David E Newby

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Endogenous angiotensin II contributes to basal peripheral vascular tone in sodium deplete but not sodium replete man
    D E Newby
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, UK
    Cardiovasc Res 36:268-75. 1997
  2. doi request reprint Acute endothelial tissue plasminogen activator release in pregnancy
    A O Robb
    Centre for Reproductive Biology, University of Edinburgh, Edinburgh, UK
    J Thromb Haemost 7:138-42. 2009
  3. ncbi request reprint Vascular and fibrinolytic effects of intra-arterial tumour necrosis factor-alpha in patients with coronary heart disease
    Simon D Robinson
    Centre for Cardiovascular Sciences, University of Edinburgh, Royal Infirmary of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, U K
    Clin Sci (Lond) 110:353-60. 2006
  4. pmc Comparative effects of glyceryl trinitrate and amyl nitrite on pulse wave reflection and augmentation index
    Lynn D Greig
    Western General Hospital, Edinburgh, UK
    Br J Clin Pharmacol 59:265-70. 2005
  5. ncbi request reprint B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure
    Nicholas L M Cruden
    Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom, EH16 4SB
    Arterioscler Thromb Vasc Biol 25:772-7. 2005
  6. ncbi request reprint Molecular imaging of the atherosclerotic plaque using positron emission tomography
    I S Toor
    DE Newby British Heart Foundation University Centre for Cardiovascular Science University of Edinburgh Chancellor s Building 49 Little France Crescent Edinburgh EH16 4SB Email
    J R Coll Physicians Edinb 44:139-45. 2014
  7. pmc Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: study protocol for randomized controlled trial
    David E Newby
    University of Edinburgh BHF Centre for Cardiovascular Science, Chancellor s Building, 49 Little France Crescent, Edinburgh, EH16 SU4, UK
    Trials 13:184. 2012
  8. pmc Systematic assessment in an animal model of the angiogenic potential of different human cell sources for therapeutic revascularization
    G Robin Barclay
    SNBTS Cell Therapy Research Group, Scottish Centre for Regenerative Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Stem Cell Res Ther 3:23. 2012
  9. pmc Left ventricular remodeling and hypertrophy in patients with aortic stenosis: insights from cardiovascular magnetic resonance
    Marc R Dweck
    Royal Brompton Hospital, Sydney Street, London, SW3 6NP, United Kingdom
    J Cardiovasc Magn Reson 14:50. 2012
  10. pmc Beneficial cardiovascular effects of reducing exposure to particulate air pollution with a simple facemask
    Jeremy P Langrish
    Centre for Cardiovascular Sciences, Edinburgh University, Edinburgh, UK
    Part Fibre Toxicol 6:8. 2009

Detail Information

Publications164 found, 100 shown here

  1. ncbi request reprint Endogenous angiotensin II contributes to basal peripheral vascular tone in sodium deplete but not sodium replete man
    D E Newby
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, UK
    Cardiovasc Res 36:268-75. 1997
    ..However, the role of angiotensin II, a key hormone regulating cardiovascular and renal function, in the regulation of peripheral vascular tone has not been fully characterised...
  2. doi request reprint Acute endothelial tissue plasminogen activator release in pregnancy
    A O Robb
    Centre for Reproductive Biology, University of Edinburgh, Edinburgh, UK
    J Thromb Haemost 7:138-42. 2009
    ..The aim of the study was to assess the effect of pregnancy on the acute release of tissue plasminogen activator (t-PA) from the endothelium...
  3. ncbi request reprint Vascular and fibrinolytic effects of intra-arterial tumour necrosis factor-alpha in patients with coronary heart disease
    Simon D Robinson
    Centre for Cardiovascular Sciences, University of Edinburgh, Royal Infirmary of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, U K
    Clin Sci (Lond) 110:353-60. 2006
    ..We suggest that the adverse prognosis associated with elevated plasma t-PA concentrations relates to the underlying causative association with vascular inflammation and injury...
  4. pmc Comparative effects of glyceryl trinitrate and amyl nitrite on pulse wave reflection and augmentation index
    Lynn D Greig
    Western General Hospital, Edinburgh, UK
    Br J Clin Pharmacol 59:265-70. 2005
    ..The aim of this study was to compare the effects of two short-acting nitrates, GTN and amyl nitrite, which have differing pharmacodynamic profiles...
  5. ncbi request reprint B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure
    Nicholas L M Cruden
    Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom, EH16 4SB
    Arterioscler Thromb Vasc Biol 25:772-7. 2005
    ..We investigated the contribution of the B1 receptor to the maintenance of vascular tone and t-PA release in patients with heart failure...
  6. ncbi request reprint Molecular imaging of the atherosclerotic plaque using positron emission tomography
    I S Toor
    DE Newby British Heart Foundation University Centre for Cardiovascular Science University of Edinburgh Chancellor s Building 49 Little France Crescent Edinburgh EH16 4SB Email
    J R Coll Physicians Edinb 44:139-45. 2014
    ..We will also discuss the potential of PET/CT molecular imaging as both a screening tool for novel therapeutic interventions and as a means of improving cardiovascular risk stratification. ..
