B G Neville

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Childhood convulsive status epilepticus: epidemiology, management and outcome
    B G R Neville
    Neurosciences Unit, University College, Institute of Child Health, and Great Ormond Street Hospital for Children, NHS Trust, London, UK
    Acta Neurol Scand Suppl 186:21-4. 2007
  2. doi request reprint Role of ESSENCE for preschool children with neurodevelopmental disorders
    Brian Neville
    UCL Institute of Child Health, Neurosciences Unit, London, United Kingdom
    Brain Dev 35:128-32. 2013
  3. pmc Decorticate, decerebrate and opisthotonic posturing and seizures in Kenyan children with cerebral malaria
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research, Kenya
    Malar J 4:57. 2005
  4. pmc Impaired everyday memory associated with encephalopathy of severe malaria: the role of seizures and hippocampal damage
    Michael Kihara
    The Centre for Geographical Medicine Research, Kenya Medical Research Institute, Kilifi, Kenya
    Malar J 8:273. 2009
  5. pmc Haptoglobin HP2-2 genotype, alpha-thalassaemia and acute seizures in children living in a malaria-endemic area
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Epilepsy Res 81:114-8. 2008
  6. pmc The incidence, aetiology and outcome of acute seizures in children admitted to a rural Kenyan district hospital
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    BMC Pediatr 8:5. 2008
  7. doi request reprint Febrile seizures - semiology in humans and animal models: evidence of focality and heterogeneity
    Brian G R Neville
    UCL Institute of Child Health, Neurosciences Unit, Mecklenburgh Square, London WC1N 1EH, UK
    Brain Dev 32:33-6. 2010
  8. ncbi request reprint Childhood convulsive status epilepticus: epidemiology, management and outcome
    B G R Neville
    Neurosciences Unit, University College, Institute of Child Health, and Great Ormond Street Hospital for Children, NHS Trust, London, UK
    Acta Neurol Scand 115:21-4. 2007
  9. ncbi request reprint Sepiapterin reductase deficiency: a congenital dopa-responsive motor and cognitive disorder
    B G R Neville
    Neurosciences Unit, Institute of Child Health UCL, London, UK
    Brain 128:2291-6. 2005
  10. ncbi request reprint The treatment and management of alternating hemiplegia of childhood
    B G R Neville
    Neurosciences Unit, Institute of Child Health, University College London, London, UK
    Dev Med Child Neurol 49:777-80. 2007

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Childhood convulsive status epilepticus: epidemiology, management and outcome
    B G R Neville
    Neurosciences Unit, University College, Institute of Child Health, and Great Ormond Street Hospital for Children, NHS Trust, London, UK
    Acta Neurol Scand Suppl 186:21-4. 2007
    ..More than two doses of benzodiazepines increase the rate of respiratory depression without obvious benefit. The 1 year recurrence rate is 17% and the hospital mortality is about 3%...
  2. doi request reprint Role of ESSENCE for preschool children with neurodevelopmental disorders
    Brian Neville
    UCL Institute of Child Health, Neurosciences Unit, London, United Kingdom
    Brain Dev 35:128-32. 2013
    ..It includes a discussion of causal sequences which have yet to be applied comprehensively to the neurodevelopment disorders...
  3. pmc Decorticate, decerebrate and opisthotonic posturing and seizures in Kenyan children with cerebral malaria
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research, Kenya
    Malar J 4:57. 2005
    ..Abnormal motor posturing is often observed in children with cerebral malaria, but the aetiology and pathogenesis is poorly understood. This study examined the risk factors and outcome of posturing in Kenyan children with cerebral malaria...
  4. pmc Impaired everyday memory associated with encephalopathy of severe malaria: the role of seizures and hippocampal damage
    Michael Kihara
    The Centre for Geographical Medicine Research, Kenya Medical Research Institute, Kilifi, Kenya
    Malar J 8:273. 2009
    ..Prolonged febrile seizures are associated with hippocampal damage and impaired memory. It was hypothesized that severe malaria causes impaired everyday memory which may be associated with hippocampal damage...
  5. pmc Haptoglobin HP2-2 genotype, alpha-thalassaemia and acute seizures in children living in a malaria-endemic area
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Epilepsy Res 81:114-8. 2008
    ..We conclude that the HP2-2 polymorphism and deletions in alpha-globin gene are not risk factors for acute seizures in children. Future studies should examine other susceptibility genes...
