Stephen G Oliver

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae
    Michaela de Clare
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    BMC Biol 11:24. 2013
  2. ncbi The genetic control of growth rate: a systems biology study in yeast
    Pinar Pir
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    BMC Syst Biol 6:4. 2012
  3. ncbi Application of the comprehensive set of heterozygous yeast deletion mutants to elucidate the molecular basis of cellular chromium toxicity
    Sara Holland
    School of Biology, Institute of Genetics, The University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Genome Biol 8:R268. 2007
  4. ncbi Further developments towards a genome-scale metabolic model of yeast
    Paul D Dobson
    School of Chemistry, The University of Manchester, Manchester M13 9PL, UK
    BMC Syst Biol 4:145. 2010
  5. ncbi Data capture in bioinformatics: requirements and experiences with Pedro
    Daniel Jameson
    School of Chemistry, Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK
    BMC Bioinformatics 9:183. 2008
  6. ncbi Information management for high content live cell imaging
    Daniel Jameson
    Manchester Centre for Integrative Systems Biology, School of Chemistry, and Manchester Interdisciplinary Biocentre, University of Manchester, 131, Princess St, Manchester, M1 7DN, UK
    BMC Bioinformatics 10:226. 2009
  7. ncbi Nutrient control of eukaryote cell growth: a systems biology study in yeast
    Alex Gutteridge
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
    BMC Biol 8:68. 2010
  8. ncbi The transcription activity of Gis1 is negatively modulated by proteasome-mediated limited proteolysis
    Nianshu Zhang
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 285:6465-76. 2010
  9. ncbi JmjN interacts with JmjC to ensure selective proteolysis of Gis1 by the proteasome
    Zhenzhen Quan
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Microbiology 157:2694-701. 2011
  10. ncbi Yeast systems biology: the challenge of eukaryotic complexity
    Juan I Castrillo
    Department of Biochemistry, Cambridge Systems Biology Centre, University of Cambridge, Cambridge CB21GA, UK
    Methods Mol Biol 759:3-28. 2011

Collaborators

  • Nianshu Zhang
  • Pinar Pir
  • Jian Wu
  • Juan I Castrillo
  • Julian L Griffin
  • Andrew Hayes
  • Alan Tunnacliffe
  • Andy Hesketh
  • Douglas B Kell
  • Kathryn S Lilley
  • Jessica A Downs
  • Daniel Jameson
  • Michaela de Clare
  • Zhenzhen Quan
  • Sooraj Ratnakumar
  • Alex Gutteridge
  • Paul D Dobson
  • Neil Swainston
  • Christopher M Titman
  • Konstantinos Gkargkas
  • Norman W Paton
  • Duygu Dikicioglu
  • Jacob G Bundy
  • Sara Holland
  • Michael Wilson
  • Bharat M Rash
  • Natalie J Stanford
  • Olusegun Oshota
  • Duncan Hull
  • Chuan Lu
  • Evangelos Simeonidis
  • Warwick B Dunn
  • Karin Lanthaler
  • Pedro Mendes
  • Paul Fisher
  • Robert D Stevens
  • Marie Brown
  • Ross D King
  • Kieran Smallbone
  • Philip D Charles
  • John Ankers
  • Tony Griffiths
  • Paul L Carmichael
  • Stephnie Kennedy
  • Andrew D Scott
  • Michael R H White
  • David A Turner
  • David G Spiller
  • Sheila Ryan
  • Pinar Alper
  • Kevin Garwood
  • Betul Kirdar
  • Chris Garwood
  • Kutlu O Ulgen
  • Tim Booth
  • Z Ilsen Onsan
  • Roy A Browne
  • David C Hoyle
  • Edward M Clayson
  • Kevin M Brindle
  • Tom Reader
  • Nicola Burton
  • Theodora Sideri
  • Daniela Delneri
  • Simon V Avery
  • Balazs Papp
  • Emma Lodwig
  • Ian Clarke
  • Rebecca Harmston
  • Richard J Reece

