Alvin W Nienow

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc Reactor engineering in large scale animal cell culture
    Alvin W Nienow
    Centre for Bioprocess Engineering, The University of Birmingham, Birmingham, B15 2TT, UK
    Cytotechnology 50:9-33. 2006
  2. doi request reprint Scale-down/scale-up studies leading to improved commercial beer fermentation
    Alvin W Nienow
    Centre for Bioprocess Engineering, University of Birmingham, UK
    Biotechnol J 6:911-25. 2011
  3. doi request reprint Studies supporting the use of mechanical mixing in large scale beer fermentations
    Alvin W Nienow
    Department of Chemical Engineering, Centre for Bioprocess Engineering, University of Birmingham, Birmingham, B15 2TT, UK
    Biotechnol Lett 32:623-33. 2010
  4. doi request reprint A quantitative approach for understanding small-scale human mesenchymal stem cell culture - implications for large-scale bioprocess development
    Qasim A Rafiq
    Centre for Biological Engineering, Department of Chemical Engineering, Loughborough University, Leicestershire LE11 3TU England, UK
    Biotechnol J 8:459-71. 2013
  5. doi request reprint Expansion of human mesenchymal stem cells on microcarriers
    Christopher J Hewitt
    Department of Chemical Engineering, Centre for Biological Engineering, Loughborough University, Leicestershire, UK
    Biotechnol Lett 33:2325-35. 2011
  6. ncbi request reprint The application of multi-parameter flow cytometry to the study of recombinant Escherichia coli batch fermentation processes
    Gareth Lewis
    School of Engineering Chemical Engineering, The University of Birmingham, B15 2TT, Edgbaston, UK
    J Ind Microbiol Biotechnol 31:311-22. 2004
  7. doi request reprint Culture of human mesenchymal stem cells on microcarriers in a 5 l stirred-tank bioreactor
    Qasim A Rafiq
    Department of Chemical Engineering, Centre for Biological Engineering, Loughborough University, Leicestershire, LE11 3TU, UK
    Biotechnol Lett 35:1233-45. 2013
  8. doi request reprint Large-scale expansion and exploitation of pluripotent stem cells for regenerative medicine purposes: beyond the T flask
    Andrew J Want
    Centre for Biological Engineering, Department of Chemical Engineering, Loughborough University, Leicestershire, UK
    Regen Med 7:71-84. 2012
  9. ncbi request reprint The use of phase inversion temperature (PIT) microemulsion technology to enhance oil utilisation during Streptomyces rimosus fed-batch fermentations to produce oxytetracycline
    Panos A Papapanagiotou
    Biochemical Engineering, Department of Chemical Engineering, The University of Birmingham, B15 2TT, Edgbaston, Birmingham, UK
    Biotechnol Lett 27:1579-85. 2005
  10. ncbi request reprint Further studies related to the scale-up of high cell density Escherichia coli fed-batch fermentations: the additional effect of a changing microenvironment when using aqueous ammonia to control pH
    Helen Onyeaka
    Biochemical Engineering, Centre for Formulation Engineering, School of Engineering Chemical Engineering, The University of Birmingham, Edgbaston B15 2TT, UK
    Biotechnol Bioeng 84:474-84. 2003

Collaborators

  • Christopher J Hewitt
  • Karen Coopman
  • Qasim A Rafiq
  • Andrew J Want
  • Panos A Papapanagiotou
  • Gareth Lewis
  • Helen Onyeaka
  • Kathryn M Brosnan
  • Jean Pierre Molitor
  • Henry Quinn
  • Ian W Taylor

