J T O'Brien

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc Severe deep white matter lesions and outcome in elderly patients with major depressive disorder: follow up study
    J O'BRIEN
    Department of Psychiatry and Institute for the Health of the Elderly, University of Newcastle upon Tyne, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE
    BMJ 317:982-4. 1998
  2. ncbi Relevant clinical outcomes in probable vascular dementia and Alzheimer's disease with cerebrovascular disease
    JOHN O'BRIEN
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Sci 203:41-8. 2002
  3. ncbi Transient response to imatinib mesylate (STI571) in a patient with the ETV6-ABL t(9;12) translocation
    Stephen G O'Brien
    School of Clinical and Laboratory Sciences and the School of Biochemistry and Genetics, University of Newcastle, United Kingdom
    Blood 99:3465-7. 2002
  4. ncbi Cognitive associations of subcortical white matter lesions in older people
    John T O'Brien
    Institute for Ageing and Health, Wolfson Research Centre, University of Newcastle upon Tyne, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Ann N Y Acad Sci 977:436-44. 2002
  5. doi Diagnostic accuracy of 123I-FP-CIT SPECT in possible dementia with Lewy bodies
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Br J Psychiatry 194:34-9. 2009
  6. ncbi Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia
    J T O'Brien
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Neurology 56:1386-8. 2001
  7. doi Role of imaging techniques in the diagnosis of dementia
    J T O'Brien
    Newcastle University, Institute for Ageing and Health, Wolfson Research Centre, Newcastle upon Tyne, UK
    Br J Radiol 80:S71-7. 2007
  8. ncbi Brain atrophy and white matter hyperintensity change in older adults and relationship to blood pressure. Brain atrophy, WMH change and blood pressure
    Michael J Firbank
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol 254:713-21. 2007
  9. pmc Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia
    S G O'Brien
    Department of Haematology, University of Newcastle Medical School, Royal Victoria Infirmary, New Castle NE1 4LP, UK
    Br J Cancer 89:1855-9. 2003
  10. ncbi Combined magnetic resonance imaging and single-photon emission tomography scanning in the discrimination of Alzheimer's disease from age-matched controls
    J T O'Brien
    University of Newcastle upon Tyne, UK
    Int Psychogeriatr 13:149-61. 2001

Detail Information

Publications62

  1. pmc Severe deep white matter lesions and outcome in elderly patients with major depressive disorder: follow up study
    J O'BRIEN
    Department of Psychiatry and Institute for the Health of the Elderly, University of Newcastle upon Tyne, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE
    BMJ 317:982-4. 1998
    ..To determine the difference in outcome among elderly people with major depression who do and do not have severe white matter lesions on magnetic resonance imaging...
  2. ncbi Relevant clinical outcomes in probable vascular dementia and Alzheimer's disease with cerebrovascular disease
    JOHN O'BRIEN
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Sci 203:41-8. 2002
    ..Such differences in untreated outcome need to be considered when interpreting trial results using outcome measures that were largely designed for studies of patients with AD...
  3. ncbi Transient response to imatinib mesylate (STI571) in a patient with the ETV6-ABL t(9;12) translocation
    Stephen G O'Brien
    School of Clinical and Laboratory Sciences and the School of Biochemistry and Genetics, University of Newcastle, United Kingdom
    Blood 99:3465-7. 2002
    ..This case has implications for the design of future studies using STI571 in leukemias involving ABL-encoded fusion proteins other than BCR-ABL...
  4. ncbi Cognitive associations of subcortical white matter lesions in older people
    John T O'Brien
    Institute for Ageing and Health, Wolfson Research Centre, University of Newcastle upon Tyne, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Ann N Y Acad Sci 977:436-44. 2002
    ....
  5. doi Diagnostic accuracy of 123I-FP-CIT SPECT in possible dementia with Lewy bodies
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Br J Psychiatry 194:34-9. 2009
    ..123)I-FP-CIT SPECT (single photon emission computed tomography) can help in the differential diagnosis of probable dementia with Lewy bodies (Lewy body dementia) and Alzheimer's disease...
  6. ncbi Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia
    J T O'Brien
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Neurology 56:1386-8. 2001
    ..The authors found accelerating atrophy with increasing severity of cognitive impairment, further emphasizing the need for early diagnosis and intervention in dementia...
  7. doi Role of imaging techniques in the diagnosis of dementia
    J T O'Brien
    Newcastle University, Institute for Ageing and Health, Wolfson Research Centre, Newcastle upon Tyne, UK
    Br J Radiol 80:S71-7. 2007
    ..Newer techniques show great promise to detect specific neuroreceptor changes as well as pathological underpinnings of dementia, such as amyloid and tau pathology...
