Bela Novak

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Irreversible cell-cycle transitions are due to systems-level feedback
    Bela Novak
    Oxford Centre for Integrative Systems Biology, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
    Nat Cell Biol 9:724-8. 2007
  2. pmc Design principles of biochemical oscillators
    Bela Novak
    Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Nat Rev Mol Cell Biol 9:981-91. 2008
  3. pmc Regulated protein kinases and phosphatases in cell cycle decisions
    Bela Novak
    Centre for Integrative Systems Biology and Department of Biochemistry, Oxford University, Oxford, UK
    Curr Opin Cell Biol 22:801-8. 2010
  4. doi request reprint Systems-level feedback in cell-cycle control
    Bela Novak
    Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Biochem Soc Trans 38:1242-6. 2010
  5. doi request reprint The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles
    P K Vinod
    Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, UK
    Biophys Chem 177:1-6. 2013
  6. pmc System-level feedbacks make the anaphase switch irreversible
    Enuo He
    Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    Proc Natl Acad Sci U S A 108:10016-21. 2011
  7. pmc Molecular mechanisms creating bistable switches at cell cycle transitions
    Anael Verdugo
    Department of Biochemistry, University of Oxford, Oxford, UK
    Open Biol 3:120179. 2013
  8. doi request reprint Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1
    Elwy Okaz
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Cell 151:603-18. 2012
  9. pmc Switches and latches: a biochemical tug-of-war between the kinases and phosphatases that control mitosis
    Maria Rosa Domingo-Sananes
    Department of Biochemistry, Oxford Centre for Integrative Systems Biology, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Philos Trans R Soc Lond B Biol Sci 366:3584-94. 2011
  10. pmc Computational modelling of mitotic exit in budding yeast: the role of separase and Cdc14 endocycles
    P K Vinod
    Department of Biochemistry, Oxford Centre for Integrative Systems Biology, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    J R Soc Interface 8:1128-41. 2011

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Irreversible cell-cycle transitions are due to systems-level feedback
    Bela Novak
    Oxford Centre for Integrative Systems Biology, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
    Nat Cell Biol 9:724-8. 2007
    ..This systems-level view of irreversibility is supported by many experimental observations...
  2. pmc Design principles of biochemical oscillators
    Bela Novak
    Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Nat Rev Mol Cell Biol 9:981-91. 2008
    ..Positive feedback is one mechanism to delay the negative-feedback signal. Biological oscillators can be classified according to the topology of the positive- and negative-feedback loops in the underlying regulatory mechanism...
  3. pmc Regulated protein kinases and phosphatases in cell cycle decisions
    Bela Novak
    Centre for Integrative Systems Biology and Department of Biochemistry, Oxford University, Oxford, UK
    Curr Opin Cell Biol 22:801-8. 2010
    ..These general principles are applied to cell cycle transitions, with special emphasis on the roles of regulated phosphatases in orchestrating progression from one phase to the next of the DNA replication-division cycle...
  4. doi request reprint Systems-level feedback in cell-cycle control
    Bela Novak
    Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Biochem Soc Trans 38:1242-6. 2010
    ..The checkpoint-controlled cell cycles are always driven by a negative-feedback loop amplified by double-negative feedbacks (antagonism)...
  5. doi request reprint The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles
    P K Vinod
    Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, UK
    Biophys Chem 177:1-6. 2013
    ..We show that Emi2 interferes with the intrinsic time-delay in APC/C activation and inactivation to increase the amplitude as well as shorten the period of Cyclin B oscillation...
  6. pmc System-level feedbacks make the anaphase switch irreversible
    Enuo He
    Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    Proc Natl Acad Sci U S A 108:10016-21. 2011
    ..These and other puzzles associated with the mitotic checkpoint are addressed by a proposed molecular mechanism, which involves two positive feedback loops that create a bistable response of the checkpoint to chromosomal tension...
  7. pmc Molecular mechanisms creating bistable switches at cell cycle transitions
    Anael Verdugo
    Department of Biochemistry, University of Oxford, Oxford, UK
    Open Biol 3:120179. 2013
    ..Variations of the motif might support irreversible cellular decision-making in other contexts...
  8. doi request reprint Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1
    Elwy Okaz
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Cell 151:603-18. 2012
    ..Thus, control of prophase I by meiotic mechanisms depends on the suppression of the alternative, mitotic mechanisms by a meiosis-specific form of the APC/C...