  6. pmc The incidence, aetiology and outcome of acute seizures in children admitted to a rural Kenyan district hospital
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    BMC Pediatr 8:5. 2008
    ..We determined the incidence, aetiological factors and the immediate outcome of seizures in a rural malaria endemic area in coastal Kenya...
  7. doi request reprint Febrile seizures - semiology in humans and animal models: evidence of focality and heterogeneity
    Brian G R Neville
    UCL Institute of Child Health, Neurosciences Unit, Mecklenburgh Square, London WC1N 1EH, UK
    Brain Dev 32:33-6. 2010
    ..Seizure semiology also suggests that a proportion of such seizures may be non-epileptic reflex asystolic attacks. Seizure semiology in febrile seizures deserves closer scrutiny...
  8. ncbi request reprint Childhood convulsive status epilepticus: epidemiology, management and outcome
    B G R Neville
    Neurosciences Unit, University College, Institute of Child Health, and Great Ormond Street Hospital for Children, NHS Trust, London, UK
    Acta Neurol Scand 115:21-4. 2007
    ..More than two doses of benzodiazepines increase the rate of respiratory depression without obvious benefit. The 1 year recurrence rate is 17% and the hospital mortality is about 3%...
  9. ncbi request reprint Sepiapterin reductase deficiency: a congenital dopa-responsive motor and cognitive disorder
    B G R Neville
    Neurosciences Unit, Institute of Child Health UCL, London, UK
    Brain 128:2291-6. 2005
    ..Clinically and molecularly the condition shows autosomal recessive inheritance...
  10. ncbi request reprint The treatment and management of alternating hemiplegia of childhood
    B G R Neville
    Neurosciences Unit, Institute of Child Health, University College London, London, UK
    Dev Med Child Neurol 49:777-80. 2007
    ..The diagnostic and management predicament of child, parent, and paediatrician in complex rare disorders are well illustrated by this condition...
  11. doi request reprint Febrile seizures are a syndrome of secondarily generalized hippocampal epilepsy
    Brian Neville
    Neurosciences Unit and Great Ormond Street Hospital for Children NHS Trust, London, UK
    Dev Med Child Neurol 52:1151-3. 2010
    ..Retrospective data relates mesial temporal sclerosis to such early prolonged febrile seizures. Animal models of prolonged seizures causing hippocampal damage show limbic seizures at low dose of the precipitants...
  12. ncbi request reprint Clinical trial design in status epilepticus: problems and solutions
    Brian G R Neville
    Neurosciences Unit, UCL Institute of Child Health, London, UK
    Epilepsia 48:56-8. 2007
  13. ncbi request reprint Worster-Drought syndrome, a mild tetraplegic perisylvian cerebral palsy. Review of 47 cases
    M Clark
    Institute of Child Health UCL and Great Ormond Street Hospital for Children NHS Trust, London, UK
    Brain 123:2160-70. 2000
    ..WDS is startlingly absent from epidemiological studies of the cerebral palsies and rarely diagnosed, presumably because of lack of clinical awareness of the condition and lack of major gross motor impairments...
  14. ncbi request reprint Quantitative magnetic resonance characterization of mesial temporal sclerosis in childhood
    R C Scott
    Neurosciences Unit, Institute of Child Health, University College London, UK
    Neurology 56:1659-65. 2001
    ..To investigate whether quantitative MR techniques can be used to distinguish between mesial temporal sclerosis in patients with a history of prolonged febrile convulsion and in patients without such a history...
  15. ncbi request reprint Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial
    R C Scott
    Wolfson Centre, Institute of Child Health, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Lancet 353:623-6. 1999
    ..We aimed to find out whether there are differences in efficacy and adverse events between buccal administration of liquid midazolam and rectal administration of liquid diazepam in the acute treatment of seizures...
  16. ncbi request reprint Visual-evoked potential evidence of chiasmal hypoplasia
    D A Thompson
    Ophthalmology Department, Great Ormond Street Hospital NHS Trust, London, England
    Ophthalmology 106:2354-61. 1999
    ....
  17. pmc Persistent neurocognitive impairments associated with severe falciparum malaria in Kenyan children
    J A Carter
    Centre for International Child Health, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    J Neurol Neurosurg Psychiatry 76:476-81. 2005
    ..The aim of this study was to provide a detailed characterisation of impairments in this subgroup...