Detail Information

Publications16

  1. ncbi Copy-number variation of cancer-gene orthologs is sufficient to induce cancer-like symptoms in Saccharomyces cerevisiae
    Michaela de Clare
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    BMC Biol 11:24. 2013
    ..Since haploproficiency under nutrient-sufficient conditions is a novel phenotype, we sought here to characterise a subset of the yeast haploproficient genes which seem particularly relevant to human cancers...
  2. ncbi The genetic control of growth rate: a systems biology study in yeast
    Pinar Pir
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    BMC Syst Biol 6:4. 2012
    ..It has not been determined whether the set of HFC genes is the same at all growth rates or whether it is the same in conditions of nutrient limitation or excess...
  3. ncbi Application of the comprehensive set of heterozygous yeast deletion mutants to elucidate the molecular basis of cellular chromium toxicity
    Sara Holland
    School of Biology, Institute of Genetics, The University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Genome Biol 8:R268. 2007
    ..Microarray-based screens of these heterozygotes are truly genome-wide as they include both essential and non-essential genes...
  4. ncbi Further developments towards a genome-scale metabolic model of yeast
    Paul D Dobson
    School of Chemistry, The University of Manchester, Manchester M13 9PL, UK
    BMC Syst Biol 4:145. 2010
    ....
  5. ncbi Data capture in bioinformatics: requirements and experiences with Pedro
    Daniel Jameson
    School of Chemistry, Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK
    BMC Bioinformatics 9:183. 2008
    ....
  6. ncbi Information management for high content live cell imaging
    Daniel Jameson
    Manchester Centre for Integrative Systems Biology, School of Chemistry, and Manchester Interdisciplinary Biocentre, University of Manchester, 131, Princess St, Manchester, M1 7DN, UK
    BMC Bioinformatics 10:226. 2009
    ..There is therefore a requirement for an information management solution that facilitates the indexing of experimental metadata and results of high content live cell imaging experiments...
  7. ncbi Nutrient control of eukaryote cell growth: a systems biology study in yeast
    Alex Gutteridge
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK
    BMC Biol 8:68. 2010
    ....
  8. ncbi The transcription activity of Gis1 is negatively modulated by proteasome-mediated limited proteolysis
    Nianshu Zhang
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 285:6465-76. 2010
    ..Furthermore, we have revealed that the kinase activity of Rim15 is essential for this regulation...
  9. ncbi JmjN interacts with JmjC to ensure selective proteolysis of Gis1 by the proteasome
    Zhenzhen Quan
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Microbiology 157:2694-701. 2011
    ..Together, these data suggest that JmjN and JmjC interact physically to form a structural unit that ensures the stability and appropriate transcription activity of Gis1...
  10. ncbi Yeast systems biology: the challenge of eukaryotic complexity
    Juan I Castrillo
    Department of Biochemistry, Cambridge Systems Biology Centre, University of Cambridge, Cambridge CB21GA, UK
    Methods Mol Biol 759:3-28. 2011
    ..Selected examples of the latest discoveries in eukaryote complexity and systems biology studies using yeast as a reference model and their applications in biotechnology and medicine are presented...
  11. ncbi Integration of metabolic modeling and phenotypic data in evaluation and improvement of ethanol production using respiration-deficient mutants of Saccharomyces cerevisiae
    Duygu Dikicioglu
    Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom
    Appl Environ Microbiol 74:5809-16. 2008
    ....
  12. ncbi Phenomic and transcriptomic analyses reveal that autophagy plays a major role in desiccation tolerance in Saccharomyces cerevisiae
    Sooraj Ratnakumar
    Department of Chemical Engineering and Biotechnology, Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QT, UK
    Mol Biosyst 7:139-49. 2011
    ..Changes in nitrogen metabolism were evident during the drying process and parts of the environmental stress response were activated, repressing ribosome production and inducing genes for coping with oxidative and osmotic stress...
  13. ncbi Haploinsufficiency and the sex chromosomes from yeasts to humans
    Michaela de Clare
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, UK
    BMC Biol 9:15. 2011
    ..Haploinsufficiency is increasingly implicated in human disease, and so predicting this phenotype could provide insights into the genetic mechanisms behind many human diseases, including some cancers...
  14. ncbi A metabolomic and multivariate statistical process to assess the effects of genotoxins in Saccharomyces cerevisiae
    Christopher M Titman
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    Mol Biosyst 5:1913-24. 2009
    ..Finally, predictive models were built for distinguishing the genotoxic carcinogens from the control group according to the metabolic profile of the cell culture media...
  15. ncbi Gis1 is required for transcriptional reprogramming of carbon metabolism and the stress response during transition into stationary phase in yeast
    Nianshu Zhang
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Microbiology 155:1690-8. 2009
    ..In agreement with this, Rim15p is shown to act in parallel with Hog1p to defend cells against osmotic stress...
  16. ncbi Evaluation of predicted network modules in yeast metabolism using NMR-based metabolite profiling
    Jacob G Bundy
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    Genome Res 17:510-9. 2007
    ....