John T O'Brien

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects
    John T O'Brien
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, U K
    Am J Psychiatry 161:2081-90. 2004
  2. ncbi Vascular cognitive impairment
    John T O'Brien
    Institute for Aging and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 2:89-98. 2003
  3. doi Nicotinic 123I-5IA-85380 single photon emission computed tomography as a predictor of cognitive progression in Alzheimer's disease and dementia with Lewy bodies
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    Am J Geriatr Psychiatry 18:86-90. 2010
  4. ncbi Atrophy is associated with posterior cingulate white matter disruption in dementia with Lewy bodies and Alzheimer's disease
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Neuroimage 36:1-7. 2007
  5. ncbi A comparison of (99m)Tc-HMPAO SPET changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping
    Sean J Colloby
    Wolfson Research Centre, The Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Eur J Nucl Med Mol Imaging 29:615-22. 2002
  6. doi Plasma homocysteine and cognitive decline in older hypertensive subjects
    Sunil K Narayan
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Int Psychogeriatr 23:1607-15. 2011
  7. doi A comparison of 99mTc-exametazime and 123I-FP-CIT SPECT imaging in the differential diagnosis of Alzheimer's disease and dementia with Lewy bodies
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Int Psychogeriatr 20:1124-40. 2008
  8. ncbi White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study
    John T O'Brien
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 14:834-41. 2006
  9. doi NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors
    Christopher M Morris
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Neurobiol Aging 32:554.e1-6. 2011
  10. ncbi White matter hyperintensities and depression--preliminary results from the LADIS study
    Michael J Firbank
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 20:674-9. 2005

Detail Information

Publications106 found, 100 shown here

  1. ncbi A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects
    John T O'Brien
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, U K
    Am J Psychiatry 161:2081-90. 2004
    ..This study determined whether cognitive impairments and structural brain changes in older depressed subjects, especially in the hippocampus, are related to hypercortisolemia...
  2. ncbi Vascular cognitive impairment
    John T O'Brien
    Institute for Aging and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 2:89-98. 2003
    ..Clinical trials in vascular cognitive impairment are in their infancy but support the value of therapeutic interventions for symptomatic treatment...
  3. doi Nicotinic 123I-5IA-85380 single photon emission computed tomography as a predictor of cognitive progression in Alzheimer's disease and dementia with Lewy bodies
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    Am J Geriatr Psychiatry 18:86-90. 2010
    ....
  4. ncbi Atrophy is associated with posterior cingulate white matter disruption in dementia with Lewy bodies and Alzheimer's disease
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Neuroimage 36:1-7. 2007
    ..Future studies are needed to determine whether the disruption precedes or is consequent on atrophy or hypometabolism...
  5. ncbi A comparison of (99m)Tc-HMPAO SPET changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping
    Sean J Colloby
    Wolfson Research Centre, The Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Eur J Nucl Med Mol Imaging 29:615-22. 2002
    ..In conclusion, we found evidence of frontal and parietal hypoperfusion in both AD and DLB, while temporal perfusion deficits were observed exclusively in AD and parieto-occipital deficits in DLB...
  6. doi Plasma homocysteine and cognitive decline in older hypertensive subjects
    Sunil K Narayan
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Int Psychogeriatr 23:1607-15. 2011
    ..We examined the relationship between plasma homocysteine and cognitive decline in an older hypertensive population...
  7. doi A comparison of 99mTc-exametazime and 123I-FP-CIT SPECT imaging in the differential diagnosis of Alzheimer's disease and dementia with Lewy bodies
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Int Psychogeriatr 20:1124-40. 2008
    ....
  8. ncbi White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study
    John T O'Brien
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 14:834-41. 2006
    ..This study investigates the relationship between location and burden of WMH and lacunes on depressive features in older people...
  9. doi NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors
    Christopher M Morris
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Neurobiol Aging 32:554.e1-6. 2011
    ..001). We hypothesize that this may be mediated by reduction of nitric oxide production and cerebral perfusion. Our findings, if replicated widely, have implications for treatments to ameliorate cognitive decline in stroke survivors...