  18. ncbi request reprint A systematic review of the epidemiology of status epilepticus
    R F M Chin
    Institute of Child Health, University College London, London, UK and Great Ormond Street Hospital for Children NHS Trust, London WCIN IEH, UK
    Eur J Neurol 11:800-10. 2004
    ..Most studies are primarily or exclusively based on adult populations. There is limited information on the association of ethnicity and socio-economic status and SE...
  19. pmc Meningitis is a common cause of convulsive status epilepticus with fever
    R F M Chin
    Neurosciences Unit, Institute of Child Health, University College London, and Great Ormond Street Hospital for Children NHS Trust, London, UK
    Arch Dis Child 90:66-9. 2005
    ..In children with convulsive status epilepticus (CSE) with fever, to determine the likelihood of acute bacterial meningitis (ABM), the proportion that are treated with antibiotics, and the proportion that have diagnostic CSF sampling...
  20. pmc Inappropriate emergency management of status epilepticus in children contributes to need for intensive care
    R F M Chin
    Neurosciences Unit, Institute of Child Health, University College London, WC1N 1EH, UK
    J Neurol Neurosurg Psychiatry 75:1584-8. 2004
    ..This may provide insight into reasons for admission to PIC and provide a framework for the development of strategies that decrease the requirement for intensive care...
  21. pmc Dyskinesias and associated psychiatric disorders following streptococcal infections
    R C Dale
    Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK
    Arch Dis Child 89:604-10. 2004
    ..Recently, other post-streptococcal movement disorders have been described, including motor tics and dystonia. Associated emotional and behavioural alteration is characteristic...
  22. ncbi request reprint Magnetic resonance imaging findings within 5 days of status epilepticus in childhood
    Rod C Scott
    Great Ormond Street Hospital for Children NHS Trust, Institute of Child Health, University College London, London, UK
    Brain 125:1951-9. 2002
    ..A systematic longitudinal study is required to characterize the evolution of these abnormalities and to determine whether any patient develops MTS...
  23. ncbi request reprint Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children
    R C Dale
    Departments of Neurology, Radiology and Histopathology, Great Ormond Street Hospital for Children and Institute of Child Health, University College London, London, UK
    Brain 123:2407-22. 2000
    ..These differences in the presentation of ADEM/MDEM compared with multiple sclerosis may help in the prognosis given to families regarding the possibility of later development of multiple sclerosis...
  24. ncbi request reprint Clinical outcomes of hemispherectomy for epilepsy in childhood and adolescence
    A M Devlin
    Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK
    Brain 126:556-66. 2003
    ..No significant cognitive deterioration or loss of language occurred, and four children showed significant cognitive improvement. Behavioural improvement was reported in 92% of those who had behaviour problems pre-operatively...
  25. ncbi request reprint Randomised controlled trial to assess acceptability of phenobarbital for childhood epilepsy in rural India
    D K Pal
    Neurosciences Unit, University College London, UK
    Lancet 351:19-23. 1998
    ..We undertook a randomised comparison of phenobarbital and phenytoin to assess the acceptability and efficacy of phenobarbital as monotherapy for childhood epilepsy in rural India...
  26. ncbi request reprint Impact of interictal epileptic activity on normal brain function in epileptic encephalopathy: an electroencephalography-functional magnetic resonance imaging study
    X De Tiege
    Neuroscience Unit, UCL Institute of Child Health, London, UK
    Epilepsy Behav 11:460-5. 2007
    ..The relative activations could possibly indicate the source of epileptic activity rapidly spreading to other brain regions...
  27. ncbi request reprint Psychopathology in children with epilepsy before and after temporal lobe resection
    A McLellan
    Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK
    Dev Med Child Neurol 47:666-72. 2005
    ..Parents require counselling on these issues in the preoperative work-up...
  28. ncbi request reprint Transient exacerbation of hemiplegia following minor head trauma in Sturge-Weber syndrome
    Z Zolkipli
    Department of Paediatric Neurology, Great Ormond Street Hospital Cognitive Neurosciences Unit, UCL Institute of Child Health, London, UK
    Dev Med Child Neurol 49:697-9. 2007
    ..An additional pilot survey suggests that this may affect up to 20% of patients...
  29. ncbi request reprint Convulsive status epilepticus in children with intractable epilepsy is frequently focal in origin
    Mohammed Jan
    Department of Pediatrics, King Abdulaziz University Hospital and College of Medicine and Allied Health Sciences, Jeddah, Saudi Arabia
    Can J Neurol Sci 29:65-7. 2002
    ..Convulsive status epilepticus (CSE) is a common neurological emergency. Our objectives were to study children with recurrent nonfebrile CSE to assess the evidence for focal origin...
