Stefan Neubauer

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Cardiac magnetic resonance spectroscopy
    Stefan Neubauer
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford OX3 9DU, UK
    Curr Cardiol Rep 5:75-82. 2003
  2. pmc Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease
    Rajarshi Banerjee
    Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, West Wing, Level 6, John Radcliffe Hospital, Oxford, UK
    J Hepatol 60:69-77. 2014
  3. pmc Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches
    Steffen E Petersen
    Centre Lead for Advanced Cardiovascular Imaging, William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts, The London Chest Hospital, Bonner Road, London E2 9JX, UK
    J Cardiovasc Magn Reson 15:46. 2013
  4. pmc Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of gender
    Daniel Augustine
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Cardiovasc Magn Reson 15:8. 2013
  5. pmc Comparison of T1 mapping techniques for ECV quantification. Histological validation and reproducibility of ShMOLLI versus multibreath-hold T1 quantification equilibrium contrast CMR
    Marianna Fontana
    The Heart Hospital, 16 18 Westmoreland Street, London, W1G 8PH, United Kingdom
    J Cardiovasc Magn Reson 14:88. 2012
  6. pmc Non-contrast T1-mapping detects acute myocardial edema with high diagnostic accuracy: a comparison to T2-weighted cardiovascular magnetic resonance
    Vanessa M Ferreira
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Cardiovasc Magn Reson 14:42. 2012
  7. pmc Cardiovascular magnetic resonance by non contrast T1-mapping allows assessment of severity of injury in acute myocardial infarction
    Erica Dall'Armellina
    Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Cardiovasc Magn Reson 14:15. 2012
  8. pmc Cardiovascular magnetic resonance activity in the United Kingdom: a survey on behalf of the British Society of Cardiovascular Magnetic Resonance
    Renjith Antony
    Scottish National Advanced Heart Failure Service, Golden Jubilee Hospital, Agamemnon Street, Glasgow, G81 4DY, UK
    J Cardiovasc Magn Reson 13:57. 2011
  9. pmc Accelerating global left-ventricular function assessment in mice using reduced slice acquisition and three-dimensional guide-point modelling
    Alistair A Young
    Department of Anatomy with Radiology, University of Auckland, Auckland, New Zealand
    J Cardiovasc Magn Reson 13:49. 2011
  10. pmc Uncomplicated obesity is associated with abnormal aortic function assessed by cardiovascular magnetic resonance
    Monique R Robinson
    Oxford Centre for Clinical Magnetic Resonance Research OCMR, Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    J Cardiovasc Magn Reson 10:10. 2008

Collaborators

Detail Information

Publications140 found, 100 shown here

  1. ncbi request reprint Cardiac magnetic resonance spectroscopy
    Stefan Neubauer
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford OX3 9DU, UK
    Curr Cardiol Rep 5:75-82. 2003
    ..New patient studies demonstrate the potential value of MRS as a clinical diagnostic tool in patients with ischemic heart disease, heart failure, cardiac transplantation, valve disease, and genetic cardiomyopathy...
  2. pmc Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease
    Rajarshi Banerjee
    Oxford Centre for Clinical Magnetic Resonance Research, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, West Wing, Level 6, John Radcliffe Hospital, Oxford, UK
    J Hepatol 60:69-77. 2014
    ..In this study, we aimed to assess the diagnostic accuracy of a novel magnetic resonance protocol for liver tissue characterisation...
  3. pmc Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches
    Steffen E Petersen
    Centre Lead for Advanced Cardiovascular Imaging, William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts, The London Chest Hospital, Bonner Road, London E2 9JX, UK
    J Cardiovasc Magn Reson 15:46. 2013
    ....
  4. pmc Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of gender
    Daniel Augustine
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Cardiovasc Magn Reson 15:8. 2013
    ..We used it to record deformation parameters in healthy adults and compared values to those obtained by tagging...
  5. pmc Comparison of T1 mapping techniques for ECV quantification. Histological validation and reproducibility of ShMOLLI versus multibreath-hold T1 quantification equilibrium contrast CMR
    Marianna Fontana
    The Heart Hospital, 16 18 Westmoreland Street, London, W1G 8PH, United Kingdom
    J Cardiovasc Magn Reson 14:88. 2012
    ..Newer, faster sequences for T1 mapping promise whole heart coverage and improved clinical utility, but have not been validated...
  6. pmc Non-contrast T1-mapping detects acute myocardial edema with high diagnostic accuracy: a comparison to T2-weighted cardiovascular magnetic resonance
    Vanessa M Ferreira
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Cardiovasc Magn Reson 14:42. 2012
    ..Quantitative T1-mapping is also sensitive to changes in free water content. We hypothesized that T1-mapping would have a higher diagnostic performance in detecting acute edema than dark-blood and bright-blood T2w-CMR...