  7. pmc Role of multidetector computed tomography in the diagnosis and management of patients attending the rapid access chest pain clinic, The Scottish computed tomography of the heart (SCOT-HEART) trial: study protocol for randomized controlled trial
    David E Newby
    University of Edinburgh BHF Centre for Cardiovascular Science, Chancellor s Building, 49 Little France Crescent, Edinburgh, EH16 SU4, UK
    Trials 13:184. 2012
    ..However, this technology has not been robustly evaluated in its application to the clinic...
  8. pmc Systematic assessment in an animal model of the angiogenic potential of different human cell sources for therapeutic revascularization
    G Robin Barclay
    SNBTS Cell Therapy Research Group, Scottish Centre for Regenerative Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Stem Cell Res Ther 3:23. 2012
    ..It should be possible to produce autologous EOC for therapeutic use, and evaluate the effect of EPC distinct from, or in synergy with, the proangiogenic effects of HPC therapies...
  9. pmc Left ventricular remodeling and hypertrophy in patients with aortic stenosis: insights from cardiovascular magnetic resonance
    Marc R Dweck
    Royal Brompton Hospital, Sydney Street, London, SW3 6NP, United Kingdom
    J Cardiovasc Magn Reson 14:50. 2012
    ..We sought to investigate the degree and patterns of hypertrophy in aortic stenosis using CMR...
  10. pmc Beneficial cardiovascular effects of reducing exposure to particulate air pollution with a simple facemask
    Jeremy P Langrish
    Centre for Cardiovascular Sciences, Edinburgh University, Edinburgh, UK
    Part Fibre Toxicol 6:8. 2009
    ..abstract:..
  11. pmc Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions
    Stefan Barath
    Department of Public Health and Clinical Medicine, Umea University, Sweden
    Part Fibre Toxicol 7:19. 2010
    ..Controlled human exposure studies have demonstrated impaired vascular function after inhalation of exhaust generated by a diesel engine under idling conditions...
  12. pmc Experimental exposure to diesel exhaust increases arterial stiffness in man
    Magnus Lundback
    Department of Respiratory Medicine and Allergy, University Hospital, Umea, Sweden
    Part Fibre Toxicol 6:7. 2009
    ..abstract:..
  13. pmc Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust
    Sofian Metassan
    Division of Cardiovascular and Diabetes Research, Section on Mechanisms of Thrombosis, Leeds Institute for Genetics Health and Therapeutics, Faculty of Medicine and Health, University of Leeds, Leeds, UK
    Part Fibre Toxicol 7:17. 2010
    ..These data show that there are no prothrombotic changes in fibrin clot structure in young, healthy individuals exposed to diesel exhaust...
  14. pmc Non-invasive assessment of coronary artery bypass graft patency using 16-slice computed tomography angiography
    Emma S Houslay
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    J Cardiothorac Surg 2:27. 2007
    ..We evaluated computed tomography as a non-invasive means of assessing graft patency...
  15. pmc Generation Scotland: Donor DNA Databank; A control DNA resource
    Shona M Kerr
    Medical Genetics Section, Centre for Molecular Medicine, University of Edinburgh, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK
    BMC Med Genet 11:166. 2010
    ..The Generation Scotland: Donor DNA Databank (GS:3D) aims to help solve this problem by providing a resource of control DNA and plasma samples accessible for research...
  16. pmc Emerging medical treatments for aortic stenosis: statins, angiotensin converting enzyme inhibitors, or both?
    D E Newby
    Department of Cardiology, Royal Infirmary, Edinburgh, UK
    Heart 92:729-34. 2006
    ..In particular, statins and angiotensin converting enzyme inhibitors appear to hold promise but definitive evidence from large clinical trials is awaited...
  17. ncbi request reprint Abnormal endothelin B receptor vasomotor responses in patients with Hirschsprung's disease
    D E Newby
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Edinburgh, UK
    QJM 95:159-63. 2002
    ..Hirschsprung's disease is associated with defects in the endothelin-3 and endothelin B receptor genes...
  18. pmc Hypercholesterolaemia and lipid lowering treatment do not affect the acute endogenous fibrinolytic capacity in vivo
    D E Newby
    Department of Cardiology, University of Edinburgh, Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, UK
    Heart 87:48-53. 2002
    ..To assess acute tissue plasminogen activator (t-PA) release in vivo in patients with hypercholesterolaemia in the presence and absence of lipid lowering treatment and in matched normocholesterolaemic controls...
