Gisela Orozco

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc Sex-specific differences in effect size estimates at established complex trait loci
    Gisela Orozco
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, UK
    Int J Epidemiol 41:1376-82. 2012
  2. pmc Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23
    Gisela Orozco
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
    Hum Mol Genet 18:2693-9. 2009
  3. doi request reprint HLA-DPB1-COL11A2 and three additional xMHC loci are independently associated with RA in a UK cohort
    G Orozco
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
    Genes Immun 12:169-75. 2011
  4. pmc Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus
    Gisela Orozco
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Manchester M13 9PT, UK
    Ann Rheum Dis 70:463-8. 2011
  5. ncbi request reprint Update on the genetic risk factors for rheumatoid arthritis
    Gisela Orozco
    Arthritis Research Campaign Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Expert Rev Clin Immunol 6:61-75. 2010
  6. pmc Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study
    Gisela Orozco
    Epidemiology Unit, Faculty of Medical and Human Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 69:813-6. 2010
  7. doi request reprint Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study
    Gisela Orozco
    Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, UK
    Arthritis Rheumatol 66:24-30. 2014
  8. pmc Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis
    John Bowes
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
    Ann Rheum Dis 70:1641-4. 2011
  9. doi request reprint A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21
    R B Warren
    Dermatological Sciences, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, UK
    Br J Dermatol 164:660-4. 2011
  10. pmc Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-analysis of genome-wide data
    Kate McAllister
    University of Manchester, NIHR Manchester Musculoskeletal Biomedical Research Unit, and Manchester Academic Health Science Centre, Manchester, UK
    Arthritis Rheum 65:3058-62. 2013

Detail Information

Publications13

  1. pmc Sex-specific differences in effect size estimates at established complex trait loci
    Gisela Orozco
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, UK
    Int J Epidemiol 41:1376-82. 2012
    ....
  2. pmc Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23
    Gisela Orozco
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
    Hum Mol Genet 18:2693-9. 2009
    ..This is the first study to show that the confirmed loci from the GWA studies, that confer only a modest effect size, could harbour a significantly greater effect once the effect of additional risk variants are accounted for...
  3. doi request reprint HLA-DPB1-COL11A2 and three additional xMHC loci are independently associated with RA in a UK cohort
    G Orozco
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
    Genes Immun 12:169-75. 2011
    ..In addition, association with three novel independent RA loci in the xMHC region (ZNF391, OR2H1 and C6orf26-RDBP) has been detected...
  4. pmc Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus
    Gisela Orozco
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Manchester M13 9PT, UK
    Ann Rheum Dis 70:463-8. 2011
    ..Evidence is beginning to emerge that there may be susceptibility loci for rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) that are common to both diseases...
  5. ncbi request reprint Update on the genetic risk factors for rheumatoid arthritis
    Gisela Orozco
    Arthritis Research Campaign Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Expert Rev Clin Immunol 6:61-75. 2010
    ..Finally, we discuss what still needs to be accomplished before a more complete picture of the genetic risk to RA can be attained...
  6. pmc Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study
    Gisela Orozco
    Epidemiology Unit, Faculty of Medical and Human Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 69:813-6. 2010
    ..The aim of the current study was to validate these potential RA susceptibility markers in a UK population...
  7. doi request reprint Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study
    Gisela Orozco
    Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, UK
    Arthritis Rheumatol 66:24-30. 2014
    ..This study was undertaken to extend our previous RA GWAS in a UK cohort, adding more independent RA cases and healthy controls, with the aim of detecting novel association signals for susceptibility to RA in a homogeneous UK cohort...
  8. pmc Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis
    John Bowes
    Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK
    Ann Rheum Dis 70:1641-4. 2011
    ....
  9. doi request reprint A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21
    R B Warren
    Dermatological Sciences, Salford Royal NHS Foundation Trust, The University of Manchester, Manchester Academic Health Science Centre, UK
    Br J Dermatol 164:660-4. 2011
    ..Many autoimmune diseases share common susceptibility loci suggesting similar underlying cellular mechanisms involved in disease expression...
  10. pmc Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-analysis of genome-wide data
    Kate McAllister
    University of Manchester, NIHR Manchester Musculoskeletal Biomedical Research Unit, and Manchester Academic Health Science Centre, Manchester, UK
    Arthritis Rheum 65:3058-62. 2013
    ..The aim of this study was to determine whether these potentially significant loci are involved in the pathogenesis of RA, and to explore whether any of the loci are associated with a specific RA serotype...
  11. pmc Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis
    John Bowes
    Arthritis Research UK, Epidemiology Unit, University of Manchester, Manchester, UK
    Hum Genet 128:627-33. 2010
    ....
  12. doi request reprint Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis
    Gisela Orozco
    Arthritis Research UK Epidemiology Unit, School of Translational Medicine, University of Manchester, Manchester, UK
    BJU Int 111:1148-55. 2013
    ..These results could have potential public heath impact in terms of screening and chemoprevention...
  13. pmc Synthetic associations in the context of genome-wide association scan signals
    Gisela Orozco
    Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, UK
    Hum Mol Genet 19:R137-44. 2010
    ..In this review, we draw from empirical and theoretical data to summarize evidence showing that synthetic associations do not underlie many reported GWAS associations...