Chris J Norbury

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint 3' Uridylation and the regulation of RNA function in the cytoplasm
    Chris J Norbury
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Biochem Soc Trans 38:1150-3. 2010
  2. doi request reprint Special issue: Novel RNA nucleotidyl transferases and gene regulation. Preface
    Chris J Norbury
    Biochim Biophys Acta 1779:205. 2008
  3. pmc Requirement of fission yeast Cid14 in polyadenylation of rRNAs
    Thein Z Win
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
    Mol Cell Biol 26:1710-21. 2006
  4. ncbi request reprint Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase
    Luke A Yates
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Struct Mol Biol 19:782-7. 2012
  5. pmc Decapping is preceded by 3' uridylation in a novel pathway of bulk mRNA turnover
    Olivia S Rissland
    Sir William Dunn School of Pathology, University of Oxford, UK
    Nat Struct Mol Biol 16:616-23. 2009
  6. ncbi request reprint The Cid1 poly(U) polymerase
    Olivia S Rissland
    Sir William Dunn School of Pathology, University of Oxford, UK
    Biochim Biophys Acta 1779:286-94. 2008
  7. pmc Inactivation of the pre-mRNA cleavage and polyadenylation factor Pfs2 in fission yeast causes lethal cell cycle defects
    Shao Win Wang
    Department of Zoology, Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford OX1 3RE, United Kingdom
    Mol Cell Biol 25:2288-96. 2005
  8. doi request reprint RNA decay via 3' uridylation
    Daniel D Scott
    University of Oxford, Sir William Dunn School of Pathology, Oxford, UK
    Biochim Biophys Acta 1829:654-65. 2013
  9. doi request reprint Cytoplasmic RNA: a case of the tail wagging the dog
    Chris J Norbury
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Mol Cell Biol 14:643-53. 2013
  10. doi request reprint Polyadenylation and beyond: emerging roles for noncanonical poly(A) polymerases
    Marie Joëlle Schmidt
    Sir William Dunn School of Pathology, University of Oxford, UK
    Wiley Interdiscip Rev RNA 1:142-51. 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint 3' Uridylation and the regulation of RNA function in the cytoplasm
    Chris J Norbury
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Biochem Soc Trans 38:1150-3. 2010
    ..This modification may also form the basis of a widespread mechanism for the initiation of the decay of polyadenylated mRNAs in organisms other than fission yeast...
  2. doi request reprint Special issue: Novel RNA nucleotidyl transferases and gene regulation. Preface
    Chris J Norbury
    Biochim Biophys Acta 1779:205. 2008
  3. pmc Requirement of fission yeast Cid14 in polyadenylation of rRNAs
    Thein Z Win
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
    Mol Cell Biol 26:1710-21. 2006
    ..Polyadenylation-assisted nuclear RNA turnover is therefore likely to be a common eukaryotic mechanism affecting diverse biological processes...
  4. ncbi request reprint Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase
    Luke A Yates
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Struct Mol Biol 19:782-7. 2012
    ..Overall, our structures provide a basis for understanding the activity of Cid1 and a mechanism of UTP selectivity conserved in its human orthologs, suggesting potential implications for anticancer drug design...
  5. pmc Decapping is preceded by 3' uridylation in a novel pathway of bulk mRNA turnover
    Olivia S Rissland
    Sir William Dunn School of Pathology, University of Oxford, UK
    Nat Struct Mol Biol 16:616-23. 2009
    ..As human cells contain Cid1 orthologs, uridylation may form the basis of a widespread, conserved mechanism of mRNA decay...
  6. ncbi request reprint The Cid1 poly(U) polymerase
    Olivia S Rissland
    Sir William Dunn School of Pathology, University of Oxford, UK
    Biochim Biophys Acta 1779:286-94. 2008
    ..Here, we review the literature on Cid1, other PUPs and uridylation, a conserved and previously under-appreciated mechanism of RNA regulation...
  7. pmc Inactivation of the pre-mRNA cleavage and polyadenylation factor Pfs2 in fission yeast causes lethal cell cycle defects
    Shao Win Wang
    Department of Zoology, Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford OX1 3RE, United Kingdom
    Mol Cell Biol 25:2288-96. 2005
    ..Mutations in pfs2 were suppressed by overexpression of the putative mRNA 3'-end cleavage factor Cft1. These data suggest unexpected links between mRNA 3'-end processing and chromosome replication and segregation...