  7. pmc Cardiovascular magnetic resonance by non contrast T1-mapping allows assessment of severity of injury in acute myocardial infarction
    Erica Dall'Armellina
    Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Cardiovasc Magn Reson 14:15. 2012
    ....
  8. pmc Cardiovascular magnetic resonance activity in the United Kingdom: a survey on behalf of the British Society of Cardiovascular Magnetic Resonance
    Renjith Antony
    Scottish National Advanced Heart Failure Service, Golden Jubilee Hospital, Agamemnon Street, Glasgow, G81 4DY, UK
    J Cardiovasc Magn Reson 13:57. 2011
    ..The indications, complexity and capabilities of cardiovascular magnetic resonance (CMR) have rapidly expanded. Whether actual service provision and training have developed in parallel is unknown...
  9. pmc Accelerating global left-ventricular function assessment in mice using reduced slice acquisition and three-dimensional guide-point modelling
    Alistair A Young
    Department of Anatomy with Radiology, University of Auckland, Auckland, New Zealand
    J Cardiovasc Magn Reson 13:49. 2011
    ....
  10. pmc Uncomplicated obesity is associated with abnormal aortic function assessed by cardiovascular magnetic resonance
    Monique R Robinson
    Oxford Centre for Clinical Magnetic Resonance Research OCMR, Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    J Cardiovasc Magn Reson 10:10. 2008
    ..We hypothesised that obesity, uncomplicated by other cardiovascular risk factors, is independently associated with aortic function...
  11. pmc Review of Journal of Cardiovascular Magnetic Resonance 2009
    D J Pennell
    CMR Unit Royal Brompton Hospital, Sydney Street, London SW3 6NP UK, National Heart and Lung Institute, Imperial College, Exhibition Road, London, SW7 2AZ UK
    J Cardiovasc Magn Reson 12:15. 2010
    ..I hope that you find the open-access system increases wider reading and citation of your papers, and that you will continue to send your quality manuscripts to JCMR for publication...
  12. pmc Society for Cardiovascular Magnetic Resonance guidelines for reporting cardiovascular magnetic resonance examinations
    W Gregory Hundley
    Department of Internal Medicine, Section on Cardiology and Radiology, Wake Forest University School of Medicine, Winston Salem, USA
    J Cardiovasc Magn Reson 11:5. 2009
    ....
  13. ncbi request reprint Effects of off-pump versus on-pump coronary surgery on reversible and irreversible myocardial injury: a randomized trial using cardiovascular magnetic resonance imaging and biochemical markers
    Joseph B Selvanayagam
    Department of Cardiovascular Medicine, Level 5, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Circulation 109:345-50. 2004
    ..We hypothesized that OPCABG surgery would result in reduced postoperative reversible (stunning) and irreversible myocardial injury, as assessed by cardiovascular MRI (CMRI)...
  14. ncbi request reprint Cardiac physiology investigated by new methods of imaging
    Stefan Neubauer
    University of Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital ORH Trust
    Clin Med 7:189-91. 2007
  15. ncbi request reprint The failing heart--an engine out of fuel
    Stefan Neubauer
    Department of Cardiovascular Medicine, University of Oxford and John Radcliffe Hospital, Oxford, United Kingdom
    N Engl J Med 356:1140-51. 2007
  16. pmc Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction
    Craig A Lygate
    Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Cardiovasc Res 96:466-75. 2012
    ....
  17. doi request reprint Reproducibility and accuracy of automated measurement for dynamic arterial lumen area by cardiovascular magnetic resonance
    Clare E Jackson
    Department of Cardiovascular Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, OX3 9DU, UK
    Int J Cardiovasc Imaging 25:797-808. 2009
    ..We have proved over a large number of subjects the superiority of this automated method for evaluating dynamic area changes over the Gold-standard manual approach...
  18. ncbi request reprint Evidence for microvascular dysfunction in hypertrophic cardiomyopathy: new insights from multiparametric magnetic resonance imaging
    Steffen E Petersen
    University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Circulation 115:2418-25. 2007
    ....
  19. doi request reprint Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: an MRI and MRS study
    Wen Zhang
    Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford, UK
    J Mol Cell Cardiol 45:754-60. 2008
    ..We conclude that the absence of dystrophin in adult mdx mouse heart, as in the heart of human patient, is associated with right ventricular dilatation, left ventricular diastolic dysfunction and abnormal energy metabolism...
  20. doi request reprint Relationship between regional myocardial oxygenation and perfusion in patients with coronary artery disease: insights from cardiovascular magnetic resonance and positron emission tomography
    Theodoros D Karamitsos
    Department of Cardiovascular Medicine, Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom
    Circ Cardiovasc Imaging 3:32-40. 2010
    ..Thus, we sought to apply BOLD CMR at 3 T and oxygen-15-labeled water PET in patients with CAD and normal volunteers to better understand the relationship between regional myocardial oxygenation and blood flow during vasodilator stress...
