Donal O Carroll
Affiliation: University of Edinburgh
Davis M, Carrieri C, Saini H, van Dongen S, Leonardi T, Bussotti G, et al
. Transposon-driven transcription is a conserved feature of vertebrate spermatogenesis and transcript evolution. EMBO Rep. 2017;18:1231-1247 pubmed publisher
..In summary, we demonstrate that LTRs can act as tissue-specific promoters and contribute to post-mitotic spermatogenic transcriptome diversity. ..
Paris J, Morgan M, Campos J, Spencer G, Shmakova A, Ivanova I, et al
. Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell. 2019;: pubmed publisher
..Thus, we identify YTHDF2 as a unique therapeutic target whose inhibition selectively targets LSCs while promoting HSC expansion. ..
Morgan M, Kabayama Y, Much C, Ivanova I, Di Giacomo M, Auchynnikava T, et al
. A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis. Cell Res. 2019;29:221-232 pubmed publisher
..In conclusion, we have identified a novel requirement for 3' uridylation-programmed zygotene mRNA clearance in pachytene spermatocytes that is essential for male meiotic progression. ..
Vasiliauskaite L, Berrens R, Ivanova I, Carrieri C, Reik W, Enright A, et al
. Defective germline reprogramming rewires the spermatogonial transcriptome. Nat Struct Mol Biol. 2018;25:394-404 pubmed publisher
..In summary, defective reprogramming deregulates the spermatogonial transcriptome and may underlie spermatogonial dysfunction. ..
Carrieri C, Comazzetto S, Grover A, Morgan M, Buness A, Nerlov C, et al
. A transit-amplifying population underpins the efficient regenerative capacity of the testis. J Exp Med. 2017;214:1631-1641 pubmed publisher
..In summary, the mouse testis has adopted a regenerative strategy to expand stem cell activity by incorporating a transit-amplifying population to the effective stem cell pool, thus ensuring rapid and efficient tissue repair. ..
Ivanova I, Much C, Di Giacomo M, Azzi C, Morgan M, Moreira P, et al
. The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence. Mol Cell. 2017;67:1059-1067.e4 pubmed publisher
..In summary, the m6A-reader YTHDF2 is an intrinsic determinant of mammalian oocyte competence and early zygotic development. ..