Edward J Okello

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint In vitro anti-beta-secretase and dual anti-cholinesterase activities of Camellia sinensis L. (tea) relevant to treatment of dementia
    Edward J Okello
    School of Biology, Ridley Building, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Phytother Res 18:624-7. 2004
  2. doi request reprint In vitro protective effects of colon-available extract of Camellia sinensis (tea) against hydrogen peroxide and beta-amyloid (Aβ((1-42))) induced cytotoxicity in differentiated PC12 cells
    E J Okello
    School of Agriculture, Food and Rural Development, Newcastle University, Newcastle upon Tyne, United Kingdom
    Phytomedicine 18:691-6. 2011
  3. ncbi request reprint Inhibition of acetylcholinesterase by green and white tea and their simulated intestinal metabolites
    Edward J Okello
    Medicinal Plant Research Group, School of Agriculture, Food and Rural Development, Newcastle University, Newcastle upon Tyne NE1 7RU, United Kingdom
    Food Funct 3:651-61. 2012
  4. doi request reprint Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults
    David O Kennedy
    Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, UK
    J Psychopharmacol 25:1088-100. 2011
  5. ncbi request reprint Butyryl- and acetyl-cholinesterase inhibitory activities in essential oils of Salvia species and their constituents
    Sergey U Savelev
    School of Biology, Medicinal Plants Research Centre, Ridley Building, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Phytother Res 18:315-24. 2004
  6. doi request reprint Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation
    David O Kennedy
    Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, United Kingdom
    Am J Clin Nutr 91:1590-7. 2010
  7. doi request reprint An aqueous extract of Withania somnifera root inhibits amyloid β fibril formation in vitro
    Suresh Kumar
    Faculty of Science, Agriculture and Engineering, School of Agriculture, Food and Rural Development, Newcastle University, Newcastle upon Tyne NE1 7RU, UK
    Phytother Res 26:113-7. 2012
  8. doi request reprint Use of plant-derived products to control arthropods of veterinary importance: a review
    David R George
    School of Agriculture, Food and Rural Development, Newcastle University, Newcastle upon Tyne, United Kingdom
    Ann N Y Acad Sci 1149:23-6. 2008
  9. ncbi request reprint Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery
    David O Kennedy
    Human Cognitive Neuroscience Unit, Division of Psychology, University of Northumbria, Newcastle upon Tyne, UK
    Neuropsychopharmacology 31:845-52. 2006
  10. doi request reprint Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients
    Andrea Tasker
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neurosci Lett 442:297-9. 2008

Detail Information

Publications10

  1. ncbi request reprint In vitro anti-beta-secretase and dual anti-cholinesterase activities of Camellia sinensis L. (tea) relevant to treatment of dementia
    Edward J Okello
    School of Biology, Ridley Building, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Phytother Res 18:624-7. 2004
    ....
  2. doi request reprint In vitro protective effects of colon-available extract of Camellia sinensis (tea) against hydrogen peroxide and beta-amyloid (Aβ((1-42))) induced cytotoxicity in differentiated PC12 cells
    E J Okello
    School of Agriculture, Food and Rural Development, Newcastle University, Newcastle upon Tyne, United Kingdom
    Phytomedicine 18:691-6. 2011
    ..These results demonstrate that potentially bioavailable green tea metabolites are able to ameliorate both H(2)O(2) and Aβ((1-42)) induced cytotoxicity...
  3. ncbi request reprint Inhibition of acetylcholinesterase by green and white tea and their simulated intestinal metabolites
    Edward J Okello
    Medicinal Plant Research Group, School of Agriculture, Food and Rural Development, Newcastle University, Newcastle upon Tyne NE1 7RU, United Kingdom
    Food Funct 3:651-61. 2012
    ..We have also shown the activities of a number of metabolites,however, further research is required to determine their potential bioavailability...
  4. doi request reprint Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults
    David O Kennedy
    Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, UK
    J Psychopharmacol 25:1088-100. 2011
    ....
  5. ncbi request reprint Butyryl- and acetyl-cholinesterase inhibitory activities in essential oils of Salvia species and their constituents
    Sergey U Savelev
    School of Biology, Medicinal Plants Research Centre, Ridley Building, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Phytother Res 18:315-24. 2004
    ..Analyses of the chemical composition of the oils and anti-butyrylcholinesterase activity of their constituents revealed that none of the compounds tested would account for the total activity of the oils and that synergy is likely...
  6. doi request reprint Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation
    David O Kennedy
    Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, United Kingdom
    Am J Clin Nutr 91:1590-7. 2010
    ..Resveratrol may therefore modulate aspects of brain function in humans...
  7. doi request reprint An aqueous extract of Withania somnifera root inhibits amyloid β fibril formation in vitro
    Suresh Kumar
    Faculty of Science, Agriculture and Engineering, School of Agriculture, Food and Rural Development, Newcastle University, Newcastle upon Tyne NE1 7RU, UK
    Phytother Res 26:113-7. 2012
    ..These results suggest that the aqueous extract of W. somnifera root has an ability to inhibit the formation of mature amyloid-β fibrils in vitro, which are known to lead to amyloid plaque formation in vivo...
  8. doi request reprint Use of plant-derived products to control arthropods of veterinary importance: a review
    David R George
    School of Agriculture, Food and Rural Development, Newcastle University, Newcastle upon Tyne, United Kingdom
    Ann N Y Acad Sci 1149:23-6. 2008
    ..This review highlights instances in which such products have been used with success against pests of domestic animals, livestock, apiculture, and poultry...
  9. ncbi request reprint Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery
    David O Kennedy
    Human Cognitive Neuroscience Unit, Division of Psychology, University of Northumbria, Newcastle upon Tyne, UK
    Neuropsychopharmacology 31:845-52. 2006
    ..The results confirm previous observations of the cholinesterase inhibiting properties of S. officinalis, and improved mood and cognitive performance following the administration of single doses to healthy young participants...
  10. doi request reprint Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients
    Andrea Tasker
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neurosci Lett 442:297-9. 2008
    ..Linear regression analysis, controlling for gender, diagnosis, age at death and study centre, showed that the number of BCHE-K alleles was associated with increasing BuChE activity (p=0.009)...