  10. ncbi White matter hyperintensities and depression--preliminary results from the LADIS study
    Michael J Firbank
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 20:674-9. 2005
    ..White matter hyperintensities have been associated with the development of depression in older subjects, though the details of this relationship are not fully understood...
  11. ncbi Progression of white matter hyperintensities in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia: a comparison with normal aging
    Emma J Burton
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 14:842-9. 2006
    ..The objective of this study was to investigate cross-sectional and longitudinal white matter hyperintensity (WMH) changes in older subjects with clinically diagnosed dementia...
  12. ncbi Dementia with Lewy bodies
    Ian G McKeith
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
    Semin Clin Neuropsychiatry 8:46-57. 2003
    ..Dementia developing late in the course of PD shares many of the same clinical and pathological characteristics...
  13. ncbi Extrapyramidal features in Parkinson's disease with and without dementia and dementia with Lewy bodies: A cross-sectional comparative study
    David J Burn
    Department of Neurology, Regional Neurosciences Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Mov Disord 18:884-9. 2003
    ..Neurodegeneration within the cholinergic system is likely to mediate many of these motor problems, as well as playing a significant role in determining the neuropsychiatric symptomatology of both PDD and DLB...
  14. doi Does posterior cortical atrophy on MRI discriminate between Alzheimer's disease, dementia with Lewy bodies, and normal aging?
    James O'Donovan
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Int Psychogeriatr 25:111-9. 2013
    ..Therefore, we assessed whether visual rating scales for assessing posterior atrophy (PA), medial temporal lobe atrophy (MTA), and ventricular enlargement (VEn) aid in the discrimination between AD, DLB, and normal aging...
  15. pmc Characterizing dementia with Lewy bodies by means of diffusion tensor imaging
    Rosie Watson
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
    Neurology 79:906-14. 2012
    ..To investigate patterns of in vivo white matter tract change using diffusion tensor imaging (DTI), we conducted a cross-sectional study of dementia with Lewy bodies (DLB) in comparison with Alzheimer disease (AD) and normal aging...
  16. pmc Visual cortex in dementia with Lewy bodies: magnetic resonance imaging study
    John Paul Taylor
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, UK
    Br J Psychiatry 200:491-8. 2012
    ..Visual hallucinations and visuoperceptual deficits are common in dementia with Lewy bodies, suggesting that cortical visual function may be abnormal...
  17. doi Hippocampal neuronal atrophy and cognitive function in delayed poststroke and aging-related dementias
    Elizabeth Gemmell
    Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Stroke 43:808-14. 2012
    ..We have previously shown delayed poststroke dementia in elderly (≥75 years old) stroke survivors is associated with medial temporal lobe atrophy; however, the basis of the structural and functional changes is unknown...
  18. ncbi Brain atrophy and white matter hyperintensity change in older adults and relationship to blood pressure. Brain atrophy, WMH change and blood pressure
    Michael J Firbank
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol 254:713-21. 2007
    ..These changes are independent. Successful hypertension treatment was associated with reduced risk of WMH progression and possibly brain atrophy...
  19. doi Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Br J Psychiatry 199:404-10. 2011
    ..There is strong evidence linking vascular disease to WMH, but limited evidence on its association with subcortical volumes...
  20. pmc Visual hallucinations in dementia with Lewy bodies: transcranial magnetic stimulation study
    John Paul Taylor
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Br J Psychiatry 199:492-500. 2011
    ..The aetiology of visual hallucinations is poorly understood in dementia with Lewy bodies. Pathological alterations in visual cortical excitability may be one contributory mechanism...
  21. doi Covariance 99mTc-exametazime SPECT patterns in Alzheimer's disease and dementia with Lewy bodies: utility in differential diagnosis
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    J Geriatr Psychiatry Neurol 23:54-62. 2010
    ..Principal component analysis captures additional sources of variance and if perfusion SPECT is the only scan available, this procedure may offer extra information...
  22. doi Nicotinic alpha4beta2 receptor binding in dementia with Lewy bodies using 123I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinations
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 40:1056-63. 2008
    ....
