JOHN O'BRIEN

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi Association of behaviour change techniques with effectiveness of dietary interventions among adults of retirement age: a systematic review and meta-analysis of randomised controlled trials
    Jose Lara
    Human Nutrition Research Centre, Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    BMC Med 12:177. 2014
  2. ncbi Clinical practice with anti-dementia drugs: a revised (second) consensus statement from the British Association for Psychopharmacology
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    J Psychopharmacol 25:997-1019. 2011
  3. pmc DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT
    Rob Jones
    Section of Old Age Psychiatry, The University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Trials 10:57. 2009
  4. ncbi Correlation of entorhinal amyloid with memory in Alzheimer's and vascular but not Lewy body dementia
    Alan Thomas
    Institute for Ageing and Health, Newcastle, UK
    Dement Geriatr Cogn Disord 19:57-60. 2005
  5. ncbi Hyperintensities and fronto-subcortical atrophy on MRI are substrates of mild cognitive deficits after stroke
    Emma Burton
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 16:113-8. 2003
  6. ncbi Cognitive decline in a prospectively studied group of stroke survivors, with a particular emphasis on the >75's
    Kath Lowery
    Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Age Ageing 31:24-7. 2002
  7. ncbi White matter hyperintensities are associated with impairment of memory, attention, and global cognitive performance in older stroke patients
    Emma J Burton
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle, UK
    Stroke 35:1270-5. 2004
  8. ncbi Functional imaging in Parkinson's disease and dementia with Lewy bodies
    Sean Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    J Geriatr Psychiatry Neurol 17:158-63. 2004
  9. ncbi Dementia with Lewy bodies
    Ian McKeith
    Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, UK
    Lancet Neurol 3:19-28. 2004
  10. ncbi Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study
    Ian McKeith
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Lancet Neurol 6:305-13. 2007

Collaborators

Detail Information

Publications18

  1. ncbi Association of behaviour change techniques with effectiveness of dietary interventions among adults of retirement age: a systematic review and meta-analysis of randomised controlled trials
    Jose Lara
    Human Nutrition Research Centre, Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    BMC Med 12:177. 2014
    ..The aim of this study was to identify the behaviour change techniques (BCTs) used in complex dietary behaviour change interventions and to explore the association between BCTs utilised and intervention effectiveness...
  2. ncbi Clinical practice with anti-dementia drugs: a revised (second) consensus statement from the British Association for Psychopharmacology
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
    J Psychopharmacol 25:997-1019. 2011
    ..Although results of pivotal studies are awaited, results to date have been equivocal and no disease-modifying agents are either licensed or can be currently recommended for clinical use...
  3. pmc DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT
    Rob Jones
    Section of Old Age Psychiatry, The University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Trials 10:57. 2009
    ..The aim of this trial is to establish the most effective drug option for people with AD who are progressing from moderate to severe dementia despite treatment with donepezil...
  4. ncbi Correlation of entorhinal amyloid with memory in Alzheimer's and vascular but not Lewy body dementia
    Alan Thomas
    Institute for Ageing and Health, Newcastle, UK
    Dement Geriatr Cogn Disord 19:57-60. 2005
    ..To examine the relationship of the anatomic distribution of amyloid deposition to focal and global cognitive dysfunction in different subtypes of dementia...
  5. ncbi Hyperintensities and fronto-subcortical atrophy on MRI are substrates of mild cognitive deficits after stroke
    Emma Burton
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 16:113-8. 2003
    ..The current study determines the MRI correlations of the early neuropsychological post-stroke cognitive deficits...
  6. ncbi Cognitive decline in a prospectively studied group of stroke survivors, with a particular emphasis on the >75's
    Kath Lowery
    Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Age Ageing 31:24-7. 2002
    ..Although cognitive decline is frequent after stroke, there has been very little work focussing upon older age groups, in whom the majority of strokes occur...
  7. ncbi White matter hyperintensities are associated with impairment of memory, attention, and global cognitive performance in older stroke patients
    Emma J Burton
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle, UK
    Stroke 35:1270-5. 2004
    ..We hypothesized that processing speed and executive dysfunction will be associated with frontal WMH whereas impaired memory will be associated with temporal WMH...
  8. ncbi Functional imaging in Parkinson's disease and dementia with Lewy bodies
    Sean Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    J Geriatr Psychiatry Neurol 17:158-63. 2004
    ....
  9. ncbi Dementia with Lewy bodies
    Ian McKeith
    Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, UK
    Lancet Neurol 3:19-28. 2004
    ..Clear guidance on the management of DLB is urgently needed. Virtually unrecognised 20 years ago, DLB could within this decade be one of the most treatable neurodegenerative disorders of late life...
  10. ncbi Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study
    Ian McKeith
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Lancet Neurol 6:305-13. 2007
    ..Diagnostic accuracy, positive and negative predictive values, and inter-reader agreement were the secondary endpoints and a subgroup of possible DLB patients was also included...
  11. ncbi Dementia associated with psychiatric disorders
    JOHN O'BRIEN
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Int Psychogeriatr 17:S207-21. 2005
    ..The paper also discusses some of the mechanisms that may contribute to the expression of the cognitive deficits in these disorders and their potential relationship with common causes of dementia...
  12. ncbi Muscarinic receptors in basal ganglia in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease
    Margaret A Piggott
    MRC University of Newcastle Centre in Clinical Brain Ageing, MRC Building, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle upon Tyne, UK
    J Chem Neuroanat 25:161-73. 2003
    ..Low density of striatal M1 receptors may relate to the extent of movement disorder in DLB, and to a reduced risk of parkinsonism with acetylcholinesterase inhibition...
  13. ncbi Language impairment in dementia: impact on symptoms and care needs in residential homes
    Dawn Potkins
    Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
    Int J Geriatr Psychiatry 18:1002-6. 2003
    ..Social skills and capacity for self care may be compromised. Few studies have evaluated the impact of language problems on symptoms and socialization in people with dementia in care environments...
  14. ncbi Behavioral symptoms in vascular cognitive impairment and vascular dementia
    JOHN O'BRIEN
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Int Psychogeriatr 15:133-8. 2003
    ..There is a particularly strong relationship between cerebrovascular disease and depression...
  15. ncbi Profile of neuropsychological deficits in older stroke survivors without dementia
    Clive Ballard
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Dement Geriatr Cogn Disord 16:52-6. 2003
    ..Few studies have examined the profile of cognitive impairments in older stroke patients without dementia...
  16. ncbi Relevant clinical outcomes in probable vascular dementia and Alzheimer's disease with cerebrovascular disease
    JOHN O'BRIEN
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Sci 203:41-8. 2002
    ..Such differences in untreated outcome need to be considered when interpreting trial results using outcome measures that were largely designed for studies of patients with AD...
  17. ncbi Neuroimaging of dementia with Lewy bodies
    John Paul Taylor
    Institute for Ageing and Health, Wolfson Research Centre, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Neuroimaging Clin N Am 22:67-81, viii. 2012
    ..Imaging research on DLB has had significant ramifications in terms of raising the profile of DLB and helping define it as a distinctive and separate disease entity from AD...
  18. ncbi Clinical and neuropathological correlates of apolipoprotein E genotype in dementia with Lewy bodies
    Andrew B Singleton
    Medical Research Council University of Newcastle upon Tyne, Centre Development in Clinical Brain Ageing, MRC Building, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 14:167-75. 2002
    ..This study demonstrates that DLB shares the APO epsilon4 allele with AD as a common risk factor, but that there are differences in the way the epsilon4 allele affects the phenotypic expression of disease...