Research Topics
Genomes and GenesSpecies | John T O'BrienSummaryAffiliation: University of Newcastle Country: UK Publications
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Detail Information
Publications
Vascular cognitive impairmentJohn T O'Brien
Institute for Aging and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
Lancet Neurol 2:89-98. 2003..Clinical trials in vascular cognitive impairment are in their infancy but support the value of therapeutic interventions for symptomatic treatment...- A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjectsJohn T O'Brien
Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, U K
Am J Psychiatry 161:2081-90. 2004..This study determined whether cognitive impairments and structural brain changes in older depressed subjects, especially in the hippocampus, are related to hypercortisolemia... 
Nicotinic 123I-5IA-85380 single photon emission computed tomography as a predictor of cognitive progression in Alzheimer's disease and dementia with Lewy bodiesSean J Colloby
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
Am J Geriatr Psychiatry 18:86-90. 2010....- Atrophy is associated with posterior cingulate white matter disruption in dementia with Lewy bodies and Alzheimer's diseaseMichael J Firbank
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
Neuroimage 36:1-7. 2007..Future studies are needed to determine whether the disruption precedes or is consequent on atrophy or hypometabolism... - Plasma homocysteine and cognitive decline in older hypertensive subjectsSunil K Narayan
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
Int Psychogeriatr 23:1607-15. 2011..We examined the relationship between plasma homocysteine and cognitive decline in an older hypertensive population... - A comparison of 99mTc-exametazime and 123I-FP-CIT SPECT imaging in the differential diagnosis of Alzheimer's disease and dementia with Lewy bodiesSean J Colloby
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
Int Psychogeriatr 20:1124-40. 2008.... - NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivorsChristopher M Morris
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
Neurobiol Aging 32:554.e1-6. 2011..001). We hypothesize that this may be mediated by reduction of nitric oxide production and cerebral perfusion. Our findings, if replicated widely, have implications for treatments to ameliorate cognitive decline in stroke survivors... 
Characterizing dementia with Lewy bodies by means of diffusion tensor imagingRosie Watson
Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
Neurology 79:906-14. 2012..To investigate patterns of in vivo white matter tract change using diffusion tensor imaging (DTI), we conducted a cross-sectional study of dementia with Lewy bodies (DLB) in comparison with Alzheimer disease (AD) and normal aging...- Visual cortex in dementia with Lewy bodies: magnetic resonance imaging studyJohn Paul Taylor
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, UK
Br J Psychiatry 200:491-8. 2012..Visual hallucinations and visuoperceptual deficits are common in dementia with Lewy bodies, suggesting that cortical visual function may be abnormal... - Hippocampal neuronal atrophy and cognitive function in delayed poststroke and aging-related dementiasElizabeth Gemmell
Centre for Brain Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
Stroke 43:808-14. 2012..We have previously shown delayed poststroke dementia in elderly (≥75 years old) stroke survivors is associated with medial temporal lobe atrophy; however, the basis of the structural and functional changes is unknown... - Brain atrophy and white matter hyperintensity change in older adults and relationship to blood pressure. Brain atrophy, WMH change and blood pressureMichael J Firbank
Institute for Ageing and Health, Wolfson Research Centre, Newcastle upon Tyne, NE4 6BE, UK
J Neurol 254:713-21. 2007..These changes are independent. Successful hypertension treatment was associated with reduced risk of WMH progression and possibly brain atrophy... - Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depressionSean J Colloby
Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
Br J Psychiatry 199:404-10. 2011..There is strong evidence linking vascular disease to WMH, but limited evidence on its association with subcortical volumes... - Visual hallucinations in dementia with Lewy bodies: transcranial magnetic stimulation studyJohn Paul Taylor
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