  30. pmc Treatment of community-onset, childhood convulsive status epilepticus: a prospective, population-based study
    Richard F M Chin
    Neurosciences Unit, Institute of Child Health, University College London and Great Ormond Street Hospital for Children NHS Trust, London, UK
    Lancet Neurol 7:696-703. 2008
    ..We report the findings from a systematic, population-based study on the treatment of community-onset childhood CSE...
  31. ncbi request reprint Prolonged febrile seizures are associated with hippocampal vasogenic edema and developmental changes
    Rod C Scott
    Neurosciences Unit, Institute of Child Health, University College London, London, UK
    Epilepsia 47:1493-8. 2006
    ....
  32. ncbi request reprint Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study
    Richard F M Chin
    Neurosciences Unit, Institute of Child Health, University College London, and Great Ormond Street Hospital for Children NHS Trust, London, UK
    Lancet 368:222-9. 2006
    ..Thus we undertook the North London Status Epilepticus in Childhood Surveillance Study (NLSTEPSS): a prospective, population-based study of convulsive status epilepticus in childhood, to obtain a uniquely paediatric perspective...
  33. ncbi request reprint Autistic regression associated with seizure onset in an infant with tuberous sclerosis
    Ayla Humphrey
    Developmental Psychiatry Section, University of Cambridge, UK
    Dev Med Child Neurol 48:609-11. 2006
    ..The case suggests the need to consider if possible visual field defects with vigabatrin outweigh the potentially deleterious effects of uncontrolled seizures...
  34. ncbi request reprint Abnormalities in hippocampi remote from the seizure focus: a T2 relaxometry study
    Rod C Scott
    Neurosciences Unit, Institute of Child Health, University College London, and Great Ormond Street Hospital for Children NHS Trust, UK
    Brain 126:1968-74. 2003
    ....
  35. ncbi request reprint Hippocampal abnormalities after prolonged febrile convulsion: a longitudinal MRI study
    Rod C Scott
    Neurosciences Unit, Institute of Child Health, University College London, UK
    Brain 126:2551-7. 2003
    ..Alternatively, the asymmetry could represent return (post-acute oedema) to a pre-existing hippocampal abnormality similar to that identified in family members of patients with MTS and a history of PFC...
  36. ncbi request reprint Neuro-cognitive impairment following acquired central nervous system infections in childhood: a systematic review
    Julie A Carter
    Neurosciences Unit, Institute of Child Health, The Wolfson Centre, Mecklenburgh Square, WC1N 2AP, London, UK
    Brain Res Brain Res Rev 43:57-69. 2003
    ..Higher morbidity for similar mortality in acute bacterial meningitis compared with cerebral malaria in the epidemiological data may suggest future research directions for clinical research to devise more effective interventions...
  37. ncbi request reprint Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity
    Russell C Dale
    Neurosciences Unit, Great Ormond Street Hospital and Institute of Child Health, and Department of Neuroinflammation, Institute of Neurology, University College London, UK
    Brain 127:21-33. 2004
    ..We believe an EL-like syndrome is still prevalent, and propose that this syndrome may be secondary to autoimmunity against deep grey matter neurons...
  38. ncbi request reprint Predictors of long-term outcome in very preterm infants: gestational age versus neonatal cranial ultrasound
    Brigitte Vollmer
    Department of Pediatrics, University College London Medical School, Bloomsbury Campus, London, United Kingdom
    Pediatrics 112:1108-14. 2003
    ....
  39. ncbi request reprint Increased prevalence of epilepsy associated with severe falciparum malaria in children
    Julie A Carter
    Neurosciences Unit, Institute of Child Health, The Wolfson Centre, London, United Kingdom
    Epilepsia 45:978-81. 2004
    ..The relation between falciparum malaria and epilepsy is undetermined; thus we measured the prevalence and characteristics of epilepsy in children with a history of severe malaria...
  40. ncbi request reprint Post-streptococcal autoimmune neuropsychiatric disease presenting as paroxysmal dystonic choreoathetosis
    Russell C Dale
    Department of Neurology, Great Ormond Street Hospital NHS Trust and Institute of Child Health, London, United Kingdom
    Mov Disord 17:817-20. 2002
    ..We propose that autoantibodies produced in post-streptococcal neuropsychiatric disease cause alteration in neurotransmission, possibly secondary to ion channel binding...
