Research Topics
| Martin O'NeillSummaryAffiliation: University of Cambridge Country: UK Publications
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Detail Information
Publications
Adaptive coding of reward value by dopamine neuronsPhilippe N Tobler
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK, and Institute of Physiology, University of Fribourg, CH-1700 Fribourg, Switzerland
Science 307:1642-5. 2005..Responses shifted relative to the expected reward value, and the gain adjusted to the variance of reward value. In this way, dopamine neurons maintained their reward sensitivity over a large range of reward values...- The effect of striatal dopamine depletion and the adenosine A2A antagonist KW-6002 on reversal learning in ratsMartin O'Neill
School of Psychology, University of St Andrews, KY16 9JU Scotland, UK
Neurobiol Learn Mem 88:75-81. 2007.... 
Coding of reward risk by orbitofrontal neurons is mostly distinct from coding of reward valueMartin O'Neill
Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB23DY, UK
Neuron 68:789-800. 2010..Furthermore, a small but statistically significant fraction of risk responses also coded reward value. These risk signals may provide physiological correlates for the role of the orbitofrontal cortex in risk processing...
Adaptation of reward sensitivity in orbitofrontal neuronsShunsuke Kobayashi
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
J Neurosci 30:534-44. 2010..The observed neuronal adaptation would optimize discrimination and contribute to the efficient coding of a large variety of potential rewards by neurons with limited dynamic range...- Responses of amygdala neurons to positive reward-predicting stimuli depend on background reward (contingency) rather than stimulus-reward pairing (contiguity)Maria A Bermudez
Dept of Physiology, Development, and Neuroscience University of Cambridge, Cambridge, UK
J Neurophysiol 103:1158-70. 2010.... - Risky business: disambiguating ambiguity-related responses in the brainMartin O'Neill
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY, United Kingdom
J Neurophysiol 102:645-7. 2009..In this review, we discuss how the variables defined in economics and cognitive psychology frameworks can be dissociated... - Short-term temporal discounting of reward value in human ventral striatumLucy Gregorios-Pippas
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
J Neurophysiol 101:1507-23. 2009..Comparisons with electrophysiological animal data suggest that ventral striatal reward discounting may involve dopaminergic and orbitofrontal inputs... - Subjective neuronal coding of reward: temporal value discounting and riskWolfram Schultz
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Eur J Neurosci 31:2124-35. 2010..However, these data do not rule out that other neurons or brain structures may code reward according to its objective value and risk... - Multiple dopamine functions at different time coursesWolfram Schultz
Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
Annu Rev Neurosci 30:259-88. 2007.... - Dopamine signals for reward value and risk: basic and recent dataWolfram Schultz
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
Behav Brain Funct 6:24. 2010..This review provides an updated overview about the basic signals of dopamine neurons to environmental stimuli... - Influence of reward delays on responses of dopamine neuronsShunsuke Kobayashi
Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB23DY, United Kingdom
J Neurosci 28:7837-46. 2008..These dopamine reward value signals might serve as useful inputs for brain mechanisms involved in economic choices between delayed rewards... - Introduction. Neuroeconomics: the promise and the profitWolfram Schultz
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Philos Trans R Soc Lond B Biol Sci 363:3767-9. 2008..Perhaps we can even learn why some decisions are apparently paradoxical or pathological. The knowledge could be used to create situations that avoid suboptimal decisions and harm... - Explicit neural signals reflecting reward uncertaintyWolfram Schultz
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Philos Trans R Soc Lond B Biol Sci 363:3801-11. 2008..The brain can use the uncertainty signals to assess the uncertainty of rewards, influence learning, modulate the value of uncertain rewards and make appropriate behavioural choices between only partly known options... - Risk-dependent reward value signal in human prefrontal cortexPhilippe N Tobler
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
Proc Natl Acad Sci U S A 106:7185-90. 2009..These results demonstrate an aggregate risk and value signal in the prefrontal cortex that would be compatible with basic assumptions underlying the mean-variance approach to utility... - Neuronal distortions of reward probability without choicePhilippe N Tobler
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
J Neurosci 28:11703-11. 2008..Input of the distorted probability estimations to decision-making mechanisms are likely to contribute to well known inconsistencies in preferences formalized in theories of behavioral economics... - Neural correlates of value, risk, and risk aversion contributing to decision making under riskGeorge I Christopoulos
Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
J Neurosci 29:12574-83. 2009..More generally, these biological data contribute to the validity of the theoretical decision parameters for actual decisions under risk... - Learning-related human brain activations reflecting individual financesPhilippe N Tobler
Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
Neuron 54:167-75. 2007..The inverse relationship of behavioral and neuronal learning speed with personal finances is compatible with the general concept of decreasing marginal utility with increasing wealth... - Coding of predicted reward omission by dopamine neurons in a conditioned inhibition paradigmPhilippe N Tobler
Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom
J Neurosci 23:10402-10. 2003..The neuronal responses appear to reflect reward prediction errors, thus suggesting an extension of the correspondence between learning theory and activity of single dopamine neurons to the prediction of nonreward... - Neural coding of basic reward terms of animal learning theory, game theory, microeconomics and behavioural ecologyWolfram Schultz
