Ken K Ong

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Early determinants of obesity
    Ken K Ong
    MRC Epidemiology Unit, Cambridge, UK
    Endocr Dev 19:53-61. 2010
  2. pmc Mendelian Randomisation Study of Childhood BMI and Early Menarche
    Hannah S Mumby
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, P O Box 285, Cambridge CB2 0QQ, UK
    J Obes 2011:180729. 2011
  3. pmc Variability in the heritability of body mass index: a systematic review and meta-regression
    Cathy E Elks
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science Cambridge, UK
    Front Endocrinol (Lausanne) 3:29. 2012
  4. pmc Implications of adopting the WHO 2006 Child Growth Standard in the UK: two prospective cohort studies
    C Wright
    Division of Developmental Medicine, University of Glasgow, Glasgow, UK
    Arch Dis Child 93:566-9. 2008
  5. pmc Protocol for systematic reviews of determinants/correlates of obesity-related dietary and physical activity behaviors in young children (preschool 0 to 6 years): evidence mapping and syntheses
    Rajalakshmi Lakshman
    MRC Epidemiology Unit, Addenbrookes Hospital, Box 285, Cambridge CB2 0QQ, UK
    Syst Rev 2:28. 2013
  6. doi request reprint Childhood stunting and mortality between 36 and 64 years: the British 1946 Birth Cohort Study
    Ken K Ong
    Medical Research Council Unit for Lifelong Health and Ageing, London WC1B 5JU, United Kingdom
    J Clin Endocrinol Metab 98:2070-7. 2013
  7. pmc Childhood weight gain and thyroid autoimmunity at age 60-64 years: the 1946 British birth cohort study
    Ken K Ong
    Medical Research Council Unit for Lifelong Health and Ageing, London, United Kingdom
    J Clin Endocrinol Metab 98:1435-42. 2013
  8. pmc Timing of voice breaking in males associated with growth and weight gain across the life course
    Ken K Ong
    Medical Research Council, Unit for Lifelong Health and Ageing, London WC1B 5JU, United Kingdom
    J Clin Endocrinol Metab 97:2844-52. 2012
  9. pmc Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes
    A Vella
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabetologia 51:811-5. 2008
  10. ncbi request reprint Catch-up growth in small for gestational age babies: good or bad?
    Ken K Ong
    MRC Epidemiology Unit, Cambridge, UK
    Curr Opin Endocrinol Diabetes Obes 14:30-4. 2007

Detail Information

Publications96

  1. ncbi request reprint Early determinants of obesity
    Ken K Ong
    MRC Epidemiology Unit, Cambridge, UK
    Endocr Dev 19:53-61. 2010
    ..Such strategies could be further refined by future studies that address the specific regulation of infant adiposity, and also by studies that explore whether these life-course trajectories are modifiable during adolescence...
  2. pmc Mendelian Randomisation Study of Childhood BMI and Early Menarche
    Hannah S Mumby
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, P O Box 285, Cambridge CB2 0QQ, UK
    J Obes 2011:180729. 2011
    ....
  3. pmc Variability in the heritability of body mass index: a systematic review and meta-regression
    Cathy E Elks
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science Cambridge, UK
    Front Endocrinol (Lausanne) 3:29. 2012
    ..The genetic contribution to BMI appears to vary with age and may have a greater influence during childhood than adult life...
  4. pmc Implications of adopting the WHO 2006 Child Growth Standard in the UK: two prospective cohort studies
    C Wright
    Division of Developmental Medicine, University of Glasgow, Glasgow, UK
    Arch Dis Child 93:566-9. 2008
    ..The WHO 2006 Child Growth Standard is based on data from international optimally nourished breastfed infants from birth to age 5 years...
  5. pmc Protocol for systematic reviews of determinants/correlates of obesity-related dietary and physical activity behaviors in young children (preschool 0 to 6 years): evidence mapping and syntheses
    Rajalakshmi Lakshman
    MRC Epidemiology Unit, Addenbrookes Hospital, Box 285, Cambridge CB2 0QQ, UK
    Syst Rev 2:28. 2013
    ..For example, we need to understand whether it would be more important to target the family, childcare settings or the wider environment and identify the most effective way of changing these energy balance related behaviors...
