Affiliation: University of Newcastle
- Clinical practice with anti-dementia drugs: a revised (second) consensus statement from the British Association for PsychopharmacologyJohn T O'Brien
Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK
J Psychopharmacol 25:997-1019. 2011..Although results of pivotal studies are awaited, results to date have been equivocal and no disease-modifying agents are either licensed or can be currently recommended for clinical use...
- DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCTRob Jones
Section of Old Age Psychiatry, The University of Nottingham, A Floor, South Block, Queen s Medical Centre, Nottingham NG7 2UH, UK
Trials 10:57. 2009..The aim of this trial is to establish the most effective drug option for people with AD who are progressing from moderate to severe dementia despite treatment with donepezil...
- Dementia with Lewy bodiesIan McKeith
Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, UK
Lancet Neurol 3:19-28. 2004..Clear guidance on the management of DLB is urgently needed. Virtually unrecognised 20 years ago, DLB could within this decade be one of the most treatable neurodegenerative disorders of late life...
- Dementia associated with psychiatric disordersJOHN O'BRIEN
Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Int Psychogeriatr 17:S207-21. 2005..The paper also discusses some of the mechanisms that may contribute to the expression of the cognitive deficits in these disorders and their potential relationship with common causes of dementia...
- Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre studyIan McKeith
Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
Lancet Neurol 6:305-13. 2007..Diagnostic accuracy, positive and negative predictive values, and inter-reader agreement were the secondary endpoints and a subgroup of possible DLB patients was also included...
- Muscarinic receptors in basal ganglia in dementia with Lewy bodies, Parkinson's disease and Alzheimer's diseaseMargaret A Piggott
MRC University of Newcastle Centre in Clinical Brain Ageing, MRC Building, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle upon Tyne, UK
J Chem Neuroanat 25:161-73. 2003..Low density of striatal M1 receptors may relate to the extent of movement disorder in DLB, and to a reduced risk of parkinsonism with acetylcholinesterase inhibition...
- Behavioral symptoms in vascular cognitive impairment and vascular dementiaJOHN O'BRIEN
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
Int Psychogeriatr 15:133-8. 2003..There is a particularly strong relationship between cerebrovascular disease and depression...
- Profile of neuropsychological deficits in older stroke survivors without dementiaClive Ballard
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
Dement Geriatr Cogn Disord 16:52-6. 2003..Few studies have examined the profile of cognitive impairments in older stroke patients without dementia...
- Clinical and neuropathological correlates of apolipoprotein E genotype in dementia with Lewy bodiesAndrew B Singleton
Medical Research Council University of Newcastle upon Tyne, Centre Development in Clinical Brain Ageing, MRC Building, Newcastle upon Tyne, UK
Dement Geriatr Cogn Disord 14:167-75. 2002..This study demonstrates that DLB shares the APO epsilon4 allele with AD as a common risk factor, but that there are differences in the way the epsilon4 allele affects the phenotypic expression of disease...
- Relevant clinical outcomes in probable vascular dementia and Alzheimer's disease with cerebrovascular diseaseJOHN O'BRIEN
Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
J Neurol Sci 203:41-8. 2002..Such differences in untreated outcome need to be considered when interpreting trial results using outcome measures that were largely designed for studies of patients with AD...
- Neuroimaging of dementia with Lewy bodiesJohn Paul Taylor
Institute for Ageing and Health, Wolfson Research Centre, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
Neuroimaging Clin N Am 22:67-81, viii. 2012..Imaging research on DLB has had significant ramifications in terms of raising the profile of DLB and helping define it as a distinctive and separate disease entity from AD...