  8. ncbi Brain atrophy and white matter hyperintensity change in older adults and relationship to blood pressure. Brain atrophy, WMH change and blood pressure
    Michael J Firbank
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol 254:713-21. 2007
    ..These changes are independent. Successful hypertension treatment was associated with reduced risk of WMH progression and possibly brain atrophy...
  9. pmc Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia
    S G O'Brien
    Department of Haematology, University of Newcastle Medical School, Royal Victoria Infirmary, New Castle NE1 4LP, UK
    Br J Cancer 89:1855-9. 2003
    ..The coadministration of simvastatin with imatinib (400 mg) was well tolerated and no major safety findings were reported in this study...
  10. ncbi Combined magnetic resonance imaging and single-photon emission tomography scanning in the discrimination of Alzheimer's disease from age-matched controls
    J T O'Brien
    University of Newcastle upon Tyne, UK
    Int Psychogeriatr 13:149-61. 2001
    ..To compare the utility of temporal lobe magnetic resonance imaging (MRI) and single-photon emission tomography (SPET) scanning in discriminating between subjects with Alzheimer's disease (AD) and age-matched controls...
  11. ncbi Behavioral symptoms in vascular cognitive impairment and vascular dementia
    JOHN O'BRIEN
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Int Psychogeriatr 15:133-8. 2003
    ..There is a particularly strong relationship between cerebrovascular disease and depression...
  12. ncbi The association between white matter lesions on magnetic resonance imaging and noncognitive symptoms
    J O'BRIEN
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
    Ann N Y Acad Sci 903:482-9. 2000
    ..Further study of the neurobiological basis of WML is needed. This can best be achieved by serial clinical assessment combined with in vivo and in vitro MRI and neuropathological examination...
  13. ncbi Dementia associated with psychiatric disorders
    JOHN O'BRIEN
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Int Psychogeriatr 17:S207-21. 2005
    ..The paper also discusses some of the mechanisms that may contribute to the expression of the cognitive deficits in these disorders and their potential relationship with common causes of dementia...
  14. ncbi Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, England
    Arch Neurol 61:919-25. 2004
    ..Dementia with Lewy bodies (DLB) is a common form of late-life dementia that can be difficult to differentiate from other disorders, especially Alzheimer disease (AD), during life. At autopsy the striatal dopaminergic transporter is reduced...
  15. ncbi Medial temporal lobe width on CT scanning in Alzheimer's disease: comparison with vascular dementia, depression and dementia with Lewy bodies
    J T O'Brien
    Institute for the Health of the Elderly, University of Newcastle upon Tyne, Glasgow, UK
    Dement Geriatr Cogn Disord 11:114-8. 2000
    ..We conclude that a single cross-sectional measurement of MTL width on CT does not help differentiate between different types of dementia, though it may provide some supportive evidence when distinguishing depression from dementia...
  16. ncbi The application of serial MRI analysis techniques to the study of cerebral atrophy in late-onset dementia
    S M Paling
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Med Image Anal 8:69-79. 2004
    ..001) compared to controls. In general the analysis technique is shown to be a robust, accurate and transferable tool of potential value for future studies of dementia and related neuro-degenerative disorders...
  17. doi Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis
    E J Burton
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Brain 132:195-203. 2009
    ..Pathologically, it is more strongly related to tangle rather than plaque or Lewy body pathology in the temporal lobe. It may have utility as a means for stratifying samples in vivo on the basis of putative differences in pathology...
  18. ncbi A comparison of medial and lateral temporal lobe atrophy in dementia with Lewy bodies and Alzheimer's disease: magnetic resonance imaging volumetric study
    R Barber
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 12:198-205. 2001
    ....
  19. ncbi Quantifying fluctuation in dementia with Lewy bodies, Alzheimer's disease, and vascular dementia
    M P Walker
    Medical Research Council Neurochemical Pathology Unit, Institute for the Health of the Elderly, Newcastle, UK
    Neurology 54:1616-25. 2000
    ..Case reports and clinical observations suggest that fluctuating cognition (FC) is common in the major dementias, particularly dementia with Lewy bodies (DLB), where it is one of three core clinical diagnostic features...
  20. doi Relationship between baseline white-matter changes and development of late-life depressive symptoms: 3-year results from the LADIS study
    A Teodorczuk
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Psychol Med 40:603-10. 2010
    ..We investigated whether baseline severity of cerebral white-matter changes predict longer-term future depressive outcomes in a community sample of non-disabled older adults...