  8. doi request reprint RNA decay via 3' uridylation
    Daniel D Scott
    University of Oxford, Sir William Dunn School of Pathology, Oxford, UK
    Biochim Biophys Acta 1829:654-65. 2013
    ..The extent to which other uridylation-dependent mechanisms of RNA decay are similarly regulated awaits further investigation. This article is part of a Special Issue entitled: RNA Decay mechanisms...
  9. doi request reprint Cytoplasmic RNA: a case of the tail wagging the dog
    Chris J Norbury
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Rev Mol Cell Biol 14:643-53. 2013
    ..These terminal uridylyl transferases promote the turnover of certain mRNAs but also modify microRNAs, their precursors and other small RNAs to modulate their stability or biological functions. ..
  10. doi request reprint Polyadenylation and beyond: emerging roles for noncanonical poly(A) polymerases
    Marie Joëlle Schmidt
    Sir William Dunn School of Pathology, University of Oxford, UK
    Wiley Interdiscip Rev RNA 1:142-51. 2010
    ..Here we review the current knowledge of these enzymes, with an emphasis on the human proteins, and highlight recent discoveries that have implications far beyond the understanding of RNA metabolism itself...
  11. pmc Activation of AP-1-dependent transcription by a truncated translation initiation factor
    Caroline C L Jenkins
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Eukaryot Cell 4:1840-50. 2005
    ..Int6CT therefore activates Pap1-dependent transcription by a novel mechanism...
  12. pmc Efficient RNA polyuridylation by noncanonical poly(A) polymerases
    Olivia S Rissland
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Mol Cell Biol 27:3612-24. 2007
    ..Finally, Hs2 (ZCCHC6), a human ortholog of Cid1, shows similar activity. These data suggest that uridylation of mRNA forms the basis of an evolutionarily conserved mechanism of gene regulation...
  13. pmc The human cytoplasmic RNA terminal U-transferase ZCCHC11 targets histone mRNAs for degradation
    Marie Joëlle Schmidt
    University of Oxford, Sir William Dunn School of Pathology, Oxford OX1 3RE, United Kingdom
    RNA 17:39-44. 2011
    ..Our data indicate that ZCCHC11 is the terminal U-transferase responsible for targeting human histone mRNAs for degradation following inhibition or completion of DNA replication...
  14. doi request reprint Transcriptional and cellular responses to defective mitochondrial proteolysis in fission yeast
    Suranjana Guha
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    J Mol Biol 408:222-37. 2011
    ..Based on these findings, we posit that excess iron accumulation could contribute to the pathology of human neurodegenerative disorders arising from defects in m-AAA function...
  15. ncbi request reprint Telomere maintenance: all's well that ends well
    Li Phing Liew
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Arch Toxicol 83:407-16. 2009
    ..Of particular interest in this respect are the ways in which telomere-binding proteins and components of the DNA damage response machinery may facilitate replication fork progression through telomeres...
  16. ncbi request reprint The long and short of microRNA
    Luke A Yates
    Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Cell 153:516-9. 2013
    ....
  17. ncbi request reprint The Cid1 family of non-canonical poly(A) polymerases
    Abigail L Stevenson
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Yeast 23:991-1000. 2006
    ..Cid1-like proteins have important roles in diverse biological processes, including RNA surveillance pathways, DNA integrity checkpoint responses and RNAi-dependent heterochromatin formation...
  18. pmc The INT6 cancer gene and MEK signaling pathways converge during zebrafish development
    Michal Grzmil
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 2:e959. 2007
    ..INT6 expression is altered in human cancers, but the precise role of disrupted INT6 in tumorigenesis remains unclear, and an animal model to study Int-6 physiological function has been lacking...
  19. ncbi request reprint Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrity
    Thein Z Win
    Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
    J Cell Sci 117:4769-78. 2004
    ..Our data are consistent with the notion that Top3 has a key function in homologous recombinational repair during S phase that is essential for ensuring subsequent fidelity of chromosome segregation...
  20. pmc Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest
    Rebecca L Read
    Cancer Research UK Molecular Oncology Laboratory, University of Oxford Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 99:12079-84. 2002
    ..Cytoplasmic polyadenylation is known to be an important regulatory mechanism during early development in animals. Our findings in yeast suggest that this level of gene regulation is of more general significance in eukaryotic cells...