Jane E Norman
Affiliation: University of Edinburgh
- Trial protocol OPPTIMUM-- does progesterone prophylaxis for the prevention of preterm labour improve outcome?Jane E Norman
University of Edinburgh MRC Centre for Reproductive Health, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TY, UK
BMC Pregnancy Childbirth 12:79. 2012....
- Progestogens to prevent preterm birth in twin pregnancies: an individual participant data meta-analysis of randomized trialsEwoud Schuit
Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
BMC Pregnancy Childbirth 12:13. 2012....
- Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysisJane E Norman
Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, UK
Lancet 373:2034-40. 2009..We investigated the use of progesterone for prevention of preterm birth in twin pregnancy...
- The effect of changing patterns of obstetric care in Scotland (1980-2004) on rates of preterm birth and its neonatal consequences: perinatal database studyJane E Norman
University of Edinburgh Centre for Reproductive Biology, Edinburgh, UK
PLoS Med 6:e1000153. 2009..We aimed, in a population-based database of 5 million people, to determine the temporal trends and obstetric antecedents of singleton preterm birth and its associated neonatal mortality and morbidity for the period 1980-2004...
- Effect of prolonged in vivo administration of progesterone in pregnancy on myometrial gene expression, peripheral blood leukocyte activation, and circulating steroid hormone levelsJane E Norman
Centre for Reproductive Biology, Queen s Medical Research Centre, University of Edinburgh, Edinburgh, United Kingdom
Reprod Sci 18:435-46. 2011..We aimed to investigate the effects of progesterone on gene expression and function of both myometrium and circulating leukocytes...
- The consequences of obesity and excess weight gain in pregnancyJane E Norman
Tommy s Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TY, UK
Proc Nutr Soc 70:450-6. 2011..Lastly, we discuss the nature and rationale for possible intervention strategies in obese pregnant women...
- Maternal obesity has little effect on the immediate offspring but impacts on the next generationVicky King
Medical Research Council University of Edinburgh Centre for Reproductive Health, University British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
Endocrinology 154:2514-24. 2013..This suggests that the consequences of the current dietary obesity epidemic may also have an impact on the descendants of obese individuals, even when the phenotype of the F1 appears largely unaffected. ..
- Outcomes of induction of labour in women with previous caesarean delivery: a retrospective cohort study using a population databaseSarah J Stock
MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom
PLoS ONE 8:e60404. 2013..The aim of this study was to describe outcomes of IOL at 39-41 weeks in women with one previous caesarean delivery and to compare outcomes of IOL or planned caesarean delivery to those of expectant management...
- A novel antiinflammatory role for the short-chain fatty acids in human laborChiara Voltolini
Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
Endocrinology 153:395-403. 2012..Suppression of inflammatory pathways by SCFA may be therapeutically beneficial for pregnant women at risk of pathogen-induced preterm delivery...
- Outcomes of elective induction of labour compared with expectant management: population based studySarah J Stock
Tommy s Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, UK
BMJ 344:e2838. 2012..To determine neonatal outcomes (perinatal mortality and special care unit admission) and maternal outcomes (mode of delivery, delivery complications) of elective induction of labour compared with expectant management...
- Prokineticin 1 induces inflammatory response in human myometrium: a potential role in initiating term and preterm parturitionMarta R Gorowiec
Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh, United Kingdom
Am J Pathol 179:2709-19. 2011..We propose that PROK1 is a novel inflammatory mediator that can contribute to the onset of human parturition at term and partially mediate premature onset of inflammatory pathways during bacterial infection...
- Maternal and neonatal outcomes of successful Kielland's rotational forceps deliverySarah J Stock
University of Edinburgh MRC Centre for Reproductive Health, Queen s Medical Royal, the Infirmary of Edinburgh, Little France, Edinburgh, UK
Obstet Gynecol 121:1032-9. 2013..To estimate the rates of early neonatal and maternal complications in a consecutive series of successful Kielland's rotational forceps deliveries...
- Novel use of proton magnetic resonance spectroscopy (1HMRS) to non-invasively assess placental metabolismFiona C Denison
MRC Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, Lothian, United Kingdom
PLoS ONE 7:e42926. 2012..We hypothesised that abnormal placental (1)H MRS may be an earlier biomarker of intrauterine hypoxia, affording the opportunity to optimise timing of delivery in at-risk fetuses...
- Immediate versus deferred delivery of the preterm baby with suspected fetal compromise for improving outcomesSarah J Stock
MRC Centre for Reproductive Health, University of Edinburgh Queen s Medical Research Centre, Edinburgh, UK
Cochrane Database Syst Rev 7:CD008968. 2012..Immediate delivery of the preterm fetus with suspected compromise may decrease the risk of damage due to intrauterine hypoxia. However, it may also increase the risks of prematurity...
- Evaluation of an FFQ to assess total energy and nutrient intakes in severely obese pregnant womenNor A Mohd-Shukri
Endocrinology Unit, University BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
Public Health Nutr 16:1427-35. 2013..The aim of the present study was to compare nutrient intakes assessed by an FFQ with those obtained from a food diary among severely obese pregnant women...
- Anti-inflammatory mediators as physiological and pharmacological regulators of parturitionSara F Rinaldi
MRC Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, EH16 4TJ, UK
Expert Rev Clin Immunol 7:675-96. 2011....
- Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275 person yearsRebecca M Reynolds
Endocrinology Unit, BHF University Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH14 6TJ, UK
BMJ 347:f4539. 2013..To determine whether maternal obesity during pregnancy is associated with increased mortality from cardiovascular events in adult offspring...
- A role for lipoxin A4 as anti-inflammatory and proresolution mediator in human parturitionDavid Maldonado-Pérez
Division of Reproductive and Developmental Sciences, University of Edinburgh, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
FASEB J 25:569-75. 2011..05), compared to vehicle-treated controls. We demonstrate for the first time a potential role for lipoxin A(4) and its receptor in the resolution of the inflammatory events of both physiological and pathological labor...