  9. pmc Switches and latches: a biochemical tug-of-war between the kinases and phosphatases that control mitosis
    Maria Rosa Domingo-Sananes
    Department of Biochemistry, Oxford Centre for Integrative Systems Biology, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Philos Trans R Soc Lond B Biol Sci 366:3584-94. 2011
    ..The bistable character of the switch implies the existence of a CycB threshold for entry into mitosis. The end of G2 phase is determined by the point where CycB level crosses the CycB threshold for Cdk1 activation...
  10. pmc Computational modelling of mitotic exit in budding yeast: the role of separase and Cdc14 endocycles
    P K Vinod
    Department of Biochemistry, Oxford Centre for Integrative Systems Biology, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    J R Soc Interface 8:1128-41. 2011
    ..The model is also used for the systematic analysis of the recently discovered Cdc14 endocycles. The significance of Cdc14 endocycles in eukaryotic cell cycle control is discussed as well...
  11. pmc Dynamical scenarios for chromosome bi-orientation
    Tongli Zhang
    Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Biophys J 104:2595-606. 2013
    ..Based on our results and supported by experimental data, we put forward a trial-and-error oscillation and a stochastic bistable switch as two elegant mechanisms with the potential to promote bi-orientation both efficiently and robustly. ..
  12. pmc Cell cycle commitment in budding yeast emerges from the cooperation of multiple bistable switches
    Tongli Zhang
    Oxford Centre for Integrative Systems Biology OCISB, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Open Biol 1:110009. 2011
    ....
  13. doi request reprint Interplay of transcriptional and proteolytic regulation in driving robust cell cycle progression
    Paula Freire
    Department of Biochemistry, University of Oxford, Oxford, UK
    Mol Biosyst 8:863-70. 2012
    ..We show that both regulated transcription and degradation are part of feedback loops in the network which ensure robust function against parametric variations that can arise from the mutations and/or variations in protein levels...
  14. pmc Minimal models for cell-cycle control based on competitive inhibition and multisite phosphorylations of Cdk substrates
    Claude Gérard
    Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Biophys J 104:1367-79. 2013
    ....
  15. pmc Bistability by multiple phosphorylation of regulatory proteins
    Orsolya Kapuy
    Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Prog Biophys Mol Biol 100:47-56. 2009
    ....
  16. doi request reprint Different effects of redundant feedback loops on a bistable switch
    Maria Rosa Domingo-Sananes
    Department of Biochemistry, Oxford Centre for Integrative Systems Biology, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Chaos 20:045120. 2010
    ..We speculate that this conclusion could be general for other bistable systems with redundant feedback loops...
  17. pmc Role for regulated phosphatase activity in generating mitotic oscillations in Xenopus cell-free extracts
    Tongli Zhang
    Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    Proc Natl Acad Sci U S A 110:20539-44. 2013
    ....
  18. pmc System-level feedbacks control cell cycle progression
    Orsolya Kapuy
    Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, UK
    FEBS Lett 583:3992-8. 2009
    ..We have also argued that bistability underlies irreversible transitions between low and high Cdk activity states and thereby ensures directionality of cell cycle progression...
  19. pmc microRNA as a Potential Vector for the Propagation of Robustness in Protein Expression and Oscillatory Dynamics within a ceRNA Network
    Claude Gérard
    Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 8:e83372. 2013
    ..Thus, by means of computational models, we show that miRNAs could act as vectors allowing the propagation of robustness in protein synthesis as well as oscillatory behaviors within ceRNA networks. ..
  20. doi request reprint The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation
    Michael J Cundell
    University of Oxford, Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK
    Mol Cell 52:393-405. 2013
    ..Therefore, temporal order during mitotic exit is promoted by the metazoan BEG pathway. ..
  21. pmc Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model
    Bernhard Schmierer
    Oxford Centre for Integrative Systems Biology OCISB, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    BMC Syst Biol 4:139. 2010
    ..Competition by ARD proteins for FIH is hypothesised to affect FIH activity towards HIFα; however the extent of this competition and its effect on the HIF-dependent hypoxic response are unknown...
  22. doi request reprint Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint
    Barry E McGuinness
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom
    Curr Biol 19:369-80. 2009
    ..Experimental approaches hitherto used to inactivate the SAC in oocytes suffer from a number of drawbacks...