  6. doi request reprint Childhood stunting and mortality between 36 and 64 years: the British 1946 Birth Cohort Study
    Ken K Ong
    Medical Research Council Unit for Lifelong Health and Ageing, London WC1B 5JU, United Kingdom
    J Clin Endocrinol Metab 98:2070-7. 2013
    ..Our aim was to examine the associations between childhood or adult height and adult mortality...
  7. pmc Childhood weight gain and thyroid autoimmunity at age 60-64 years: the 1946 British birth cohort study
    Ken K Ong
    Medical Research Council Unit for Lifelong Health and Ageing, London, United Kingdom
    J Clin Endocrinol Metab 98:1435-42. 2013
    ..We used a life-course approach to examine the potential association of childhood or adult body weight with the risk of thyroid autoimmunity and other thyroid disorders at age 60-64 years in a large population-based birth cohort study...
  8. pmc Timing of voice breaking in males associated with growth and weight gain across the life course
    Ken K Ong
    Medical Research Council, Unit for Lifelong Health and Ageing, London WC1B 5JU, United Kingdom
    J Clin Endocrinol Metab 97:2844-52. 2012
    ....
  9. pmc Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes
    A Vella
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabetologia 51:811-5. 2008
    ..We therefore examined the association between common genetic variation in IGF1 and predisposition to type 1 diabetes, childhood growth and metabolism...
  10. ncbi request reprint Catch-up growth in small for gestational age babies: good or bad?
    Ken K Ong
    MRC Epidemiology Unit, Cambridge, UK
    Curr Opin Endocrinol Diabetes Obes 14:30-4. 2007
    ..Increasing trends towards childhood overweight and its metabolic consequences, and their epidemiological associations with lower birth weight, have led to critical assessments of the benefits and disadvantages of rapid early growth...
  11. ncbi request reprint Infancy weight gain predicts childhood body fat and age at menarche in girls
    Ken K Ong
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 94:1527-32. 2009
    ..Rapid postnatal weight gain has been associated with subsequent increased childhood adiposity. However, the contribution of rapid weight gain during specific infancy periods is not clear...
  12. ncbi request reprint Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions
    Ken K Ong
    Medical Research Council Epidemiology Unit, Cambridge, UK
    Acta Paediatr 95:904-8. 2006
    ..Further evidence is needed, and we will need to rigorously test the benefits and risks of any interventions. However, the concept of "healthy" rapid catch-up infancy growth is an attractive prospect...
  13. pmc Genetic variation in LIN28B is associated with the timing of puberty
    Ken K Ong
    Medical Research Council MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 41:729-33. 2009
    ..These studies identify variation in LIN28B, a potent and specific regulator of microRNA processing, as the first genetic determinant regulating the timing of human pubertal growth and development...
  14. ncbi request reprint Sex-discordant associations with adiponectin levels and lipid profiles in children
    Ken K Ong
    MRC Epidemiology Unit, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, U K
    Diabetes 55:1337-41. 2006
    ..Our data suggest a complex age- and sex-related regulation of adiponectin secretion or clearance...
  15. ncbi request reprint Size at birth, postnatal growth and risk of obesity
    K K Ong
    MRC Epidemiology Unit, Strangeways Research Laboratory, Cambridge, UK
    Horm Res 65:65-9. 2006
    ....
  16. doi request reprint Insulin-like growth factor I concentrations in infancy predict differential gains in body length and adiposity: the Cambridge Baby Growth Study
    Ken K Ong
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Am J Clin Nutr 90:156-61. 2009
    ..Formula milk-fed infants show faster rates of growth and weight gain than do breastfed infants, and they have higher concentrations of insulin-like growth factor I (IGF-I)...
  17. pmc Communicating the benefits of breast feeding
    Ken K Ong
    MRC Epidemiology Unit, Cambridge, UK
    Arch Dis Child 92:471-2. 2007
  18. pmc Associations between the pubertal timing-related variant in LIN28B and BMI vary across the life course
    Ken K Ong
    Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Clin Endocrinol Metab 96:E125-9. 2011
    ..The common C allele of rs314276 in LIN28B has been robustly associated with earlier age at menarche in girls and associated with earlier timing of other pubertal traits in both sexes...