Detail Information

Publications10

  1. pmc Reactor engineering in large scale animal cell culture
    Alvin W Nienow
    Centre for Bioprocess Engineering, The University of Birmingham, Birmingham, B15 2TT, UK
    Cytotechnology 50:9-33. 2006
    ..Microcarrier culture is also briefly addressed. Finally, some recommendations for bioreactor configuration and operating strategy are given...
  2. doi request reprint Scale-down/scale-up studies leading to improved commercial beer fermentation
    Alvin W Nienow
    Centre for Bioprocess Engineering, University of Birmingham, UK
    Biotechnol J 6:911-25. 2011
    ..Suggestions for further studies are made: one concerning the impact of homogenization on the removal of vicinal diketones and the other on the location of bubble formation at the commercial scale...
  3. doi request reprint Studies supporting the use of mechanical mixing in large scale beer fermentations
    Alvin W Nienow
    Department of Chemical Engineering, Centre for Bioprocess Engineering, University of Birmingham, Birmingham, B15 2TT, UK
    Biotechnol Lett 32:623-33. 2010
    ..It is suggested that this reluctance of the brewing industry to use (adequate) mechanical agitation is another example where the myth of shear damage has had a detrimental effect on the optimal operation of commercial bioprocessing...
  4. doi request reprint A quantitative approach for understanding small-scale human mesenchymal stem cell culture - implications for large-scale bioprocess development
    Qasim A Rafiq
    Centre for Biological Engineering, Department of Chemical Engineering, Loughborough University, Leicestershire LE11 3TU England, UK
    Biotechnol J 8:459-71. 2013
    ....
  5. doi request reprint Expansion of human mesenchymal stem cells on microcarriers
    Christopher J Hewitt
    Department of Chemical Engineering, Centre for Biological Engineering, Loughborough University, Leicestershire, UK
    Biotechnol Lett 33:2325-35. 2011
    ..These findings were interpreted using Kolmogorov's theory of isotropic turbulence...
  6. ncbi request reprint The application of multi-parameter flow cytometry to the study of recombinant Escherichia coli batch fermentation processes
    Gareth Lewis
    School of Engineering Chemical Engineering, The University of Birmingham, B15 2TT, Edgbaston, UK
    J Ind Microbiol Biotechnol 31:311-22. 2004
    ..Further, we discuss the possibility of optimising inclusion body formation by manipulating the fermentation conditions based on these rapid "real-time" measurements...
  7. doi request reprint Culture of human mesenchymal stem cells on microcarriers in a 5 l stirred-tank bioreactor
    Qasim A Rafiq
    Department of Chemical Engineering, Centre for Biological Engineering, Loughborough University, Leicestershire, LE11 3TU, UK
    Biotechnol Lett 35:1233-45. 2013
    ..Neither the upstream nor downstream bioprocessing unit operations had a discernible effect on cell quality with the harvested cells retaining their immunophenotypic markers, key morphological features and differentiation capacity...
  8. doi request reprint Large-scale expansion and exploitation of pluripotent stem cells for regenerative medicine purposes: beyond the T flask
    Andrew J Want
    Centre for Biological Engineering, Department of Chemical Engineering, Loughborough University, Leicestershire, UK
    Regen Med 7:71-84. 2012
    ..This represents the first step in defining the full extent of the challenges facing bioprocess engineers in the exploitation of large-scale human pluripotent stem cell manufacture...
  9. ncbi request reprint The use of phase inversion temperature (PIT) microemulsion technology to enhance oil utilisation during Streptomyces rimosus fed-batch fermentations to produce oxytetracycline
    Panos A Papapanagiotou
    Biochemical Engineering, Department of Chemical Engineering, The University of Birmingham, B15 2TT, Edgbaston, Birmingham, UK
    Biotechnol Lett 27:1579-85. 2005
    ..Importantly, microbial utilisation of the surfactant was confirmed for the first time...
  10. ncbi request reprint Further studies related to the scale-up of high cell density Escherichia coli fed-batch fermentations: the additional effect of a changing microenvironment when using aqueous ammonia to control pH
    Helen Onyeaka
    Biochemical Engineering, Centre for Formulation Engineering, School of Engineering Chemical Engineering, The University of Birmingham, Edgbaston B15 2TT, UK
    Biotechnol Bioeng 84:474-84. 2003
    ....