Br J Psychiatry 199:492-500. 2011..The aetiology of visual hallucinations is poorly understood in dementia with Lewy bodies. Pathological alterations in visual cortical excitability may be one contributory mechanism... - Covariance 99mTc-exametazime SPECT patterns in Alzheimer's disease and dementia with Lewy bodies: utility in differential diagnosisSean J Colloby
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
J Geriatr Psychiatry Neurol 23:54-62. 2010..Principal component analysis captures additional sources of variance and if perfusion SPECT is the only scan available, this procedure may offer extra information... - Nicotinic alpha4beta2 receptor binding in dementia with Lewy bodies using 123I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinationsJohn T O'Brien
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Neuroimage 40:1056-63. 2008.... - Progression of dopaminergic degeneration in dementia with Lewy bodies and Parkinson's disease with and without dementia assessed using 123I-FP-CIT SPECTSean J Colloby
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle University, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
Eur J Nucl Med Mol Imaging 32:1176-85. 2005.... - Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivorsLouise M Allan
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
Brain 134:3716-27. 2011..Careful monitoring and treatment of modifiable vascular risk factors may be of benefit in preventing post-stroke dementia in the general population... - Validation of a fully automated hippocampal segmentation method on patients with dementiaMichael J Firbank
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Westgate Road, Newcastle upon Tyne NE4 6BE, United Kingdom
Hum Brain Mapp 29:1442-9. 2008..Linear regression between manual and automated volume gave V(auto) = V(manual) x 0.83 + 401 ml. The method provides an acceptable automated alternative to manual segmentation which may be of value in large studies... - Cortical thickness and VBM-DARTEL in late-life depressionSean J Colloby
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
J Affect Disord 133:158-64. 2011..The objective was to investigate GM changes in older depressed and similar aged healthy subjects using two different methods, cortical thickness in frontal lobe structures and voxel-based morphometry (VBM)... - Cholinesterase inhibitors in advanced Dementia with Lewy bodies: increase or stop?Sanjeet Pakrasi
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
Int J Geriatr Psychiatry 21:719-21. 2006..There is little data on stopping cholinesterase inhibitors in Dementia with Lewy bodies (DLB). Equally, it is not known if increasing the dose of cholinesterase inhibitors may help neuropsychiatric symptoms in advanced DLB... - High resolution imaging of the medial temporal lobe in Alzheimer's disease and dementia with Lewy bodiesMichael J Firbank
Institute for Ageing and Health, Newcastle University, Newcastle, UK
J Alzheimers Dis 21:1129-40. 2010..Future studies should investigate whether subiculum thickness or the hypointense line could be a diagnostic feature to help discriminate AD from DLB... - Neuroimaging predictors of death and dementia in a cohort of older stroke survivorsMichael J Firbank
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
J Neurol Neurosurg Psychiatry 83:263-7. 2012..Subjects had a cognitive assessment at 3 months post stroke to exclude dementia, and had an MRI scan (n=106) at that time. Subjects were then followed longitudinally for incident dementia and/or death... - Cholinesterase inhibitor use does not significantly influence the ability of 123I-FP-CIT imaging to distinguish Alzheimer's disease from dementia with Lewy bodiesJohn Paul Taylor
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
J Neurol Neurosurg Psychiatry 78:1069-71. 2007..As ChEi are frequently used in people with dementia, it is important to determine whether their use affects 123I-FP-CIT uptake in the striatum... - A study of orthostatic hypotension in late-life depressionJonathan Richardson
Institute for Ageing and Health, Newcastle University, England, UK
Am J Geriatr Psychiatry 17:996-9. 2009..Studies examining vascular risk factors in depression report conflicting evidence but have not assessed orthostatic hypotension, a recently recognized risk factor for white matter hyperintensities... - Medial temporal atrophy rather than white matter hyperintensities predict cognitive decline in stroke survivorsMichael J Firbank
Institute for Ageing and Health, University of Newcastle, Wolfson Research Centre, Newcastle upon Tyne NE4 6BE, UK