  19. pmc Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth
    Cathy E Elks
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
    PLoS Med 7:e1000284. 2010
    ..Exploration of these genotype associations in children may provide insights into the timing of weight changes leading to adult obesity...
  20. pmc Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies
    Marcel den Hoed
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetes 59:2980-8. 2010
    ..We examined associations of variants in these loci with anthropometric traits in children and adolescents...
  21. doi request reprint Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
    Shengxu Li
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Am J Clin Nutr 91:184-90. 2010
    ..Large-scale genome-wide association studies have identified 12 genetic loci that are robustly associated with body mass index (BMI)...
  22. pmc Adult obesity susceptibility variants are associated with greater childhood weight gain and a faster tempo of growth: the 1946 British Birth Cohort Study
    Cathy E Elks
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, United Kingdom
    Am J Clin Nutr 95:1150-6. 2012
    ..Longitudinal growth associations with genetic variants identified for adult BMI may provide insights into the timing of obesity susceptibility...
  23. pmc Life course variations in the associations between FTO and MC4R gene variants and body size
    Rebecca Hardy
    MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College London, 33 Bedford Place, London, UK
    Hum Mol Genet 19:545-52. 2010
    ..Studies of the aetiology of obesity spanning different age groups may identify age-specific determinants of weight gain...
  24. ncbi request reprint The insulin gene variable number of tandem repeat: associations and interactions with childhood body fat mass and insulin secretion in normal children
    Barbara Heude
    Medical Research Council Epidemiology Unit, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, United Kingdom
    J Clin Endocrinol Metab 91:2770-5. 2006
    ..Polymorphism at the insulin gene (INS) variable number of tandem repeat (VNTR) shows variable associations with childhood body mass index (BMI) in different populations...
  25. ncbi request reprint Prediction of childhood obesity by infancy weight gain: an individual-level meta-analysis
    Celine Druet
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Paediatr Perinat Epidemiol 26:19-26. 2012
    ..A risk score combining birthweight and infant weight gain (or simply infant weight), together with mother's body mass index and sex may allow early stratification of infants at risk of childhood obesity...
  26. pmc Associations between paternally transmitted fetal IGF2 variants and maternal circulating glucose concentrations in pregnancy
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Diabetes 60:3090-6. 2011
    ..To test the hypothesis that polymorphic variation in the paternally transmitted fetal IGF2 gene is associated with maternal glucose concentrations in the third trimester of pregnancy...
  27. pmc Increased placental glucose transport rates in pregnant mice carrying fetuses with targeted disruption of their placental-specific Igf2 transcripts are not associated with raised circulating glucose concentrations
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Exp Diabetes Res 2011:171376. 2011
    ..0 ± 9.1% of control values; P = .9) or e18 (91.4 ± 13.4%; P = .3), suggesting that effects on transplacental glucose transport in these mice are not mediated through changes in maternal glucose concentrations...
  28. doi request reprint Association between a common variant near MC4R and change in body mass index develops by two weeks of age
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Horm Res Paediatr 73:275-80. 2010
    ..Our objective was to test the association between rs17782313 and neonatal weight gain in a contemporary population...
  29. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  30. pmc Raised late pregnancy glucose concentrations in mice carrying pups with targeted disruption of H19delta13
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge, U K
    Diabetes 59:282-6. 2010
    ..To test this hypothesis we evaluated the effects of fetal disruption of murine H19(Delta13) on maternal glucose concentrations in pregnancy...
  31. ncbi request reprint Growth hormone binding protein levels in children are associated with birth weight, postnatal weight gain, and insulin secretion
    Ken K Ong
    Medical Research Council Epidemiology Unit, Cambridge CB2 0QQ, UK
    Metabolism 56:1412-7. 2007
    ..Increased GH sensitivity in such children could contribute to links between rapid infancy weight gain and subsequent faster rates of childhood growth and maturation...
  32. ncbi request reprint Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals
    Tuomas O Kilpeläinen
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    Am J Clin Nutr 93:851-60. 2011
    ..High birth weight is associated with adult body mass index (BMI). We hypothesized that birth weight and BMI may partly share a common genetic background...
  33. ncbi request reprint Heritability of childhood weight gain from birth and risk markers for adult metabolic disease in prepubertal twins
    Kathryn Beardsall
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Cambridge CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 94:3708-13. 2009
    ..We utilized a twin model to explore these hypotheses...
