Marie Louise Newell

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Social care of children born to HIV-infected mothers in Europe. European Collaborative Study
    C Thorne
    Department of Paediatric Epidemiology, Institute of Child Health, London, UK
    AIDS Care 10:7-16. 1998
  2. ncbi request reprint CD4 cell response to antiretroviral therapy in children with vertically acquired HIV infection: is it associated with age at initiation?
    Marie Louise Newell
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, United Kingdom
    J Infect Dis 193:954-62. 2006
  3. ncbi request reprint Higher rates of post-partum complications in HIV-infected than in uninfected women irrespective of mode of delivery
    Simona Fiore
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    AIDS 18:933-8. 2004
  4. ncbi request reprint Antenatal and perinatal strategies to prevent mother-to-child transmission of HIV infection
    Marie Louise Newell
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Trans R Soc Trop Med Hyg 97:22-4. 2003
  5. ncbi request reprint Current issues in the prevention of mother-to-child transmission of HIV-1 infection
    Marie Louise Newell
    Infectious Disease Group, Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, UK
    Trans R Soc Trop Med Hyg 100:1-5. 2006
  6. pmc Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USA
    Marie Louise Newell
    Centre of Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    BMC Infect Dis 7:60. 2007
  7. ncbi request reprint Mother-to-child transmission of hepatitis C virus infection
    Marie Louise Newell
    Centre for Paediatric Epidemiology, Institute of Child Health, London, UK
    Drugs Today (Barc) 38:321-37. 2002
  8. ncbi request reprint Height, weight, and growth in children born to mothers with HIV-1 infection in Europe
    Marie Louise Newell
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College, London, United Kingdom
    Pediatrics 111:e52-60. 2003
  9. ncbi request reprint Child mortality and HIV infection in Africa: a review
    Marie Louise Newell
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    AIDS 18:S27-34. 2004
  10. ncbi request reprint Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis
    Marie Louise Newell
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London WC1N 1EH, UK
    Lancet 364:1236-43. 2004

Detail Information

Publications100

  1. ncbi request reprint Social care of children born to HIV-infected mothers in Europe. European Collaborative Study
    C Thorne
    Department of Paediatric Epidemiology, Institute of Child Health, London, UK
    AIDS Care 10:7-16. 1998
    ..The type of alternative care varied according to maternal characteristics, child's age and geographic location. The mothers of 98 children had died and average age at maternal death was four years...
  2. ncbi request reprint CD4 cell response to antiretroviral therapy in children with vertically acquired HIV infection: is it associated with age at initiation?
    Marie Louise Newell
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, United Kingdom
    J Infect Dis 193:954-62. 2006
    ..Considerable uncertainty remains as to whether early initiation of antiretroviral therapy (ART) in children with vertically acquired human immunodeficiency virus (HIV) infection increases the benefit in terms of immunological response...
  3. ncbi request reprint Higher rates of post-partum complications in HIV-infected than in uninfected women irrespective of mode of delivery
    Simona Fiore
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    AIDS 18:933-8. 2004
    ..To inform the debate on the use of elective caesarean section (CS) delivery in HIV-infected women, we investigated the occurrence of clinical events in the immediate post-partum period in women delivering in 13 European centres...
  4. ncbi request reprint Antenatal and perinatal strategies to prevent mother-to-child transmission of HIV infection
    Marie Louise Newell
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Trans R Soc Trop Med Hyg 97:22-4. 2003
    ..Micronutrient supplementation, including vitamin A, does not reduce MTCT of HIV, but may improve pregnancy outcome generally...
  5. ncbi request reprint Current issues in the prevention of mother-to-child transmission of HIV-1 infection
    Marie Louise Newell
    Infectious Disease Group, Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, UK
    Trans R Soc Trop Med Hyg 100:1-5. 2006
    ..In light of the high mortality in all children of HIV-infected women, programmes for prevention of MTCT should be monitored not only in terms of HIV transmission avoided but also in terms of child survival...
  6. pmc Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USA
    Marie Louise Newell
    Centre of Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    BMC Infect Dis 7:60. 2007
    ....
  7. ncbi request reprint Mother-to-child transmission of hepatitis C virus infection
    Marie Louise Newell
    Centre for Paediatric Epidemiology, Institute of Child Health, London, UK
    Drugs Today (Barc) 38:321-37. 2002
    ..The long-term natural history of vertically acquired HCV needs further elucidation and the efficacy of potential therapies for infected children need to be evaluated in randomized controlled trials...