  19. pmc Invasive assessment of the coronary circulation: intravascular ultrasound and Doppler
    David E Newby
    Cardiovascular Research, Department of Cardiology, Royal Infirmary, 1 Lauriston Place, Edinburgh EH3 9YW
    Br J Clin Pharmacol 53:561-75. 2002
  20. ncbi request reprint Impaired coronary tissue plasminogen activator release is associated with coronary atherosclerosis and cigarette smoking: direct link between endothelial dysfunction and atherothrombosis
    D E Newby
    Departments of Cardiology, University of Edinburgh, Royal Infirmary, United Kingdom
    Circulation 103:1936-41. 2001
    ..The aim of the study was to establish the influence of proximal coronary artery atheroma and smoking habit on the stimulated release of tissue plasminogen activator (tPA) from the heart...
  21. ncbi request reprint Hyperdynamic circulation in liver cirrhosis: not peripheral vasodilatation but 'splanchnic steal'
    D E Newby
    Department of Cardiology, University of Edinburgh, Royal Infirmary, Edinburgh, UK
    QJM 95:827-30. 2002
  22. ncbi request reprint Reduced responsiveness to endothelin-1 in peripheral resistance vessels of patients with syndrome X
    D E Newby
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Scotland, United Kingdom
    J Am Coll Cardiol 31:1585-90. 1998
    ..This study sought to assess the contribution and action of nitric oxide and endothelin-1 in peripheral resistance vessels of patients with syndrome X...
  23. ncbi request reprint Peripheral vascular tone in patients with cirrhosis: role of the renin-angiotensin and sympathetic nervous systems
    D E Newby
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, Scotland, UK
    Cardiovasc Res 38:221-8. 1998
    ..The aims of the study were to establish the roles of angiotensin II and of the cardiopulmonary baroreceptor reflex in the regulation of peripheral vascular tone in patients with cirrhosis...
  24. ncbi request reprint The L-arginine/nitric oxide pathway contributes to the acute release of tissue plasminogen activator in vivo in man
    D E Newby
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, UK
    Cardiovasc Res 38:485-92. 1998
    ..Using the nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA), we examined the contribution of endogenous nitric oxide to substance P-induced t-PA release in vivo in man...
  25. ncbi request reprint A 'same day' direct-access chest pain clinic: improved management and reduced hospitalization
    D E Newby
    Department of Cardiology, Royal Infirmary, Edinburgh, UK
    QJM 91:333-7. 1998
    ....
  26. pmc Regulation of peripheral vascular tone in patients with heart failure: contribution of angiotensin II
    D E Newby
    Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, UK
    Heart 80:134-40. 1998
    ..To determine directly the contribution of angiotensin II to basal and sympathetically stimulated peripheral arteriolar tone in patients with heart failure...
  27. ncbi request reprint Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction
    D E Newby
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Edinburgh, Scotland
    Circulation 99:1411-5. 1999
    ..Smoking is a known risk factor for arterial thrombosis and myocardial infarction, and it causes endothelial dysfunction. We therefore examined the effects of cigarette smoking on substance P-induced tPA release in vivo in humans...
  28. pmc Substance P-induced vasodilatation is mediated by the neurokinin type 1 receptor but does not contribute to basal vascular tone in man
    D E Newby
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, Scotland, UK
    Br J Clin Pharmacol 48:336-44. 1999
    ....
  29. ncbi request reprint Local and systemic effects of intra-arterial desmopressin in healthy volunteers and patients with type 3 von Willebrand disease. Role of interleukin-6
    D E Newby
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, UK
    Thromb Haemost 84:195-203. 2000
    ..Patients with type 3 vWD appear to have a generalised failure to release t-PA acutely despite a normal interleukin-6 response to desmopressin infusion...
  30. ncbi request reprint An in vivo model for the assessment of acute fibrinolytic capacity of the endothelium
    D E Newby
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Scotland, UK
    Thromb Haemost 78:1242-8. 1997
    ..This model should provide a useful and selective method of assessing the in vivo capacity of the forearm endothelium to release t-PA acutely...
  31. ncbi request reprint Contribution of endothelin 1 to the vascular effects of diesel exhaust inhalation in humans
    Jeremy P Langrish
    Centre for Cardiovascular Sciences, University of Edinburgh, 49 Little France Crescent, Edinburgh, United Kingdom
    Hypertension 54:910-5. 2009
    ..Given the tonic interaction between the ET and NO systems, we conclude that diesel exhaust inhalation alters vascular reactivity to ET-1 probably through its effects on NO bioavailability...
  32. doi request reprint Marked impairment of protease-activated receptor type 1-mediated vasodilation and fibrinolysis in cigarette smokers: smoking, thrombin, and vascular responses in vivo
    Ninian N Lang
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    J Am Coll Cardiol 52:33-9. 2008
    ..We sought to test the hypothesis that cigarette smoking adversely alters protease-activated receptor type 1 (PAR-1)-mediated vascular effects in vivo in humans...
  33. pmc Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man
    Jeremy P Langrish
    University British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    J Am Heart Assoc 2:e004309. 2013
    ..Diesel exhaust inhalation causes cardiovascular dysfunction including impaired vascular reactivity, increased blood pressure, and arterial stiffness. We investigated the role of nitric oxide (NO) bioavailability in mediating these effects...
