Research Topics
| P N NewsomeSummaryAffiliation: University of Edinburgh Country: UK Publications
| Collaborators
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Detail Information
Publications
Bone marrow stem cells contribute to alcohol liver fibrosis in humansEvangelos Dalakas
Department of Hepatology, University of Edinburgh, Edinburgh, UK
Stem Cells Dev 19:1417-25. 2010..Alcohol liver injury mobilizes CD34(+) stem cells into the circulation and recruits them into the liver. These BMSCs contribute to the hepatic myofibroblast population but not to parenchymal lineages and do not promote hepatocyte repair...
Low serum retinol levels are associated with hepatocellular carcinoma in patients with chronic liver diseaseP N Newsome
Department of Medicine, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK
Aliment Pharmacol Ther 14:1295-301. 2000..Retinol and other vitamin A derivatives affect the differentiation and growth of many tissues and have anti-tumour properties...- Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusionPhilip N Newsome
Department of Hepatology, Chancellor s Building, University of Edinburgh, Edinburgh EH16 4SB, Scotland, UK
Gastroenterology 124:1891-900. 2003..We also wanted to test whether such differentiated cells were the result of cellular fusion or true stem cell transdifferentiation... - Serum from patients with fulminant hepatic failure causes hepatocyte detachment and apoptosis by a beta(1)-integrin pathwayPhilip N Newsome
Department of Hepatology, University of Edinburgh, Edinburgh, UK
Hepatology 40:636-45. 2004..This finding has important implications in the future of cellular transplantation for liver and other organ diseases... - An improved ex vivo method of primary porcine hepatocyte isolation for use in bioartificial liver systemsL J Nelson
Dept of Medicine, University of Edinburgh, UK
Eur J Gastroenterol Hepatol 12:923-30. 2000..Although in vivo isolation of porcine hepatocytes can give high yield and viability, such methods are time-consuming and expensive, requiring specialist surgical facilities... - Hematopoietic stem cell trafficking in liver injuryEvangelos Dalakas
Hepatology Unit, Chancellor s Building, The University of Edinburgh, Edinburgh, UK
FASEB J 19:1225-31. 2005..This review focuses on the complex interaction of chemokines, adhesion molecules, and extracellular matrix factors required for successful migration and engraftment of HSCs into the liver... - Persistence of functional hepatocyte-like cells in immune-compromised miceCatherine M Payne
MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK
Liver Int 31:254-62. 2011..Human embryonic stem cells (hESCs) can be efficiently differentiated to hepatocyte-like cells (HLCs) in vitro and demonstrate many of the functions and gene expression found in the adult liver... - Which hepatocyte will it be? Hepatocyte choice for bioartificial liver support systemsJ Tsiaoussis
Department of Internal Medicine, Liver Unit, Royal Infirmary of Edinburgh, Edinburgh, Scotland
Liver Transpl 7:2-10. 2001..Finally, improvements in culture conditions, such as supplemented media, biodegradable scaffolds, and coculture, offer the possibility of prolonging the differentiated function of hepatocytes in a BAL... 
Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signalingDavid C Hay
Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
Proc Natl Acad Sci U S A 105:12301-6. 2008..These studies represent an important step toward the use of hESC-derived hepatocytes in high-throughput metabolic analysis of human liver function...- Potential of hematopoietic stem cell therapy in hepatology: a critical reviewSteven Masson
Department of Hepatology, Chancellor's Building, University of Edinburgh, Edinburgh EH16 4SB, UK
Stem Cells 22:897-907. 2004....