  8. ncbi request reprint Height, weight, and growth in children born to mothers with HIV-1 infection in Europe
    Marie Louise Newell
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College, London, United Kingdom
    Pediatrics 111:e52-60. 2003
    ....
  9. ncbi request reprint Child mortality and HIV infection in Africa: a review
    Marie Louise Newell
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    AIDS 18:S27-34. 2004
    ..To review the available data relating to child mortality in Africa by the HIV infection status of mothers and children...
  10. ncbi request reprint Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis
    Marie Louise Newell
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London WC1N 1EH, UK
    Lancet 364:1236-43. 2004
    ..With individual data from seven randomised mother-to-child transmission (MTCT) intervention trials, we estimate mortality in African children born to HIV-infected mothers and analyse selected risk factors...
  11. ncbi request reprint Antiretroviral therapy and mother-to-child transmission of HIV-1
    Marie Louise Newell
    University College London, Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Expert Rev Anti Infect Ther 2:717-32. 2004
    ..However, postnatal transmission of infection through breastfeeding significantly reduces the longer-term efficacy of these strategies. Ongoing research is focusing on the use of antiretroviral therapy in the breastfeeding period...
  12. ncbi request reprint Vertical transmission of HIV-1 infection
    M L Newell
    Department of Epidemiology and Public Health, Institute of Child Health, London, UK
    Trans R Soc Trop Med Hyg 94:1-2. 2000
    ....
  13. pmc Prevention of mother-to-child transmission of HIV: challenges for the current decade
    M L Newell
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, WC1N 1EH, England
    Bull World Health Organ 79:1138-44. 2001
    ..More widely applicable interventions are being developed, such as cleansing of the birth canal and antiretroviral therapy during the breastfeeding period...
  14. pmc Effect of women's groups and volunteer peer counselling on rates of mortality, morbidity, and health behaviours in mothers and children in rural Malawi (MaiMwana): a factorial, cluster-randomised controlled trial
    Sonia Lewycka
    Institute for Global Health, University College London, London, UK
    Lancet 381:1721-35. 2013
    ..Women's groups and health education by peer counsellors can improve the health of mothers and children. We assessed their effects on mortality and breastfeeding rates in rural Malawi...
  15. pmc Predictors of pregnancy and changes in pregnancy incidence among HIV-positive women accessing HIV clinical care
    Susie E Huntington
    Medical Research Council MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, UK
    AIDS 27:95-103. 2013
    ..To describe predictors of pregnancy and changes in pregnancy incidence among HIV-positive women accessing HIV clinical care...
  16. pmc MaiMwana women's groups: a community mobilisation intervention to improve mother and child health and reduce mortality in rural Malawi
    Mikey Rosato
    Centre for International Health and Development, UCL, Institute of Child Health, 30 Guilford St, London WC1N 1EH
    Malawi Med J 22:112-9. 2010
    ..Their impact, implementation and cost-effectiveness have been rigorously evaluated through a randomized controlled trial design. The results of these evaluations will be reported in 2011...
  17. pmc Research report--Volunteer infant feeding and care counselors: a health education intervention to improve mother and child health and reduce mortality in rural Malawi
    Mikey Rosato
    Centre for International Health and Development, UCL, Institute of Child Health, 30 Guilford St, London WC1N 1EH Centre for Anthropological Research, University of Johannesburg, PO Box 524, Auckland Park, 2006, South Africa
    Malawi Med J 24:39-42. 2012
    ..The impact is being evaluated through a cluster randomised controlled trial and results will be reported in 2012...
  18. ncbi request reprint Within and between race differences in lymphocyte, CD4+, CD8+ and neutrophil levels in HIV-uninfected children with or without HIV exposure in Europe and Uganda
    Madeleine Bunders
    Centre for Paediatric Epidemiology, Institute of Child Health, University College, London, UK
    Ann Trop Paediatr 26:169-79. 2006
    ..Racial immuno-haematological differences have been reported in children but to date have not been well quantified...
  19. ncbi request reprint Disease progression in children with vertically-acquired HIV infection in sub-Saharan Africa: reviewing the need for HIV treatment
    Kirsty Little
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    Curr HIV Res 5:139-53. 2007
    ..Additionally, improvements in health infrastructures could improve care provision, not only through improved detection and monitoring but also through treatment of co-morbidities and nutritional support...
  20. ncbi request reprint Breastmilk RNA viral load in HIV-infected South African women: effects of subclinical mastitis and infant feeding
    Juana F Willumsen
    Centre for International Child Health, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    AIDS 17:407-14. 2003
    ..To investigate determinants of breastmilk RNA viral load among HIV-infected South African women, with particular attention to infant feeding mode and subclinical mastitis...