  23. ncbi Progression of dopaminergic degeneration in dementia with Lewy bodies and Parkinson's disease with and without dementia assessed using 123I-FP-CIT SPECT
    Sean J Colloby
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle University, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Eur J Nucl Med Mol Imaging 32:1176-85. 2005
    ....
  24. ncbi Change in perfusion, hallucinations and fluctuations in consciousness in dementia with Lewy bodies
    John T O'Brien
    Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Psychiatry Res 139:79-88. 2005
    ..We have identified important neural correlates of key clinical features in Lewy body dementia and postulate that the associations can be understood through the influence of the cholinergic system on attention...
  25. pmc Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors
    Louise M Allan
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    Brain 134:3716-27. 2011
    ..Careful monitoring and treatment of modifiable vascular risk factors may be of benefit in preventing post-stroke dementia in the general population...
  26. ncbi Validation of a fully automated hippocampal segmentation method on patients with dementia
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Westgate Road, Newcastle upon Tyne NE4 6BE, United Kingdom
    Hum Brain Mapp 29:1442-9. 2008
    ..Linear regression between manual and automated volume gave V(auto) = V(manual) x 0.83 + 401 ml. The method provides an acceptable automated alternative to manual segmentation which may be of value in large studies...
  27. ncbi Cortical thickness and VBM-DARTEL in late-life depression
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    J Affect Disord 133:158-64. 2011
    ..The objective was to investigate GM changes in older depressed and similar aged healthy subjects using two different methods, cortical thickness in frontal lobe structures and voxel-based morphometry (VBM)...
  28. doi Subcortical connectivity in dementia with Lewy bodies and Alzheimer's disease
    Eva R Kenny
    Newcastle Magnetic Resonance Centre and Institute for Ageing and Health, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
    Br J Psychiatry 203:209-14. 2013
    ....
  29. ncbi Post-stroke dementia: the contribution of thalamus and basal ganglia changes
    Marcos Antônio Lopes
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Int Psychogeriatr 24:568-76. 2012
    ..This study aimed to investigate the contribution of changes in subcortical gray matter structures to post-stroke dementia (PSD)...
  30. doi Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Br J Psychiatry 201:40-5. 2012
    ..Brain white matter changes (WMC) and depressive symptoms are linked, but the directionality of this association remains unclear...
  31. pmc Multivariate spatial covariance analysis of 99mTc-exametazime SPECT images in dementia with Lewy bodies and Alzheimer's disease: utility in differential diagnosis
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    J Cereb Blood Flow Metab 33:612-8. 2013
    ..86, sensitivity 80%, specificity 80%). Multivariate analysis of blood flow SPECT data appears to be robust and shows good diagnostic accuracy in two independent cohorts for distinguishing DLB from AD...
  32. ncbi Cholinesterase inhibitors in advanced Dementia with Lewy bodies: increase or stop?
    Sanjeet Pakrasi
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 21:719-21. 2006
    ..There is little data on stopping cholinesterase inhibitors in Dementia with Lewy bodies (DLB). Equally, it is not known if increasing the dose of cholinesterase inhibitors may help neuropsychiatric symptoms in advanced DLB...
  33. pmc Neuroimaging predictors of death and dementia in a cohort of older stroke survivors
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 83:263-7. 2012
    ..Stroke is a risk factor for subsequent death and dementia. Being able to identify subjects at particular risk would be beneficial to inform treatment and patient management...
  34. ncbi High resolution imaging of the medial temporal lobe in Alzheimer's disease and dementia with Lewy bodies
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Newcastle, UK
    J Alzheimers Dis 21:1129-40. 2010
    ..Future studies should investigate whether subiculum thickness or the hypointense line could be a diagnostic feature to help discriminate AD from DLB...
  35. doi Elevated plasma homocysteine is associated with increased brain atrophy rates in older subjects with mild hypertension
    Sunil K Narayan
    Institute for Ageing and Health, Newcastle University, UK
    Dement Geriatr Cogn Disord 31:341-8. 2011
    ..01, p = 0.29). New SBIs were uncommon. In older hypertensive individuals, plasma homocysteine levels are associated with increased rates of whole-brain atrophy but not WML progression...