Neurobiol Aging 28:1664-9. 2007..The association of MTA but not WMH with subsequent cognitive decline and increasing brain atrophy suggests a greater role for Alzheimer type than vascular pathology in delayed cognitive impairment after stroke... - Elevated plasma homocysteine is associated with increased brain atrophy rates in older subjects with mild hypertensionSunil K Narayan
Institute for Ageing and Health, Newcastle University, UK
Dement Geriatr Cogn Disord 31:341-8. 2011..01, p = 0.29). New SBIs were uncommon. In older hypertensive individuals, plasma homocysteine levels are associated with increased rates of whole-brain atrophy but not WML progression... - White matter hyperintensities, cortisol levels, brain atrophy and continuing cognitive deficits in late-life depressionSebastian Kohler
Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
Br J Psychiatry 196:143-9. 2010..Cerebrovascular changes and glucocorticoid mediated hippocampal atrophy are considered relevant for depression-related cognitive deficits, forming putative treatment targets... - Diffusion tensor imaging in Alzheimer's disease and dementia with Lewy bodiesMichael J Firbank
Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
Psychiatry Res 194:176-83. 2011.... - In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) 123I-QNB in dementia with Lewy bodies and Parkinson's disease dementiaSean J Colloby
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Neuroimage 33:423-9. 2006..123I-QNB binding was also compared to the corresponding cerebral perfusion changes in the same subjects... - Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS studyMichael J Firbank
Institute for Ageing and Health, Newcastle University Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
Br J Psychiatry 201:40-5. 2012..Brain white matter changes (WMC) and depressive symptoms are linked, but the directionality of this association remains unclear... - Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance studySean J Colloby
Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
Br J Psychiatry 200:150-5. 2012..A limited number of studies have demonstrated changes in cerebral blood flow (CBF) in older individuals with depression, but there are considerable inconsistencies between studies... - White matter changes in late-life depression: a diffusion tensor imaging studySean J Colloby
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
J Affect Disord 135:216-20. 2011..The objective was to investigate the integrity of white matter tracts in subjects with LLD compared to similar aged healthy individuals using diffusion tensor imaging (DTI)... - Functional connectivity in late-life depression using resting-state functional magnetic resonance imagingEva R Kenny
Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
Am J Geriatr Psychiatry 18:643-51. 2010..To investigate whether there are differences in brain connectivity in late-life depression (LLD) and nondepressed subjects using the left and right heads of caudate nuclei (hCN) as the seed regions... - Diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's diseaseMichael J Firbank
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Westgate Road, Newcastle upon Tyne, UK
Psychiatry Res 155:135-45. 2007..We conclude that there are subtle changes visible with diffusion imaging in DLB and AD which may reflect disrupted connectivity and underlie observed perfusion changes in these disorders... - Subjective memory complaints, white-matter lesions, depressive symptoms, and cognition in elderly patientsThais S C Minett
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
Am J Geriatr Psychiatry 13:665-71. 2005..The authors sought to determine whether SMCs are related to WML, independently of the presence of depressive symptoms, which are known to be associated with both. The relationship between SMC and cognition was also examined... - Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imagingEmma J Burton
Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
Mov Disord 20:1571-6. 2005..Serial MRI may be a useful tool for monitoring disease progression in PDD and further studies should investigate its utility for early diagnosis... - Clinical practice with anti-dementia drugs: a revised (second) consensus statement from the British Association for PsychopharmacologyJohn T O'Brien
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
J Psychopharmacol 25:997-1019. 2011..Although results of pivotal studies are awaited, results to date have been equivocal and no disease-modifying agents are either licensed or can be currently recommended for clinical use... - More severe functional impairment in dementia with lewy bodies than Alzheimer disease is related to extrapyramidal motor dysfunctionIan G McKeith
Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
Am J Geriatr Psychiatry 14:582-8. 2006..The objective of this study was to compare functional impairments in dementia with Lewy bodies (DLB) and Alzheimer disease (AD) and their relationship with motor and neuropsychiatric symptoms... - Functional connectivity in cortical regions in dementia with Lewy bodies and Alzheimer's diseaseEva R Kenny
Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
Brain 135:569-81. 2012..This implicates areas beyond visual sensory input level in the visual symptoms and visual-perceptual dysfunction seen in dementia with Lewy bodies... - Platelet immunoglobulin and amyloid precursor protein as potential peripheral biomarkers for Alzheimer's disease: findings from a pilot studyElizabeta B Mukaetova-Ladinska
Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle, UK
Age Ageing 41:408-12. 2012..Since cerebrospinal fluid analysis and molecular neuroimaging are not routinely used in many countries, blood biomarker molecules may be more readily applicable in a routine clinical setting... - The application of statistical parametric mapping to 123I-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's diseaseSean J Colloby
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Neuroimage 23:956-66. 2004.... - Homocysteine is associated with hippocampal and white matter atrophy in older subjects with mild hypertensionMichael J Firbank
Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
Int Psychogeriatr 22:804-11. 2010..Plasma homocysteine has been associated with reduced brain volumes in cross-sectional studies. We aimed to investigate if homocysteine is associated with ongoing atrophy, and if so, if this is localized to gray or white matter... - Magnetic resonance imaging in lewy body dementiasRosie Watson
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, UK
Dement Geriatr Cogn Disord 28:493-506. 2009.... - Levodopa use and sleep in patients with dementia with Lewy bodiesSophie Molloy
Wolfson Research Centre, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
Mov Disord 24:609-12. 2009..Levodopa treatment did not affect sleep or lead to increased EDS in DLB patients. The use of levodopa does not appear to adversely affect subjective sleep measures or increase EDS in DLB patients... - Development of a novel FMRI compatible visual perception prototype battery to test older people with and without dementiaJoshua S Wood
Institute for Cellular Medicine, Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
J Geriatr Psychiatry Neurol 24:73-83. 2011..We aimed to develop, pilot, and test a novel visuocognitive prototype test battery which addressed these issues, suitable for both clinical and functional imaging use... - Characteristics of visual hallucinations in Parkinson disease dementia and dementia with lewy bodiesUrs P Mosimann
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
Am J Geriatr Psychiatry 14:153-60. 2006..Recurrent visual hallucinations (RVH) are common in both disorders. The authors have compared details of hallucination characteristics and associated neuropsychiatric features in DLB and PDD... - Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS StudyMani S Krishnan
Institute for Ageing and Health, University of Newcastle upon Tyne, UK
Int J Geriatr Psychiatry 21:983-9. 2006..However, it remains controversial as to whether PVL, DWML, or both are most strongly associated with depression and this was the aim of the current study... - A volumetric study of MRI signal hyperintensities in late-life depressionMichael J Firbank
Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK NE4 6BE
Am J Geriatr Psychiatry 12:606-12. 2004..The authors investigated whether the regional location varied between depressed and normal subjects and determined the relationship of magnetic resonance (MR) signal hyperintensities to known clinical risk factors for vascular disease... - Vascular cognitive impairmentJohn T O'Brien
Institute for Ageing and Health, Wolfson Research Centre, Newcastle upon Tyne, UK
Am J Geriatr Psychiatry 14:724-33. 2006..It begins with a discussion on the historical background, which is important to understand the different and somewhat confusing terminology that currently exists in the field... - Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodiesUrs P Mosimann
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
Brain 128:1267-76. 2005..The similarities in saccade performance in PDD and DLB underline the overlap between these conditions and underscore differences from Alzheimer's disease and Parkinson's disease... - The spectrum of nonmotor symptoms in early Parkinson diseaseTien K Khoo