  21. ncbi request reprint Growth in the first 5 years of life is unaffected in children with perinatally-acquired hepatitis C infection
    Kristy England
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, United Kingdom
    J Pediatr 147:227-32. 2005
    ..To identify the effect of vertical hepatitis C virus (HCV) infection or exposure on growth in childhood...
  22. ncbi request reprint Age-related standards for total lymphocyte, CD4+ and CD8+ T cell counts in children born in Europe
    Madeleine Bunders
    Institute of Child Health, University College London, United Kingdom
    Pediatr Infect Dis J 24:595-600. 2005
    ..Standards are essential for diagnosing and monitoring childhood diseases such as pediatric human immunodeficiency virus (HIV) infection...
  23. ncbi request reprint Antenatal and neonatal antiretroviral therapy in HIV-infected women and their infants: a review of safety issues
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College, 30 Guilford Street, WC1N 1EH London, UK
    Med Wieku Rozwoj 7:425-36. 2003
    ....
  24. ncbi request reprint The safety of antiretroviral drugs in pregnancy
    Claire Thorne
    University College London, Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Expert Opin Drug Saf 4:323-35. 2005
    ..Based on current knowledge, the immense benefits of antiretroviral prophylaxis in reducing the risk of MTCT, far outweigh the potential for adverse effects...
  25. ncbi request reprint Mother-to-child transmission of HIV infection and its prevention
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    Curr HIV Res 1:447-62. 2003
    ..However, the key to prevention of paediatric HIV infections is adequate prevention of infection in women of reproductive age...
  26. ncbi request reprint Increased risk of adverse pregnancy outcomes in HIV-infected women treated with highly active antiretroviral therapy in Europe
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    AIDS 18:2337-9. 2004
    ..05, 95% CI 1.43, 2.95), particularly severe prematurity. The implication of increased prematurity is evidenced in high neonatal mortality in these groups (0.66% for infants at 34-36 weeks and 7.37% at < 34 weeks' gestation)...
  27. ncbi request reprint Injecting drug use in pregnant HIV-infected women in Europe
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK
    Med Wieku Rozwoj 10:1005-16. 2006
    ..to describe the characteristics of pregnant HIV-infected women with past or current injecting drug use (IDU) and their infants in a large European cohort...
  28. doi request reprint Policies and practices for the clinical management of HIV/HCV coinfected children in Europe: an epidemiological survey
    Kirsty England
    MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, UK
    Eur J Pediatr 168:915-7. 2009
    ..Limited experience in the clinical management of this group and the lack of an evidence base to guide policy may be a barrier to achieving optimal care and treatment...
  29. ncbi request reprint Antiretroviral therapy in pregnancy: balancing the risk of preterm delivery with prevention of mother-to-child HIV transmission
    Claire L Townsend
    Medical Research Council Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, UK
    Antivir Ther 15:775-83. 2010
    ..We aimed to quantify the incremental risk-benefit ratio for HAART compared with zidovudine monotherapy with respect to these outcomes...
  30. ncbi request reprint European participation in an international perinatal trial
    Simona Fiore
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College, 30 Guilford Street, WC1N 1EH London, UK
    Med Wieku Rozwoj 7:449-58. 2003
    ..To compare the population enrolled in a Phase III trial to that enrolled during the same period in a parallel longitudinal cohort, and to assess the generalisability of the trial results...
  31. ncbi request reprint Treatment options for the prevention of mother-to-child transmission of HIV
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Curr Opin Investig Drugs 6:804-11. 2005
    ....
  32. ncbi request reprint Does exposure to antiretroviral therapy affect growth in the first 18 months of life in uninfected children born to HIV-infected women?
    Claire Hankin
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, United Kingdom
    J Acquir Immune Defic Syndr 40:364-70. 2005
    ..10 [P = 0.019]; height, -0.12 [P = 0.008]; and OFC, -0.14 [P = 0.001]). Although the effect of combination therapy exposure is minimal, long-term monitoring of these children is important...
  33. ncbi request reprint Vertically acquired paediatric coinfection with HIV and hepatitis C virus
    Kirsty England
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Lancet Infect Dis 6:83-90. 2006
    ..Future research must therefore focus on vertically acquired HIV/HCV coinfection to inform treatment trials addressing coinfection management...
