Jonathan D Rohrer
    Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 25:179-88. 2010
    ..In summary, although the PSP-PNFA syndrome overlaps with PNFA without PSP, certain neuropsychological and neuroanatomical differences may help predict the development of a PSP syndrome...
  40. doi Recognition of psychogenic non-epileptic seizures: a curable neurophobia?
    Sean S O'Sullivan
    Cork University Hospital Neurosciences Department, University College Cork, Ireland
    J Neurol Neurosurg Psychiatry 84:228-31. 2013
    ..The majority of 'PNES status' cases are likely to be seen in the emergency department or similar non-specialised units, where patients are initially assessed and managed by physicians of varying expertise in neurology...
  41. ncbi Evaluation of stroke management in an Irish university teaching hospital: the Royal College of Physicians stroke audit package
    S J Pittock
    Department of Neurology, Beaumont Hospital, Dublin, Ireland
    Ir J Med Sci 170:163-8. 2001
    ..There are few data regarding the standard of stroke care in Ireland...
  42. ncbi Access to health services in Ireland for people with Multiple Sclerosis and Motor Neurone Disease
    O Hardiman
    Neurology, Beaumont Hospital, Dublin, Ireland
    Ir Med J 96:200-3. 2003
    ..Voluntary organisations often bridge the gap in service provision. An investment in services for people with chronic neurological disability is urgently required...
  43. ncbi Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004
    O O'Toole
    Department of Neurology, Beaumont Hospital, and and RCSI, Dublin 9, Ireland
    J Neurol Neurosurg Psychiatry 79:30-2. 2008
    ..We conducted a prospective, population based study to examine trends in incidence and prevalence of amyotrophic lateral sclerosis (ALS) in Ireland from 1995 to 2004...
  44. ncbi Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues
    G Logroscino
    Department of Epidemiology HSPH 3 819 Harvard University, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
    J Neurol Neurosurg Psychiatry 79:6-11. 2008
    ....
  45. ncbi Treatment of refractory chronic daily headache with the atypical antipsychotic ziprasidone--a case series
    C M Cahill
    Department of Psychiatry, Royal College of Surgeons in Ireland and Beaumont Hospital, Education and Research Centre, Beaumont Hospital, Dublin 9, Republic of Ireland
    Cephalalgia 25:822-6. 2005
  46. ncbi Evidence of reduced frequency of spinal muscular atrophy type I in the Cuban population
    T Zaldivar
    Cuban Institute of Neurology and Neurosurgery, Havana, Cuba
    Neurology 65:636-8. 2005
    ..89 per 100,000 for blacks, and 0.96 per 100,000 for those of mixed ethnicity. Type 1 SMA may occur less frequently in individuals of African ancestry...
  47. ncbi A novel candidate region for ALS on chromosome 14q11.2
    M J Greenway
    Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland
    Neurology 63:1936-8. 2004
    ..These observations propose a candidate region for ALS on chromosome 14q11.2 and suggest that other genes with similar function to VEGF may be important in the pathogenesis of ALS...
  48. ncbi Chronic ataxic neuropathy with cold agglutinins: atypical phenotype and response to anti-CD20 antibodies
    K Siddiqui
    Department of Neurology, Beaumont Hospital, Dublin, Republic of Ireland
    Neurology 61:1307-8. 2003
  49. pmc Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes
    J C Schymick
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, Maryland, USA
    J Neurol Neurosurg Psychiatry 78:754-6. 2007
    ..Clinical and pathological overlap between amyotrophic lateral sclerosis (ALS) and FTD prompted us to screen PGRN in patients with ALS and ALS-FTD...
  50. ncbi EFNS task force on management of amyotrophic lateral sclerosis: guidelines for diagnosing and clinical care of patients and relatives
    P M Andersen
    Department of Neurology, Umea University Hospital, Sweden
    Eur J Neurol 12:921-38. 2005
    ..Advance directives for palliative end of life care are important and should be fully discussed early with the patient and relatives respecting the patients social and cultural background...
  51. ncbi ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)
    N Parkinson
    MRC Prion Unit, Institute of Neurology, University College London, London, UK
    Neurology 67:1074-7. 2006
    ..Neuropathology of the Q206H case showed lower motor neuron predominant disease with ubiquitylated inclusions in motor neurons. Antibodies to p62 (sequestosome 1) showed novel oligodendroglial inclusions in the motor cortex...
  52. ncbi Effect of referral bias on assessing survival in als
    G Logroscino
    Neurology 69:939; author reply 939-40. 2007
  53. ncbi Elevated serum angiogenin levels in ALS
    S Cronin
    Department of Physiology, Royal College of Surgeons in Ireland, Ireland
    Neurology 67:1833-6. 2006
    ..In endothelium, angiogenin can regulate expression of VEGF. To date, the patterns of serum angiogenin expression among patients with ALS have not been assessed...
  54. pmc Vacuolar leucoencephalopathy and pulvinar sign in association with coeliac disease
    A M Ryan
    J Neurol Neurosurg Psychiatry 78:98-9. 2007
  55. ncbi Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS
    E F Goodall
    Department of Clinical Neuroscience, The Medical School, University of Birmingham, Birmingham, UK
    Neurology 65:934-7. 2005
    ..They found that the H63D polymorphism is overrepresented in individuals with sporadic ALS (odds ratio 1.85, CI: 1.35 to 2.54)...
  56. pmc Effect of a multidisciplinary amyotrophic lateral sclerosis (ALS) clinic on ALS survival: a population based study, 1996-2000
    B J Traynor
    Department of Neurology, Beaumont Hospital, Dublin, Ireland
    J Neurol Neurosurg Psychiatry 74:1258-61. 2003
    ..The impact of multidisciplinary management has not been previously evaluated...