Jane E Norman

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Leukocytes are primed in peripheral blood for activation during term and preterm labour
    M Yuan
    Centre for Reproductive Biology, The Queen s Medical Research Centre, University of Edinburgh, Edinburgh EH16 4TY, UK
    Mol Hum Reprod 15:713-24. 2009
  2. pmc Trial protocol OPPTIMUM-- does progesterone prophylaxis for the prevention of preterm labour improve outcome?
    Jane E Norman
    University of Edinburgh MRC Centre for Reproductive Health, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TY, UK
    BMC Pregnancy Childbirth 12:79. 2012
  3. pmc Progestogens to prevent preterm birth in twin pregnancies: an individual participant data meta-analysis of randomized trials
    Ewoud Schuit
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    BMC Pregnancy Childbirth 12:13. 2012
  4. doi Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis
    Jane E Norman
    Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, UK
    Lancet 373:2034-40. 2009
  5. doi The consequences of obesity and excess weight gain in pregnancy
    Jane E Norman
    Tommy s Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TY, UK
    Proc Nutr Soc 70:450-6. 2011
  6. doi Effect of prolonged in vivo administration of progesterone in pregnancy on myometrial gene expression, peripheral blood leukocyte activation, and circulating steroid hormone levels
    Jane E Norman
    Centre for Reproductive Biology, Queen s Medical Research Centre, University of Edinburgh, Edinburgh, United Kingdom
    Reprod Sci 18:435-46. 2011
  7. pmc The effect of changing patterns of obstetric care in Scotland (1980-2004) on rates of preterm birth and its neonatal consequences: perinatal database study
    Jane E Norman
    University of Edinburgh Centre for Reproductive Biology, Edinburgh, UK
    PLoS Med 6:e1000153. 2009
  8. pmc Outcomes of induction of labour in women with previous caesarean delivery: a retrospective cohort study using a population database
    Sarah J Stock
    MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e60404. 2013
  9. pmc Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275 person years
    Rebecca M Reynolds
    Endocrinology Unit, BHF University Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH14 6TJ, UK
    BMJ 347:f4539. 2013
  10. pmc Decidual neutrophil infiltration is not required for preterm birth in a mouse model of infection-induced preterm labor
    Sara F Rinaldi
    Medical Research Council Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Immunol 192:2315-25. 2014

