G S Ogg

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Longitudinal phenotypic analysis of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes: correlation with disease progression
    G S Ogg
    MRC Human Immunology Unit, Institute of Molecular Medicine, Oxford OX3 9DS, United Kingdom
    J Virol 73:9153-60. 1999
  2. ncbi request reprint Quantitation of antigen-specific CD8+ T-cell responses
    G S Ogg
    Molecular Immunology, Institute of Molecular Medicine, Oxford, UK
    Immunol Lett 66:77-80. 1999
  3. ncbi request reprint HLA-peptide tetrameric complexes
    G S Ogg
    Institute of Molecular Medicine, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK
    Curr Opin Immunol 10:393-6. 1998
  4. doi request reprint Identification of an immunodominant region of Fel d 1 and characterization of constituent epitopes
    E A L Bateman
    MRC Human Immunology Unit, Oxford NIHR Biomedical Research Centre, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Clin Exp Allergy 38:1760-8. 2008
  5. ncbi request reprint Direct isolation, phenotyping and cloning of low-frequency antigen-specific cytotoxic T lymphocytes from peripheral blood
    P R Dunbar
    Molecular Immunology Group, Institute of Molecular Medicine, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital Oxford, OX3 9DS, UK
    Curr Biol 8:413-6. 1998
  6. ncbi request reprint The role of skin-homing T cells in extrinsic atopic dermatitis
    S L Seneviratne
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, and Department of Dermatology, Churchill Hospital, Oxford OX3 9DS
    QJM 100:19-27. 2007
  7. ncbi request reprint Cutting edge: rapid cloning of tumor-specific CTL suitable for adoptive immunotherapy of melanoma
    P R Dunbar
    Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 162:6959-62. 1999
  8. pmc Varicella zoster virus glycoprotein E-specific CD4+ T cells show evidence of recent activation and effector differentiation, consistent with frequent exposure to replicative cycle antigens in healthy immune donors
    G N Malavige
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    Clin Exp Immunol 152:522-31. 2008
  9. ncbi request reprint Severe atopic dermatitis is associated with a reduced frequency of IL-10 producing allergen-specific CD4+ T cells
    S L Seneviratne
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Clin Exp Dermatol 31:689-94. 2006
  10. doi request reprint Human antimicrobial peptides LL-37 and human β-defensin-2 reduce viral replication in keratinocytes infected with varicella zoster virus
    L R Crack
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford and NIHR Research Centre, Oxford, Oxfordshire, UK
    Clin Exp Dermatol 37:534-43. 2012