  34. ncbi request reprint Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure
    Nicholas L M Cruden
    Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom EH16 4SB
    Arterioscler Thromb Vasc Biol 24:1043-8. 2004
    ..Using B9340, a bradykinin receptor antagonist, we determined the contribution of bradykinin to the systemic hemodynamic effects of long-term ACE inhibition in patients with chronic heart failure...
  35. doi request reprint Vascular B1 kinin receptors in patients with congestive heart failure
    Ninian N Lang
    Centre for Cardiovascular Science, University of Edinburgh, United Kingdom and thedaggerDepartment of Cardiology, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, United Kingdom
    J Cardiovasc Pharmacol 52:438-44. 2008
    ..Blood flow and t-PA release were unaffected by B1 agonism or antagonism in the presence and absence HOE-140. Our findings do not support a role for crosstalk between the B1 and B2 kinin receptors in the human peripheral circulation...
  36. pmc Ischaemia-reperfusion injury impairs tissue plasminogen activator release in man
    Christian M Pedersen
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Eur Heart J 33:1920-7. 2012
    ..The effects of IR injury and preconditioning on endothelium-dependent tissue plasminogen activator (t-PA) release, an important mediator of endogenous fibrinolysis, remain unknown...
  37. doi request reprint Vasomotor and fibrinolytic responses to kinin receptor agonists in the atherosclerotic human lower limb
    Nicholas L M Cruden
    Centre for Cardiovascular Science, University of Edinburgh, Room F2339, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 5SB, UK
    Heart Vessels 27:179-85. 2012
    ..In keeping with previous data, bradykinin-mediated tissue plasminogen activator release was augmented in the presence of angiotensin-converting enzyme inhibition consistent with its putative vascular protective effect...
  38. doi request reprint Particle traps prevent adverse vascular and prothrombotic effects of diesel engine exhaust inhalation in men
    Andrew J Lucking
    University of Edinburgh, Royal Infirmary, 49 Little France Crescent, Edinburgh, UK
    Circulation 123:1721-8. 2011
    ..The aim of the present study was to establish whether an exhaust particle trap could prevent these adverse cardiovascular effects in men...
  39. ncbi request reprint Acute effects of glucocorticoids on endothelial fibrinolytic and vasodilator function in humans
    Anna R Dover
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, UK
    J Cardiovasc Pharmacol 50:321-6. 2007
    ..These findings suggest that glucocorticoids do not exert acute effects on endothelial function in vivo in humans...
  40. ncbi request reprint Adverse cardiovascular effects of air pollution
    Nicholas L Mills
    Centre for Cardiovascular Science, University of Edinburgh, UK
    Nat Clin Pract Cardiovasc Med 6:36-44. 2009
    ..An increased understanding of the mediators and mechanisms of these processes is necessary if we are to develop strategies to protect individuals at risk and reduce the effect of air pollution on cardiovascular disease...
  41. ncbi request reprint Vascular dysfunction in chronic obstructive pulmonary disease
    John D Maclay
    Centre for Inflammation Research, Edinburgh University, Edinburgh, United Kingdom
    Am J Respir Crit Care Med 180:513-20. 2009
    ..It is unclear whether such associations relate to the presence of COPD or prior smoking habit...
  42. pmc Effects of acute insulin-induced hypoglycemia on indices of inflammation: putative mechanism for aggravating vascular disease in diabetes
    Rohana J Wright
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK
    Diabetes Care 33:1591-7. 2010
    ..To examine the effects of acute insulin-induced hypoglycemia on inflammation, endothelial dysfunction, and platelet activation in adults with and without type 1 diabetes...
  43. ncbi request reprint Neutral endopeptidase inhibition augments vascular actions of bradykinin in patients treated with angiotensin-converting enzyme inhibition
    Nicholas L M Cruden
    Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom, EH16 4SB
    Hypertension 44:913-8. 2004
    ....
  44. ncbi request reprint Intra-arterial tumor necrosis factor-alpha impairs endothelium-dependent vasodilatation and stimulates local tissue plasminogen activator release in humans
    Stanley Chia
    Department of Cardiology, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK
    Arterioscler Thromb Vasc Biol 23:695-701. 2003
    ..We assessed the direct effects of local intra-arterial tumor necrosis factor-alpha (TNF-alpha), interleukin-6, and endotoxin on blood flow and endogenous tissue plasminogen activator (t-PA) release in vivo in humans...
  45. pmc Diesel exhaust particulate induces pulmonary and systemic inflammation in rats without impairing endothelial function ex vivo or in vivo
    Sarah Robertson
    Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, UK
    Part Fibre Toxicol 9:9. 2012
    ..We hypothesised that pulmonary exposure to diesel exhaust particles (DEP) would cause endothelial dysfunction in rats as a consequence of pulmonary and systemic inflammation...
  46. ncbi request reprint Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans
    Ingibjörg J Gudmundsdóttir
    Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary, 49 Little France Crescent, Edinburgh, EH16 4SB, UK
    Circulation 114:1625-32. 2006
    ..The aim of the present study was to determine the direct vascular actions of PAR-1 agonism in humans...
