J P Neoptolemos

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. ncbi request reprint Adjuvant therapy in pancreatic cancer: historical and current perspectives
    J P Neoptolemos
    Department of Surgery, University of Liverpool, Liverpool, UK
    Ann Oncol 14:675-92. 2003
  2. ncbi request reprint Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial
    John P Neoptolemos
    Liverpool Cancer Research UK Cancer Trials Unit, Cancer Research UK Centre, University of Liverpool, Fifth Floor, UCD Bldg, Daulby Street, Liverpool, L69 3GA, United Kingdom
    JAMA 304:1073-81. 2010
  3. pmc Meta-analysis of randomised adjuvant therapy trials for pancreatic cancer
    D D Stocken
    Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK
    Br J Cancer 92:1372-81. 2005
  4. pmc Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer
    C Dive
    Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
    Br J Cancer 102:577-82. 2010
  5. doi request reprint Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial
    John P Neoptolemos
    Institute of Translational Medicine, Liverpool Cancer Trials Unit, Liverpool Cancer Research United Kingdom Centre, University of Liverpool, Liverpool, England, United Kingdom
    JAMA 308:147-56. 2012
  6. ncbi request reprint Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study
    J P Neoptolemos
    University Department of Surgery, Royal Liverpool University Hospital, UK
    Lancet 355:1955-60. 2000
  7. pmc Influence of resection margins on survival for patients with pancreatic cancer treated by adjuvant chemoradiation and/or chemotherapy in the ESPAC-1 randomized controlled trial
    J P Neoptolemos
    Department of Surgery, Liverpool University, 5th Floor UCD Building, Daulby Street, Liverpool, L69 3GA, United Kingdom
    Ann Surg 234:758-68. 2001
  8. ncbi request reprint [Adjuvant and additive therapy for cancer of the pancreas]
    J P Neoptolemos
    Department of Surgery, Liverpool University, Liverpool, United Kingdom
    Chirurg 74:191-201. 2003
  9. pmc Adjuvant 5-fluorouracil and folinic acid vs observation for pancreatic cancer: composite data from the ESPAC-1 and -3(v1) trials
    J P Neoptolemos
    CR UK Liverpool Cancer Trials Unit, University of Liverpool Cancer Research Centre, Liverpool, UK
    Br J Cancer 100:246-50. 2009
  10. ncbi request reprint Influence of resection margins and treatment on survival in patients with pancreatic cancer: meta-analysis of randomized controlled trials
    Giovanni Butturini
    Division of Surgery and Oncology, School of Cancer Studies, Royal Liverpool University Hospital, 5th Floor, UCD Bldg, Daulby St, Liverpool L69 3GA, England
    Arch Surg 143:75-83; discussion 83. 2008