  21. ncbi request reprint How to perform an accurate assessment of cardiac function in mice using high-resolution magnetic resonance imaging
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, UK
    J Cardiovasc Magn Reson 8:693-701. 2006
    ..Here, we describe a protocol that allows for a quick and reproducible approach of obtaining the relevant cardiac views for cine-MRI, and we explain how an accurate experimental image analysis can be performed...
  22. ncbi request reprint Myocardial oxygenation in coronary artery disease: insights from blood oxygen level-dependent magnetic resonance imaging at 3 tesla
    Jayanth R Arnold
    University of Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, United Kingdom
    J Am Coll Cardiol 59:1954-64. 2012
    ..The purpose of this study was to assess the diagnostic accuracy of blood oxygen-level dependent (BOLD) MRI in suspected coronary artery disease (CAD)...
  23. ncbi request reprint Systemic levels of endothelin correlate with systemic inflammation and not with myocardial injury or left ventricular ejection fraction in patients undergoing percutaneous coronary intervention and on-pump coronary artery bypass grafting
    Florim Cuculi
    Oxford Heart Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Interact Cardiovasc Thorac Surg 13:585-9. 2011
    ..44, P = 0.0002). ET-1 rise is more pronounced in on-pump CABG and ET-1 production could be driven by periprocedural inflammatory reaction...
  24. pmc Multimodal cardiovascular magnetic resonance quantifies regional variation in vascular structure and function in patients with coronary artery disease: relationships with coronary disease severity
    Ilias Kylintireas
    Department of Cardiovascular Medicine, University of Oxford and Oxford Centre for Clinical Magnetic Resonance Research, Oxford, UK
    J Cardiovasc Magn Reson 13:61. 2011
    ..Previous studies have focused on patients with pre-identified carotid atheroma. We define these vascular parameters in patients presenting with coronary artery disease and test their relations to its extent and severity...
  25. ncbi request reprint Myocardial steatosis and left ventricular contractile dysfunction in patients with severe aortic stenosis
    Masliza Mahmod
    Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom
    Circ Cardiovasc Imaging 6:808-16. 2013
    ..Aortic stenosis (AS) leads to left ventricular (LV) hypertrophy and dysfunction. We hypothesized that cardiac steatosis is involved in the pathophysiology and also assessed whether it is reversible after aortic valve replacement...
  26. ncbi request reprint Cardiovascular magnetic resonance perfusion imaging at 3-tesla for the detection of coronary artery disease: a comparison with 1.5-tesla
    Adrian S H Cheng
    University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom
    J Am Coll Cardiol 49:2440-9. 2007
    ..This study was designed to establish the diagnostic accuracy of cardiovascular magnetic resonance (CMR) perfusion imaging at 3-Tesla (T) in suspected coronary artery disease (CAD)...
  27. pmc Feasibility and safety of high-dose adenosine perfusion cardiovascular magnetic resonance
    Theodoros D Karamitsos
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, UK
    J Cardiovasc Magn Reson 12:66. 2010
    ..The aim of the present study was to assess the tolerance and safety of a high-dose adenosine protocol in patients with inadequate haemodynamic response to the standard adenosine protocol when undergoing CMR perfusion imaging...
  28. doi request reprint Myocardial injury following coronary artery surgery versus angioplasty (MICASA): a randomised trial using biochemical markers and cardiac magnetic resonance imaging
    William J van Gaal
    Oxford Heart Centre, John Radcliffe Hospital, Oxford, UK
    EuroIntervention 6:703-10. 2011
    ....
  29. doi request reprint (31)P cardiac magnetic resonance spectroscopy during leg exercise at 3 Tesla
    Lucy E Hudsmith
    The University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, Oxford, OX3 9DU, UK
    Int J Cardiovasc Imaging 25:819-26. 2009
    ..When applied to patients with heart disease, this protocol should provide insights into physiological and pathological cardiac metabolism...
  30. pmc Human non-contrast T1 values and correlation with histology in diffuse fibrosis
    Sacha Bull
    Department of Cardiovascular Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Level 0, Headley Way, Oxford OX3 9DU, UK
    Heart 99:932-7. 2013
    ..Aortic stenosis (AS) leads to diffuse fibrosis in the myocardium, which is linked to adverse outcome. Myocardial T1 values change with tissue composition...
  31. ncbi request reprint Sex-specific characteristics of cardiac function, geometry, and mass in young adult elite athletes
    Steffen E Petersen
    University of Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Magn Reson Imaging 24:297-303. 2006
    ..To study young adult elite athletes with age- and sex-matched sedentary controls to assess sex-specific differences for left ventricular (LV) and right ventricular (RV) volumes and mass as well as for LV contraction and relaxation...