  34. pmc Breastfeeding and infant temperament at age three months
    Blandine de Lauzon-Guillain
    Medical Research Council Epidemiology Unit, Cambridge, United Kingdom
    PLoS ONE 7:e29326. 2012
    ..Infant temperament scores were related to mode of infant milk feeding at age 3 months (breast only; formula milk only; or mixed) with adjustment for infant's age at assessment and an index of deprivation...
  35. pmc Common polymorphic variation in the genetically diverse African insulin gene and its association with size at birth
    Clive J Petry
    Department of Paediatrics, Box 116, Addenbrooke s Hospital, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK
    Hum Genet 126:375-84. 2009
    ....
  36. doi request reprint Maternally transmitted foetal H19 variants and associations with birth weight
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Hum Genet 130:663-70. 2011
    ..Polymorphic variation in H19 is not associated with significant changes in maternal glucose tolerance in the third trimester of pregnancy...
  37. ncbi request reprint Higher fasting plasma free fatty acid levels are associated with lower insulin secretion in children and adults and a higher incidence of type 2 diabetes
    Burak Salgin
    University Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 97:3302-9. 2012
    ..There are limited data in humans on the association between fasting free fatty acid (FFA) levels and pancreatic β-cell function...
  38. pmc TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population
    Ruth J F Loos
    Medical Research Council Epidemiology Unit, Strangeways Research Laboratory, Cambridge, UK
    Diabetes 56:1943-7. 2007
    ....
  39. ncbi request reprint Early age at menarche associated with cardiovascular disease and mortality
    Rajalakshmi Lakshman
    Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 94:4953-60. 2009
    ..The relationship between age at menarche and cardiovascular disease remains unclear. Two recent studies found an inverse association between age at menarche and all-cause mortality...
  40. pmc Ghrelin receptor gene polymorphisms and body size in children and adults
    Edwin A Garcia
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    J Clin Endocrinol Metab 93:4158-61. 2008
    ..Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with human obesity and growth...
  41. pmc Lamin A/C polymorphisms, type 2 diabetes, and the metabolic syndrome: case-control and quantitative trait studies
    Jose L Mesa
    Medical Research Center Epidemiology Unit, Cambridge, U K
    Diabetes 56:884-9. 2007
    ..Thus, it appears unlikely that variation at LMNA substantially increases the risk of type 2 diabetes or related traits in U.K. Europids...
  42. pmc Higher levels of IGF-I and adrenal androgens at age 8 years are associated with earlier age at menarche in girls
    Ajay Thankamony
    Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 97:E786-90. 2012
    ..Earlier age at menarche is associated with rapid infancy weight gain and childhood obesity. The role of hormone levels in mediating these associations is unclear...
  43. ncbi request reprint Lack of association between common polymorphisms in the 17beta-hydroxysteroid dehydrogenase type V gene (HSD17B5) and precocious pubarche
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge CB2 2QQ, UK
    J Steroid Biochem Mol Biol 105:176-80. 2007
    ..Precocious pubarche (PP) is a clinical entity pointing to adrenal androgen excess from mid-childhood onward and is associated with ovarian androgen excess from puberty onward. It is therefore a strong risk factor for PCOS...
  44. pmc Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital Level 8, Box 116, Cambridge CB2 2QQ, UK
    BMC Genet 6:22. 2005
    ....
  45. pmc Study of association between common variation in the insulin-like growth factor 2 gene and indices of obesity and body size in middle-aged men and women
    Barbara Heude
    Medical Research Council Epidemiology Unit, Strangeways Research Laboratory, Cambridge CB1 8RN, United Kingdom
    J Clin Endocrinol Metab 92:2734-8. 2007
    ..Previous studies have reported that polymorphisms in IGF2 are associated with body weight and body mass index (BMI), but the results have been inconsistent...
  46. pmc Earlier mother's age at menarche predicts rapid infancy growth and childhood obesity
    Ken K Ong
    Medical Research Council Epidemiology Unit, Cambridge, United Kingdom
    PLoS Med 4:e132. 2007
    ..As age at menarche is a heritable trait, we hypothesised that age at menarche in the mother may in turn predict her children's early growth and obesity risk...