  34. ncbi request reprint HIV and HCV progression in parenterally coinfected children
    Kirsty England
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, London, UK
    Curr HIV Res 7:346-53. 2009
    ....
  35. ncbi request reprint Age-related lymphocyte and neutrophil levels in children of hepatitis C-infected women
    Lucy Pembrey
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health and Great Ormond Hospital for Children NHS Trust, University College London, London, UK
    Pediatr Infect Dis J 27:800-7. 2008
    ....
  36. pmc A cluster randomised controlled trial of the community effectiveness of two interventions in rural Malawi to improve health care and to reduce maternal, newborn and infant mortality
    Sonia Lewycka
    Centre for International Health and Development, UCL Institute of Child Health, London, UK
    Trials 11:88. 2010
    ..The MaiMwana Project aims to test community-based interventions that tackle maternal and child health problems through increasing awareness and local action...
  37. ncbi request reprint Are girls more at risk of intrauterine-acquired HIV infection than boys?
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College, London, UK
    AIDS 18:344-7. 2004
    ..Girls were at a 1.5 times increased risk of MTCT overall, but the sex effect was limited to elective caesarean section deliveries, suggesting that girls may have an increased risk of intrauterine transmission compared with boys...
  38. ncbi request reprint Older children and adolescents surviving with vertically acquired HIV infection
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
    J Acquir Immune Defic Syndr 29:396-401. 2002
    ..As they enter adolescence, additional services are needed including support with disclosure to others, therapy, and sexual health...
  39. ncbi request reprint Modelling HIV-RNA viral load in vertically infected children
    Linsay Gray
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    Stat Med 23:769-81. 2004
    ..Although Hughes' methodology is the best approach, its implementation is not necessary for the identification of the optimal model...
  40. ncbi request reprint The management of HCV infected pregnant women and their children European paediatric HCV network
    Lucy Pembrey
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
    J Hepatol 43:515-25. 2005
    ..As evidence accumulates relating to mother-to-child (vertical) transmission of hepatitis C virus (HCV), it is timely to draw up guidelines for the clinical management of HCV infected pregnant women and their children...
  41. pmc Decreased chronic morbidity but elevated HIV associated cytokine levels in HIV-infected older adults receiving HIV treatment: benefit of enhanced access to care?
    Portia C Mutevedzi
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Somkhele, South Africa University College London, Department of Infection and Population Health, London, United Kingdom
    PLoS ONE 8:e77379. 2013
    ..The association of HIV with chronic morbidity and inflammatory markers (cytokines) in older adults (50+years) is potentially relevant for clinical care, but data from African populations is scarce...
  42. pmc Reduction in early mortality on antiretroviral therapy for adults in rural South Africa since change in CD4+ cell count eligibility criteria
    Richard J Lessells
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Somkhele, South Africa Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom Department of Infection and Population Health, University College London, London, United Kingdom The Brighton Doctoral College, Brighton and Sussex Medical School, United Kingdom and University College London Institute of Child Health, London, United Kingdom
    J Acquir Immune Defic Syndr 65:e17-24. 2014
    ..To explore the impact of expanded eligibility criteria for antiretroviral therapy (ART) on median CD4⁺ cell count at ART initiation and early mortality on ART...
  43. ncbi request reprint Prevention of mother-to-child transmission of HIV infection
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Curr Opin Infect Dis 17:247-52. 2004
    ..There is a need for alternative, easier and more effective interventions for population-based programmes...
  44. ncbi request reprint Inter-laboratory comparison of HCV-RNA assay results: implications for multi-centre research
    Lucy Pembrey
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, United Kingdom
    J Med Virol 69:195-201. 2003
    ..Multivariate analysis of data collected in multi-centre studies should therefore allow for centre and/or assay used...
  45. ncbi request reprint Estimating the number of vertically HIV-infected children eligible for antiretroviral treatment in resource-limited settings
    Kirsty Little
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health UCL, 30 Guilford Street, London, UK
    Int J Epidemiol 36:679-87. 2007
    ....
  46. ncbi request reprint Excluding hepatitis C virus (HCV) infection by serology in young infants of HCV-infected mothers
    Kirsty England
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Acta Paediatr 94:444-50. 2005
    ..To identify the age at which HCV infection can be accurately excluded by serology in young children born to HCV-infected mothers and to determine an appropriate schedule of antibody testing, most informative to clinical practice...
  47. ncbi request reprint Safety of agents used to prevent mother-to-child transmission of HIV: is there any cause for concern?
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Drug Saf 30:203-13. 2007
    ..However, these potential adverse effects require further and longer term monitoring because they are likely to be rare and to occur later in childhood...