  32. ncbi request reprint Residual ischemia after revascularization in multivessel coronary artery disease: insights from measurement of absolute myocardial blood flow using magnetic resonance imaging compared with angiographic assessment
    Jayanth R Arnold
    University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
    Circ Cardiovasc Interv 6:237-45. 2013
    ..In this study, we compared the completeness of revascularization as assessed by coronary angiography and by quantitative serial perfusion imaging using cardiovascular magnetic resonance...
  33. ncbi request reprint Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo
    Andreas Schafer
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Arterioscler Thromb Vasc Biol 24:1720-6. 2004
    ..We investigated whether acute inhibition of NO production modulates platelet activation in mice and whether specific rescue of endothelial function in diabetes modifies platelet activation...
  34. ncbi request reprint Patients with syndrome X have normal transmural myocardial perfusion and oxygenation: a 3-T cardiovascular magnetic resonance imaging study
    Theodoros D Karamitsos
    Department of Cardiovascular Medicine, Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK
    Circ Cardiovasc Imaging 5:194-200. 2012
    ....
  35. ncbi request reprint Impaired endothelial responses in apparently healthy young people associated with subclinical variation in blood pressure and cardiovascular phenotype
    Merzaka Lazdam
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Am J Hypertens 25:46-53. 2012
    ..We identified subjects with persistently reduced, or declining, endothelial function during adolescence and early adulthood, without apparent cardiovascular risk, and investigated the clinical relevance of this finding...
  36. doi request reprint With the "universal definition," measurement of creatine kinase-myocardial band rather than troponin allows more accurate diagnosis of periprocedural necrosis and infarction after coronary intervention
    Chris C S Lim
    Oxford Heart Centre, John Radcliffe Hospital, United Kingdom
    J Am Coll Cardiol 57:653-61. 2011
    ..We aimed to assess the differential implications of creatine kinase-myocardial band (CK-MB) and troponin measurement with the universal definition of periprocedural injury after percutaneous coronary intervention...
  37. ncbi request reprint Functional and structural vascular remodeling in elite rowers assessed by cardiovascular magnetic resonance
    Steffen E Petersen
    University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom
    J Am Coll Cardiol 48:790-7. 2006
    ..We aimed to noninvasively quantify the effects of chronic exercise training on both peripheral and central conduit artery function and structure with high-resolution magnetic resonance imaging (MRI)...
  38. ncbi request reprint Effect of distal embolization on myocardial perfusion reserve after percutaneous coronary intervention: a quantitative magnetic resonance perfusion study
    Joseph B Selvanayagam
    University of Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK
    Circulation 116:1458-64. 2007
    ....
  39. pmc Creatine uptake in mouse hearts with genetically altered creatine levels
    Michiel Ten Hove
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    J Mol Cell Cardiol 45:453-9. 2008
    ..In addition, our results strongly suggest that CrT activity is predominantly regulated by mechanisms other than alterations in gene expression...
  40. doi request reprint The effect of obesity and weight loss on aortic pulse wave velocity as assessed by magnetic resonance imaging
    Oliver J Rider
    Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Obesity (Silver Spring) 18:2311-6. 2010
    ..Significant weight loss results in improvements in aortic PWV. This may provide a potential link between both obesity and increased mortality, and the reduction in mortality that occurs with weight loss...
  41. ncbi request reprint Mechanisms of creatine depletion in chronically failing rat heart
    Michiel Ten Hove
    Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, OX3 7BN Oxford, UK
    J Mol Cell Cardiol 38:309-13. 2005
    ..The creatine transporter may be a potential therapeutic target to prevent energetic imbalance in heart failure...
  42. ncbi request reprint Insulin resistance, abnormal energy metabolism and increased ischemic damage in the chronically infarcted rat heart
    Andrew J Murray
    University Laboratory of Physiology, University of Oxford, Parks Rd, Oxford, OX1 3PT, England, UK
    Cardiovasc Res 71:149-57. 2006
    ..A decreased capacity for glucose uptake would lower glycolytic adenosine triphosphate (ATP) production and thereby increase ischemic injury in the infarcted heart...
  43. ncbi request reprint T(1) mapping for the diagnosis of acute myocarditis using CMR: comparison to T2-weighted and late gadolinium enhanced imaging
    Vanessa M Ferreira
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    JACC Cardiovasc Imaging 6:1048-58. 2013
    ....
  44. ncbi request reprint Noncontrast T1 mapping for the diagnosis of cardiac amyloidosis
    Theodoros D Karamitsos
    University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    JACC Cardiovasc Imaging 6:488-97. 2013
    ..This study sought to explore the potential role of noncontrast myocardial T1 mapping for detection of cardiac involvement in patients with primary amyloid light-chain (AL) amyloidosis...