From the Institute for Ageing and Health T K K, A J Y, G W D, J T O, D J Burn and Industrial Statistics Research Unit S C, Newcastle University, Newcastle upon Tyne Imperial College D J Brooks, MRC Clinical Sciences Centre, London and Cambridge Centre for Brain Repair R A B, Cambridge University, Cambridge, UK
Neurology 80:276-81. 2013..Our aim was to determine the frequency of NMS in a cohort of patients with newly diagnosed PD... - Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementiasSean J Colloby
Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
Brain 135:2798-808. 2012..However, dysfunctional nigral neurons may have an additional effect on striatal uptake in vivo but their respective role remains to be elucidated... - Does posterior cortical atrophy on MRI discriminate between Alzheimer's disease, dementia with Lewy bodies, and normal aging?James O'Donovan
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
Int Psychogeriatr 25:111-9. 2013..Therefore, we assessed whether visual rating scales for assessing posterior atrophy (PA), medial temporal lobe atrophy (MTA), and ventricular enlargement (VEn) aid in the discrimination between AD, DLB, and normal aging... - Effects of rapid tryptophan depletion on salivary cortisol in older people recovered from depression, and the healthy elderlyRichard J Porter
Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, University of Otago, New Zealand, and Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
J Psychopharmacol 21:71-5. 2007..However, they demonstrated reduced reactivity of the HPA axis compared to healthy subjects... - High resolution imaging of the medial temporal lobe in Alzheimer's disease and dementia with lewy bodiesMichael J Firbank
Institute for Ageing and Health, Newcastle University, Newcastle, UK
J Alzheimers Dis 21:1129-40. 2010..Future studies should investigate whether subiculum thickness or the hypointense line could be a diagnostic feature to help discriminate AD from DLB... - Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodiesMasafumi Ihara
Institute for Ageing and Health, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
Acta Neuropathol 119:579-89. 2010.... - Depression and cognition in older adultsAlan J Thomas
Institute for Ageing and Health, Newcastle University, Newcastle, UK
Curr Opin Psychiatry 21:8-13. 2008..This review identifies and clarifies recent progress in this rapidly developing research area... - Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodiesJohn T O'Brien
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, England
Arch Neurol 61:919-25. 2004..Dementia with Lewy bodies (DLB) is a common form of late-life dementia that can be difficult to differentiate from other disorders, especially Alzheimer disease (AD), during life. At autopsy the striatal dopaminergic transporter is reduced... - PET imaging of brain amyloid in dementia: a reviewHarriet Quigley
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
Int J Geriatr Psychiatry 26:991-9. 2011.... - Hippocampal volume change in depression: late- and early-onset illness comparedAdrian J Lloyd
School of Neurology, Neurobiology and Psychiatry, University of Psychiatry, University Newcastle, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Br J Psychiatry 184:488-95. 2004..Evidence for structural hippocampal change in depression is limited despite reports of neuronal damage due to hypercortisolaemia and vascular pathology... - A volumetric magnetic resonance imaging study of entorhinal cortex volume in dementia with lewy bodies. A comparison with Alzheimer's disease and Parkinson's disease with and without dementiaEva R Kenny
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
Dement Geriatr Cogn Disord 26:218-25. 2008.... - Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementiaEmma J Burton
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
Neurobiol Aging 33:1228-36. 2012.... - Diagnostic accuracy of 123I-FP-CIT SPECT in possible dementia with Lewy bodiesJohn T O'Brien
Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
Br J Psychiatry 194:34-9. 2009..123)I-FP-CIT SPECT (single photon emission computed tomography) can help in the differential diagnosis of probable dementia with Lewy bodies (Lewy body dementia) and Alzheimer's disease... - A neuropathological study of periventricular white matter hyperintensities in major depressionAlan J Thomas
Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
