Genomes and Genes
Affiliation: University of Birmingham
- The CD4+ T-cell response to adenovirus is focused against conserved residues within the hexon proteinDavid Onion
CRUK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, UK
J Gen Virol 88:2417-25. 2007..Three CD4 T-cell epitopes are described, which map to highly conserved regions of the hexon protein...
- A lentiviral vector that activates latent human immunodeficiency virus-1 proviruses by the overexpression of tat and that kills the infected cellsDavid Macías
Departamento de Biologia Experimental, Universidad de Jaen, Jaen, Spain
Hum Gene Ther 20:1259-68. 2009..In summary, we have developed a vector system that is efficient in activating latent HIV-1 proviruses but that needs further improvement to kill infected cells...
- Antivector and tumor immune responses following adenovirus-directed enzyme prodrug therapy for the treatment of prostate cancerDavid Onion
Cancer Research UK Institute of Cancer Sciences, University of Birmingham, Birmingham, UK
Hum Gene Ther 20:1249-58. 2009....
- Viral gene therapy strategies: from basic science to clinical applicationLawrence S Young
Cancer Research UK Institute for Cancer Studies, University of Birmingham Medical School, UK
J Pathol 208:299-318. 2006....
- HLA-Peptide Multimer Selection of Adenovirus-specific T Cells For Adoptive T-Cell TherapyGeothy Chakupurakal
School of Cancer Sciences, University of Birmingham University Medical School, Birmingham, UK
J Immunother 36:423-31. 2013..The efficacy of these cells needs to be further evaluated in the setting of a clinical trial. ..
- Adenovirus vector-specific T cells demonstrate a unique memory phenotype with high proliferative potential and coexpression of CCR5 and integrin alpha4beta7Geothy Chakupurakal
University of Birmingham, Birmingham, UK
AIDS 24:205-10. 2010..This led to the suggestion that the Ad based vector may boost the number of CD4 chemokine receptor 5 (CCR5) T cells, target cells for HIV infection...
- Adenovirus type 5 interactions with human blood cells may compromise systemic deliveryMark Lyons
Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK
Mol Ther 14:118-28. 2006..This may increase antigen presentation following intravenous injection, while blood cell binding may both decrease access of the virus to extravascular targets and inhibit infection of cells to which the virus does gain access...