  45. ncbi request reprint Right ventricular systolic dysfunction in young adults born preterm
    Adam J Lewandowski
    Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX39DU, UK
    Circulation 128:713-20. 2013
    ..Animal studies suggest that cardiomyocyte changes are evident in both ventricles after preterm birth; therefore, we investigated whether these young adults also have differences in their right ventricular structure and function...
  46. ncbi request reprint Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease
    Cheerag Shirodaria
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
    Circulation 115:2262-70. 2007
    ..We compared the effects of folic acid on human vessels using pharmacological high-dose versus low-dose treatment, equivalent to dietary folate fortification...
  47. pmc Normal variation of magnetic resonance T1 relaxation times in the human population at 1.5 T using ShMOLLI
    Stefan K Piechnik
    Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK
    J Cardiovasc Magn Reson 15:13. 2013
    ..We aimed to assess the variability of myocardial T1 relaxation times in the normal human population estimated with recently proposed Shortened Modified Look-Locker Inversion recovery (ShMOLLI) T1 mapping technique...
  48. pmc Gender-specific differences in left ventricular remodelling in obesity: insights from cardiovascular magnetic resonance imaging
    Oliver J Rider
    Department of Cardiovascular Medicine, University of Oxford, UK
    Eur Heart J 34:292-9. 2013
    ....
  49. ncbi request reprint Differentiation of athlete's heart from pathological forms of cardiac hypertrophy by means of geometric indices derived from cardiovascular magnetic resonance
    Steffen E Petersen
    Department of Cardiovascular Medicine, University of Oxford, Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, UK
    J Cardiovasc Magn Reson 7:551-8. 2005
    ....
  50. doi request reprint Effects of off-pump versus on-pump coronary artery bypass grafting on early and late right ventricular function
    Tammy J Pegg
    University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom
    Circulation 117:2202-10. 2008
    ....
  51. pmc Prediction of global left ventricular functional recovery in patients with heart failure undergoing surgical revascularisation, based on late gadolinium enhancement cardiovascular magnetic resonance
    Tammy J Pegg
    University of Oxford Centre for Clinical Magnetic Resonance Research, UK
    J Cardiovasc Magn Reson 12:56. 2010
    ..Finally, we examined which segmental transmural threshold of scarring best predicted global LV recovery...
  52. ncbi request reprint Effects of steady state free precession parameters on cardiac mass, function, and volumes
    Maureen C Hogan
    University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Int J Cardiovasc Imaging 23:583-9. 2007
    ..We aimed to investigate comparability of LV volumes, function, and mass acquired with three steady-state free precession (SSFP) pulse sequences, simulating typical vendor and protocol specific differences in data acquisition...
  53. ncbi request reprint High-resolution, multicontrast three-dimensional-MRI characterizes atherosclerotic plaque composition in ApoE-/- mice ex vivo
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    J Magn Reson Imaging 20:981-9. 2004
    ..To systematically investigate intrinsic MR contrast mechanisms that would facilitate plaque characterization and quantification in the aortic root and brachiocephalic artery of ApoE-/- mice ex vivo...
  54. ncbi request reprint Myocardial perfusion imaging after coronary artery bypass surgery using cardiovascular magnetic resonance: a validation study
    J Ranjit Arnold
    University of Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, United Kingdom
    Circ Cardiovasc Imaging 4:312-8. 2011
    ..The objective of this study was to test whether absolute quantification of perfusion with cardiovascular magnetic resonance systematically underestimates MBF in segments subtended by bypass grafts...
  55. doi request reprint Ventricular hypertrophy and cavity dilatation in relation to body mass index in women with uncomplicated obesity
    Oliver J Rider
    Department of Cardiovascular Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK
    Heart 97:203-8. 2011
    ..Our hypothesis was that, instead, initiation of ventricular hypertrophy in obesity may be explained by changes in hormonal milieu and not by cavity dilatation...
  56. pmc Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity
    Darci Phillips
    Department of Cardiovascular Medicine, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK
    J Mol Cell Cardiol 48:582-90. 2010
    ....
  57. pmc Early changes in arterial structure and function following statin initiation: quantification by magnetic resonance imaging
    Justin M S Lee
    Department of Cardiovascular Medicine, University of Oxford, United Kingdom
    Atherosclerosis 197:951-8. 2008
    ..50, P<0.001; R(2)=0.22, P<0.05, respectively). Improvements in aortic distensibility and brachial endothelial function that were apparent after 3 months treatment were sustained at the 12-month time point...
  58. ncbi request reprint nNOS gene deletion exacerbates pathological left ventricular remodeling and functional deterioration after myocardial infarction
    Dana Dawson
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Circulation 112:3729-37. 2005
    ..Furthermore, myocardial nNOS expression and activity increase in failing hearts, raising the possibility that nNOS may influence left ventricular (LV) remodeling progression and functional deterioration after myocardial infarction (MI)...