J Affect Disord 76:49-54. 2003..We hypothesised that different pathologies would be associated with the same MRI appearance of PVH and that such causes would be similar in depressed and control subjects... - Depression and vascular disease: what is the relationship?Alan J Thomas
Wolfson Research Centre, Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
J Affect Disord 79:81-95. 2004..the 'vascular depression' hypothesis proposes that vascular disease predisposes to, precipitates or perpetuates depression, and this proposal has stimulated further research into the relationship of depression to vascular disease... - When should drug treatment be started for people with dementia?Baldev Singh
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
Maturitas 62:230-4. 2009..Once dementia is apparent, early treatment is effective and makes obvious clinical sense, though argument continues over whether it is really cost effective at these early stages... - A study of orthostatic hypotension, heart rate variability and baroreflex sensitivity in late-life depressionAkshya Vasudev
Institute for Ageing and Health, Newcastle University, UK
J Affect Disord 131:374-8. 2011..To determine if subjects with late-life depression have significant cardiovascular autonomic abnormalities (orthostatic blood pressure drop, heart rate variability and baroreflex sensitivity)... - Emission tomography in dementiaSanjeet Pakrasi
Institute for Health and Ageing, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
Nucl Med Commun 26:189-96. 2005.... - Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with lewy bodiesClive G Ballard
Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Am J Psychiatry 161:843-9. 2004..This investigation was undertaken to clarify the neuropathological substrates of key psychiatric symptoms in dementia with Lewy bodies... - Regulation of attention and response to therapy in dementia by butyrylcholinesteraseKirsty K O'Brien
MRC Building, MRC University of Newcastle Centre Development for Clinical Brain Ageing, Newcastle upon Tyne, NE1 3BZ, UK
Pharmacogenetics 13:231-9. 2003..Inhibitors of the enzyme acetylcholinesterase are an effective dementia treatment, though the role of the related enzyme butyrylcholinesterase is less well understood... - Vascular factors and depressionEmma Teper
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
Int J Geriatr Psychiatry 23:993-1000. 2008..This paper examines possible mechanisms that may explain the bi-directional relationship between vascular disease and depression... - Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controlsEmma J Burton
The Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Newcastle, UK
Brain 127:791-800. 2004..This provides important information about the pattern of cerebral atrophy in Parkinson's disease and PDD... - A 3-month, randomized, placebo-controlled, neuroleptic discontinuation study in 100 people with dementia: the neuropsychiatric inventory median cutoff is a predictor of clinical outcomeClive G Ballard
Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
J Clin Psychiatry 65:114-9. 2004..Although few placebo-controlled neuroleptic discontinuation studies have been conducted in people with dementia, such studies are essential to inform key clinical decisions... - Validation of automated white matter hyperintensity segmentationSean D Smart
Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
J Aging Res 2011:391783. 2011..Discussion. Using our previously reported software, we demonstrated good segmentation of WMHs in a fully automated fashion... - Ischemic basis for deep white matter hyperintensities in major depression: a neuropathological studyAlan J Thomas
Department of Psychiatry, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, England
Arch Gen Psychiatry 59:785-92. 2002..We investigated the neuropathological basis of these lesions in depression, hypothesizing that they would be more frequently ischemic in origin in depressed subjects... - Cognitive associations of subcortical white matter lesions in older peopleJohn T O'Brien
Institute for Ageing and Health, Wolfson Research Centre, University of Newcastle upon Tyne, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Ann N Y Acad Sci 977:436-44. 2002.... - Evidence and mechanisms of retrogenesis in Alzheimer's and other dementias: management and treatment importBarry Reisberg
Alzheimer's Disease Education and Resources Program, New York University School of Medicine, New York, USA
Am J Alzheimers Dis Other Demen 17:202-12. 2002..A science of AD management can be formulated on the basis of the DA of the Alzheimer's patient, taking into consideration differences of AD from normal development as well as homologies... - Subjective memory complaints: presence, severity and future outcome in normal older subjectsLidia Glodzik-Sobanska
