Ben Nichols

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint A distinct class of endosome mediates clathrin-independent endocytosis to the Golgi complex
    Benjamin J Nichols
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Cell Biol 4:374-8. 2002
  2. ncbi request reprint GM1-containing lipid rafts are depleted within clathrin-coated pits
    B J Nichols
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Curr Biol 13:686-90. 2003
  3. ncbi request reprint Caveosomes and endocytosis of lipid rafts
    Ben Nichols
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    J Cell Sci 116:4707-14. 2003
  4. pmc The role of flotillins in regulating aβ production, investigated using flotillin 1-/-, flotillin 2-/- double knockout mice
    Vassilis Bitsikas
    Laboratory of Molecular Biology, Medical Research Council, Cambridge, Cambridgeshire, United Kingdom
    PLoS ONE 9:e85217. 2014
  5. pmc Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae
    Carsten Gram Hansen
    MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK
    Nat Commun 4:1831. 2013
  6. pmc Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment
    Alexander Ludwig
    MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, England, UK
    J Cell Biol 191:771-81. 2010
  7. pmc SDPR induces membrane curvature and functions in the formation of caveolae
    Carsten G Hansen
    MRC LMB, Cambridge, UK
    Nat Cell Biol 11:807-14. 2009
  8. pmc Functional interdependence between septin and actin cytoskeleton
    Katja Schmidt
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    BMC Cell Biol 5:43. 2004
  9. pmc Endocytosis of lipid-anchored proteins: excluding GEECs from the crowd
    Ben Nichols
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB20QH, England, UK
    J Cell Biol 186:457-9. 2009
  10. ncbi request reprint Endocytosis without clathrin coats
    B J Nichols
    MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK
    Trends Cell Biol 11:406-12. 2001

Collaborators

Detail Information

Publications17

  1. ncbi request reprint A distinct class of endosome mediates clathrin-independent endocytosis to the Golgi complex
    Benjamin J Nichols
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Cell Biol 4:374-8. 2002
    ..Caveolin-1-positive endosomes are sites for the sorting of caveolin-1 away from Golgi-bound cargoes, although caveolin-1 itself is unlikely to have a direct function in PM to Golgi transport...
  2. ncbi request reprint GM1-containing lipid rafts are depleted within clathrin-coated pits
    B J Nichols
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Curr Biol 13:686-90. 2003
    ..The data provide evidence for a model in which lipid rafts are distributed uniformly across most of the PM of nonpolarized cells but are prevented from entering clathrin-coated pits...
  3. ncbi request reprint Caveosomes and endocytosis of lipid rafts
    Ben Nichols
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    J Cell Sci 116:4707-14. 2003
    ..It is likely that there are mechanisms that allow recruitment and targeting of specific molecules to caveosomes...
  4. pmc The role of flotillins in regulating aβ production, investigated using flotillin 1-/-, flotillin 2-/- double knockout mice
    Vassilis Bitsikas
    Laboratory of Molecular Biology, Medical Research Council, Cambridge, Cambridgeshire, United Kingdom
    PLoS ONE 9:e85217. 2014
    ..The availability of flotillin 1-/-, flotillin 2-/- mice, which have no overt phenotypes, will facilitate research into flotillin function in vivo. ..
  5. pmc Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae
    Carsten Gram Hansen
    MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK
    Nat Commun 4:1831. 2013
    ..Cavin 1, however, is essential for normal oligomerization of caveolin 1. Our data reveal that endothelial caveolae are heterogeneous, and identify cavin 2 as a determinant of this heterogeneity...
  6. pmc Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment
    Alexander Ludwig
    MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, England, UK
    J Cell Biol 191:771-81. 2010
    ..We conclude that the association between flotillin microdomains and cortical cytoskeleton has important functions during neutrophil migration, in uropod formation, and in the regulation of myosin IIa...
  7. pmc SDPR induces membrane curvature and functions in the formation of caveolae
    Carsten G Hansen
    MRC LMB, Cambridge, UK
    Nat Cell Biol 11:807-14. 2009
    ..Loss of caveolae reduces the propensity of STB to induce membrane tubulation. We conclude that SDPR is a membrane-curvature-inducing component of caveolae, and that STB-induced membrane tubulation is facilitated by caveolae...
  8. pmc Functional interdependence between septin and actin cytoskeleton
    Katja Schmidt
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    BMC Cell Biol 5:43. 2004
    ..How this interaction is regulated is not known. Moreover, evidence that Septin2 is remodelled or redistributed in response to other changes in actin organisation is lacking...
  9. pmc Endocytosis of lipid-anchored proteins: excluding GEECs from the crowd
    Ben Nichols
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB20QH, England, UK
    J Cell Biol 186:457-9. 2009
    ..In this issue, Bhagatji et al. (2009. J. Cell Biol. doi:10.1083/jcb.200903102) provide an original mechanism for the sorting of lipid-anchored proteins that involves exclusion of bulky extracellular domains from clathrin-coated pits...
  10. ncbi request reprint Endocytosis without clathrin coats
    B J Nichols
    MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK
    Trends Cell Biol 11:406-12. 2001
    ....
  11. ncbi request reprint The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles
    Thomas Schwarz-Romond
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    J Cell Sci 118:5269-77. 2005
    ..Our evidence indicates that Dvl2 and Axin puncta are dynamic protein assemblies rather than cytoplasmic vesicles...
  12. ncbi request reprint Lipid raft proteins have a random distribution during localized activation of the T-cell receptor
    Oleg O Glebov
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Nat Cell Biol 6:238-43. 2004
    ..However, measurements of FRET and ratio imaging showed that there was no detectable clustering and no overall enrichment of GPI-linked proteins or CTB in these regions...
  13. ncbi request reprint Modulation of lateral diffusion in the plasma membrane by protein density
    Manfred Frick
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Curr Biol 17:462-7. 2007
    ..Our data imply that slow diffusion over micron-scale distances is an intrinsic property of the membrane itself and that the density of proteins within the membrane is a significant parameter in determining rates of lateral diffusion...
  14. ncbi request reprint Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells
    Oleg O Glebov
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Cell Biol 8:46-54. 2006
    ..We propose that flotillin-1 is one determinant of a clathrin-independent endocytic pathway in mammalian cells...
  15. pmc Dynamics of putative raft-associated proteins at the cell surface
    Anne K Kenworthy
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bldg 18T, Rm 101, 18 Library Dr, Bethesda, MD 20895, USA
    J Cell Biol 165:735-46. 2004
    ..Thus, raft association is not the dominant factor in determining long-range protein mobility at the cell surface...
  16. ncbi request reprint Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding
    Manfred Frick
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Curr Biol 17:1151-6. 2007
    ..Key attributes of this machinery are the dependence on coassembly of both flotillins and the inference that flotillin microdomains can exist in either flat or invaginated states...
  17. ncbi request reprint A barrier to lateral diffusion in the cleavage furrow of dividing mammalian cells
    Katja Schmidt
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom
    Curr Biol 14:1002-6. 2004
    ..Diffusion of lipid raft proteins in the inner and outer leaflets of the membrane was not directly coupled. The distribution of Septin proteins, as opposed to cortical actin, was consistent with a functional role in limiting diffusion...