  59. pmc Blunted myocardial oxygenation response during vasodilator stress in patients with hypertrophic cardiomyopathy
    Theodoros D Karamitsos
    University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Am Coll Cardiol 61:1169-76. 2013
    ....
  60. ncbi request reprint Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice
    Craig A Lygate
    Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, UK
    Circ Res 112:945-55. 2013
    ....
  61. pmc Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age
    Craig A Lygate
    Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
    Basic Res Cardiol 107:276. 2012
    ..However, the observation that a primary defect in CK can, under the right conditions, result in heart failure suggests that impaired CK activity in the failing heart could contribute to disease progression...
  62. ncbi request reprint Effects of catecholamine stress on diastolic function and myocardial energetics in obesity
    Oliver J Rider
    Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
    Circulation 125:1511-9. 2012
    ..We assessed whether, in obesity, derangement of energetics and diastolic function is further altered during acute cardiac stress...
  63. ncbi request reprint CINE-MR imaging of the normal and infarcted rat heart using an 11.7 T vertical bore MR system
    Damian J Tyler
    Department of Physiology, University of Oxford, Oxford, United Kingdom
    J Cardiovasc Magn Reson 8:327-33. 2006
    ..Hence, we conclude that vertical bore MR systems can be used to measure in vivo cardiac function in normal and infarcted rat hearts...
  64. ncbi request reprint Early diagnosis of perioperative myocardial infarction after coronary bypass grafting: a study using biomarkers and cardiac magnetic resonance imaging
    Chris C S Lim
    Oxford Heart Centre, John Radcliffe Hospital, Oxford, United Kingdom
    Ann Thorac Surg 92:2046-53. 2011
    ..This study characterized early changes in biomarkers after revascularization injury during on-pump CABG...
  65. pmc Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold
    Stefan K Piechnik
    University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
    J Cardiovasc Magn Reson 12:69. 2010
    ..In this work we propose and validate a novel, clinically applicable, pulse sequence for myocardial T1-mapping that is compatible with typical limits for end-expiration breath-holding in patients...
  66. doi request reprint Tolerance and safety of adenosine stress perfusion cardiovascular magnetic resonance imaging in patients with severe coronary artery disease
    Theodoros D Karamitsos
    Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Int J Cardiovasc Imaging 25:277-83. 2009
    ....
  67. ncbi request reprint Value of delayed-enhancement cardiovascular magnetic resonance imaging in predicting myocardial viability after surgical revascularization
    Joseph B Selvanayagam
    University of Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Circulation 110:1535-41. 2004
    ....
  68. ncbi request reprint Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway
    Simon D Bamforth
    Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 36:1189-96. 2004
    ..We propose that an abnormal Nodal-Pitx2c pathway represents a unifying mechanism for the cardiovascular malformations observed in Cited2(-/-) mice, and that such malformations may be the sole manifestation of a laterality defect...
  69. ncbi request reprint Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice
    Michiel Ten Hove
    Department of Cardiovascular Medicine, University of Oxford, Oxford, England
    Circulation 111:2477-85. 2005
    ..To characterize the role of a substantially impaired CK/PCr system in heart, we studied the cardiac phenotype of wild-type (WT) and GAMT-/- mice...
  70. doi request reprint Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background
    Craig A Lygate
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    J Mol Cell Cardiol 46:93-9. 2009
    ....
  71. doi request reprint Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp
    Cameron J Holloway
    1 Department of Physiology, Anatomy, and Genetics, Sherrington Bldg, University of Oxford, Oxford OX1 3PT, UK
    FASEB J 25:792-6. 2011
    ..Thus, a decrease in cardiac PCr/ATP may be a universal response to periods of sustained low oxygen availability, underlying hypoxia-induced cardiac dysfunction in healthy human heart and in patients with cardiopulmonary diseases...
  72. ncbi request reprint Determination of cardiac volumes and mass with FLASH and SSFP cine sequences at 1.5 vs. 3 Tesla: a validation study
    Lucy E Hudsmith
    University of Oxford Center for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK
    J Magn Reson Imaging 24:312-8. 2006
    ..To assess the feasibility of SSFP imaging in patients at 3 T and to determine comparability to volume data acquired at 1.5 T...
  73. ncbi request reprint Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice
    Julie Wallis
    Department of Cardiovascular Medicine, University of Oxford, Oxford, England
    Circulation 112:3131-9. 2005
    ..Previously, it has not been possible to increase myocardial creatine and phosphocreatine concentrations to supranormal levels because they are subject to tight regulation by the sarcolemmal creatine transporter (CrT)...
  74. ncbi request reprint Atherosclerosis and arterial stiffness in obstructive sleep apnea--a cardiovascular magnetic resonance study
    Ilias Kylintireas
    Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Atherosclerosis 222:483-9. 2012
    ..Our aim was to assess whether OSA is independently associated with atherosclerosis and vascular dysfunction as assessed by cardiovascular magnetic resonance (CMR)...