  48. pmc Using two on-going HIV studies to obtain clinical data from before, during and after pregnancy for HIV-positive women
    Susie E Huntington
    Research Department of Infection and Population Health, University College London, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
    BMC Med Res Methodol 12:110. 2012
    ..A methodology was developed to find and match records for women reported to both studies thereby obtaining clinical and treatment data on pregnant HIV-positive women not available from either dataset alone...
  49. ncbi request reprint Maternal and infant factors and lymphocyte, CD4 and CD8 cell counts in uninfected children of HIV-1-infected mothers
    Madeleine Bunders
    Institue of Child Health, University College, London, UK
    AIDS 19:1071-9. 2005
    ..To evaluate the effects of antiretroviral treatment (ART) for mother-to-child transmission of HIV and infant/maternal characteristics on total lymphocytes (TLC) and lymphocyte subsets in uninfected children of HIV-1-infected mothers...
  50. pmc Response to antiretroviral therapy (ART): comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women
    Susie Huntington
    Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    BMC Infect Dis 14:127. 2014
    ..Short-term zidovudine monotherapy (ZDVm) remains an option for some pregnant HIV-positive women not requiring treatment for their own health but may affect treatment responses once antiretroviral therapy (ART) is subsequently started...
  51. pmc Is the Risk of HIV Acquisition Increased during and Immediately after Pregnancy? A Secondary Analysis of Pooled HIV Community-Based Studies from the ALPHA Network
    Milly Marston
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 8:e82219. 2013
    ..However these studies are unable to tell us what the overall impact of pregnancy is on HIV acquisition in the general population...
  52. ncbi request reprint HIV
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Semin Fetal Neonatal Med 12:174-81. 2007
    ..However, based on current knowledge, the immense benefits of antiretroviral prophylaxis in reducing MTCT risk far outweigh the potential for adverse effects...
  53. ncbi request reprint Is there a case for hepatitis C infection screening in the antenatal period?
    Lucy Pembrey
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH
    J Med Screen 10:161-8. 2003
    ..In this paper we review the evidence on which this decision was based, addressing the criteria that need to be considered before the introduction of a new screening programme...
  54. pmc Routine provision of nevirapine to women of unknown serostatus: at best a temporary solution to prevent MTCT
    Marie Louise Newell
    Institute of Child Health, University College London, London, England
    Bull World Health Organ 83:228-9. 2005
  55. ncbi request reprint Antiretroviral therapy-associated modulation of Th1 and Th2 immune responses in HIV-infected pregnant women
    Simona Fiore
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London UCL, London, UK
    J Reprod Immunol 70:143-50. 2006
    ..0-1.17; p=0.005). HAART use in pregnancy provides significant benefits in delaying HIV disease progression and reducing the risk of mother-to-child-transmission, but may be counterproductive in terms of successful pregnancy outcome...
  56. ncbi request reprint Effect of HIV infection on pregnancy-related mortality in sub-Saharan Africa: secondary analyses of pooled community-based data from the network for Analysing Longitudinal Population-based HIV/AIDS data on Africa (ALPHA)
    Basia Zaba
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 381:1763-71. 2013
    ..We used longitudinal data from the Analysing Longitudinal Population-based HIV/AIDS data on Africa (ALPHA) network to estimate the excess mortality associated with HIV during pregnancy and the post-partum period in sub-Saharan Africa...
  57. pmc Sexual behaviour in a rural high HIV prevalence South African community: time trends in the antiretroviral treatment era
    Nuala McGrath
    aAcademic Unit of Primary Care and Population Sciences, and Division of Social Statistics and Demography, University of Southampton, Southampton, UK bAfrica Centre for Health and Population Studies, University of KwaZulu Natal, Somkhele, South Africa cDepartment of Infectious Disease Epidemiology, Imperial College London, London, UK dDepartment of Global Health, Harvard School of Public Health, Boston, USA eFaculty of Medicine, University of Southampton, Southampton, UK
    AIDS 27:2461-70. 2013
    ....
  58. ncbi request reprint Prevention of HIV transmission through breast-feeding: strengthening the research agenda
    Francois Dabis
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College, London, UK
    J Acquir Immune Defic Syndr 35:167-8. 2004
    ..These papers summarize the current state of knowledge and highlight the outstanding issues that will need to be addressed in the very near future before research advances can be translated into public health practice...