  36. doi A study of orthostatic hypotension in late-life depression
    Jonathan Richardson
    Institute for Ageing and Health, Newcastle University, England, UK
    Am J Geriatr Psychiatry 17:996-9. 2009
    ..Studies examining vascular risk factors in depression report conflicting evidence but have not assessed orthostatic hypotension, a recently recognized risk factor for white matter hyperintensities...
  37. pmc Cholinesterase inhibitor use does not significantly influence the ability of 123I-FP-CIT imaging to distinguish Alzheimer's disease from dementia with Lewy bodies
    John Paul Taylor
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 78:1069-71. 2007
    ..As ChEi are frequently used in people with dementia, it is important to determine whether their use affects 123I-FP-CIT uptake in the striatum...
  38. doi Diffusion tensor imaging in Alzheimer's disease and dementia with Lewy bodies
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Psychiatry Res 194:176-83. 2011
    ....
  39. ncbi In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) 123I-QNB in dementia with Lewy bodies and Parkinson's disease dementia
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 33:423-9. 2006
    ..123I-QNB binding was also compared to the corresponding cerebral perfusion changes in the same subjects...
  40. doi White matter hyperintensities, cortisol levels, brain atrophy and continuing cognitive deficits in late-life depression
    Sebastian Kohler
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Br J Psychiatry 196:143-9. 2010
    ..Cerebrovascular changes and glucocorticoid mediated hippocampal atrophy are considered relevant for depression-related cognitive deficits, forming putative treatment targets...
  41. ncbi Medial temporal atrophy rather than white matter hyperintensities predict cognitive decline in stroke survivors
    Michael J Firbank
    Institute for Ageing and Health, University of Newcastle, Wolfson Research Centre, Newcastle upon Tyne NE4 6BE, UK
    Neurobiol Aging 28:1664-9. 2007
    ..The association of MTA but not WMH with subsequent cognitive decline and increasing brain atrophy suggests a greater role for Alzheimer type than vascular pathology in delayed cognitive impairment after stroke...
  42. ncbi Distinct cognitive phenotypes in Alzheimer's disease in older people
    Emma R L C Vardy
    Department of Older Peoples Medicine, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, High Heaton, Newcastle upon Tyne, UK
    Int Psychogeriatr 25:1659-66. 2013
    ..It is increasingly recognized that the cognitive profile may be heterogeneous. We hypothesized that it would be possible to define distinct “cognitive phenotypes” in older people with AD...
  43. ncbi Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression
    Michelle Hendricksen
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Am J Psychiatry 161:1096-102. 2004
    ....
  44. doi Intensive blood pressure lowering increases cerebral blood flow in older subjects with hypertension
    Dinesh Tryambake
    Institute for Ageing and Health, Newcastle University, Stroke Research Group, Level 6, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Hypertension 61:1309-15. 2013
    ..These findings suggest hypertension in older people shifts the autoregulatory CBF curve rightward and downward and is reversible with BP lowering...
  45. doi Increase in platelet immunoglobulin in Alzheimer's disease is normalised following cholinesterase inhibitor treatment: preliminary results
    Elizabeta B Mukaetova-Ladinska
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle, UK
    J Alzheimers Dis 32:431-6. 2012
    ....
  46. doi Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance study
    Sean J Colloby
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Br J Psychiatry 200:150-5. 2012
    ..A limited number of studies have demonstrated changes in cerebral blood flow (CBF) in older individuals with depression, but there are considerable inconsistencies between studies...
  47. doi White matter changes in late-life depression: a diffusion tensor imaging study
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    J Affect Disord 135:216-20. 2011
    ..The objective was to investigate the integrity of white matter tracts in subjects with LLD compared to similar aged healthy individuals using diffusion tensor imaging (DTI)...
  48. doi Functional connectivity in late-life depression using resting-state functional magnetic resonance imaging
    Eva R Kenny
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 18:643-51. 2010
    ..To investigate whether there are differences in brain connectivity in late-life depression (LLD) and nondepressed subjects using the left and right heads of caudate nuclei (hCN) as the seed regions...