  47. ncbi request reprint Potentiation of bradykinin-induced tissue plasminogen activator release by angiotensin-converting enzyme inhibition
    C Labinjoh
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, United Kingdom
    J Am Coll Cardiol 38:1402-8. 2001
    ..These findings suggest that the beneficial clinical and vascular effects of ACE inhibition may, in part, be mediated through local augmentation of bradykinin-induced t-PA release...
  48. ncbi request reprint Diesel exhaust inhalation increases thrombus formation in man
    Andrew J Lucking
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Eur Heart J 29:3043-51. 2008
    ..The aim of this study is to investigate the effect of diesel exhaust inhalation on platelet activation and thrombus formation in men...
  49. ncbi request reprint Coronary arterial 18F-sodium fluoride uptake: a novel marker of plaque biology
    Marc R Dweck
    Centre for Cardiovascular Sciences, University of Edinburgh, United Kingdom
    J Am Coll Cardiol 59:1539-48. 2012
    ....
  50. doi request reprint Nanoparticles and the cardiovascular system: a critical review
    Ken Donaldson
    Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Nanomedicine (Lond) 8:403-23. 2013
    ....
  51. doi request reprint Effect of ω-3 fatty acid supplementation on endothelial function, endogenous fibrinolysis and platelet activation in male cigarette smokers
    Jehangir N Din
    Centre for Cardiovascular Sciences, University of Edinburgh, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Heart 99:168-74. 2013
    ....
  52. ncbi request reprint A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis
    S Joanna Cowell
    Department of Cardiology, Royal Infirmary, Edinburgh, United Kingdom
    N Engl J Med 352:2389-97. 2005
    ..We hypothesized that intensive lipid-lowering therapy would halt the progression of calcific aortic stenosis or induce its regression...
  53. ncbi request reprint Vitamin C has no effect on endothelium-dependent vasomotion and acute endogenous fibrinolysis in healthy smokers
    M Paola Pellegrini
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Cardiovasc Pharmacol 44:117-24. 2004
    ..We conclude that the adverse vascular actions of smoking are not principally mediated through oxidative stress...
  54. ncbi request reprint Exposure to nitrogen dioxide is not associated with vascular dysfunction in man
    Jeremy P Langrish
    Centre for Cardiovascular Sciences, University of Edinburgh, United Kingdom
    Inhal Toxicol 22:192-8. 2010
    ..It is unclear whether these effects are mediated through combustion-derived particulate matter or gaseous components, such as nitrogen dioxide...
  55. ncbi request reprint Role of the endothelium in the vascular effects of the thrombin receptor (protease-activated receptor type 1) in humans
    Ingibjörg J Gudmundsdóttir
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    J Am Coll Cardiol 51:1749-56. 2008
    ..The purpose of this study was to determine the role of the endothelium in the vascular actions of protease-activated receptor type 1 (PAR-1) activation in vivo in man...
  56. pmc Enhanced vasodilatation to endothelin antagonism in patients with compensated cirrhosis and the role of nitric oxide
    A Helmy
    Liver Unit, Department of Medicine, Royal Infirmary of Edinburgh, and Clinical Pharmacology Unit and Research Centre, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Gut 52:410-5. 2003
    ....
  57. pmc Diesel exhaust particulate increases the size and complexity of lesions in atherosclerotic mice
    Mark R Miller
    Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, EH16 4TJ Edinburgh, Scotland, UK
    Part Fibre Toxicol 10:61. 2013
    ..We hypothesized that DEP exposure would increase and destabilise atherosclerotic lesions in apolipoprotein E deficient (ApoE-/-) mice...
  58. ncbi request reprint Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis
    Nicholas L Mills
    Centre for Cardiovascular Science, Edinburgh University, Edinburgh, Scotland
    Circulation 112:3930-6. 2005
    ..The study aim was to investigate the effects of diesel exhaust inhalation on vascular and endothelial function in humans...
  59. ncbi request reprint Bradykinin receptor antagonism and endothelial tissue plasminogen activator release in humans
    Fraser N Witherow
    Cardiovascular Research, University of Edinburgh, University of Edinburgh, Royal Infirmary of Edinburgh, UK
    Arterioscler Thromb Vasc Biol 23:1667-70. 2003
    ..We sought to assess pharmacodynamic responses to the bradykinin antagonist B9340 and to determine the contribution of the endothelial bradykinin receptor to stimulated tissue plasminogen activator (t-PA) release in humans...
  60. ncbi request reprint Ultrasmall superparamagnetic particles of iron oxide in patients with acute myocardial infarction: early clinical experience
    Shirjel R Alam
    Centre of Cardiovascular Science, Clinical Research Imaging Centre, Edinburgh, UK
    Circ Cardiovasc Imaging 5:559-65. 2012
    ..Magnetic resonance imaging using ultrasmall superparamagnetic particles of iron oxide can detect cellular inflammation in tissues, and we therefore explored their role in acute MI in humans...
