Martin O'Neill

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Adaptive coding of reward value by dopamine neurons
    Philippe N Tobler
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK, and Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Science 307:1642-5. 2005
  2. ncbi request reprint The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in rats
    Martin O'Neill
    School of Psychology, University of St Andrews, KY16 9JU Scotland, UK
    Neurobiol Learn Mem 88:75-81. 2007
  3. doi request reprint Coding of reward risk by orbitofrontal neurons is mostly distinct from coding of reward value
    Martin O'Neill
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB23DY, UK
    Neuron 68:789-800. 2010
  4. pmc Adaptation of reward sensitivity in orbitofrontal neurons
    Shunsuke Kobayashi
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    J Neurosci 30:534-44. 2010
  5. pmc Responses of amygdala neurons to positive reward-predicting stimuli depend on background reward (contingency) rather than stimulus-reward pairing (contiguity)
    Maria A Bermudez
    Dept of Physiology, Development, and Neuroscience University of Cambridge, Cambridge, UK
    J Neurophysiol 103:1158-70. 2010
  6. doi request reprint Risky business: disambiguating ambiguity-related responses in the brain
    Martin O'Neill
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY, United Kingdom
    J Neurophysiol 102:645-7. 2009
  7. pmc Short-term temporal discounting of reward value in human ventral striatum
    Lucy Gregorios-Pippas
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    J Neurophysiol 101:1507-23. 2009
  8. doi request reprint Subjective neuronal coding of reward: temporal value discounting and risk
    Wolfram Schultz
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Eur J Neurosci 31:2124-35. 2010
  9. ncbi request reprint Multiple dopamine functions at different time courses
    Wolfram Schultz
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Annu Rev Neurosci 30:259-88. 2007
  10. pmc Dopamine signals for reward value and risk: basic and recent data
    Wolfram Schultz
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
    Behav Brain Funct 6:24. 2010

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Adaptive coding of reward value by dopamine neurons
    Philippe N Tobler
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK, and Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Science 307:1642-5. 2005
    ..Responses shifted relative to the expected reward value, and the gain adjusted to the variance of reward value. In this way, dopamine neurons maintained their reward sensitivity over a large range of reward values...
  2. ncbi request reprint The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in rats
    Martin O'Neill
    School of Psychology, University of St Andrews, KY16 9JU Scotland, UK
    Neurobiol Learn Mem 88:75-81. 2007
    ....
  3. doi request reprint Coding of reward risk by orbitofrontal neurons is mostly distinct from coding of reward value
    Martin O'Neill
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB23DY, UK
    Neuron 68:789-800. 2010
    ..Furthermore, a small but statistically significant fraction of risk responses also coded reward value. These risk signals may provide physiological correlates for the role of the orbitofrontal cortex in risk processing...
  4. pmc Adaptation of reward sensitivity in orbitofrontal neurons
    Shunsuke Kobayashi
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    J Neurosci 30:534-44. 2010
    ..The observed neuronal adaptation would optimize discrimination and contribute to the efficient coding of a large variety of potential rewards by neurons with limited dynamic range...
  5. pmc Responses of amygdala neurons to positive reward-predicting stimuli depend on background reward (contingency) rather than stimulus-reward pairing (contiguity)
    Maria A Bermudez
    Dept of Physiology, Development, and Neuroscience University of Cambridge, Cambridge, UK
    J Neurophysiol 103:1158-70. 2010
    ....
  6. doi request reprint Risky business: disambiguating ambiguity-related responses in the brain
    Martin O'Neill
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY, United Kingdom
    J Neurophysiol 102:645-7. 2009
    ..In this review, we discuss how the variables defined in economics and cognitive psychology frameworks can be dissociated...
  7. pmc Short-term temporal discounting of reward value in human ventral striatum
    Lucy Gregorios-Pippas
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    J Neurophysiol 101:1507-23. 2009
    ..Comparisons with electrophysiological animal data suggest that ventral striatal reward discounting may involve dopaminergic and orbitofrontal inputs...
  8. doi request reprint Subjective neuronal coding of reward: temporal value discounting and risk
    Wolfram Schultz
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Eur J Neurosci 31:2124-35. 2010
    ..However, these data do not rule out that other neurons or brain structures may code reward according to its objective value and risk...
  9. ncbi request reprint Multiple dopamine functions at different time courses
    Wolfram Schultz
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Annu Rev Neurosci 30:259-88. 2007
    ....
  10. pmc Dopamine signals for reward value and risk: basic and recent data
    Wolfram Schultz
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
    Behav Brain Funct 6:24. 2010
    ..This review provides an updated overview about the basic signals of dopamine neurons to environmental stimuli...
