Elaine R Nimmo

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease
    Colin L Noble
    Gastrointestinal Unit, Western General Hospital, University of Edinburgh, Edinburgh, Scotland
    Gastroenterology 129:1854-64. 2005
  2. doi request reprint TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease
    Elaine R Nimmo
    Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh, UK
    Gastroenterology 141:972-981.e1-2. 2011
  3. ncbi request reprint Investigation of NOD1/CARD4 variation in inflammatory bowel disease using a haplotype-tagging strategy
    Johan Van Limbergen
    Gastrointestinal Unit, Western General Hospital, University of Edinburgh, UK
    Hum Mol Genet 16:2175-86. 2007
  4. doi request reprint Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease
    Johan Van Limbergen
    Gastrointestinal Unit, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom
    Gastroenterology 135:1114-22. 2008
  5. doi request reprint The intermediate filament protein, vimentin, is a regulator of NOD2 activity
    Craig Stevens
    Centre for Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Gut 62:695-707. 2013
  6. ncbi request reprint Genetics of the innate immune response in inflammatory bowel disease
    Johan Van Limbergen
    Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK
    Inflamm Bowel Dis 13:338-55. 2007
  7. doi request reprint Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway
    Elaine R Nimmo
    Gastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
    Inflamm Bowel Dis 18:889-99. 2012
  8. ncbi request reprint The genetics of inflammatory bowel disease
    Johan Van Limbergen
    Gastrointestinal Unit, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom
    Am J Gastroenterol 102:2820-31. 2007
  9. pmc Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways
    Charlie W Lees
    Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Med 5:e239. 2008
  10. ncbi request reprint New genes in inflammatory bowel disease: lessons for complex diseases?
    Daniel R Gaya
    Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Lancet 367:1271-84. 2006

Collaborators

Detail Information

Publications14

  1. ncbi request reprint The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease
    Colin L Noble
    Gastrointestinal Unit, Western General Hospital, University of Edinburgh, Edinburgh, Scotland
    Gastroenterology 129:1854-64. 2005
    ..We investigated associations with disease susceptibility, phenotype, and evidence for epistasis with CARD15 in 679 patients with Crohn's disease (CD) or ulcerative colitis (UC)...
  2. doi request reprint TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease
    Elaine R Nimmo
    Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh, UK
    Gastroenterology 141:972-981.e1-2. 2011
    ..The mechanisms by which specific mutations in NOD2/CARD15 increase the risk for Crohn's disease (CD) are unclear. We identified proteins that interact with NOD2 and investigated them by expression, genetic, and functional analyses...
  3. ncbi request reprint Investigation of NOD1/CARD4 variation in inflammatory bowel disease using a haplotype-tagging strategy
    Johan Van Limbergen
    Gastrointestinal Unit, Western General Hospital, University of Edinburgh, UK
    Hum Mol Genet 16:2175-86. 2007
    ..NOD2/CARD15 variant carriage had no influence on NOD1/CARD4 effect on IBD susceptibility. This study represents the first application of a gene -wide haplotype-tagging approach to assess, in detail, the contribution of NOD1/CARD4 in IBD...
  4. doi request reprint Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease
    Johan Van Limbergen
    Gastrointestinal Unit, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom
    Gastroenterology 135:1114-22. 2008
    ..We analyzed disease phenotypes and progression of childhood-onset disease and compared them with characteristics of adult-onset disease in patients in Scotland...
  5. doi request reprint The intermediate filament protein, vimentin, is a regulator of NOD2 activity
    Craig Stevens
    Centre for Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Gut 62:695-707. 2013
    ..Having previously identified vimentin as a novel NOD2-interacting protein, the authors aimed to investigate the regulatory effects of vimentin on NOD2 function and the association of variants in Vim with CD susceptibility...
  6. ncbi request reprint Genetics of the innate immune response in inflammatory bowel disease
    Johan Van Limbergen
    Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK
    Inflamm Bowel Dis 13:338-55. 2007
    ..We will focus on germline variation of genes encoding pathogen-recognition receptors, proteins involved in epithelial homeostasis and secreted antimicrobial proteins...
  7. doi request reprint Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway
    Elaine R Nimmo
    Gastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
    Inflamm Bowel Dis 18:889-99. 2012
    ..The contribution of epigenetic alterations to disease pathogenesis is emerging as a research priority...
  8. ncbi request reprint The genetics of inflammatory bowel disease
    Johan Van Limbergen
    Gastrointestinal Unit, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Edinburgh, United Kingdom
    Am J Gastroenterol 102:2820-31. 2007
    ..Overall, these studies promise to change our fundamental understanding of IBD pathophysiology and to have implications for clinical practice...
  9. pmc Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways
    Charlie W Lees
    Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Med 5:e239. 2008
    ....
  10. ncbi request reprint New genes in inflammatory bowel disease: lessons for complex diseases?
    Daniel R Gaya
    Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Lancet 367:1271-84. 2006
    ..We review the recent advances in the genetics of inflammatory bowel disease, with particular emphasis on the data that have been generated since the discovery of the CARD15 (NOD2) gene in 2001...
  11. doi request reprint Beyond gene discovery in inflammatory bowel disease: the emerging role of epigenetics
    Nicholas T Ventham
    Gastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland
    Gastroenterology 145:293-308. 2013
    ..We review recent progress in identification of genetic factors associated with IBD and discuss epigenetic mechanisms that could affect development and progression of IBD. ..
  12. ncbi request reprint Molecular genetics of Crohn's disease
    Richard K Russell
    University of Edinburgh Department of Medical Sciences, School of Clinical and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, UK
    Curr Opin Genet Dev 14:264-70. 2004
    ..Functional studies promise to increase understanding of the primary pathophysiology involved in Crohn's disease and these discoveries may yet change clinical practice...
  13. ncbi request reprint Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis
    Gwo Tzer Ho
    Gastrointestinal Unit, Western General Hospital, Edinburgh, Scotland, UK
    Gastroenterology 128:288-96. 2005
    ..The MDR1 exonic single nucleotide polymorphisms (SNPs) C3435T and G2677T have been shown to correlate with activity/expression of P-glycoprotein 170...
  14. ncbi request reprint Disease location, anti-Saccharomyces cerevisiae antibody, and NOD2/CARD15 genotype influence the progression of disease behavior in Crohn's disease
    Ben R K Smith
    Gastrointestinal Unit, University of Edinburgh, Department of Medical Sciences, School of Clinical and Molecular Medicine, Western General Hospital, United Kingdom
    Inflamm Bowel Dis 10:521-8. 2004
    ..Clinical and biological influences on disease progression remain unclear. We examined the associations of CD disease progression at diagnosis and for up to 20 years of follow-up...