Research Topics
| Chris J NorburySummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
3' Uridylation and the regulation of RNA function in the cytoplasmChris J Norbury
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Biochem Soc Trans 38:1150-3. 2010..This modification may also form the basis of a widespread mechanism for the initiation of the decay of polyadenylated mRNAs in organisms other than fission yeast...
Special issue: Novel RNA nucleotidyl transferases and gene regulation. PrefaceChris J Norbury
Biochim Biophys Acta 1779:205. 2008- Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferaseLuke A Yates
Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Nat Struct Mol Biol 19:782-7. 2012..Overall, our structures provide a basis for understanding the activity of Cid1 and a mechanism of UTP selectivity conserved in its human orthologs, suggesting potential implications for anticancer drug design... 
Decapping is preceded by 3' uridylation in a novel pathway of bulk mRNA turnoverOlivia S Rissland
Sir William Dunn School of Pathology, University of Oxford, UK
Nat Struct Mol Biol 16:616-23. 2009..As human cells contain Cid1 orthologs, uridylation may form the basis of a widespread, conserved mechanism of mRNA decay...- The Cid1 poly(U) polymeraseOlivia S Rissland
Sir William Dunn School of Pathology, University of Oxford, UK
Biochim Biophys Acta 1779:286-94. 2008..Here, we review the literature on Cid1, other PUPs and uridylation, a conserved and previously under-appreciated mechanism of RNA regulation... - Polyadenylation and beyond: emerging roles for noncanonical poly(A) polymerasesMarie Joëlle Schmidt
Sir William Dunn School of Pathology, University of Oxford, UK
Wiley Interdiscip Rev RNA 1:142-51. 2010..Here we review the current knowledge of these enzymes, with an emphasis on the human proteins, and highlight recent discoveries that have implications far beyond the understanding of RNA metabolism itself... - Efficient RNA polyuridylation by noncanonical poly(A) polymerasesOlivia S Rissland
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
Mol Cell Biol 27:3612-24. 2007..Finally, Hs2 (ZCCHC6), a human ortholog of Cid1, shows similar activity. These data suggest that uridylation of mRNA forms the basis of an evolutionarily conserved mechanism of gene regulation... - The human cytoplasmic RNA terminal U-transferase ZCCHC11 targets histone mRNAs for degradationMarie Joëlle Schmidt
University of Oxford, Sir William Dunn School of Pathology, Oxford OX1 3RE, United Kingdom
RNA 17:39-44. 2011..Our data indicate that ZCCHC11 is the terminal U-transferase responsible for targeting human histone mRNAs for degradation following inhibition or completion of DNA replication... - Transcriptional and cellular responses to defective mitochondrial proteolysis in fission yeastSuranjana Guha
Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
J Mol Biol 408:222-37. 2011..Based on these findings, we posit that excess iron accumulation could contribute to the pathology of human neurodegenerative disorders arising from defects in m-AAA function... - The Cid1 family of non-canonical poly(A) polymerasesAbigail L Stevenson
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
Yeast 23:991-1000. 2006..Cid1-like proteins have important roles in diverse biological processes, including RNA surveillance pathways, DNA integrity checkpoint responses and RNAi-dependent heterochromatin formation... - Requirement for Schizosaccharomyces pombe Top3 in the maintenance of chromosome integrityThein Z Win
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
J Cell Sci 117:4769-78. 2004..Our data are consistent with the notion that Top3 has a key function in homologous recombinational repair during S phase that is essential for ensuring subsequent fidelity of chromosome segregation... - Inactivation of the pre-mRNA cleavage and polyadenylation factor Pfs2 in fission yeast causes lethal cell cycle defectsShao Win Wang
Department of Zoology, Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford OX1 3RE, United Kingdom
Mol Cell Biol 25:2288-96. 2005..Mutations in pfs2 were suppressed by overexpression of the putative mRNA 3'-end cleavage factor Cft1. These data suggest unexpected links between mRNA 3'-end processing and chromosome replication and segregation... - Activation of AP-1-dependent transcription by a truncated translation initiation factorCaroline C L Jenkins
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
Eukaryot Cell 4:1840-50. 2005..Int6CT therefore activates Pap1-dependent transcription by a novel mechanism... - Requirement of fission yeast Cid14 in polyadenylation of rRNAsThein Z Win
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
Mol Cell Biol 26:1710-21. 2006..Polyadenylation-assisted nuclear RNA turnover is therefore likely to be a common eukaryotic mechanism affecting diverse biological processes... - Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrestRebecca L Read
Cancer Research UK Molecular Oncology Laboratory, University of Oxford Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
Proc Natl Acad Sci U S A 99:12079-84. 2002..Cytoplasmic polyadenylation is known to be an important regulatory mechanism during early development in animals. Our findings in yeast suggest that this level of gene regulation is of more general significance in eukaryotic cells...