Genomes and Genes
D J Obbard
Affiliation: University of Edinburgh
- Obbard D, Gordon K, Buck A, Jiggins F. The evolution of RNAi as a defence against viruses and transposable elements. Philos Trans R Soc Lond B Biol Sci. 2009;364:99-115 pubmed publisher..Over longer time scales, key RNAi genes are repeatedly duplicated or lost across the metazoan phylogeny, with important implications for RNAi as an immune defence. ..
- Obbard D, Jiggins F, Halligan D, Little T. Natural selection drives extremely rapid evolution in antiviral RNAi genes. Curr Biol. 2006;16:580-5 pubmed..This is a signature of host-pathogen arms races and implies that the ancient battle between RNA viruses and host antiviral RNAi genes is active and significant in shaping RNAi function. ..
- Obbard D, Harris S, Buggs R, Pannell J. Hybridization, polyploidy, and the evolution of sexual systems in Mercurialis (Euphorbiaceae). Evolution. 2006;60:1801-15 pubmed..huetii and monoecious tetraploid M. annua, an event that brought together the genes for specialist males with those for hermaphrodites...
- Obbard D, Jiggins F, Bradshaw N, Little T. Recent and recurrent selective sweeps of the antiviral RNAi gene Argonaute-2 in three species of Drosophila. Mol Biol Evol. 2011;28:1043-56 pubmed publisher..In summary, our results show that selection by parasites can consistently target the same genes in multiple species, resulting in areas of the genome that have markedly reduced genetic diversity. ..