  49. ncbi Subjective memory complaints, white-matter lesions, depressive symptoms, and cognition in elderly patients
    Thais S C Minett
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
    Am J Geriatr Psychiatry 13:665-71. 2005
    ..The authors sought to determine whether SMCs are related to WML, independently of the presence of depressive symptoms, which are known to be associated with both. The relationship between SMC and cognition was also examined...
  50. ncbi Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imaging
    Emma J Burton
    Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Mov Disord 20:1571-6. 2005
    ..Serial MRI may be a useful tool for monitoring disease progression in PDD and further studies should investigate its utility for early diagnosis...
  51. ncbi Diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Westgate Road, Newcastle upon Tyne, UK
    Psychiatry Res 155:135-45. 2007
    ..We conclude that there are subtle changes visible with diffusion imaging in DLB and AD which may reflect disrupted connectivity and underlie observed perfusion changes in these disorders...
  52. ncbi Clinical practice with anti-dementia drugs: a revised (second) consensus statement from the British Association for Psychopharmacology
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    J Psychopharmacol 25:997-1019. 2011
    ..Although results of pivotal studies are awaited, results to date have been equivocal and no disease-modifying agents are either licensed or can be currently recommended for clinical use...
  53. ncbi More severe functional impairment in dementia with lewy bodies than Alzheimer disease is related to extrapyramidal motor dysfunction
    Ian G McKeith
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 14:582-8. 2006
    ..The objective of this study was to compare functional impairments in dementia with Lewy bodies (DLB) and Alzheimer disease (AD) and their relationship with motor and neuropsychiatric symptoms...
  54. doi Platelet immunoglobulin and amyloid precursor protein as potential peripheral biomarkers for Alzheimer's disease: findings from a pilot study
    Elizabeta B Mukaetova-Ladinska
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle, UK
    Age Ageing 41:408-12. 2012
    ..Since cerebrospinal fluid analysis and molecular neuroimaging are not routinely used in many countries, blood biomarker molecules may be more readily applicable in a routine clinical setting...
  55. pmc Functional connectivity in cortical regions in dementia with Lewy bodies and Alzheimer's disease
    Eva R Kenny
    Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Brain 135:569-81. 2012
    ..This implicates areas beyond visual sensory input level in the visual symptoms and visual-perceptual dysfunction seen in dementia with Lewy bodies...
  56. doi Homocysteine is associated with hippocampal and white matter atrophy in older subjects with mild hypertension
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Int Psychogeriatr 22:804-11. 2010
    ..Plasma homocysteine has been associated with reduced brain volumes in cross-sectional studies. We aimed to investigate if homocysteine is associated with ongoing atrophy, and if so, if this is localized to gray or white matter...
  57. ncbi The application of statistical parametric mapping to 123I-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 23:956-66. 2004
    ....
  58. ncbi Patterns of gray matter atrophy in dementia with Lewy bodies: a voxel-based morphometry study
    Rosie Watson
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle University, Newcastle upon Tyne, UK
    Int Psychogeriatr 24:532-40. 2012
    ..We aimed to compare the patterns of gray matter atrophy in DLB with those in Alzheimer's disease (AD) and normal aging, and to investigate the relationship between atrophy and cognitive measures...
  59. doi Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementia
    Emma J Burton
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Neurobiol Aging 33:1228-36. 2012
    ....
  60. ncbi Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies
    Urs P Mosimann
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Brain 128:1267-76. 2005
    ..The similarities in saccade performance in PDD and DLB underline the overlap between these conditions and underscore differences from Alzheimer's disease and Parkinson's disease...
  61. doi Development of a novel FMRI compatible visual perception prototype battery to test older people with and without dementia
    Joshua S Wood
    Institute for Cellular Medicine, Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
    J Geriatr Psychiatry Neurol 24:73-83. 2011
    ..We aimed to develop, pilot, and test a novel visuocognitive prototype test battery which addressed these issues, suitable for both clinical and functional imaging use...