Collaborators

Detail Information

Publications24

  1. pmc Leukocytes are primed in peripheral blood for activation during term and preterm labour
    M Yuan
    Centre for Reproductive Biology, The Queen s Medical Research Centre, University of Edinburgh, Edinburgh EH16 4TY, UK
    Mol Hum Reprod 15:713-24. 2009
    ..These data may lead to novel therapies and diagnostic tools for the prevention and/or diagnosis of preterm birth...
  2. pmc Trial protocol OPPTIMUM-- does progesterone prophylaxis for the prevention of preterm labour improve outcome?
    Jane E Norman
    University of Edinburgh MRC Centre for Reproductive Health, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TY, UK
    BMC Pregnancy Childbirth 12:79. 2012
    ....
  3. pmc Progestogens to prevent preterm birth in twin pregnancies: an individual participant data meta-analysis of randomized trials
    Ewoud Schuit
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    BMC Pregnancy Childbirth 12:13. 2012
    ....
  4. doi Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis
    Jane E Norman
    Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, UK
    Lancet 373:2034-40. 2009
    ..We investigated the use of progesterone for prevention of preterm birth in twin pregnancy...
  5. doi The consequences of obesity and excess weight gain in pregnancy
    Jane E Norman
    Tommy s Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TY, UK
    Proc Nutr Soc 70:450-6. 2011
    ..Lastly, we discuss the nature and rationale for possible intervention strategies in obese pregnant women...
  6. doi Effect of prolonged in vivo administration of progesterone in pregnancy on myometrial gene expression, peripheral blood leukocyte activation, and circulating steroid hormone levels
    Jane E Norman
    Centre for Reproductive Biology, Queen s Medical Research Centre, University of Edinburgh, Edinburgh, United Kingdom
    Reprod Sci 18:435-46. 2011
    ..We aimed to investigate the effects of progesterone on gene expression and function of both myometrium and circulating leukocytes...
  7. pmc The effect of changing patterns of obstetric care in Scotland (1980-2004) on rates of preterm birth and its neonatal consequences: perinatal database study
    Jane E Norman
    University of Edinburgh Centre for Reproductive Biology, Edinburgh, UK
    PLoS Med 6:e1000153. 2009
    ..We aimed, in a population-based database of 5 million people, to determine the temporal trends and obstetric antecedents of singleton preterm birth and its associated neonatal mortality and morbidity for the period 1980-2004...
  8. pmc Outcomes of induction of labour in women with previous caesarean delivery: a retrospective cohort study using a population database
    Sarah J Stock
    MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e60404. 2013
    ..The aim of this study was to describe outcomes of IOL at 39-41 weeks in women with one previous caesarean delivery and to compare outcomes of IOL or planned caesarean delivery to those of expectant management...
  9. pmc Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275 person years
    Rebecca M Reynolds
    Endocrinology Unit, BHF University Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH14 6TJ, UK
    BMJ 347:f4539. 2013
    ..To determine whether maternal obesity during pregnancy is associated with increased mortality from cardiovascular events in adult offspring...
  10. pmc Decidual neutrophil infiltration is not required for preterm birth in a mouse model of infection-induced preterm labor
    Sara F Rinaldi
    Medical Research Council Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Immunol 192:2315-25. 2014
    ....
  11. doi Maternal obesity has little effect on the immediate offspring but impacts on the next generation
    Vicky King
    Medical Research Council University of Edinburgh Centre for Reproductive Health, University British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 154:2514-24. 2013
    ..This suggests that the consequences of the current dietary obesity epidemic may also have an impact on the descendants of obese individuals, even when the phenotype of the F1 appears largely unaffected. ..
  12. doi A novel antiinflammatory role for the short-chain fatty acids in human labor
    Chiara Voltolini
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 153:395-403. 2012
    ..Suppression of inflammatory pathways by SCFA may be therapeutically beneficial for pregnant women at risk of pathogen-induced preterm delivery...
  13. pmc Prokineticin 1 induces inflammatory response in human myometrium: a potential role in initiating term and preterm parturition
    Marta R Gorowiec
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    Am J Pathol 179:2709-19. 2011
    ..We propose that PROK1 is a novel inflammatory mediator that can contribute to the onset of human parturition at term and partially mediate premature onset of inflammatory pathways during bacterial infection...
  14. pmc Outcomes of elective induction of labour compared with expectant management: population based study
    Sarah J Stock
    Tommy s Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, UK
    BMJ 344:e2838. 2012
    ..To determine neonatal outcomes (perinatal mortality and special care unit admission) and maternal outcomes (mode of delivery, delivery complications) of elective induction of labour compared with expectant management...
  15. doi Evaluation of an FFQ to assess total energy and nutrient intakes in severely obese pregnant women
    Nor A Mohd-Shukri
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Public Health Nutr 16:1427-35. 2013
    ..The aim of the present study was to compare nutrient intakes assessed by an FFQ with those obtained from a food diary among severely obese pregnant women...
  16. doi Maternal and neonatal outcomes of successful Kielland's rotational forceps delivery
    Sarah J Stock
    University of Edinburgh MRC Centre for Reproductive Health, Queen s Medical Royal, the Infirmary of Edinburgh, Little France, Edinburgh, UK
    Obstet Gynecol 121:1032-9. 2013
    ..To estimate the rates of early neonatal and maternal complications in a consecutive series of successful Kielland's rotational forceps deliveries...
  17. pmc Novel use of proton magnetic resonance spectroscopy (1HMRS) to non-invasively assess placental metabolism
    Fiona C Denison
    MRC Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, Lothian, United Kingdom
    PLoS ONE 7:e42926. 2012
    ..We hypothesised that abnormal placental (1)H MRS may be an earlier biomarker of intrauterine hypoxia, affording the opportunity to optimise timing of delivery in at-risk fetuses...
  18. doi Immediate versus deferred delivery of the preterm baby with suspected fetal compromise for improving outcomes
    Sarah J Stock
    MRC Centre for Reproductive Health, University of Edinburgh Queen s Medical Research Centre, Edinburgh, UK
    Cochrane Database Syst Rev 7:CD008968. 2012
    ..Immediate delivery of the preterm fetus with suspected compromise may decrease the risk of damage due to intrauterine hypoxia. However, it may also increase the risks of prematurity...
  19. pmc A computational model of lipopolysaccharide-induced nuclear factor kappa B activation: a key signalling pathway in infection-induced preterm labour
    Gemma C Sharp
    Medical Research Council MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e70180. 2013
    ....
  20. ncbi Intergenerational transmission of postpartum hemorrhage risk: analysis of 2 Scottish birth cohorts
    Gemma C Sharp
    MRC Center for Reproductive Health, University of Edinburgh, Edinburgh, Scotland, UK Electronic address
    Am J Obstet Gynecol 211:51.e1-7. 2014
    ..The purpose of this study was to determine risk factors for postpartum hemorrhage (PPH) that includes intergenerational transmission of risk of postpartum hemorrhage...
  21. doi Lipopolysaccharide promotes contraction of uterine myocytes via activation of Rho/ROCK signaling pathways
    James L Hutchinson
    1MRC Centre for Reproductive Health, University of Edinburgh, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    FASEB J 28:94-105. 2014
    ....
  22. doi Anti-inflammatory mediators as physiological and pharmacological regulators of parturition
    Sara F Rinaldi
    MRC Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, EH16 4TJ, UK
    Expert Rev Clin Immunol 7:675-96. 2011
    ....
  23. pmc Pregnancy in obese mice protects selectively against visceral adiposity and is associated with increased adipocyte estrogen signalling
    Silvia M A Pedroni
    Tommy s Centre for Maternal and Fetal Health, The University of Edinburgh, Queen s Medical Research Institute, Edinburgh, United Kingdom MRC Centre for Reproductive Health, The University of Edinburgh, Queen s Medical Research Institute, Edinburgh, United Kingdom
    PLoS ONE 9:e94680. 2014
    ....
  24. doi A role for lipoxin A4 as anti-inflammatory and proresolution mediator in human parturition
    David Maldonado-Pérez
    Division of Reproductive and Developmental Sciences, University of Edinburgh, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    FASEB J 25:569-75. 2011
    ..05), compared to vehicle-treated controls. We demonstrate for the first time a potential role for lipoxin A(4) and its receptor in the resolution of the inflammatory events of both physiological and pathological labor...