  47. ncbi request reprint Association between birth weight and visceral fat in adults
    Emanuella De Lucia Rolfe
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    Am J Clin Nutr 92:347-52. 2010
    ..Several studies reported inverse associations between birth weight and central adiposity in adults. However, few studies investigated the contributions of different abdominal fat compartments...
  48. ncbi request reprint Genetic variation in the type 2 insulin-like growth factor receptor gene and disparity in childhood height
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Growth Horm IGF Res 15:363-8. 2005
    ..We hypothesised that polymorphisms in the IGF2R gene could alter size at birth and childhood growth...
  49. ncbi request reprint Early and late weight gain and the timing of puberty
    David B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Cambridge CB2 2QQ, UK
    Mol Cell Endocrinol 254:140-5. 2006
    ..Trans-generational recurrence of low birth weight, early catch-up weight gain, earlier menarche, and shorter adult stature have been observed in women, and could contribute to the strong heritability in age at menarche...
  50. doi request reprint Validation of ultrasound estimates of visceral fat in black South African adolescents
    Emanuella De Lucia Rolfe
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Obesity (Silver Spring) 19:1892-7. 2011
    ..Black South African adolescents have relatively little VAT compared to elderly whites, and we therefore provide new ultrasound-based prediction equations for VAT specific to this group...
  51. ncbi request reprint Dietary energy intake at the age of 4 months predicts postnatal weight gain and childhood body mass index
    Ken K Ong
    Medical Research Council Epidemiology Unit, Cambridge, United Kingdom
    Pediatrics 117:e503-8. 2006
    ..The objective of this study was to determine whether different feeding patterns and energy intakes that are provided to infants affect body weight and BMI later in childhood...
  52. ncbi request reprint Opposing influences of prenatal and postnatal weight gain on adrenarche in normal boys and girls
    Ken K Ong
    Department of Pediatrics, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    J Clin Endocrinol Metab 89:2647-51. 2004
    ..We suggest that higher adrenal androgen secretion could contribute to links between early growth and adult disease risks, possibly by enhancing insulin resistance and central fat deposition...
  53. ncbi request reprint Flutamide metformin for post-menarcheal girls with preclinical ovarian androgen excess: evidence for differential response by androgen receptor genotype
    Ken K Ong
    Medical Research Council Epidemiology Unit, Cambridge CB0 2QQ, UK
    Eur J Endocrinol 157:661-8. 2007
    ..We hypothesised that girls with shorter AR gene CAG repeat alleles, and thus greater receptor sensitivity, might benefit more from the addition of low-dose flutamide...
  54. doi request reprint Birth size, infant weight gain, and motor development influence adult physical performance
    Charlotte L Ridgway
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    Med Sci Sports Exerc 41:1212-21. 2009
    ....
  55. ncbi request reprint Associations between common variation in the aromatase gene promoter region and testosterone concentrations in two young female populations
    Clive J Petry
    Department of Paediatrics, University of Cambridge, UK
    J Steroid Biochem Mol Biol 98:199-206. 2006
    ..The variable associations with androgen-related clinical features could possibly reflect the tissue-specific promoters of the aromatase gene...
  56. pmc Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits
    Joshua C Randall
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS Genet 9:e1003500. 2013
    ..The PPARG locus is of specific interest due to its role in diabetes genetics and therapy. Our results demonstrate the value of sex-specific GWAS to unravel the sexually dimorphic genetic underpinning of complex traits...
  57. ncbi request reprint Birth weight, infant growth and insulin resistance
    Ken K Ong
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital Box 116, Cambridge CB2 2QQ, UK
    Eur J Endocrinol 151:U131-9. 2004
    ..Their recognition may help the development of targeted early interventions to prevent the progression towards adult disease...
  58. pmc Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
    Cathy E Elks
    Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 42:1077-85. 2010
    ..Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing...
  59. doi request reprint Early childhood predictors of adult body composition
    Celine Druet
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Box 285, Cambridge CB2 0QQ, UK
    Best Pract Res Clin Endocrinol Metab 22:489-502. 2008
    ..Future studies should explore their timing of action and potential interactions with markers of antenatal growth restraint...