  21. ncbi The natural history of psychosis and depression in dementia with Lewy bodies and Alzheimer's disease: persistence and new cases over 1 year of follow-up
    C G Ballard
    Medical Research Council, Neurochemical Pathology Unit, Newcastle upon Tyne, England
    J Clin Psychiatry 62:46-9. 2001
    ..Few data are available regarding the natural course of psychiatric symptoms in dementia with Lewy bodies and Alzheimer's disease. To acquire this information is essential to inform differential diagnosis and treatment decisions...
  22. ncbi Atrophy of the putamen in dementia with Lewy bodies but not Alzheimer's disease: an MRI study
    D A Cousins
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Neurology 61:1191-5. 2003
    ....
  23. doi Poor attentional function predicts cognitive decline in patients with non-demented Parkinson's disease independent of motor phenotype
    J P Taylor
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 79:1318-23. 2008
    ..People with PD display attentional deficits; however, it is not clear whether attentional deficits in patients with non-demented PD are associated with (i) PIGD phenotype and/or (ii) subsequent cognitive decline...
  24. ncbi MRI volumetric correlates of white matter lesions in dementia with Lewy bodies and Alzheimer's disease
    R Barber
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 15:911-6. 2000
    ..In particular, PVH appear to be linked to atrophic processes involving ventricular enlargement and DWMH to ischaemic risk factors...
  25. pmc Motor subtype and cognitive decline in Parkinson's disease, Parkinson's disease with dementia, and dementia with Lewy bodies
    D J Burn
    Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 77:585-9. 2006
    ....
  26. pmc The role of levodopa in the management of dementia with Lewy bodies
    S Molloy
    Regional Neurosciences Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 76:1200-3. 2005
    ..Levodopa is currently the gold standard oral therapy for Parkinson's disease (PD), but its use in DLB has been tempered by concerns of exacerbating neuropsychiatric symptoms...
  27. ncbi APOE epsilon4 and cognitive decline in older stroke patients with early cognitive impairment
    C G Ballard
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Rd, Newcastle upon Tyne, NE4 6BE, UK
    Neurology 63:1399-402. 2004
    ..Dementia is common post stroke, but the potential role of early cognitive impairment and APOE epsilon4 as risk factors is unclear...
  28. ncbi White matter changes and late-life depressive symptoms: longitudinal study
    A Teodorczuk
    Institute for Ageing and Health, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Br J Psychiatry 191:212-7. 2007
    ..Evidence from cross-sectional studies suggests a link between cerebral age-related white matter changes and depressive symptoms in older people, although the temporal association remains unclear...
  29. doi Alterations in nicotinic α4β2 receptor binding in vascular dementia using ¹²³I-5IA-85380 SPECT: comparison with regional cerebral blood flow
    S J Colloby
    Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Neurobiol Aging 32:293-301. 2011
    ..I-5IA-85380 binding was compared to corresponding regional cerebral blood flow (rCBF) changes in the same subjects...
  30. doi Quantitative neurodegenerative pathology does not explain the degree of hippocampal atrophy on MRI in degenerative dementia
    E J Burton
    Institute for Ageing and Health, Newcastle University, UK
    Int J Geriatr Psychiatry 27:1267-74. 2012
    ..The purpose of this study was to investigate the neuropathological substrates underlying in vivo hippocampal atrophy on magnetic resonance imaging (MRI) in autopsy confirmed neurodegenerative dementia cases...
  31. ncbi Depression in late life, cognitive decline and white matter pathology in two clinico-pathologically investigated cases
    A J Lloyd
    Clinical Research Associate, Wolfson Research Centre, Newcastle General Hospital, Newcastle NE4 6BE, UK
    Int J Geriatr Psychiatry 16:281-7. 2001
    ..Neither patient exhibited Alzheimer pathology outwith the norm for their age. We believe this to be the first report of neuropathological findings in depression with white matter changes...
  32. ncbi Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry
    E J Burton
    Institute for Ageing and Health, University of Newcastle upon Tyne, United Kingdom
    Neuroimage 17:618-30. 2002
    ..Comparison of dementia groups showed preservation of the medial temporal lobe, hippocampus, and amygdala in DLB relative to AD. Significant gray matter loss was also observed in the thalamus of AD patients compared to DLB...
  33. ncbi Hippocampal atrophy, whole brain volume, and white matter lesions in older hypertensive subjects
    R M Wiseman
    Institute for Aging and Health, University of Newcastle upon Tyne, UK
    Neurology 63:1892-7. 2004
    ..To determine the potential role of whole brain atrophy, hippocampal atrophy, or both, and small vessel disease/white matter lesions as mechanisms underlying the cognitive impairment associated with hypertension...