  59. ncbi request reprint Do self-assessments of health predict future mortality in rural South Africa? The case of KwaZulu-Natal in the era of antiretroviral treatment
    Analia Olgiati
    Harvard Center for Population and Development Studies, Cambridge, MA 02138, USA
    Trop Med Int Health 17:844-53. 2012
    ....
  60. doi request reprint Fertility intentions of HIV-infected women in the United Kingdom
    Susan Cliffe
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, UK
    AIDS Care 23:1093-101. 2011
    ..These findings highlight the need for specialised family planning and reproductive health services targeting this population...
  61. pmc Design and methods of a longitudinal study investigating the impact of antiretroviral treatment on the partnerships and sexual behaviour of HIV-infected individuals in rural KwaZulu-Natal, South Africa
    Nuala McGrath
    London School of Hygiene and Tropical Medicine, London, UK
    BMC Public Health 11:121. 2011
    ..This includes improving the availability of longitudinal demographic and health data on HIV-infected individuals who have accessed ART services but who are not yet ART-eligible...
  62. ncbi request reprint Age- and sex-related reference ranges of alanine aminotransferase levels in children: European paediatric HCV network
    Kirsty England
    MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, UK
    J Pediatr Gastroenterol Nutr 49:71-7. 2009
    ..Recently, ALT reference ranges for adults were queried and revised ranges proposed with lower upper limits of normality. The appropriateness of current paediatric ALT reference ranges is unclear...
  63. pmc Treatment switches during pregnancy among HIV-positive women on antiretroviral therapy at conception
    Susie E Huntington
    UCL Medical School, Royal Free Campus, UK
    AIDS 25:1647-55. 2011
    ....
  64. pmc Net survival of perinatally and postnatally HIV-infected children: a pooled analysis of individual data from sub-Saharan Africa
    Milly Marston
    London School of Hygiene and Tropical Medicine, London, UK
    Int J Epidemiol 40:385-96. 2011
    ..With more data on timing of infection, which may be associated with disease progression, a separate representation of children infected early and late was proposed...
  65. doi request reprint British HIV Association and Children's HIV Association position statement on infant feeding in the UK 2011
    G P Taylor
    British HIV Association BHIVA, BHIVA Secretariat, Mediscript Ltd, London, UK
    HIV Med 12:389-93. 2011
    ....
  66. ncbi request reprint Women's groups' perceptions of maternal health issues in rural Malawi
    Mikey Rosato
    Centre for International Health and Development, Institute of Child Health, University College London, UK
    Lancet 368:1180-8. 2006
    ..Surveys have indicated a poor awareness of maternal health problems by individual women. We report the perceptions of women's groups to such issues in the rural Mchinji district of Malawi...
  67. ncbi request reprint Neurodevelopment in children born to HIV-infected mothers by infection and treatment status
    Kirsty Le Doaré
    Centre for International Health and Development, and eMRC Centre of Epidemiology for Child Health, University College London, Institute of Child Health, London, United Kingdom
    Pediatrics 130:e1326-44. 2012
    ..We reviewed the impact of HIV, HIV exposure, and antiretroviral therapy/prophylaxis on neurodevelopmental outcomes of HIV-infected and HIV-exposed-uninfected infants and children...
  68. pmc Unpacking the recommended indicator for concurrent sexual partnerships
    Jeffrey W Eaton
    Department of Infectious Disease Epidemiology, Imperial College London, UK
    AIDS 26:1037-9. 2012
    ..The discrepancy is only partially explained by disproportionate missing data in those with more sexual partners...
  69. pmc Starting a home and mobile HIV testing service in a rural area of South Africa
    Hendramoorthy Maheswaran
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Somkhele, South Africa
    J Acquir Immune Defic Syndr 59:e43-6. 2012
    ..To compare users of a home and mobile HIV counseling and testing service implemented in rural KwaZulu-Natal, South Africa...
  70. ncbi request reprint Interventions to improve the performance of HIV health systems for treatment-as-prevention in sub-Saharan Africa: the experimental evidence
    Till Barnighausen
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Mtubatuba, KwaZulu Natal, South Africa
    Curr Opin HIV AIDS 7:140-50. 2012
    ..We review the experimental evidence on interventions to increase these rates...
  71. ncbi request reprint Managing mother-to-child transmission of HIV infection in developed-country settings
    Claire Thorne
    Institute of Child Health, Centre for Paediatric Epidemiology and Biostatistics, 30 Guilford Street, London, WC1N 1EH, UK
    Womens Health (Lond Engl) 1:385-99. 2005
    ....