  61. ncbi request reprint Endothelial fibrinolytic capacity predicts future adverse cardiovascular events in patients with coronary heart disease
    Simon D Robinson
    Centre for Cardiovascular Sciences, University of Edinburgh, Royal Infirmary of Edinburgh, 49 Little France Crescent, Edinburgh, Scotland, EH16 4SB, UK
    Arterioscler Thromb Vasc Biol 27:1651-6. 2007
    ..We assessed whether endothelial fibrinolytic capacity predicts atherothrombotic events in patients with coronary heart disease...
  62. ncbi request reprint Inducible nitric oxide synthase activity does not contribute to the maintenance of peripheral vascular tone in patients with heart failure
    Anna R Dover
    Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Clin Sci (Lond) 111:275-80. 2006
    ..We conclude that iNOS activity does not contribute to peripheral vascular tone in patients with symptomatic heart failure...
  63. ncbi request reprint Acute systemic inflammation enhances endothelium-dependent tissue plasminogen activator release in men
    Stanley Chia
    Cardiovascular Research, University of Edinburgh, Royal Infirmary of Edinburgh, United Kingdom
    J Am Coll Cardiol 41:333-9. 2003
    ..The purpose of this study was to investigate in vivo the effects of acute systemic inflammation on the endogenous fibrinolytic capacity in men...
  64. pmc Direct comparison of selective endothelin A and non-selective endothelin A/B receptor blockade in chronic heart failure
    S J Leslie
    Department of Medical Sciences, The University of Edinburgh, Western General Hospital, Edinburgh, UK
    Heart 91:914-9. 2005
    ..To investigate the potential differential effects of selective endothelin (ET) A and dual ET-A/B receptor blockade in patients with chronic heart failure...
  65. ncbi request reprint The constituents and mechanisms of generation of 'endothelial cell--colony forming units'
    Gareth J Padfield
    British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Chancellor s Building, Edinburgh EH16 4SU, UK
    Cardiovasc Res 100:288-96. 2013
    ..The formation of endothelial cell-colony forming units (EC-CFUs) is increased by vascular injury, although their function in vivo is unclear. We, therefore, examined the constituents of EC-CFUs and the mechanisms of their generation...
  66. pmc Cardiovascular effects of tumour necrosis factor α antagonism in patients with acute myocardial infarction: a first in human study
    Gareth J Padfield
    British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Heart 99:1330-5. 2013
    ..We wished to determine the effects of TNF-α antagonism on endothelial function and platelet activation in patients with acute myocardial infarction...
  67. doi request reprint Sustained cardiovascular actions of APJ agonism during renin-angiotensin system activation and in patients with heart failure
    Gareth D Barnes
    British Heart Foundation University of Edinburgh Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Circ Heart Fail 6:482-91. 2013
    ..To assess cardiovascular actions of APJ agonism during prolonged (Pyr(1))apelin-13 infusion and renin-angiotensin system activation...
  68. doi request reprint Diagnosis of myocardial infarction following hospitalisation for exacerbation of COPD
    David A McAllister
    ELEGI Colt Laboratories, Queens Medial Research Institute, University of Edinburgh, Edinburgh, UK
    Eur Respir J 39:1097-103. 2012
    ..Overall, one in 12 patients met the criteria for myocardial infarction. Whether these patients would benefit from further cardiac investigation is unknown...
  69. ncbi request reprint Altered endothelin-1 vasoreactivity in patients with untreated normal-pressure glaucoma
    Emer Henry
    Princess Alexandra Eye Pavilion, and The Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, United Kingdom
    Invest Ophthalmol Vis Sci 47:2528-32. 2006
    ..Endothelin (ET)-1 vasoreactivity was assessed in the peripheral circulation of patients with NPG...
  70. pmc Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease
    Nicholas L Mills
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 116:709-15. 2008
    ..Exposure to fine particulate air pollution is associated with increased cardiovascular morbidity and mortality. We previously demonstrated that exposure to dilute diesel exhaust causes vascular dysfunction in humans...
  71. pmc Vasodilator effects of the endothelin ET receptor selective antagonist BMS-193884 in healthy men
    Neeraj Dhaun
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Edinburgh, UK
    Br J Clin Pharmacol 60:611-22. 2005
    ..We investigated the haemodynamic effects of locally and systemically active doses of BMS-193884, an endothelin A (ET(A)) receptor selective ERA, and its influence on vasoconstriction to endothelin-1 (ET-1) in healthy men...
  72. doi request reprint Randomized controlled trial of dual antiplatelet therapy in patients undergoing surgery for critical limb ischemia
    Anne Burdess
    Departments of Clinical and Surgical Sciences, The University of Edinburgh, Edinburgh, United Kingdom
    Ann Surg 252:37-42. 2010
    ..We hypothesized that perioperative dual antiplatelet therapy would improve biomarkers of atherothrombosis without causing unacceptable bleeding in patients undergoing surgery for critical limb ischemia...