  34. doi A comparison of neurocognitive impairment in younger and older adults with major depression
    A J Thomas
    Institute for Ageing and Health, Newcastle University, UK
    Psychol Med 39:725-33. 2009
    ..We hypothesized that ageing alone would not fully explain the increased neurocognitive impairment in late-life depression but that differences in the illness explain the greater decrements in memory and executive function...
  35. ncbi Elevation in late-life depression of intercellular adhesion molecule-1 expression in the dorsolateral prefrontal cortex
    A J Thomas
    Department of Psychiatry, University of Newcastle upon Tyne, UK
    Am J Psychiatry 157:1682-4. 2000
    ..The authors investigated this association by determining whether intercellular adhesion molecule-1 (ICAM-1), a marker of ischemia-induced inflammation, is elevated in the dorsolateral prefrontal cortex in depression...
  36. ncbi Apolipoprotein E epsilon4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias
    R Barber
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, England
    Arch Neurol 56:961-5. 1999
    ..To examine the relationship between the apolipoprotein E (APOE) epsilon4 genotype, medial temporal lobe atrophy, and white matter hyperintensities on magnetic resonance imaging in late-life dementias...
  37. pmc Longitudinal change in 99mTcHMPAO cerebral perfusion SPECT in Parkinson's disease over one year
    M J Firbank
    Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 76:1448-51. 2005
    ..Brain perfusion deficits have been reported previously in subjects with Parkinson's disease in comparison with healthy controls...
  38. ncbi Visual perception in Parkinson disease dementia and dementia with Lewy bodies
    U P Mosimann
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, UK
    Neurology 63:2091-6. 2004
    ..To quantify visual discrimination, space-motion, and object-form perception in patients with Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB), and Alzheimer disease (AD)...
  39. pmc Effect of levodopa on cognitive function in Parkinson's disease with and without dementia and dementia with Lewy bodies
    S A Molloy
    Institute of Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 77:1323-8. 2006
    ..Therefore, the effect of L-dopa on the cognitive profile of dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) is unclear...
  40. ncbi Medial temporal lobe atrophy on MRI in dementia with Lewy bodies
    R Barber
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
    Neurology 52:1153-8. 1999
    ....
  41. pmc Glial fibrillary acidic protein in late life major depressive disorder: an immunocytochemical study
    S Davis
    Wolfson Research Centre, Institute for Aging and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 73:556-60. 2002
    ....
  42. doi The pattern and course of cognitive impairment in late-life depression
    S Kohler
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Psychol Med 40:591-602. 2010
    ..To investigate this, we followed the pattern of cognitive impairments over time and examined the effects of current mood, remission status, age of depression onset and antidepressant (AD) treatment on these deficits...
  43. pmc Cerebral blood flow by arterial spin labeling in poststroke dementia
    M J Firbank
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Neurology 76:1478-84. 2011
    ..To investigate the relationship between cerebral blood flow and dementia in older stroke survivors and subjects with Alzheimer disease (AD)...
  44. ncbi MRI volumetric study of dementia with Lewy bodies: a comparison with AD and vascular dementia
    R Barber
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
    Neurology 54:1304-9. 2000
    ..To compare global and regional atrophy on MRI in subjects with dementia with Lewy bodies (DLB), AD, vascular dementia (VaD), and normal aging. In addition, the relationship between APOE-epsilon4 genotype and volumetric indices was examined...
  45. ncbi Regional cerebral blood flow in Parkinson's disease with and without dementia
    M J Firbank
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK
    Neuroimage 20:1309-19. 2003
    ..The perfusion deficits in PDD are similar those in DLB, and in a location associated with visual processing, and may be associated with the visuospatial perception deficits which are present in persons with DLB and PDD...
  46. ncbi Visual hallucinations are associated with lower alpha bungarotoxin binding in dementia with Lewy bodies
    J A Court
    Joint MRC University of Newcastle Centre Development in Clinical Brain Ageing, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Pharmacol Biochem Behav 70:571-9. 2001
    ..001). Loss of cortical alpha 7 nicotinic receptors may contribute to hallucinations and delusional misidentification in DLB, with implications for treatment and understanding the mechanisms of psychotic symptoms in dementia...
  47. ncbi A study of the serotonin transporter in the prefrontal cortex in late-life depression and Alzheimer's disease with and without depression
    A J Thomas
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Neuropathol Appl Neurobiol 32:296-303. 2006
    ..In a group of subjects more typical of late-life depression we did not identify any alterations in SERT density...
  48. ncbi Changes in DWI and MRS associated with white matter hyperintensities in elderly subjects
    M J Firbank
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Neurology 61:950-4. 2003
    ..To assess normal-appearing white matter (NAWM) characteristics by magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI) in elderly subjects...
