Research Topics
| Ben NicholsSummaryAffiliation: University of Cambridge Country: UK Publications
| Collaborators
|
Detail Information
Publications
A distinct class of endosome mediates clathrin-independent endocytosis to the Golgi complexBenjamin J Nichols
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Nat Cell Biol 4:374-8. 2002..Caveolin-1-positive endosomes are sites for the sorting of caveolin-1 away from Golgi-bound cargoes, although caveolin-1 itself is unlikely to have a direct function in PM to Golgi transport...- GM1-containing lipid rafts are depleted within clathrin-coated pitsB J Nichols
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
Curr Biol 13:686-90. 2003..The data provide evidence for a model in which lipid rafts are distributed uniformly across most of the PM of nonpolarized cells but are prevented from entering clathrin-coated pits... - Caveosomes and endocytosis of lipid raftsBen Nichols
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
J Cell Sci 116:4707-14. 2003..It is likely that there are mechanisms that allow recruitment and targeting of specific molecules to caveosomes... - Functional interdependence between septin and actin cytoskeletonKatja Schmidt
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
BMC Cell Biol 5:43. 2004..How this interaction is regulated is not known. Moreover, evidence that Septin2 is remodelled or redistributed in response to other changes in actin organisation is lacking... - Endocytosis without clathrin coatsB J Nichols
MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK
Trends Cell Biol 11:406-12. 2001.... - Endocytosis of lipid-anchored proteins: excluding GEECs from the crowdBen Nichols
Medical Research Council Laboratory of Molecular Biology, Cambridge CB20QH, England, UK
J Cell Biol 186:457-9. 2009..In this issue, Bhagatji et al. (2009. J. Cell Biol. doi:10.1083/jcb.200903102) provide an original mechanism for the sorting of lipid-anchored proteins that involves exclusion of bulky extracellular domains from clathrin-coated pits... - Lipid raft proteins have a random distribution during localized activation of the T-cell receptorOleg O Glebov
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
Nat Cell Biol 6:238-43. 2004..However, measurements of FRET and ratio imaging showed that there was no detectable clustering and no overall enrichment of GPI-linked proteins or CTB in these regions... - Dynamics of putative raft-associated proteins at the cell surfaceAnne K Kenworthy
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bldg. 18T, Rm. 101, 18 Library Dr, Bethesda, MD 20895, USA
J Cell Biol 165:735-46. 2004..Thus, raft association is not the dominant factor in determining long-range protein mobility at the cell surface... - The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesiclesThomas Schwarz-Romond
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
J Cell Sci 118:5269-77. 2005..Our evidence indicates that Dvl2 and Axin puncta are dynamic protein assemblies rather than cytoplasmic vesicles... - Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cellsOleg O Glebov
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Nat Cell Biol 8:46-54. 2006..We propose that flotillin-1 is one determinant of a clathrin-independent endocytic pathway in mammalian cells... - Modulation of lateral diffusion in the plasma membrane by protein densityManfred Frick
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
Curr Biol 17:462-7. 2007..Our data imply that slow diffusion over micron-scale distances is an intrinsic property of the membrane itself and that the density of proteins within the membrane is a significant parameter in determining rates of lateral diffusion... - Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle buddingManfred Frick
Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
Curr Biol 17:1151-6. 2007..Key attributes of this machinery are the dependence on coassembly of both flotillins and the inference that flotillin microdomains can exist in either flat or invaginated states... - A barrier to lateral diffusion in the cleavage furrow of dividing mammalian cellsKatja Schmidt
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom
Curr Biol 14:1002-6. 2004..Diffusion of lipid raft proteins in the inner and outer leaflets of the membrane was not directly coupled. The distribution of Septin proteins, as opposed to cortical actin, was consistent with a functional role in limiting diffusion...