  75. pmc Changes in creatine transporter function during cardiac maturation in the rat
    Alexandra Fischer
    Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
    BMC Dev Biol 10:70. 2010
    ....
  76. pmc Determinants of left ventricular mass in obesity; a cardiovascular magnetic resonance study
    Oliver J Rider
    Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK
    J Cardiovasc Magn Reson 11:9. 2009
    ..Using cardiovascular magnetic resonance our goal was to elucidate the main predictors of left ventricular mass in severely obese subjects free of additional cardiovascular risk factors...
  77. ncbi request reprint A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects
    Cameron J Holloway
    Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom
    Am J Clin Nutr 93:748-55. 2011
    ..High-fat, low-carbohydrate diets are widely used for weight reduction, but they may also have detrimental effects via increased circulating free fatty acid concentrations...
  78. doi request reprint Percutaneous treatment of chronic total coronary occlusions improves regional hyperemic myocardial blood flow and contractility: insights from quantitative cardiovascular magnetic resonance imaging
    Adrian S H Cheng
    University of Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom
    JACC Cardiovasc Interv 1:44-53. 2008
    ....
  79. ncbi request reprint Cardiac cine MR-imaging at 3T: FLASH vs SSFP
    Damian J Tyler
    Centre for Clinical Magnetic Resonance Research OCMR, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Cardiovasc Magn Reson 8:709-15. 2006
    ..Although SSFP contained more artifacts at 3 T, they would not prevent its clinical use. We conclude that cardiac functional examinations at 3 T should use SSFP sequences...
  80. ncbi request reprint The creatine kinase energy transport system in the failing mouse heart
    Craig A Lygate
    Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, UK
    J Mol Cell Cardiol 42:1129-36. 2007
    ....
  81. ncbi request reprint Myocardial tissue phase mapping with cine phase-contrast mr imaging: regional wall motion analysis in healthy volunteers
    Steffen E Petersen
    University of Oxford Centre for Clinical Magnetic Resonance Research, Department of Cardiovascular Medicine, John Radcliffe Hospital, England
    Radiology 238:816-26. 2006
    ....
  82. pmc Endurance exercise training blunts the deleterious effect of high-fat feeding on whole body efficiency
    Lindsay M Edwards
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 301:R320-6. 2011
    ..Neither diet led to changes in citrate synthase, ATP synthase, or mitochondrial uncoupling protein 3. We conclude that prior exercise training blunts the deleterious effect of short-term, high-fat feeding on whole body efficiency...
  83. ncbi request reprint Operator induced variability in left ventricular measurements with cardiovascular magnetic resonance is improved after training
    Theodoros D Karamitsos
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, UK
    J Cardiovasc Magn Reson 9:777-83. 2007
    ..The aim of the study was to assess the interobserver variability of the manual planimetry of LV contours amongst two experienced and six inexperienced operators before and after a two months training period...
  84. pmc Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice - a one year longitudinal MRI study
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    J Cardiovasc Magn Reson 10:9. 2008
    ..Since creatine plays an important role in the buffering and transfer of high-energy phosphate bonds in the heart, it was hypothesized that lack of creatine would be detrimental for resting cardiac performance during ageing...
  85. ncbi request reprint Assessment of motion gating strategies for mouse magnetic resonance at high magnetic fields
    Paul J Cassidy
    Oxford Cardiac Research Group Magnetic Resonance Unit, University Laboratory of Physiology, University of Oxford, Oxford, UK
    J Magn Reson Imaging 19:229-37. 2004
    ..To assess the performance of motion gating strategies for mouse cardiac magnetic resonance (MR) at high magnetic fields by quantifying the levels of motion artifact observed in images and spectra in vivo...
  86. doi request reprint CMR for characterization of the myocardium in acute coronary syndromes
    Erica Dall'Armellina
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    Nat Rev Cardiol 7:624-36. 2010
    ....
  87. doi request reprint Adenosine stress myocardial contrast echocardiography for the detection of coronary artery disease: a comparison with coronary angiography and cardiac magnetic resonance
    J Ranjit Arnold
    University of Oxford Centre for Clinical Magnetic Resonance Research, John Radcliffe Hospital, Oxford, UK
    JACC Cardiovasc Imaging 3:934-43. 2010
    ..To evaluate the accuracy of adenosine myocardial contrast echocardiography (MCE) in diagnosing coronary artery disease (CAD)...
  88. ncbi request reprint Dystrophin- and MLP-deficient mouse hearts: marked differences in morphology and function, but similar accumulation of cytoskeletal proteins
    James R Wilding
    Department of Physiology, University of Oxford, Oxford, England, UK
    FASEB J 19:79-81. 2005
    ....