  73. ncbi request reprint Increased platelet activation in patients with stable and acute exacerbation of COPD
    John D Maclay
    ELEGI Colt Laboratories, Centre for Inflammation Research, Edinburgh University, Edinburgh, UK
    Thorax 66:769-74. 2011
    ..Interaction between inflammatory cells and activated platelets is important in the pathogenesis of atherothrombosis and may contribute to cardiovascular risk in patients with COPD...
  74. ncbi request reprint Bradykinin contributes to the vasodilator effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure
    F N Witherow
    Department of Cardiovascular Research, University of Edinburgh, Royal Infirmary of Edinburgh, Scotland, UK
    Circulation 104:2177-81. 2001
    ....
  75. ncbi request reprint Air pollution and atherothrombosis
    Nicholas L Mills
    Centre for Cardiovascular Science, Edinburgh University, Edinburgh, United Kingdom
    Inhal Toxicol 19:81-9. 2007
    ....
  76. pmc Vascular effects of urocortins 2 and 3 in healthy volunteers
    Sowmya Venkatasubramanian
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    J Am Heart Assoc 2:e004267. 2013
    ..We assessed their pharmacodynamic profile and examined the role of the endothelium in mediating their vasomotor effects in vivo in man...
  77. pmc Reducing personal exposure to particulate air pollution improves cardiovascular health in patients with coronary heart disease
    Jeremy P Langrish
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 120:367-72. 2012
    ..Air pollution exposure increases cardiovascular morbidity and mortality and is a major global public health concern...
  78. ncbi request reprint Perioperative platelet and monocyte activation in patients with critical limb ischemia
    Anne Burdess
    Department of Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, United Kingdom
    J Vasc Surg 52:697-703. 2010
    ..We sought to determine the effect of surgery and vascular disease on platelet and monocyte activation in vivo in patients with CLI...
  79. ncbi request reprint The ROSE (risk stratification of syncope in the emergency department) study
    Matthew J Reed
    Department of Emergency Medicine, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    J Am Coll Cardiol 55:713-21. 2010
    ..The aim of this study was to develop and validate a clinical decision rule (CDR) to predict 1-month serious outcome and all-cause death in patients presenting with syncope to the emergency department...
  80. ncbi request reprint The vascular effects of rotigaptide in vivo in man
    Ninian N Lang
    Centre for Cardiovascular Science, University of Edinburgh, United Kingdom
    Biochem Pharmacol 76:1194-200. 2008
    ..It remains to be established whether augmentation of connexin 43 communication improves endothelial function in patients with vascular disease...
  81. doi request reprint Diesel exhaust inhalation does not affect heart rhythm or heart rate variability
    Nicholas L Mills
    Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK
    Heart 97:544-50. 2011
    ..This study was undertaken to determine the effect of diesel exhaust inhalation on heart rhythm and heart rate variability in healthy volunteers and patients with coronary heart disease...
  82. ncbi request reprint Short-term effects of transdermal nicotine on acute tissue plasminogen activator release in vivo in man
    M P Pellegrini
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Crewe Road, EH4 2XU, Edinburgh, Scotland, UK
    Cardiovasc Res 52:321-7. 2001
    ..The long-term effects of nicotine exposure, including the potential to cause depletion of endothelial t-PA stores, now needs to be assessed...
  83. doi request reprint Late outgrowth endothelial cells resemble mature endothelial cells and are not derived from bone marrow
    Olga Tura
    MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom
    Stem Cells 31:338-48. 2013
    ..Our findings suggest that EOC do not arise from bone marrow and challenge the concept of a bone marrow-derived circulating precursor for endothelial cells...
  84. doi request reprint Endogenous tissue plasminogen activator enhances fibrinolysis and limits thrombus formation in a clinical model of thrombosis
    Andrew J Lucking
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4SU, United Kingdom
    Arterioscler Thromb Vasc Biol 33:1105-11. 2013
    ..Using a clinical model of deep arterial injury, we assessed the ability of exogenous and endogenous tissue plasminogen activator (t-PA) to limit acute in situ thrombus formation...
  85. doi request reprint In vivo mononuclear cell tracking using superparamagnetic particles of iron oxide: feasibility and safety in humans
    Jennifer M J Richards
    Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Circ Cardiovasc Imaging 5:509-17. 2012
    ....
  86. pmc Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease
    David A McAllister
    ELEGI Colt Laboratories, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, EH164SB UK
    Am J Respir Crit Care Med 176:1208-14. 2007
    ....
  87. ncbi request reprint Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans
    Carmel M McEniery
    Clinical Pharmacology Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Hypertension 48:602-8. 2006
    ..001), which remained independent after adjusting for confounding factors. In healthy individuals, a decline in endothelial function is associated with increased large artery stiffness, wave reflections, and central pulse pressure...
  88. ncbi request reprint Vascular effects of apelin in vivo in man
    Alan G Japp
    Centre for Cardiovascular Science, University of Edinburgh, Chancellor s Building, Edinburgh, United Kingdom
    J Am Coll Cardiol 52:908-13. 2008
    ..This study was designed to establish the direct vascular effects of apelin in vivo in man...