  62. ncbi A volumetric study of MRI signal hyperintensities in late-life depression
    Michael J Firbank
    Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK NE4 6BE
    Am J Geriatr Psychiatry 12:606-12. 2004
    ..The authors investigated whether the regional location varied between depressed and normal subjects and determined the relationship of magnetic resonance (MR) signal hyperintensities to known clinical risk factors for vascular disease...
  63. doi Magnetic resonance imaging in lewy body dementias
    Rosie Watson
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, UK
    Dement Geriatr Cogn Disord 28:493-506. 2009
    ....
  64. ncbi Characteristics of visual hallucinations in Parkinson disease dementia and dementia with lewy bodies
    Urs P Mosimann
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Am J Geriatr Psychiatry 14:153-60. 2006
    ..Recurrent visual hallucinations (RVH) are common in both disorders. The authors have compared details of hallucination characteristics and associated neuropsychiatric features in DLB and PDD...
  65. doi Levodopa use and sleep in patients with dementia with Lewy bodies
    Sophie Molloy
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
    Mov Disord 24:609-12. 2009
    ..Levodopa treatment did not affect sleep or lead to increased EDS in DLB patients. The use of levodopa does not appear to adversely affect subjective sleep measures or increase EDS in DLB patients...
  66. ncbi Vascular cognitive impairment
    John T O'Brien
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 14:724-33. 2006
    ..It begins with a discussion on the historical background, which is important to understand the different and somewhat confusing terminology that currently exists in the field...
  67. ncbi Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study
    Mani S Krishnan
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 21:983-9. 2006
    ..However, it remains controversial as to whether PVL, DWML, or both are most strongly associated with depression and this was the aim of the current study...
  68. pmc The spectrum of nonmotor symptoms in early Parkinson disease
    Tien K Khoo
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Neurology 80:276-81. 2013
    ..Our aim was to determine the frequency of NMS in a cohort of patients with newly diagnosed PD...
  69. ncbi Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementias
    Sean J Colloby
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Brain 135:2798-808. 2012
    ..However, dysfunctional nigral neurons may have an additional effect on striatal uptake in vivo but their respective role remains to be elucidated...
  70. pmc Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodies
    Masafumi Ihara
    Institute for Ageing and Health, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
    Acta Neuropathol 119:579-89. 2010
    ....
  71. ncbi Hippocampal volume change in depression: late- and early-onset illness compared
    Adrian J Lloyd
    School of Neurology, Neurobiology and Psychiatry, University of Psychiatry, University Newcastle, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Br J Psychiatry 184:488-95. 2004
    ..Evidence for structural hippocampal change in depression is limited despite reports of neuronal damage due to hypercortisolaemia and vascular pathology...
  72. ncbi Effects of rapid tryptophan depletion on salivary cortisol in older people recovered from depression, and the healthy elderly
    Richard J Porter
    Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, New Zealand, and Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    J Psychopharmacol 21:71-5. 2007
    ..However, they demonstrated reduced reactivity of the HPA axis compared to healthy subjects...
  73. doi PET imaging of brain amyloid in dementia: a review
    Harriet Quigley
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 26:991-9. 2011
    ....
  74. ncbi Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, England
    Arch Neurol 61:919-25. 2004
    ..Dementia with Lewy bodies (DLB) is a common form of late-life dementia that can be difficult to differentiate from other disorders, especially Alzheimer disease (AD), during life. At autopsy the striatal dopaminergic transporter is reduced...
  75. ncbi High resolution imaging of the medial temporal lobe in Alzheimer's disease and dementia with lewy bodies
    Michael J Firbank
    Institute for Ageing and Health, Newcastle University, Newcastle, UK
    J Alzheimers Dis 21:1129-40. 2010
    ..Future studies should investigate whether subiculum thickness or the hypointense line could be a diagnostic feature to help discriminate AD from DLB...
  76. doi A volumetric magnetic resonance imaging study of entorhinal cortex volume in dementia with lewy bodies. A comparison with Alzheimer's disease and Parkinson's disease with and without dementia
    Eva R Kenny
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 26:218-25. 2008
    ....