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Curr Opin Neurobiol 14:139-47. 2004.... - Discrete coding of reward probability and uncertainty by dopamine neuronsChristopher D Fiorillo
Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
Science 299:1898-902. 2003..The coding of uncertainty suggests a possible role for dopamine signals in attention-based learning and risk-taking behavior... - Human neural learning depends on reward prediction errors in the blocking paradigmPhilippe N Tobler
Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, UK
J Neurophysiol 95:301-10. 2006..These data suggest that learning in primary reward structures in the human brain correlates with prediction errors in a manner that complies with principles of formal learning theory... - Behavioral theories and the neurophysiology of rewardWolfram Schultz
Department of Anatomy, University of Cambridge, CB2 3DY United Kingdom
Annu Rev Psychol 57:87-115. 2006..The neural activity can be related to basic theoretical terms of reward and uncertainty, such as contiguity, contingency, prediction error, magnitude, probability, expected value, and variance... - Getting formal with dopamine and rewardWolfram Schultz
Institute of Physiology, University of Fribourg, CH 1700, Fribourg, Switzerland
Neuron 36:241-63. 2002..Addictive psychostimulant drugs may exert their action by amplifying the dopamine reward signal... - Reward value coding distinct from risk attitude-related uncertainty coding in human reward systemsPhilippe N Tobler
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
J Neurophysiol 97:1621-32. 2007..These data demonstrate the distinct coding in key reward structures of the two basic and crucial decision parameters, expected value, and uncertainty... - Behavioral dopamine signalsWolfram Schultz
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
Trends Neurosci 30:203-10. 2007.... - Changes in behavior-related neuronal activity in the striatum during learningWolfram Schultz
Institute of Physiology, University of Fribourg, CH 1700 Fribourg, Switzerland
Trends Neurosci 26:321-8. 2003.... - Reward magnitude coding in primate amygdala neuronsMaria A Bermudez
Dept of Physiology, Development and Neuroscience, Univ of Cambridge, Cambridge, CB2 3DY, UK
J Neurophysiol 104:3424-32. 2010..These data suggest parametric reward value coding in the amygdala as a characteristic component of its function in reinforcement learning and economic decision making... - Neuronal signals for reward risk in frontal cortexWolfram Schultz
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
Ann N Y Acad Sci 1239:109-17. 2011..These neurophysiological mechanisms of reward risk on economic decisions inform and validate theories of economic decision making under uncertainty... - Neural mechanisms of observational learningChristopher J Burke
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
Proc Natl Acad Sci U S A 107:14431-6. 2010..In a functional MRI experiment, we found that brain activity in the dorsolateral prefrontal cortex and the ventromedial prefrontal cortex respectively corresponded to these two distinct observational learning signals... - Lesions of the dorsal noradrenergic bundle impair attentional set-shifting in the ratDavid S Tait
School of Psychology, University of St Andrews, St Mary s College, South Street, St Andrews, Fife KY16 9JP, UK
Eur J Neurosci 25:3719-24. 2007..The findings are also relevant to recent theorizing about the functions of the coeruleo-cortical noradrenergic system... - Orbital prefrontal cortex mediates reversal learning and not attentional set shifting in the ratKerry McAlonan
School of Psychology, University of St. Andrews, St Andrews KY16 9JU, Scotland, UK
Behav Brain Res 146:97-103. 2003..We report here the same selective impairment in reversal learning in rats as seen in primates with orbital prefrontal cortex lesions... - Lesions of the basal forebrain impair reversal learning but not shifting of attentional set in ratsDavid Scott Tait
School of Psychology, University of St Andrews, St Mary s College, South Street, St Andrews, Fife KY16 9JP, UK
Behav Brain Res 187:100-8. 2008..They also confirm the likely involvement of non-cholinergic neurons of the basal forebrain in reversal learning... - Difficulty overcoming learned non-reward during reversal learning in rats with ibotenic acid lesions of orbital prefrontal cortexDavid Scott Tait
School of Psychology, The University of St Andrews, St Mary s College, South Street, St Andrews, Fife, KY16 9JP, UK
Ann N Y Acad Sci 1121:407-20. 2007..They did not show enhanced perseveration. We conclude that an inability to overcome learned non-reward significantly contributes to OPFC lesion-induced deficits in behavioral flexibility... - Amphetamine and the adenosine A(2A) antagonist KW-6002 enhance the effects of conditional temporal probability of a stimulus in ratsVerity J Brown
School of Psychology, University of St Andrews, St Andrews, Scotland, United Kingdom
Behav Neurosci 121:535-42. 2007..The authors concluded that preparation time and expectancy (conditional temporal probability of an imperative signal) have differential effects on performance and that amphetamine and KW-6002 enhance the effect of expectancy... - The effect of the adenosine A(2A) antagonist KW-6002 on motor and motivational processes in the ratVerity J Brown
School of Psychology, University of St. Andrews, KY16 9JU Scotland, UK
Psychopharmacology (Berl) 184:46-55. 2006..CONCLUSION: Antagonism of adenosine A(2A) receptors by systemic KW-6002 speeds reaction time and enhanced motor preparatory processes as well as interacting with motivational processes... - Double dissociation of social and environmental stimulation on spatial learning and reversal learning in ratsNicole C A Schrijver
Institute of Animal Sciences, Physiology and Animal Husbandry, , Schorenstrasse 16, 8603 Schwerzenbach, Switzerland
Behav Brain Res 152:307-14. 2004..These findings strengthen the view that social and inanimate stimulation act, at least in part, upon dissociable neural substrates... - Rodent models of prefrontal cortical functionVerity J Brown
School of Psychology, University of St Andrews, St Andrews KY16 9JU, UK
Trends Neurosci 25:340-3. 2002..Nevertheless, we argue here that studies of the computational functions within the relatively undifferentiated prefrontal cortex of rats can shed light on processing in primate prefrontal cortex...