  89. ncbi request reprint A comparison of visual and quantitative assessment of left ventricular ejection fraction by cardiac magnetic resonance
    Cameron J Holloway
    Department of Physiology, University of Oxford, Oxford, UK
    Int J Cardiovasc Imaging 27:563-9. 2011
    ..4% on average, with particular inaccuracy in those with mild dysfunction. Given the important clinical information provided by LV assessment, quantitative analysis is recommended for accurate assessment...
  90. pmc Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique
    Jurgen E Schneider
    Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN UK
    BMC Dev Biol 4:16. 2004
    ..The identification of murine models of congenital cardiac malformations in high-throughput mutagenesis screens and in gene-targeted models is hindered by the opacity of the mouse embryo...
  91. pmc Refined approach for quantification of in vivo ischemia-reperfusion injury in the mouse heart
    Steffen Bohl
    Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Am J Physiol Heart Circ Physiol 297:H2054-8. 2009
    ..We have tested published approaches and challenged their practicality. As a result, we propose an improved and streamlined protocol, which consistently yields high-quality histology, thereby minimizing experimental noise and group sizes...
  92. pmc Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus
    Justin M S Lee
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Diab Vasc Dis Res 4:44-8. 2007
    ..MRI provides comprehensive vascular phenotyping in patients with type 2 diabetes and is likely to be useful in studies of disease progression and drug therapy...
  93. ncbi request reprint Left ventricular non-compaction: insights from cardiovascular magnetic resonance imaging
    Steffen E Petersen
    University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom
    J Am Coll Cardiol 46:101-5. 2005
    ..We hypothesized that pathological trabeculation could be distinguished by determining the ratio of non-compacted to compacted myocardium (NC/C ratio)...
  94. ncbi request reprint Quantification and 3D reconstruction of atherosclerotic plaque components in apolipoprotein E knockout mice using ex vivo high-resolution MRI
    Martina A McAteer
    Department of Cardiovascular Medicine, University of Oxford, United Kingdom
    Arterioscler Thromb Vasc Biol 24:2384-90. 2004
    ..To investigate the ability of high-resolution MRI to determine composition and microanatomy of atherosclerosis in mouse aortic root and brachiocephalic artery...
  95. ncbi request reprint Haemoglobin and flow-mediated vasodilation
    Per Lav Madsen
    University Laboratory of Physiology and the Department of Cardiovascular Medicine, University of Oxford, UK
    Clin Sci (Lond) 110:467-73. 2006
    ..Thus, in normal subjects, NO-mediated endothelium-related vasodilation at least partly out-balanced the 'added burden' of a low [Hb] during post-ischaemic reperfusion...
  96. ncbi request reprint Influence of contrast agent dose and image acquisition timing on the quantitative determination of nonviable myocardial tissue using delayed contrast-enhanced magnetic resonance imaging
    Steffen E Petersen
    Department of Cardiovascular Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research OCMR, John Radcliffe Hospital, Oxford, UK
    J Cardiovasc Magn Reson 6:541-8. 2004
    ..The aim of our study was to investigate the size of nonviable myocardium quantitatively as a function of time post-contrast when inversion time is held constant in patients post-myocardial infarction using two contrast agent (CA) doses...
  97. doi request reprint Magnetic resonance spectroscopy in myocardial disease
    Lucy E Hudsmith
    Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    JACC Cardiovasc Imaging 2:87-96. 2009
    ..It is hoped that future technical developments and use of higher magnetic field strengths (such as 7-T) may enable application of cardiac MRS in clinical practice...
  98. ncbi request reprint Quantitative 3-dimensional echocardiography for accurate and rapid cardiac phenotype characterization in mice
    Dana Dawson
    Department of Cardiovascular Medicine, University of Oxford, Oxford, England
    Circulation 110:1632-7. 2004
    ....
  99. ncbi request reprint Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart
    Lisa C Heather
    Cardiac Metabolism Research Group, Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, UK
    Cardiovasc Res 72:430-7. 2006
    ..We hypothesised that levels of the fatty acid transporters would be reduced in the chronically infarcted rat heart, in parallel with reduced dependence on fatty acid utilisation...
  100. ncbi request reprint Irreversible myocardial injury: assessment with cardiovascular delayed-enhancement MR imaging and comparison of 1.5 and 3.0 T--initial experience
    Adrian S H Cheng
    University of Oxford Centre for Clinical Magnetic Resonance Research and Department of Cardiovascular Medicine, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, England
    Radiology 242:735-42. 2007
    ..To prospectively compare visualization and quantification of irreversible myocardial injury in patients with chronic myocardial infarction at 1.5- and 3.0-T magnetic resonance (MR) imaging...
  101. ncbi request reprint Troponin elevation after percutaneous coronary intervention directly represents the extent of irreversible myocardial injury: insights from cardiovascular magnetic resonance imaging
    Joseph B Selvanayagam
    University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom
    Circulation 111:1027-32. 2005
    ....