  11. doi request reprint Influence of reward delays on responses of dopamine neurons
    Shunsuke Kobayashi
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB23DY, United Kingdom
    J Neurosci 28:7837-46. 2008
    ..These dopamine reward value signals might serve as useful inputs for brain mechanisms involved in economic choices between delayed rewards...
  12. pmc Introduction. Neuroeconomics: the promise and the profit
    Wolfram Schultz
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Philos Trans R Soc Lond B Biol Sci 363:3767-9. 2008
    ..Perhaps we can even learn why some decisions are apparently paradoxical or pathological. The knowledge could be used to create situations that avoid suboptimal decisions and harm...
  13. pmc Explicit neural signals reflecting reward uncertainty
    Wolfram Schultz
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Philos Trans R Soc Lond B Biol Sci 363:3801-11. 2008
    ..The brain can use the uncertainty signals to assess the uncertainty of rewards, influence learning, modulate the value of uncertain rewards and make appropriate behavioural choices between only partly known options...
  14. pmc Risk-dependent reward value signal in human prefrontal cortex
    Philippe N Tobler
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
    Proc Natl Acad Sci U S A 106:7185-90. 2009
    ..These results demonstrate an aggregate risk and value signal in the prefrontal cortex that would be compatible with basic assumptions underlying the mean-variance approach to utility...
  15. pmc Neuronal distortions of reward probability without choice
    Philippe N Tobler
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    J Neurosci 28:11703-11. 2008
    ..Input of the distorted probability estimations to decision-making mechanisms are likely to contribute to well known inconsistencies in preferences formalized in theories of behavioral economics...
  16. pmc Neural correlates of value, risk, and risk aversion contributing to decision making under risk
    George I Christopoulos
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
    J Neurosci 29:12574-83. 2009
    ..More generally, these biological data contribute to the validity of the theoretical decision parameters for actual decisions under risk...
  17. ncbi request reprint Learning-related human brain activations reflecting individual finances
    Philippe N Tobler
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
    Neuron 54:167-75. 2007
    ..The inverse relationship of behavioral and neuronal learning speed with personal finances is compatible with the general concept of decreasing marginal utility with increasing wealth...
  18. ncbi request reprint Coding of predicted reward omission by dopamine neurons in a conditioned inhibition paradigm
    Philippe N Tobler
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    J Neurosci 23:10402-10. 2003
    ..The neuronal responses appear to reflect reward prediction errors, thus suggesting an extension of the correspondence between learning theory and activity of single dopamine neurons to the prediction of nonreward...
  19. ncbi request reprint Neural coding of basic reward terms of animal learning theory, game theory, microeconomics and behavioural ecology
    Wolfram Schultz
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Curr Opin Neurobiol 14:139-47. 2004
    ....
  20. ncbi request reprint Discrete coding of reward probability and uncertainty by dopamine neurons
    Christopher D Fiorillo
    Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Science 299:1898-902. 2003
    ..The coding of uncertainty suggests a possible role for dopamine signals in attention-based learning and risk-taking behavior...
  21. pmc Human neural learning depends on reward prediction errors in the blocking paradigm
    Philippe N Tobler
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, UK
    J Neurophysiol 95:301-10. 2006
    ..These data suggest that learning in primary reward structures in the human brain correlates with prediction errors in a manner that complies with principles of formal learning theory...
  22. ncbi request reprint Behavioral theories and the neurophysiology of reward
    Wolfram Schultz
    Department of Anatomy, University of Cambridge, CB2 3DY United Kingdom
    Annu Rev Psychol 57:87-115. 2006
    ..The neural activity can be related to basic theoretical terms of reward and uncertainty, such as contiguity, contingency, prediction error, magnitude, probability, expected value, and variance...
  23. ncbi request reprint Getting formal with dopamine and reward
    Wolfram Schultz
    Institute of Physiology, University of Fribourg, CH 1700, Fribourg, Switzerland
    Neuron 36:241-63. 2002
    ..Addictive psychostimulant drugs may exert their action by amplifying the dopamine reward signal...
  24. pmc Reward value coding distinct from risk attitude-related uncertainty coding in human reward systems
    Philippe N Tobler
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    J Neurophysiol 97:1621-32. 2007
    ..These data demonstrate the distinct coding in key reward structures of the two basic and crucial decision parameters, expected value, and uncertainty...
  25. ncbi request reprint Behavioral dopamine signals
    Wolfram Schultz
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
    Trends Neurosci 30:203-10. 2007
    ....