  41. ncbi request reprint Developmental impairments following severe falciparum malaria in children
    Julie A Carter
    Neurosciences Unit, Institute of Child Health, London, UK
    Trop Med Int Health 10:3-10. 2005
    ..Thus, our objective was to investigate the long-term developmental outcome of CM and malaria with complicated seizures (M/S)...
  42. ncbi request reprint Issues in the development of cross-cultural assessments of speech and language for children
    Julie A Carter
    Neurosciences Unit, Institute of Child Health, The Wolfson Centre, London, UK
    Int J Lang Commun Disord 40:385-401. 2005
    ..However, there are few guidelines on how to develop 'culturally appropriate' assessment tools...
  43. ncbi request reprint Severe falciparum malaria and acquired childhood language disorder
    Julie A Carter
    Neurosciences Unit, Institute of Child Health, The Wolfson Centre, London, UK
    Dev Med Child Neurol 48:51-7. 2006
    ..04) was associated with significantly increased odds of an impairment-level score relative to the unexposed group. The results suggest that falciparum malaria is one of the most common causes of acquired language disorders in the tropics...
  44. ncbi request reprint Neurodevelopmental outcome of preterm infants with ventricular dilatation with and without associated haemorrhage
    Brigitte Vollmer
    Department of Paediatrics and Child Health, Institute of Child Health, UK
    Dev Med Child Neurol 48:348-52. 2006
    ..Although this study did not investigate biochemical markers of haemorrhage, we hypothesize that non-protein-bound iron is likely to be a contributing factor to white matter damage in preterm infants...
  45. ncbi request reprint Long-term neurodevelopmental outcome of preterm children with unilateral cerebral lesions diagnosed by neonatal ultrasound
    Brigitte Vollmer
    Department of Paediatrics, University College London Medical School, Rayne Institute, University Street, London WC1E 6JJ, UK
    Early Hum Dev 82:655-61. 2006
    ..This study aims to investigate the long-term outcome in a cohort of very preterm infants with unilateral cerebral lesions acquired in the perinatal period...
  46. ncbi request reprint Lower motor neuron involvement in perisylvian polymicrogyria
    Maria Clark
    Neurosciences Unit, University College London Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK
    Dev Med Child Neurol 48:842-6. 2006
    ..Possible pathogenic mechanisms are discussed but this association of upper and lower motor neuron involvement is likely to be a previously unsuspected part of a genetic or other pathogenic sequence...
  47. ncbi request reprint Molecular genetics of tetrahydrobiopterin (BH4) deficiency in the Maltese population
    Rosienne Farrugia
    Laboratory of Molecular Genetics, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta
    Mol Genet Metab 90:277-83. 2007
    ..In contrast no additional sequence diversity was found in the SPR gene whether in wild-type or mutant alleles which is also consistent with a founder effect...
  48. ncbi request reprint Attentional ability in children with epilepsy
    Rocio Sanchez-Carpintero
    Neurosciences Unit, Institute of Child Health, UCL Medical School of London, Department of Paediatric Neurology, Great Ormond Street Hospital for Children, NHS Trust, The Wolfson Centre, Mecklenburgh Square, London, England
    Epilepsia 44:1340-9. 2003
    ..Attention in children with drug-resistant epilepsy has not been addressed, and prospective studies before and after epilepsy surgery could be a useful model to study the influence of seizures on attentional ability...
  49. ncbi request reprint Taylor-type focal cortical dysplasia in infants: some MRI lesions almost disappear with maturation of myelination
    Christin M Eltze
    Institute of Child Health, University College London, United Kingdom
    Epilepsia 46:1988-92. 2005
    ..The appearances of FCD on later scans can be very subtle escaping recognition, and conclusions may be misleading with respect to diagnosis and appropriateness of surgical treatment...
  50. doi request reprint Is streamlined evaluation of children for epilepsy surgery possible?
    Shekhar G Patil
    The National Centre for Young People with Epilepsy, Lingfield, United Kingdom
    Epilepsia 49:1340-7. 2008
    ..However, the contributions of each investigation to surgical decision making has not been systematically assessed...
  51. ncbi request reprint Familial and genetic associations in Worster-Drought syndrome and perisylvian disorders
    Maria Clark
    Neurosciences Unit, University College London, Institute of Child Health, London, UK
    Am J Med Genet A 146:35-42. 2008
    ..There are grounds for considering WDS and perisylvian polymicrogyria as a spectrum of perisylvian malfunction...