  49. ncbi Clinical predictors of response to Acetyl Cholinesterase Inhibitors: experience from routine clinical use in Newcastle
    S Pakrasi
    Institute of Ageing and Health, Wolfson Research Centre, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 18:879-86. 2003
    ..There are few data on the patterns and predictors of response to AChEI therapy in routine clinical practice. We therefore investigated clinical variables that may distinguish between AChEI responders and non-responders...
  50. ncbi Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium
    I G McKeith
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Neurology 65:1863-72. 2005
    ....
  51. ncbi A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson's disease
    M J Firbank
    Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Dement Geriatr Cogn Disord 14:64-76. 2002
    ..This may aid in the diagnosis of PSP. Further research is needed to determine spectroscopic changes in other dementias, to monitor how markers change with disease progression and to establish clinical utility...
  52. doi Magnetic resonance imaging of fixed post mortem brains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter
    K E McAleese
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Neuropathol Appl Neurobiol 39:485-97. 2013
    ..The aim of this study was to evaluate the feasibility of MRI on fixed post mortem brain hemispheres to complement routine neuropathological assessment of subcortical vascular pathology...
  53. pmc Carotid sinus syndrome is common in dementia with Lewy bodies and correlates with deep white matter lesions
    R A Kenny
    MRC Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 75:966-71. 2004
    ..Carotid sinus syndrome (CSS) is a common cause of syncope in older persons. There appears to be a high prevalence of carotid sinus hypersensitivity (CSH) in patients with dementia with Lewy bodies (DLB) but not in Alzheimer's disease...
  54. pmc A neuropathological study of vascular factors in late-life depression
    A J Thomas
    Department of Psychiatry, University of Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 70:83-7. 2001
    ..Postmortem tissue was investigated to determine whether late life depression was associated with atheromatous change in large and medium vessels and microvascular disease in the brain...
  55. ncbi Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial
    Timo Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Lancet 359:1283-90. 2002
    ..We investigated the effects of galantamine in patients with a diagnosis of probable vascular dementia or Alzheimer's disease combined with cerebrovascular disease...
  56. ncbi Sleep-related outcomes in persons with mild to moderate Alzheimer disease in a placebo-controlled trial of galantamine
    Jeffrey S Markowitz
    Health Data Analytics, Princeton Junction, NJ 08550, USA
    Sleep 26:602-6. 2003
    ..To recognize the potential effect of acetylcholinesterase-inhibiting medications on sleep quality when used for the treatment of mild to moderate Alzheimer disease and describe sleep outcomes for patients treated with galantamine...
  57. ncbi Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease
    Sean Lilienfeld
    Janssen Pharmaceutical Inc, Janssen Research Foundation, Division of Janssen Pharmaceutica Ltd, 1125 Trenton Harbourton Road, Titusville, NJ 08560, USA
    CNS Drug Rev 8:159-76. 2002
    ..Galantamine may, therefore, help to reduce the overall burden and cost involved in caring for dementia patients. Taking all evidence into account, galantamine has the potential to become a first-line therapy for dementia...
  58. ncbi An open-label extension trial of galantamine in patients with probable vascular dementia and mixed dementia
    Timo Erkinjuntti
    Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland
    Clin Ther 25:1765-82. 2003
    ....
  59. ncbi Galantamine in the treatment of cognitive decline in patients with vascular dementia or Alzheimer's disease with cerebrovascular disease
    Gary Small
    Department of Psychiatry and Biobehavioral Sciences and Neuropsychiatric Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90024, USA
    CNS Drugs 17:905-14. 2003
    ....
  60. ncbi Management of patients with Alzheimer's disease plus cerebrovascular disease: 12-month treatment with galantamine
    Roger Bullock
    Kingshill Research Centre, Victoria Hospital, Swindon, UK
    Dement Geriatr Cogn Disord 17:29-34. 2004
    ..Subgroup analysis was performed of patients with AD + CVD who participated in a 6-month, multicenter, randomized, double-blind, parallel-group study and a 6-month, open-label, active-treatment extension...
  61. ncbi Cholinesterase inhibitors for Alzheimer disease
    Sean Lilienfeld
    JAMA 289:2360; author reply 2360-1. 2003
  62. ncbi A long-term comparison of galantamine and donepezil in the treatment of Alzheimer's disease
    Gordon Wilcock
    Department of Care of the Elderly, University of Bristol, Frenchay Hospital, Bristol, UK
    Drugs Aging 20:777-89. 2003
    ..To compare the long-term efficacy and safety of galantamine 24 mg/day and donepezil 10 mg/day in patients with Alzheimer's disease...