  60. pmc Ultrasound estimates of visceral and subcutaneous-abdominal adipose tissues in infancy
    Emanuella De Lucia Rolfe
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, P O Box 285, Cambridge CB2 0QQ, UK
    J Obes 2013:951954. 2013
    ..004). US measures can rank infants with higher or lower IA-AT and SCA-AT. Contrasting patterns of association with visceral and subcutaneous-abdominal adiposities indicate that they may be differentially regulated in infancy...
  61. ncbi request reprint Early elective insulin therapy can reduce hyperglycemia and increase insulin-like growth factor-I levels in very low birth weight infants
    Kathryn Beardsall
    Department of Paediatrics, University of Cambridge, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK
    J Pediatr 151:611-7, 617.e1. 2007
    ..IGF-I is the dominant hormone involved in fetal growth, and low levels have been implicated in neonatal morbidities, such as retinopathy of prematurity...
  62. pmc Anogenital distance from birth to 2 years: a population study
    Ajay Thankamony
    Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom
    Environ Health Perspect 117:1786-90. 2009
    ..5-fold greater in males. It is a reliable marker of androgen and antiandrogen effects in rodent reproductive toxicologic studies. Data on AGD in humans are sparse, with no longitudinal data collected during infancy...
  63. doi request reprint Genetics of size at birth
    David B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Level 8, Hills Road, Cambridge CB2 2QQ, U K
    Diabetes Care 30:S150-5. 2007
  64. ncbi request reprint Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gain
    Ken K Ong
    Department of Pediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 53:1128-33. 2004
    ..Our results indicate that complex prenatal and postnatal gene-maternal/fetal interactions influence size at birth and childhood risk factors for adult disease...
  65. ncbi request reprint Childhood obesity and the timing of puberty
    M Lynn Ahmed
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Cambridge, CB2 0QQ, UK
    Trends Endocrinol Metab 20:237-42. 2009
    ..Here, we describe the biological basis linking childhood obesity to early puberty and consider evidence for a trend towards its earlier onset...
  66. ncbi request reprint Effects of obesity on growth and puberty
    David B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Best Pract Res Clin Endocrinol Metab 19:375-90. 2005
    ..Rapid early weight gain, obesity and early development may have implications for later health through the development of PCOS and overall association with cancer risk...
  67. ncbi request reprint Lessons from large population studies on timing and tempo of puberty (secular trends and relation to body size): the European trend
    Ken K Ong
    Medical Research Council Epidemiology Unit, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, UK
    Mol Cell Endocrinol 254:8-12. 2006
    ....
  68. pmc Pregnancy insulin, glucose, and BMI contribute to birth outcomes in nondiabetic mothers
    Ken K Ong
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Diabetes Care 31:2193-7. 2008
    ..We investigated the effects of normal variations in maternal glycemia on birth size and other birth outcomes...
  69. doi request reprint Ultrasound measurements of visceral and subcutaneous abdominal thickness to predict abdominal adiposity among older men and women
    Ema De Lucia Rolfe
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Obesity (Silver Spring) 18:625-31. 2010
    ..In conclusion, ultrasound is a valid method to estimate visceral fat in epidemiological studies of older men and women when MRI and computed tomography are not feasible...
  70. ncbi request reprint Does the fetal genotype affect maternal physiology during pregnancy?
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK
    Trends Mol Med 13:414-21. 2007
    ..We propose that this mechanism is involved in the aetiology of PIH and GDM...
  71. doi request reprint The role of androgens in fetal growth: observational study in two genetic models of disordered androgen signalling
    Harriet L Miles
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Arch Dis Child Fetal Neonatal Ed 95:F435-8. 2010
    ..To examine the role of androgens on birth weight in genetic models of altered androgen signalling...
  72. pmc Development of a questionnaire to assess maternal attitudes towards infant growth and milk feeding practices
    Rajalakshmi R Lakshman
    MRC Epidemiology Unit, Cambridge, UK
    Int J Behav Nutr Phys Act 8:35. 2011
    ....
  73. ncbi request reprint Association of weight gain in infancy and early childhood with metabolic risk in young adults
    Ulf Ekelund
    Medical Research Council Epidemiology Unit, Cambridge CB1 9NL, United Kingdom
    J Clin Endocrinol Metab 92:98-103. 2007
    ..Early postnatal life has been suggested as an important window during which risks for long-term health may be influenced...