  72. ncbi request reprint Estimating the efficacy of interventions to prevent mother-to-child transmission of human immunodeficiency virus in breastfeeding populations: comparing statistical methods
    Ahmadou Alioum
    INSERM U 593, Institut d Epidémiologie, Santé Publique et Développement, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Am J Epidemiol 158:596-605. 2003
    ..For estimation of this proportion at age 18 months, more sophisticated methods, such as the extension of the Kaplan-Meier procedure to interval-censored data and competing risks, would be preferred...
  73. ncbi request reprint Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: a randomized trial
    Alejandro Dorenbaum
    Department of Pediatrics, University of California, San Francisco, USA
    JAMA 288:189-98. 2002
    ..However, it is unknown whether the addition of the 2-dose nevirapine regimen to standard ART would further reduce perinatal HIV transmission...
  74. ncbi request reprint Pregnancy and HIV infection: A european consensus on management
    Oriol Coll
    Hospital Clinic, University of Barcelona, Spain
    AIDS 16:S1-18. 2002
  75. ncbi request reprint Pregnancy outcomes in HIV-infected and uninfected women in rural and urban South Africa
    Nigel C Rollins
    Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Congella 4013, South Africa
    J Acquir Immune Defic Syndr 44:321-8. 2007
    ..To describe pregnancy outcomes among clade C HIV-infected and uninfected women in South Africa...
  76. ncbi request reprint Is there a difference in the efficacy of peripartum antiretroviral regimens in reducing mother-to-child transmission of HIV in Africa?
    Valeriane Leroy
    INSERM U 593, Institut d Epidémiologie, Santé Publique et Développement ISPED, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    AIDS 19:1865-75. 2005
    ....
  77. ncbi request reprint Does highly active antiretroviral therapy increase the risk of congenital abnormalities in HIV-infected women?
    Deven Patel
    J Acquir Immune Defic Syndr 40:116-8. 2005
  78. ncbi request reprint Late postnatal transmission of HIV-1 in breast-fed children: an individual patient data meta-analysis
    Anna Coutsoudis
    J Infect Dis 189:2154-66. 2004
    ....
  79. ncbi request reprint Effects of CCR5-delta32 and CCR2-64I alleles on disease progression of perinatally HIV-1-infected children: an international meta-analysis
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    AIDS 17:1631-8. 2003
    ..Among perinatally infected children, the effects of certain alleles of the CCR5 and CCR2 genes on the rate of disease progression remain unclear. We addressed the effects of CCR5-delta32 and CCR2-64I in an international meta-analysis...
  80. ncbi request reprint Maternal toxicity and pregnancy complications in human immunodeficiency virus-infected women receiving antiretroviral therapy: PACTG 316
    D Heather Watts
    National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Am J Obstet Gynecol 190:506-16. 2004
    ..The purpose of this study was to evaluate rates of maternal toxicity, pregnancy complications, and peripartum morbidity by type and duration of antiretroviral therapy (ART) during pregnancy...
  81. pmc Breast-feeding and Transmission of HIV-1
    Grace John-Stewart
    Department of Medicine, University of Washington, USA
    J Acquir Immune Defic Syndr 35:196-202. 2004
    ..Innate and acquired immune factors may act most effectively in combination to prevent primary HIV-1 infection by breast milk...
  82. ncbi request reprint Use of antiretroviral drugs to prevent HIV-1 transmission through breast-feeding: from animal studies to randomized clinical trials
    Philippe Gaillard
    World Health Organization, Reproductive Health and Research, Geneva, Switzerland
    J Acquir Immune Defic Syndr 35:178-87. 2004
    ..Laboratory studies nested within several of these trials will provide a better understanding of the pathogenesis of postnatal HIV transmission and its potential prevention using antiretroviral drugs...
  83. ncbi request reprint Maternal viral load and rate of disease progression among vertically HIV-1-infected children: an international meta-analysis
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    AIDS 18:99-108. 2004
    ....
  84. ncbi request reprint Vaccines to prevent transmission of HIV-1 via breastmilk: scientific and logistical priorities
    Katherine Luzuriaga
    University of Massachusetts Medical School, Program in Molecular Medicine, 373 Plantation Street, Suite 318, Worcester, MA 01605, USA
    Lancet 368:511-21. 2006
    ..Here, we discuss the scientific and logistical challenges for the development of paediatric HIV vaccines; available vaccines and completed or planned paediatric vaccine trials are also discussed...