  77. doi Depression and cognition in older adults
    Alan J Thomas
    Institute for Ageing and Health, Newcastle University, Newcastle, UK
    Curr Opin Psychiatry 21:8-13. 2008
    ..This review identifies and clarifies recent progress in this rapidly developing research area...
  78. ncbi A neuropathological study of periventricular white matter hyperintensities in major depression
    Alan J Thomas
    Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
    J Affect Disord 76:49-54. 2003
    ..We hypothesised that different pathologies would be associated with the same MRI appearance of PVH and that such causes would be similar in depressed and control subjects...
  79. doi Diagnostic accuracy of 123I-FP-CIT SPECT in possible dementia with Lewy bodies
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Br J Psychiatry 194:34-9. 2009
    ..123)I-FP-CIT SPECT (single photon emission computed tomography) can help in the differential diagnosis of probable dementia with Lewy bodies (Lewy body dementia) and Alzheimer's disease...
  80. doi A study of orthostatic hypotension, heart rate variability and baroreflex sensitivity in late-life depression
    Akshya Vasudev
    Institute for Ageing and Health, Newcastle University, UK
    J Affect Disord 131:374-8. 2011
    ..To determine if subjects with late-life depression have significant cardiovascular autonomic abnormalities (orthostatic blood pressure drop, heart rate variability and baroreflex sensitivity)...
  81. ncbi Depression and vascular disease: what is the relationship?
    Alan J Thomas
    Wolfson Research Centre, Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
    J Affect Disord 79:81-95. 2004
    ..the 'vascular depression' hypothesis proposes that vascular disease predisposes to, precipitates or perpetuates depression, and this proposal has stimulated further research into the relationship of depression to vascular disease...
  82. doi When should drug treatment be started for people with dementia?
    Baldev Singh
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Maturitas 62:230-4. 2009
    ..Once dementia is apparent, early treatment is effective and makes obvious clinical sense, though argument continues over whether it is really cost effective at these early stages...
  83. ncbi Regulation of attention and response to therapy in dementia by butyrylcholinesterase
    Kirsty K O'Brien
    MRC Building, MRC University of Newcastle Centre Development for Clinical Brain Ageing, Newcastle upon Tyne, NE1 3BZ, UK
    Pharmacogenetics 13:231-9. 2003
    ..Inhibitors of the enzyme acetylcholinesterase are an effective dementia treatment, though the role of the related enzyme butyrylcholinesterase is less well understood...
  84. ncbi Emission tomography in dementia
    Sanjeet Pakrasi
    Institute for Health and Ageing, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    Nucl Med Commun 26:189-96. 2005
    ....
  85. ncbi Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls
    Emma J Burton
    The Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Newcastle, UK
    Brain 127:791-800. 2004
    ..This provides important information about the pattern of cerebral atrophy in Parkinson's disease and PDD...
  86. ncbi Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with lewy bodies
    Clive G Ballard
    Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Am J Psychiatry 161:843-9. 2004
    ..This investigation was undertaken to clarify the neuropathological substrates of key psychiatric symptoms in dementia with Lewy bodies...
  87. doi Vascular factors and depression
    Emma Teper
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 23:993-1000. 2008
    ..This paper examines possible mechanisms that may explain the bi-directional relationship between vascular disease and depression...
  88. ncbi A 3-month, randomized, placebo-controlled, neuroleptic discontinuation study in 100 people with dementia: the neuropsychiatric inventory median cutoff is a predictor of clinical outcome
    Clive G Ballard
    Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
    J Clin Psychiatry 65:114-9. 2004
    ..Although few placebo-controlled neuroleptic discontinuation studies have been conducted in people with dementia, such studies are essential to inform key clinical decisions...
  89. pmc Validation of automated white matter hyperintensity segmentation
    Sean D Smart
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    J Aging Res 2011:391783. 2011
    ..Discussion. Using our previously reported software, we demonstrated good segmentation of WMHs in a fully automated fashion...