Center for Brain Health, New York University School of Medicine, New York, NY 10016, USA
Dement Geriatr Cogn Disord 24:177-84. 2007..Subjective memory complaint (SMC) in normal individuals may predict future cognitive decline. The goal of this study was to examine whether the probability of decline increases with growing intensity of complaint... - Current evidence for subjective cognitive impairment (SCI) as the pre-mild cognitive impairment (MCI) stage of subsequently manifest Alzheimer's diseaseBarry Reisberg
Int Psychogeriatr 20:1-16. 2008 - Mild cognitive impairment (MCI): a historical perspectiveBarry Reisberg
Aging and Dementia Research Center, New York University School of Medicine, New York 10016, USA
Int Psychogeriatr 20:18-31. 2008..Nevertheless, longitudinal and other studies indicate essential compatibility between GDS stage 3 MCI and Petersen's MCI duration and outcomes... - Robust and conventional neuropsychological norms: diagnosis and prediction of age-related cognitive declineSusan De Santi
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Neuropsychology 22:469-84. 2008..These findings indicate that Robust norms improve identification of healthy individuals who will decline and may be useful for selecting at-risk participants for research studies and early interventions... - The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's diseaseBarry Reisberg
Silberstein Aging and Dementia Research Center, New York University School of Medicine, New York, NY, USA
Alzheimers Dement 4:S98-S108. 2008..Subjective cognitive impairment (SCI) has been a common, but poorly understood condition, frequently occurring in older persons... - Global measures: utility in defining and measuring treatment response in dementiaBarry Reisberg
Department of Psychiatry, New York University School of Medicine, Silberstein Aging and Dementia Research Center, New York, NY 10016, USA
Int Psychogeriatr 19:421-56. 2007..For Mild Cognitive Impairment (MCI), global severity scales already appear to be one modality for the sensitive assessment of change. The CIBIC-Plus procedures might also productively be applied in future MCI therapeutic trials... - Mild cognitive impairmentSerge Gauthier
McGill Center for Studies in Aging, Douglas Hospital, Montreal, Quebec, Canada
Lancet 367:1262-70. 2006..Other definitions and subtypes of mild cognitive impairment need to be studied as potential prodromes of Alzheimer's disease and other types of dementia... - Staging: relevance for trial design in vascular burden of the brainBarry Reisberg
William and Sylvia Silberstein Aging and Dementia Research Center, New York University School of Medicine, NY 10016, USA
Int Psychogeriatr 15:231-9. 2003..Although temporal and prognostic aspects have been studied for the Alzheimer's-related portions of this clinical staging continuum, they remain to be elucidated for cerebrovascular small vessel disease... - Memantine in moderate-to-severe Alzheimer's diseaseBarry Reisberg
Department of Psychiatry, New York University School of Medicine, New York 10016, USA
N Engl J Med 348:1333-41. 2003..Overstimulation of the N-methyl-D-aspartate (NMDA) receptor by glutamate is implicated in neurodegenerative disorders. Accordingly, we investigated memantine, an NMDA antagonist, for the treatment of Alzheimer's disease... - ADCS Prevention Instrument Project: ADCS-clinicians' global impression of change scales (ADCS-CGIC), self-rated and study partner-rated versionsLon S Schneider
Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Alzheimer Dis Assoc Disord 20:S124-38. 2006..An important consideration was whether global assessments are specific and sensitive measures of change during a prevention trial... - Alzheimer's disease and medical disease conditions: a prospective cohort studyIstvan Boksay
J Am Geriatr Soc 53:2235-6. 2005 - Vascular burden of the brainBarry Reisberg
Int Psychogeriatr 15:7-10. 2003 - Diffusion tensor imaging of frontal white matter microstructure in early Alzheimer's disease: a preliminary studySteven J Choi
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA
J Geriatr Psychiatry Neurol 18:12-9. 2005.... - A 24-week open-label extension study of memantine in moderate to severe Alzheimer diseaseBarry Reisberg
Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA
Arch Neurol 63:49-54. 2006..This study is an extension of a 28-week, randomized, double-blind, placebo-controlled study of memantine in 252 patients with moderate to severe Alzheimer disease...