D J Obbard

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. Feord H, Dear F, Obbard D, van Ooijen G. A Magnesium Transport Protein Related to Mammalian SLC41 and Bacterial MgtE Contributes to Circadian Timekeeping in a Unicellular Green Alga. Genes (Basel). 2019;10: pubmed publisher
    ..We concluded that even though MgtE domain-containing proteins are only distantly related, these proteins retain a shared role in contributing to cellular timekeeping and the regulation of Mg2+i. ..
  2. Obbard D. Expansion of the metazoan virosphere: progress, pitfalls, and prospects. Curr Opin Virol. 2018;31:17-23 pubmed publisher
    ..As a consequence, this period of molecular natural history is helping to reshape our views of deep virus evolution. ..
  3. Obbard D, Harris S, Pannell J. Sexual systems and population genetic structure in an annual plant: testing the metapopulation model. Am Nat. 2006;167:354-66 pubmed
    ..In contrast, regional diversity in M. annua appears to be primarily a product of postglacial range expansion from two refugia in the eastern and western Mediterranean Basin. ..
  4. Obbard D, Welch J, Little T. Inferring selection in the Anopheles gambiae species complex: an example from immune-related serine protease inhibitors. Malar J. 2009;8:117 pubmed publisher
    ..The pitfalls of uncritically applying these tests in this species complex are highlighted, and the future prospects for detecting selection acting on the An. gambiae genome are discussed. ..
  5. Obbard D, Dudas G. The genetics of host-virus coevolution in invertebrates. Curr Opin Virol. 2014;8:73-8 pubmed publisher
  6. Dudas G, Obbard D. Are arthropods at the heart of virus evolution?. elife. 2015;4: pubmed publisher
    ..The huge diversity of negative-sense RNA viruses in insects, spiders and other arthropods suggests that these animals could be central to virus origin and evolution. ..
  7. Obbard D, Callister D, Jiggins F, Soares D, Yan G, Little T. The evolution of TEP1, an exceptionally polymorphic immunity gene in Anopheles gambiae. BMC Evol Biol. 2008;8:274 pubmed publisher
  8. Obbard D, Welch J, Kim K, Jiggins F. Quantifying adaptive evolution in the Drosophila immune system. PLoS Genet. 2009;5:e1000698 pubmed publisher
  9. Obbard D, MACLENNAN J, Kim K, Rambaut A, O Grady P, Jiggins F. Estimating divergence dates and substitution rates in the Drosophila phylogeny. Mol Biol Evol. 2012;29:3459-73 pubmed publisher
    ..As either source of error will bias estimates of divergence time, we suggest mutation rate estimates be used until better models are available. ..

More Information

Publications14

  1. Ramiro R, Reece S, Obbard D. Molecular evolution and phylogenetics of rodent malaria parasites. BMC Evol Biol. 2012;12:219 pubmed publisher
  2. Obbard D, Gordon K, Buck A, Jiggins F. The evolution of RNAi as a defence against viruses and transposable elements. Philos Trans R Soc Lond B Biol Sci. 2009;364:99-115 pubmed publisher
    ..Over longer time scales, key RNAi genes are repeatedly duplicated or lost across the metazoan phylogeny, with important implications for RNAi as an immune defence. ..
  3. Obbard D, Jiggins F, Halligan D, Little T. Natural selection drives extremely rapid evolution in antiviral RNAi genes. Curr Biol. 2006;16:580-5 pubmed
    ..This is a signature of host-pathogen arms races and implies that the ancient battle between RNA viruses and host antiviral RNAi genes is active and significant in shaping RNAi function. ..
  4. Obbard D, Harris S, Buggs R, Pannell J. Hybridization, polyploidy, and the evolution of sexual systems in Mercurialis (Euphorbiaceae). Evolution. 2006;60:1801-15 pubmed
    ..huetii and monoecious tetraploid M. annua, an event that brought together the genes for specialist males with those for hermaphrodites...
  5. Obbard D, Jiggins F, Bradshaw N, Little T. Recent and recurrent selective sweeps of the antiviral RNAi gene Argonaute-2 in three species of Drosophila. Mol Biol Evol. 2011;28:1043-56 pubmed publisher
    ..In summary, our results show that selection by parasites can consistently target the same genes in multiple species, resulting in areas of the genome that have markedly reduced genetic diversity. ..