  89. ncbi request reprint Bradykinin does not contribute to peripheral vascular tone in patients with cirrhosis and ascites
    Ahmed Helmy
    Department of Hepatology, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK
    J Cardiovasc Pharmacol 47:556-60. 2006
    ..Our findings also suggest that, in contrast to cardiovascular disease, patients with liver cirrhosis do not have marked endothelial dysfunction...
  90. ncbi request reprint Intra-arterial vasopressin in the human forearm: pharmacodynamics and the role of nitric oxide
    Jonathan T Affolter
    Department of Medical Sciences, University of Edinburgh, Western General Hospital, United Kingdom
    Clin Pharmacol Ther 74:9-16. 2003
    ..The objective of this study was to establish the pharmacodynamics, reproducibility, and nitric oxide dependence of the vasomotor actions of vasopressin in the forearm resistance vessels...
  91. pmc Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals
    Mark R Miller
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 117:611-6. 2009
    ..Diesel exhaust particulate (DEP) is a key arbiter of the adverse cardiovascular effects of air pollution...
  92. doi request reprint Influence of the menstrual cycle, pregnancy, and preeclampsia on arterial stiffness
    Amy O Robb
    Centres for Reproductive Biology, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Hypertension 53:952-8. 2009
    ..These effects may contribute to adverse cardiovascular outcomes of pregnancy and preeclampsia...
  93. ncbi request reprint Influence of differential vascular remodeling on the coronary vasomotor response
    Andrew L McLeod
    Department of Cardiology, Royal Infirmary, 51 Little France Crescent, Little France, Edinburgh EH16 4SA, UK
    Cardiovasc Res 59:520-6. 2003
    ..The study aims were to assess whether the pattern of vascular remodeling influences the physical and vasomotor responses of the coronary arteries in vivo in man...
  94. doi request reprint Diesel exhaust particulate--exposed macrophages cause marked endothelial cell activation
    Catherine A Shaw
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, UK
    Am J Respir Cell Mol Biol 44:840-51. 2011
    ..We conclude that DEP has only modest direct endothelial effects. In contrast, proinflammatory cytokines released from particle-laden MDMs appear to exacerbate endothelial activation after DEP exposure...
  95. ncbi request reprint Non-invasive measures of pulse wave velocity correlate with coronary arterial plaque load in humans
    Andrew L McLeod
    Department of Cardiology, Western General Hospital, Edinburgh, UK
    J Hypertens 22:363-8. 2004
    ..Arterial stiffness is an emerging major risk factor for cardiovascular morbidity and mortality. The aim of the present study was to assess if coronary artery plaque load correlates with non-invasive measures of arterial stiffness...
  96. ncbi request reprint Auto-titrating continuous positive airway pressure therapy in patients with chronic heart failure and obstructive sleep apnoea: a randomized placebo-controlled trial
    Lindsay A Smith
    Cardiovascular Research, Centre for Cardiovascular Science, University of Edinburgh, Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Eur Heart J 28:1221-7. 2007
    ..We aimed to determine whether treatment of OSA with continuous positive airway pressure (CPAP) would improve subjective and objective measures of heart failure severity in patients with CHF and OSA...
  97. pmc Endothelin-1 contributes to maintenance of systemic but not portal haemodynamics in patients with early cirrhosis: a randomised controlled trial
    D Tripathi
    Department of Hepatology, Royal Infirmary, 51 Little France Crescent, Edinburgh EH16 4SU, UK
    Gut 55:1290-5. 2006
    ..The aim of this study was to assess the systemic and portal haemodynamic effects of selective ET-A and ET-B receptor antagonism in patients with cirrhosis...
  98. ncbi request reprint Marked bradykinin-induced tissue plasminogen activator release in patients with heart failure maintained on long-term angiotensin-converting enzyme inhibitor therapy
    Fraser N Witherow
    Cardiovascular Research, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, Scotland, United Kingdom
    J Am Coll Cardiol 40:961-6. 2002
    ....
  99. pmc No effect on central or peripheral blood pressure of systemic urotensin II infusion in humans
    Jonathan T Affolter
    Clinical Research Centre, Department of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Br J Clin Pharmacol 54:617-21. 2002
    ..The aim of the present study was to assess systemic haemodynamic responses to intravenous urotensin II infusion in humans...
  100. doi request reprint Low serum cortisol predicts early death after acute myocardial infarction
    Rebecca M Reynolds
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Crit Care Med 38:973-5. 2010
    ..Low serum cortisol concentrations have been associated with adverse prognosis in critical illness of diverse etiology...
  101. ncbi request reprint A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury
    Mark R Miller
    Centre for Cardiovascular Science, University of Edinburgh, UK
    Cardiovasc Res 57:853-60. 2003
    ..Here we assess the inhibitory effect of SNVP on platelet adhesion to angioplastied rabbit carotid arteries...