Collaborators

Detail Information

Publications35

  1. pmc Longitudinal phenotypic analysis of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes: correlation with disease progression
    G S Ogg
    MRC Human Immunology Unit, Institute of Molecular Medicine, Oxford OX3 9DS, United Kingdom
    J Virol 73:9153-60. 1999
    ..Overall, these data support a role of HIV-specific CTL in the control of disease progression and suggest that the ultimate loss of such CTL may be preferentially from the CD27(+) CD45RO(+) subset...
  2. ncbi request reprint Quantitation of antigen-specific CD8+ T-cell responses
    G S Ogg
    Molecular Immunology, Institute of Molecular Medicine, Oxford, UK
    Immunol Lett 66:77-80. 1999
    ....
  3. ncbi request reprint HLA-peptide tetrameric complexes
    G S Ogg
    Institute of Molecular Medicine, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK
    Curr Opin Immunol 10:393-6. 1998
    ..Quantitation, phenotypic analysis and isolation of tetramer-binding cells has considerably extended our understanding of cytotoxic T lymphocyte and natural killer cell function...
  4. doi request reprint Identification of an immunodominant region of Fel d 1 and characterization of constituent epitopes
    E A L Bateman
    MRC Human Immunology Unit, Oxford NIHR Biomedical Research Centre, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Clin Exp Allergy 38:1760-8. 2008
    ..One important requirement is the identification and use of peptides that will bind to HLA molecules covering a large proportion of the population...
  5. ncbi request reprint Direct isolation, phenotyping and cloning of low-frequency antigen-specific cytotoxic T lymphocytes from peripheral blood
    P R Dunbar
    Molecular Immunology Group, Institute of Molecular Medicine, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital Oxford, OX3 9DS, UK
    Curr Biol 8:413-6. 1998
    ....
  6. ncbi request reprint The role of skin-homing T cells in extrinsic atopic dermatitis
    S L Seneviratne
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, and Department of Dermatology, Churchill Hospital, Oxford OX3 9DS
    QJM 100:19-27. 2007
    ..T cells that express Cutaneous Lymphocyte-Associated antigen (CLA) have the potential of migrating to the skin, and are hypothesized to play a role in cutaneous atopic disease...
  7. ncbi request reprint Cutting edge: rapid cloning of tumor-specific CTL suitable for adoptive immunotherapy of melanoma
    P R Dunbar
    Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 162:6959-62. 1999
    ..We show that these CTL clones express markers compatible with immunotherapeutic use in melanoma, including the cutaneous lymphocyte Ag, which is associated with homing to skin...
  8. pmc Varicella zoster virus glycoprotein E-specific CD4+ T cells show evidence of recent activation and effector differentiation, consistent with frequent exposure to replicative cycle antigens in healthy immune donors
    G N Malavige
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    Clin Exp Immunol 152:522-31. 2008
    ..These data would be compatible with frequent exposure to replicative cycle antigens in healthy donors and are consistent with a role for gE-specific CD4+ T cells in the control of viral replication...
  9. ncbi request reprint Severe atopic dermatitis is associated with a reduced frequency of IL-10 producing allergen-specific CD4+ T cells
    S L Seneviratne
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Clin Exp Dermatol 31:689-94. 2006
    ..Several studies have investigated levels of T-cell-derived interleukin (IL)-10 in individuals with atopic dermatitis, with conflicting results...
  10. doi request reprint Human antimicrobial peptides LL-37 and human β-defensin-2 reduce viral replication in keratinocytes infected with varicella zoster virus
    L R Crack
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford and NIHR Research Centre, Oxford, Oxfordshire, UK
    Clin Exp Dermatol 37:534-43. 2012
    ..There are several families of antimicrobial peptides, including cathelicidins and human β-defensins. Patients with AE are more susceptible to severe cutaneous viral infections, including varicella zoster virus (VZV)...
  11. pmc Sensitization of tumour cells to lysis by virus-specific CTL using antibody-targeted MHC class I/peptide complexes
    G S Ogg
    MRC Human Immunology Unit, Institute of Molecular Medicine, Oxford, UK
    Br J Cancer 82:1058-62. 2000
    ..28s. With further consideration to the in vivo stability of the MHC class I/peptide complexes, this system could prove a new strategy for the immunological therapy of cancer...
  12. ncbi request reprint p53-specific CD8+ T-cell responses in individuals with cutaneous squamous cell carcinoma
    A P Black
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Br J Dermatol 153:987-91. 2005
    ..Despite considerable evidence that the immune response is important in the control of cutaneous SCC, there are no studies documenting potential tumour-associated antigens...
  13. doi request reprint Tracking epitope-specific antiviral CD4+ T cell responses to a live attenuated vaccine reveals ongoing functional responses
    L Jones
    MRC Human Immunology Unit, University of Oxford, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
    Vaccine 27:7398-401. 2009
    ....
  14. doi request reprint Cytokine regulation of the epidermal barrier
    D Gutowska-Owsiak
    MRC Human Immunology Unit, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Clin Exp Allergy 43:586-98. 2013
    ..In this review, we aimed to summarize the known influences of cytokines abundantly expressed during atopic skin disease on components of epidermal barrier integrity and function...
  15. doi request reprint Phenotypic analysis of perennial airborne allergen-specific CD4+ T cells in atopic and non-atopic individuals
    L R Crack
    MRC Human Immunology Unit, University of Oxford, Weatherall Institute of Molecular Medicine, Oxford, UK
    Clin Exp Allergy 41:1555-67. 2011
    ....
  16. doi request reprint Identification of an immunodominant region of the major house dust mite allergen Der p 2 presented by common human leucocyte antigen alleles
    L R Crack
    MRC Human Immunology Unit, University of Oxford, Weatherall Institute of Molecular Medicine, Oxford, UK
    Clin Exp Dermatol 37:266-76. 2012
    ..Better understanding of the relevance of the immune response to common environmental allergens, such as the major house dust mite (HDM) allergen Der p 2, requires characterization of constituent T-cell epitopes...
  17. pmc Comparison between HIV- and CMV-specific T cell responses in long-term HIV infected donors
    L Papagno
    MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Clin Exp Immunol 130:509-17. 2002