  26. ncbi request reprint Changes in behavior-related neuronal activity in the striatum during learning
    Wolfram Schultz
    Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
    Trends Neurosci 26:321-8. 2003
    ....
  27. pmc Reward magnitude coding in primate amygdala neurons
    Maria A Bermudez
    Dept of Physiology, Development and Neuroscience, Univ of Cambridge, Cambridge, CB2 3DY, UK
    J Neurophysiol 104:3424-32. 2010
    ..These data suggest parametric reward value coding in the amygdala as a characteristic component of its function in reinforcement learning and economic decision making...
  28. doi request reprint Neuronal signals for reward risk in frontal cortex
    Wolfram Schultz
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    Ann N Y Acad Sci 1239:109-17. 2011
    ..These neurophysiological mechanisms of reward risk on economic decisions inform and validate theories of economic decision making under uncertainty...
  29. pmc Neural mechanisms of observational learning
    Christopher J Burke
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Proc Natl Acad Sci U S A 107:14431-6. 2010
    ..In a functional MRI experiment, we found that brain activity in the dorsolateral prefrontal cortex and the ventromedial prefrontal cortex respectively corresponded to these two distinct observational learning signals...
  30. ncbi request reprint Lesions of the dorsal noradrenergic bundle impair attentional set-shifting in the rat
    David S Tait
    School of Psychology, University of St Andrews, St Mary s College, South Street, St Andrews, Fife KY16 9JP, UK
    Eur J Neurosci 25:3719-24. 2007
    ..The findings are also relevant to recent theorizing about the functions of the coeruleo-cortical noradrenergic system...
  31. ncbi request reprint Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the rat
    Kerry McAlonan
    School of Psychology, University of St Andrews, St Andrews KY16 9JU, Scotland, UK
    Behav Brain Res 146:97-103. 2003
    ..We report here the same selective impairment in reversal learning in rats as seen in primates with orbital prefrontal cortex lesions...
  32. ncbi request reprint Lesions of the basal forebrain impair reversal learning but not shifting of attentional set in rats
    David Scott Tait
    School of Psychology, University of St Andrews, St Mary s College, South Street, St Andrews, Fife KY16 9JP, UK
    Behav Brain Res 187:100-8. 2008
    ..They also confirm the likely involvement of non-cholinergic neurons of the basal forebrain in reversal learning...
  33. ncbi request reprint Difficulty overcoming learned non-reward during reversal learning in rats with ibotenic acid lesions of orbital prefrontal cortex
    David Scott Tait
    School of Psychology, The University of St Andrews, St Mary s College, South Street, St Andrews, Fife, KY16 9JP, UK
    Ann N Y Acad Sci 1121:407-20. 2007
    ..They did not show enhanced perseveration. We conclude that an inability to overcome learned non-reward significantly contributes to OPFC lesion-induced deficits in behavioral flexibility...
  34. ncbi request reprint Amphetamine and the adenosine A(2A) antagonist KW-6002 enhance the effects of conditional temporal probability of a stimulus in rats
    Verity J Brown
    School of Psychology, University of St Andrews, St Andrews, Scotland, United Kingdom
    Behav Neurosci 121:535-42. 2007
    ..The authors concluded that preparation time and expectancy (conditional temporal probability of an imperative signal) have differential effects on performance and that amphetamine and KW-6002 enhance the effect of expectancy...
  35. ncbi request reprint The effect of the adenosine A(2A) antagonist KW-6002 on motor and motivational processes in the rat
    Martin O'Neill
    School of Psychology, University of St Andrews, KY16 9JU Scotland, UK
    Psychopharmacology (Berl) 184:46-55. 2006
    ..These changes reflect enhanced motor readiness. Also, reaction times are quicker when the cost of reward (amount of work required) is minimum. Antagonism of the adenosine A(2A) receptor has been shown to effect motor-related processes...
  36. ncbi request reprint Double dissociation of social and environmental stimulation on spatial learning and reversal learning in rats
    Nicole C A Schrijver
    Institute of Animal Sciences, Physiology and Animal Husbandry, ETH Zurich, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
    Behav Brain Res 152:307-14. 2004
    ..These findings strengthen the view that social and inanimate stimulation act, at least in part, upon dissociable neural substrates...
  37. ncbi request reprint Rodent models of prefrontal cortical function
    Verity J Brown
    School of Psychology, University of St Andrews, St Andrews KY16 9JU, UK
    Trends Neurosci 25:340-3. 2002
    ..Nevertheless, we argue here that studies of the computational functions within the relatively undifferentiated prefrontal cortex of rats can shed light on processing in primate prefrontal cortex...