  74. doi request reprint DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial
    Wendy N Cooper
    2 Department of Paediatrics, Box 116, Level 8, Addenbrooke s Hospital, University of Cambridge, Hills Rd, Cambridge CB2 0QQ, UK
    FASEB J 26:1782-90. 2012
    ..This pilot study is the first to analyze DNA methylation in the context of a randomized controlled trial, and it provides suggestive evidence that periconceptional maternal nutrition alters offspring methylation at imprinted loci...
  75. ncbi request reprint Babies born small for gestational age: insulin sensitivity and growth hormone treatment
    David B Dunger
    University of Cambridge, Department of Paediatrics, Addenbrooke s Hospital, Cambridge, UK
    Horm Res 64:58-65. 2005
    ....
  76. ncbi request reprint Determinants of early weaning and use of unmodified cow's milk in infants: a systematic review
    Katrien Wijndaele
    MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke s Hospital, Hills Rd, Cambridge, CB2 0QQ, United Kingdom
    J Am Diet Assoc 109:2017-28. 2009
    ..Of these determinants, improving advice given by health care providers appears the most tractable area for intervention in the short term...
  77. ncbi request reprint Session 7: Early nutrition and later health early developmental pathways of obesity and diabetes risk
    D B Dunger
    University Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Cambridge CB2 2QQ, UK
    Proc Nutr Soc 66:451-7. 2007
    ....
  78. pmc Mothers' experiences of bottle-feeding: a systematic review of qualitative and quantitative studies
    R Lakshman
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, UK
    Arch Dis Child 94:596-601. 2009
    ..Variations in formula-feeding practices can have both short- and long-term health consequences. The literature on parents' experiences of bottle-feeding was systematically reviewed to understand how formula-feeding decisions are made...
  79. ncbi request reprint The descriptive epidemiology of congenital and acquired cryptorchidism in a UK infant cohort
    C L Acerini
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Arch Dis Child 94:868-72. 2009
    ..Recent studies in other European countries suggest that the prevalence of congenital cryptorchidism continues to increase. This study aimed to explore the prevalence and natural history of congenital cryptorchidism in a UK centre...
  80. ncbi request reprint Genetic variations and normal fetal growth
    D B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, UK
    Horm Res 65:34-40. 2006
    ..This suggests that fetal genes, and in particular paternally expressed genes, may have significant effects on fetal growth during pregnancies where maternal restraint of fetal growth is less evident...
  81. doi request reprint Whole genome associated studies for age at menarche
    Cathy E Elks
    MRC Epidemiology Unit, University of Cambridge, UK
    Brief Funct Genomics 10:91-7. 2011
    ....
  82. ncbi request reprint Randomized cross-over trial of insulin glargine plus lispro or NPH insulin plus regular human insulin in adolescents with type 1 diabetes on intensive insulin regimens
    Nuala P Murphy
    Department of Paediatrics, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Diabetes Care 26:799-804. 2003
    ..To compare blood glucose control and incidence of nocturnal hypoglycemia in adolescents with type 1 diabetes on multiple injection regimens managed with either an insulin analog combination or NPH insulin plus regular human insulin...
  83. ncbi request reprint Perinatal growth failure: the road to obesity, insulin resistance and cardiovascular disease in adults
    Ken K Ong
    Department of Paediatrics, Addenbrookes Hospital Box 116, Cambridge, CB2 2QQ, UK
    Best Pract Res Clin Endocrinol Metab 16:191-207. 2002
    ..Their historical selection could explain high prevalences of type 2 diabetes in some ethnic groups, and their identification could allow targeting of potential interventions...
  84. pmc A novel school-based intervention to improve nutrition knowledge in children: cluster randomised controlled trial
    Rajalakshmi R Lakshman
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    BMC Public Health 10:123. 2010
    ..The aim of this study was to assess the effectiveness and acceptability of a novel educational intervention to increase nutrition knowledge among primary school children...
  85. pmc Infant motor development predicts sports participation at age 14 years: northern Finland birth cohort of 1966
    Charlotte L Ridgway
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    PLoS ONE 4:e6837. 2009
    ..Motor proficiency is positively associated with physical activity levels. The aim of this study is to investigate associations between the timing of infant motor development and subsequent sports participation during adolescence...