  85. doi request reprint Response to combination antiretroviral therapy: variation by age
    Caroline A Sabin
    AIDS 22:1463-73. 2008
    ..To provide information on responses to combination antiretroviral therapy in children, adolescents and older HIV-infected persons...
  86. ncbi request reprint Short communication: CD4 counts of HIV-infected pregnant women and their infected children--implications for PMTCT and treatment programmes
    Ankie Lebon
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, South Africa
    Trop Med Int Health 12:1472-4. 2007
    ..The antenatal-postnatal divide needs to be bridged with respect to the follow-up of both HIV-infected women and their exposed infants...
  87. ncbi request reprint Pregnancies in young women with vertically acquired HIV infection in Europe
    Claire Thorne
    AIDS 21:2552-6. 2007
  88. ncbi request reprint Cohort profile: the paediatric antiretroviral treatment programmes in lower-income countries (KIDS-ART-LINC) collaboration
    Elise Arrive
    Unité INSERM 593, Institut de Santé Publique, Epidémiologie et Développement ISPED, Universite Victor Segalen, Bordeaux, France
    Int J Epidemiol 37:474-80. 2008
  89. ncbi request reprint Prevalence of sexually transmitted infections in HIV-1 infected pregnant women in Europe
    Megan Landes
    Department of Family and Community Medicine, University of Toronto, Toronto, Canada
    Eur J Epidemiol 22:925-36. 2007
    ..HIV-infected women should receive adequate screening for STIs during pregnancy together with appropriate counseling and follow-up for treatment and prevention...
  90. pmc Population and antenatal-based HIV prevalence estimates in a high contracepting female population in rural South Africa
    Brian D Rice
    Africa Centre for Health and Population Studies, KwaZulu Natal, South Africa
    BMC Public Health 7:160. 2007
    ..There is particular emphasis on unrepresentative selection of ANC clinics and unrepresentative testing in the population...
  91. ncbi request reprint Response to Kourtis et al. 'Use of antiretroviral therapy in pregnant HIV-infected women and the risk of premature delivery: a meta-analysis'
    Deven Patel
    AIDS 21:1656-7; author reply1657-8. 2007
  92. ncbi request reprint Continued very high prevalence of HIV infection in rural KwaZulu-Natal, South Africa: a population-based longitudinal study
    Tanya Welz
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Durban, South Africa
    AIDS 21:1467-72. 2007
    ..To estimate the prevalence of HIV and associated sociodemographic factors including mobility and migration in a rural population in KwaZulu-Natal, South Africa...
  93. ncbi request reprint Surveillance of mother-to-child transmission prevention programmes at immunization clinics: the case for universal screening
    Nigel Rollins
    Department of Paediatrics and Child Health, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Congella 4013, South Africa
    AIDS 21:1341-7. 2007
    ..Additionally, infected infants are often not identified early and only gain access to comprehensive HIV care and treatment late in their disease...
  94. ncbi request reprint Prevalence of resistance to nevirapine in mothers and children after single-dose exposure to prevent vertical transmission of HIV-1: a meta-analysis
    Elise Arrive
    Unité INSERM 593, Bordeaux, France
    Int J Epidemiol 36:1009-21. 2007
    ..This systematic review and meta-analysis of summarized data aimed to estimate the proportion of mothers and children with NVP resistance mutations detected in plasma samples 4-8 weeks postpartum after single-dose NVP use for PMTCT...
  95. ncbi request reprint Time to undetectable viral load after highly active antiretroviral therapy initiation among HIV-infected pregnant women
    Deven Patel
    Clin Infect Dis 44:1647-56. 2007
    ....
  96. ncbi request reprint Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding in the first 6 months of life: an intervention cohort study
    Hoosen M Coovadia
    Centre for HIV AIDS Networking, University of KwaZulu Natal, South Africa
    Lancet 369:1107-16. 2007
    ..We assessed the HIV-1 transmission risks and survival associated with exclusive breastfeeding and other types of infant feeding...
  97. ncbi request reprint Protease inhibitor-associated increased risk of preterm delivery is an immunological complication of therapy
    Simona Fiore
    J Infect Dis 195:914-6; author reply 916-7. 2007
  98. doi request reprint Intervention to promote exclusive breast-feeding for the first 6 months of life in a high HIV prevalence area
    Ruth M Bland
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Mtubatuba, KwaZulu Natal, South Africa
    AIDS 22:883-91. 2008
    ..We report on a nonrandomized intervention cohort study to increase exclusive breast-feeding rates for 6 months after delivery in HIV-positive and HIV-negative women in KwaZulu-Natal, South Africa...