Richard M Nixon

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Mammographic screening in women with a family history of breast cancer: some results from the Swedish two-county trial
    R M Nixon
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, CB2 2SR, UK
    Rev Epidemiol Sante Publique 48:325-31. 2000
  2. doi Using short-term evidence to predict six-month outcomes in clinical trials of signs and symptoms in rheumatoid arthritis
    Richard M Nixon
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, UK
    Pharm Stat 8:150-62. 2009
  3. ncbi The efficacy of inhibiting tumour necrosis factor alpha and interleukin 1 in patients with rheumatoid arthritis: a meta-analysis and adjusted indirect comparisons
    R Nixon
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    Rheumatology (Oxford) 46:1140-7. 2007
  4. ncbi Using mixed treatment comparisons and meta-regression to perform indirect comparisons to estimate the efficacy of biologic treatments in rheumatoid arthritis
    R M Nixon
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 26:1237-54. 2007
  5. doi Non-parametric methods for cost-effectiveness analysis: the central limit theorem and the bootstrap compared
    Richard M Nixon
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge, UK
    Health Econ 19:316-33. 2010
  6. ncbi Parametric modelling of cost data in medical studies
    R M Nixon
    Biostatistics Unit, University Forvie Site MRC, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 23:1311-31. 2004
  7. pmc Imputation of a true endpoint from a surrogate: application to a cluster randomized controlled trial with partial information on the true endpoint
    Richard M Nixon
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, CB2 2SR, UK
    BMC Med Res Methodol 3:17. 2003
  8. ncbi Baseline adjustments for binary data in repeated cross-sectional cluster randomized trials
    R M Nixon
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, CB2 2SR, UK
    Stat Med 22:2673-92. 2003
  9. ncbi Randomization at the level of primary care practice: use of pre-intervention data and random effects models
    R M Nixon
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge, CB2 2SR, UK
    Stat Med 20:1727-38. 2001
  10. doi The Rheumatoid Arthritis Drug Development Model: a case study in Bayesian clinical trial simulation
    Richard M Nixon
    MRC Biostatistics Unit, Cambridge, UK
    Pharm Stat 8:371-89. 2009

Detail Information

Publications15

  1. ncbi Mammographic screening in women with a family history of breast cancer: some results from the Swedish two-county trial
    R M Nixon
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, CB2 2SR, UK
    Rev Epidemiol Sante Publique 48:325-31. 2000
    ..179 women aged 40-74 attending for screening. Among those women, 358 were diagnosed with breast cancer during the trial...
  2. doi Using short-term evidence to predict six-month outcomes in clinical trials of signs and symptoms in rheumatoid arthritis
    Richard M Nixon
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, UK
    Pharm Stat 8:150-62. 2009
    ..The model can be used to predict the number of patients with an ACR response for proposed six-month clinical trials given data from clinical trials of one or three months duration...
  3. ncbi The efficacy of inhibiting tumour necrosis factor alpha and interleukin 1 in patients with rheumatoid arthritis: a meta-analysis and adjusted indirect comparisons
    R Nixon
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    Rheumatology (Oxford) 46:1140-7. 2007
    ....
  4. ncbi Using mixed treatment comparisons and meta-regression to perform indirect comparisons to estimate the efficacy of biologic treatments in rheumatoid arthritis
    R M Nixon
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 26:1237-54. 2007
    ....
  5. doi Non-parametric methods for cost-effectiveness analysis: the central limit theorem and the bootstrap compared
    Richard M Nixon
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge, UK
    Health Econ 19:316-33. 2010
    ..We conclude that while in general using either method is appropriate, the CLT is easier to implement, and provides SEs that are at least as accurate as the bootstrap...
  6. ncbi Parametric modelling of cost data in medical studies
    R M Nixon
    Biostatistics Unit, University Forvie Site MRC, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 23:1311-31. 2004
    ..Investigating the sensitivity of conclusions to choice of model should thus be an essential component of analysing cost data in practice...
  7. pmc Imputation of a true endpoint from a surrogate: application to a cluster randomized controlled trial with partial information on the true endpoint
    Richard M Nixon
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, CB2 2SR, UK
    BMC Med Res Methodol 3:17. 2003
    ..Data are only available for the true end point on a sub set of the practices, but there are surrogate data for almost all of the audited practices and for most of the remaining practices...
  8. ncbi Baseline adjustments for binary data in repeated cross-sectional cluster randomized trials
    R M Nixon
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, CB2 2SR, UK
    Stat Med 22:2673-92. 2003
    ....
  9. ncbi Randomization at the level of primary care practice: use of pre-intervention data and random effects models
    R M Nixon
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge, CB2 2SR, UK
    Stat Med 20:1727-38. 2001
    ..We define and demonstrate a random effects logistic regression model that includes pre-intervention data for calculating the effectiveness of the intervention...
  10. doi The Rheumatoid Arthritis Drug Development Model: a case study in Bayesian clinical trial simulation
    Richard M Nixon
    MRC Biostatistics Unit, Cambridge, UK
    Pharm Stat 8:371-89. 2009
    ..In this case study, the results show that, depending on the trial design, the new treatment has assurances of successful drug registration in the range 0.044-0.142 for an ACR20 outcome and 0.057-0.213 for an ACR50 outcome...
  11. ncbi Methods for incorporating covariate adjustment, subgroup analysis and between-centre differences into cost-effectiveness evaluations
    Richard M Nixon
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, UK
    Health Econ 14:1217-29. 2005
    ..It is often important, however, also to investigate how cost-effectiveness varies between patient subgroups. Yet such analyses are rarely undertaken, because appropriate methods have not been sufficiently developed...
  12. ncbi Addressing the issues that arise in analysing multicentre cost data, with application to a multinational study
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    J Health Econ 25:1015-28. 2006
    ..Analysis of multinational cost data must recognise differences in mean, spread and skewness across centres, as well as the data's hierarchical structure...
  13. ncbi How sensitive are cost-effectiveness analyses to choice of parametric distributions?
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Med Decis Making 25:416-23. 2005
    ..Cost data usually have very skewed distributions and can be difficult to model. The authors investigate whether choice of distribution can make a difference to the conclusions drawn...
  14. ncbi Bayesian evaluation of breast cancer screening using data from two studies
    Jonathan P Myles
    Department of Mathematics, Statistics and Epidemiology, Cancer Research UK, London, UK
    Stat Med 22:1661-74. 2003
    ..The method is applied to the synthesis of two studies of mammographic screening in women with a family history of breast cancer, one in Manchester and one in Kopparberg, Sweden...
  15. doi Biologic drugs for rheumatoid arthritis in the Medicare program: a cost-effectiveness analysis
    Allan J Wailoo
    Health Economics and Decision Science, ScHARR, University of Sheffield, Sheffield, UK
    Arthritis Rheum 58:939-46. 2008
    ..We undertook to develop a model to compare the costs and quality-adjusted life years (QALYs) generated by each of the 4 biologic agents...