  86. doi request reprint Association between age at menarche and risk of diabetes in adults: results from the EPIC-Norfolk cohort study
    R Lakshman
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Box 285, Cambridge, CB2 0QQ, UK
    Diabetologia 51:781-6. 2008
    ..Earlier age at menarche is associated with increased BMI and obesity risk from early childhood through to adulthood. We hypothesised that earlier age at menarche would also predict subsequent diabetes risk...
  87. ncbi request reprint Reduced gains in fat and fat-free mass, and elevated leptin levels in children and adolescents with cystic fibrosis
    M L Ahme
    Department of Paediatrics, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Acta Paediatr 93:1185-91. 2004
    ..We have investigated the role of leptin (a potential satiety factor) and changes in body composition, height and weight with respect to age and clinical outcome...
  88. ncbi request reprint Endocrine and metabolic consequences of intrauterine growth retardation
    David B Dunger
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Endocrinol Metab Clin North Am 34:597-615, ix. 2005
    ....
  89. doi request reprint Insulin sensitivity and body composition in children with classical and nonclassical congenital adrenal hyperplasia
    R M Williams
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Clin Endocrinol (Oxf) 72:155-60. 2010
    ..To understand the potential mechanisms underlying these differences, we assessed insulin sensitivity and body composition in children with classical or nonclassical (late-presenting) CAH compared with normal controls...
  90. ncbi request reprint Monitoring of concordance in growth hormone therapy
    R R Kapoor
    Department of Paediatrics, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Arch Dis Child 93:147-8. 2008
    ..Lower concordance was associated with longer duration on GH therapy (p<0.005), lack of choice of delivery device (p<0.005) and short prescription durations (p<0.005), and predicted lower height velocities (p<0.05)...
  91. ncbi request reprint A randomized cross-over trial to identify the optimal use of insulin glargine in prepubertal children using a three-times daily insulin regimen
    E E Fröhlich-Reiterer
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Diabet Med 24:1406-11. 2007
    ..However, young children may not tolerate such intensive insulin regimens. We investigated the effects of glargine in various three-injections-daily insulin combinations on 24-h glucose control in prepubertal children...
  92. ncbi request reprint Androgen receptor gene CAG repeat polymorphism in the development of ovarian hyperandrogenism
    Lourdes Ibanez
    Endocrine Unit L I, Hospital Sant Joan de Deu, University of Barcelona, E 08950 Barcelona, Spain
    J Clin Endocrinol Metab 88:3333-8. 2003
    ..Shorter CAG repeat alleles in Barcelona compared with United Kingdom women could lead to higher prevalences of these conditions...
  93. ncbi request reprint Glucose and lipid metabolism in small for gestational age infants at 48 hours of age
    Rodrigo A Bazaes
    Institute for Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile
    Pediatrics 111:804-9. 2003
    ..To study the consequences of low birth weight on glucose and lipid metabolism 48 hours after delivery...
  94. ncbi request reprint Insulin sensitivity and secretion are related to catch-up growth in small-for-gestational-age infants at age 1 year: results from a prospective cohort
    Nestor Soto
    Institute of Maternal and Child Research IDIMI, Faculty of Medicine, University of Chile, Casilla 226 3, Santiago, Chile
    J Clin Endocrinol Metab 88:3645-50. 2003
    ..Fasting insulin sensitivity is more related to WCUG and current body mass index, whereas insulin secretion seems to be directly related to LCUG...
  95. ncbi request reprint Relationships of urinary adrenal steroids at age 8 years with birth weight, postnatal growth, blood pressure, and glucose metabolism
    John W Honour
    Clinical Biochemistry, University College London Hospitals, 60 Whitfield Street, London W1T 4EU, United Kingdom
    J Clin Endocrinol Metab 92:4340-5. 2007
    ....
  96. ncbi request reprint Conscious level in children with diabetic ketoacidosis is related to severity of acidosis and not to blood glucose concentration
    Julie A Edge
    Department of Paediatrics, John Radcliffe Hospital, Oxford, UK
    Pediatr Diabetes 7:11-5. 2006
    ..To ascertain whether initial depression of conscious level in children with diabetic ketoacidosis (DKA) is related to hyperosmolality, acidosis or other factors...