  90. ncbi Ischemic basis for deep white matter hyperintensities in major depression: a neuropathological study
    Alan J Thomas
    Department of Psychiatry, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, England
    Arch Gen Psychiatry 59:785-92. 2002
    ..We investigated the neuropathological basis of these lesions in depression, hypothesizing that they would be more frequently ischemic in origin in depressed subjects...
  91. ncbi Cognitive associations of subcortical white matter lesions in older people
    John T O'Brien
    Institute for Ageing and Health, Wolfson Research Centre, University of Newcastle upon Tyne, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Ann N Y Acad Sci 977:436-44. 2002
    ....
  92. doi The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's disease
    Barry Reisberg
    Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, USA
    Alzheimers Dement 4:S98-S108. 2008
    ..Subjective cognitive impairment (SCI) has been a common, but poorly understood condition, frequently occurring in older persons...
  93. ncbi Mild cognitive impairment
    Serge Gauthier
    McGill Center for Studies in Aging, Douglas Hospital, Montreal, Quebec, Canada
    Lancet 367:1262-70. 2006
    ..Other definitions and subtypes of mild cognitive impairment need to be studied as potential prodromes of Alzheimer's disease and other types of dementia...
  94. ncbi Evidence and mechanisms of retrogenesis in Alzheimer's and other dementias: management and treatment import
    Barry Reisberg
    Alzheimer s Disease Education and Resources Program, New York University School of Medicine, New York, USA
    Am J Alzheimers Dis Other Demen 17:202-12. 2002
    ..A science of AD management can be formulated on the basis of the DA of the Alzheimer's patient, taking into consideration differences of AD from normal development as well as homologies...
  95. ncbi Subjective memory complaints: presence, severity and future outcome in normal older subjects
    Lidia Glodzik-Sobanska
    Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
    Dement Geriatr Cogn Disord 24:177-84. 2007
    ..Subjective memory complaint (SMC) in normal individuals may predict future cognitive decline. The goal of this study was to examine whether the probability of decline increases with growing intensity of complaint...
  96. ncbi Mild cognitive impairment (MCI): a historical perspective
    Barry Reisberg
    Aging and Dementia Research Center, New York University School of Medicine, New York 10016, USA
    Int Psychogeriatr 20:18-31. 2008
    ..Nevertheless, longitudinal and other studies indicate essential compatibility between GDS stage 3 MCI and Petersen's MCI duration and outcomes...
  97. ncbi Current evidence for subjective cognitive impairment (SCI) as the pre-mild cognitive impairment (MCI) stage of subsequently manifest Alzheimer's disease
    Barry Reisberg
    Int Psychogeriatr 20:1-16. 2008
  98. ncbi Global measures: utility in defining and measuring treatment response in dementia
    Barry Reisberg
    Department of Psychiatry, New York University School of Medicine, Silberstein Aging and Dementia Research Center, New York, NY 10016, USA
    Int Psychogeriatr 19:421-56. 2007
    ..For Mild Cognitive Impairment (MCI), global severity scales already appear to be one modality for the sensitive assessment of change. The CIBIC-Plus procedures might also productively be applied in future MCI therapeutic trials...
  99. ncbi Staging: relevance for trial design in vascular burden of the brain
    Barry Reisberg
    William and Sylvia Silberstein Aging and Dementia Research Center, New York University School of Medicine, NY 10016, USA
    Int Psychogeriatr 15:231-9. 2003
    ..Although temporal and prognostic aspects have been studied for the Alzheimer's-related portions of this clinical staging continuum, they remain to be elucidated for cerebrovascular small vessel disease...
  100. pmc Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive decline
    Susan De Santi
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Neuropsychology 22:469-84. 2008
    ..These findings indicate that Robust norms improve identification of healthy individuals who will decline and may be useful for selecting at-risk participants for research studies and early interventions...
  101. ncbi A 24-week open-label extension study of memantine in moderate to severe Alzheimer disease
    Barry Reisberg
    Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
    Arch Neurol 63:49-54. 2006
    ..This study is an extension of a 28-week, randomized, double-blind, placebo-controlled study of memantine in 252 patients with moderate to severe Alzheimer disease...