    ..These data raise questions with regard to the role played by CD8+ T cells in the establishment and maintenance of long-term non-progression...
  18. doi request reprint Immune evasion during varicella zoster virus infection of keratinocytes
    A P Black
    MRC Human Immunology Unit, Oxford NIHR Biomedical Research Centre, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Clin Exp Dermatol 34:e941-4. 2009
    ..Interference with IFN-alpha, TNF-alpha, IFN-gamma and TLR-3 signalling in keratinocytes by VZV may contribute to immune evasion of the adaptive immune response...
  19. ncbi request reprint Immunogenicities of intravenous and intramuscular administrations of modified vaccinia virus Ankara-based multi-CTL epitope vaccine for human immunodeficiency virus type 1 in mice
    T Hanke
    Molecular Immunology Group, Institute of Molecular Medicine, University of Oxford, The John Radcliffe, UK
    J Gen Virol 79:83-90. 1998
    ..Also, the correct processing and presentation of some HLA-restricted epitopes in human cells was confirmed...
  20. pmc Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific
    J D Wilson
    Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
    J Exp Med 188:785-90. 1998
    ....
  21. ncbi request reprint HLA analysis of Sri Lankan Sinhalese predicts North Indian origin
    G N Malavige
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    Int J Immunogenet 34:313-5. 2007
    ..Taken with low-resolution typing for the remaining A, B, C, DR and DQ alleles, these data suggest a North Indian origin for the Sri Lankan Sinhalese...
  22. ncbi request reprint Detection of antigen-specific cytotoxic T lymphocytes: significance for investigative dermatology
    G S Ogg
    MRC Human Immunology Unit, Institute of Molecular Medicine, Oxford, UK
    Clin Exp Dermatol 25:312-6. 2000
    ..Recently the technique has also been applied to the study of cutaneous disease and provides insights into mechanisms of dermatopathology...
  23. doi request reprint Histamine enhances keratinocyte-mediated resolution of inflammation by promoting wound healing and response to infection
    D Gutowska-Owsiak
    MRC Human Immunology Unit, NIHR Biomedical Research Centre, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Clin Exp Dermatol 39:187-95. 2014
    ..While multiple cytokines are implicated in keratinocyte-mediated infection clearance and wound healing, little is known about the involvement of keratinocytes in promoting resolution of inflammation...
  24. doi request reprint Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes
    D Gutowska-Owsiak
    MRC Human Immunology Unit, University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Br J Dermatol 165:492-8. 2011
    ..Interleukin (IL)-22 is upregulated in lesional AE tissue, but its effects on filaggrin expression and genes associated with epidermal function have not yet been comprehensively addressed...
  25. doi request reprint Anti-lymphocyte function associated antigen-1 inhibits T-helper 2 function of human allergen-specific CD4+ T cells
    M R Ardern-Jones
    MRC Human Immunology Unit, University of Oxford, Weatherall Institute of Molecular Medicine, Oxford, OX3 9DS, UK
    Br J Dermatol 158:456-62. 2008
    ....
  26. ncbi request reprint Detection of HLA-specific IGG antibodies using single recombinant HLA alleles: the MonoLISA assay
    M C Barnardo
    Transplant Immunology, Oxford Transplant Centre and Nuffield Dept of Surgery, Churchill Hospital, Oxford, UK
    Transplantation 70:531-6. 2000
    ..We describe a new ELISA method, monoLISA, for detection of immunoglobulin (Ig)G HLA antibody using single recombinant HLA class I monomers bound to microtiter plates...
  27. pmc Interleukin-4 induced down-regulation of skin homing receptor expression by human viral-specific CD8 T cells may contribute to atopic risk of cutaneous infection
    S L Seneviratne
    Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    Clin Exp Immunol 141:107-15. 2005
    ..Furthermore, the ability to modify the local and systemic microenvironment may offer novel therapeutic strategies that influence tissue-specific T cell homing...
  28. doi request reprint Common filaggrin null alleles are not associated with hymenoptera venom allergy in Europeans
    A Aslam
    MRC Human Immunology Unit, University of Oxford, Oxford NIHR Biomedical Research Centre, Weatherall Institute of Molecular Medicine, Oxford, UK
    Int Arch Allergy Immunol 154:353-5. 2011
    ....
  29. ncbi request reprint Skewed maturation of memory HIV-specific CD8 T lymphocytes
    P Champagne
    Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland
    Nature 410:106-11. 2001
    ..These results demonstrate a skewed maturation of HIV-specific memory CD8+ T cells during HIV infection...
  30. ncbi request reprint Direct measurement of CD4+ and CD8+ T-cell responses to CMV in HIV-1-infected subjects
    K V Komanduri
    Gladstone Institute of Virology and Immunology, San Francisco, California 94141-9100, USA
    Virology 279:459-70. 2001
    ..These declines may precede the onset of CMV-associated end organ disease...
  31. pmc Cytotoxic T-cell abundance and virus load in human immunodeficiency virus type 1 and human T-cell leukaemia virus type 1
    D Wodarz
    Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540, USA
    Proc Biol Sci 268:1215-21. 2001
    ..Virus-mediated impairment of specific CTL production in HIV-1 infection can account for the negative correlation observed...
  32. ncbi request reprint Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules
    M Colonna
    Basel Institute for Immunology, Switzerland
    J Immunol 160:3096-100. 1998
    ..ILT4 may control inflammatory responses and cytotoxicity mediated by myelomonocytic cells and may modulate their Ag-presenting functions, focusing immune responses to microbial challenges and avoiding autoreactivity...
  33. ncbi request reprint HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
    V M Braud
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nature 391:795-9. 1998
    ....
  34. ncbi request reprint Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy
    C Boni
    Laboratorio di Immunopatologia Virale, Divisione Malattie Infettive, Azienda Ospedaliera di Parma, and Cattedra di Malattie Infettive, , Italy
    Hepatology 33:963-71. 2001
    ..This effect may enhance the probability that T cell-based immune therapies delivered after lamivudine treatment can successfully reconstitute a protective CTL response able to cure chronic HBV infection...
  35. ncbi request reprint Rapid effector function of circulating NC16A-specific T cells in individuals with mucous membrane pemphigoid
    A P B Black
    Immunology Group, Weatherall Institute of Molecular Medicine, Oxford OX3 9DS, U K
    Br J Dermatol 151:1160-4. 2004
    ....