Collaborators

Detail Information

Publications122 found, 100 shown here

  1. ncbi request reprint Adjuvant therapy in pancreatic cancer: historical and current perspectives
    J P Neoptolemos
    Department of Surgery, University of Liverpool, Liverpool, UK
    Ann Oncol 14:675-92. 2003
    ....
  2. ncbi request reprint Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial
    John P Neoptolemos
    Liverpool Cancer Research UK Cancer Trials Unit, Cancer Research UK Centre, University of Liverpool, Fifth Floor, UCD Bldg, Daulby Street, Liverpool, L69 3GA, United Kingdom
    JAMA 304:1073-81. 2010
    ..Gemcitabine is known to be the most effective agent in advanced disease as well as an effective agent in patients with resected pancreatic cancer...
  3. pmc Meta-analysis of randomised adjuvant therapy trials for pancreatic cancer
    D D Stocken
    Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK
    Br J Cancer 92:1372-81. 2005
    ..Further studies with chemoradiation are warranted in patients with positive resection margins, as chemotherapy appeared relatively ineffective in this patient subgroup...
  4. pmc Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer
    C Dive
    Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
    Br J Cancer 102:577-82. 2010
    ..Characterisation of baseline levels of circulating full length and cleaved CK18 specifically in patients with pancreatic cancer...
  5. doi request reprint Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial
    John P Neoptolemos
    Institute of Translational Medicine, Liverpool Cancer Trials Unit, Liverpool Cancer Research United Kingdom Centre, University of Liverpool, Liverpool, England, United Kingdom
    JAMA 308:147-56. 2012
    ..Although adjuvant chemotherapy has been shown to have a survival benefit for pancreatic cancer, there have been no randomized trials for periampullary adenocarcinomas...
  6. ncbi request reprint Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study
    J P Neoptolemos
    University Department of Surgery, Royal Liverpool University Hospital, UK
    Lancet 355:1955-60. 2000
    ..There is a pressing clinical requirement for an early simple test of severity in acute pancreatitis. We investigated the use of an assay of trypsinogen activation peptide (TAP)...
  7. pmc Influence of resection margins on survival for patients with pancreatic cancer treated by adjuvant chemoradiation and/or chemotherapy in the ESPAC-1 randomized controlled trial
    J P Neoptolemos
    Department of Surgery, Liverpool University, 5th Floor UCD Building, Daulby Street, Liverpool, L69 3GA, United Kingdom
    Ann Surg 234:758-68. 2001
    ..To assess the influence of resection margins on survival for patients with resected pancreatic cancer treated within the context of the adjuvant European Study Group for Pancreatic Cancer-1 (ESPAC-1) study...
  8. ncbi request reprint [Adjuvant and additive therapy for cancer of the pancreas]
    J P Neoptolemos
    Department of Surgery, Liverpool University, Liverpool, United Kingdom
    Chirurg 74:191-201. 2003
    ..Participation in the large, phase-3 study therefore plays a key role in the continued development of the management of pancreas cancer...
  9. pmc Adjuvant 5-fluorouracil and folinic acid vs observation for pancreatic cancer: composite data from the ESPAC-1 and -3(v1) trials
    J P Neoptolemos
    CR UK Liverpool Cancer Trials Unit, University of Liverpool Cancer Research Centre, Liverpool, UK
    Br J Cancer 100:246-50. 2009
    ..70 (95% CI=0.55-0.88) P=0.003, and the median survival of 23.2 (95% CI=20.1-26.5) months with 5FU/FA vs 16.8 (95% CI=14.3-19.2) months with resection alone supports the use of adjuvant 5FU/FA in pancreatic cancer...
  10. ncbi request reprint Influence of resection margins and treatment on survival in patients with pancreatic cancer: meta-analysis of randomized controlled trials
    Giovanni Butturini
    Division of Surgery and Oncology, School of Cancer Studies, Royal Liverpool University Hospital, 5th Floor, UCD Bldg, Daulby St, Liverpool L69 3GA, England
    Arch Surg 143:75-83; discussion 83. 2008
    ..To assess the influence of resection margins and adjuvant chemoradiotherapy or chemotherapy on survival for patients with pancreatic cancer by meta-analysis of individual data from randomized controlled trials...
  11. ncbi request reprint When is pancreatitis considered to be of biliary origin and what are the implications for management?
    N Alexakis
    Division of Surgery and Oncology, University of Liverpool, Royal Liverpool University Hospital, Liverpool, UK
    Pancreatology 7:131-41. 2007
    ....
  12. ncbi request reprint Preoperative CA19-9 levels and lymph node ratio are independent predictors of survival in patients with resected pancreatic ductal adenocarcinoma
    R A Smith
    Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool, UK
    Dig Surg 25:226-32. 2008
    ....
  13. ncbi request reprint Major resection for chronic pancreatitis in patients with vascular involvement is associated with increased postoperative mortality
    N Alexakis
    Department of Surgery, University of Liverpool, Liverpool, UK
    Br J Surg 91:1020-6. 2004
    ..The aim was to evaluate the outcome of major resection for chronic pancreatitis in patients with and without vascular involvement...
  14. ncbi request reprint Serum CA19-9 measurement increases the effectiveness of staging laparoscopy in patients with suspected pancreatic malignancy
    S Connor
    Department of Surgery, University of Liverpool, Liverpool, UK
    Dig Surg 22:80-5. 2005
    ..The aim of this study was to determine if serum carbohydrate antigen (CA19-9) levels could be used to improve the selection of patients for staging laparoscopy...
  15. ncbi request reprint Positron emission tomography does not add to computed tomography for the diagnosis and staging of pancreatic cancer
    D Lytras
    Department of Surgery, University of Liverpool, Liverpool, UK
    Dig Surg 22:55-61; discussion 62. 2005
    ..Positron emission tomography (PET) has been proposed for pancreatic cancer diagnosis and staging...
  16. ncbi request reprint Early and late complications after pancreatic necrosectomy
    S Connor
    Department of Surgery, Royal Liverpool University Hospital
    Surgery 137:499-505. 2005
    ..Surgery for pancreatic necrosis is associated with a high morbidity and mortality. The aim of this study was to review the incidence of early and late complications after pancreatic necrosectomy in a large contemporary series of patients...
  17. ncbi request reprint Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomised controlled trial
    J P Neoptolemos
    Department of Surgery, Liverpool University, Liverpool, UK
    Lancet 358:1576-85. 2001
    ..The role of adjuvant treatment in pancreatic cancer remains uncertain. The European Study Group for Pancreatic Cancer (ESPAC) assessed the roles of chemoradiotherapy and chemotherapy in a randomised study...
  18. ncbi request reprint Influence of opioid use on surgical and long-term outcome after resection for chronic pancreatitis
    N Alexakis
    Department of Surgery, Royal Liverpool University Hospital, Liverpool, UK
    Surgery 136:600-8. 2004
    ..The outcome of pancreatic resection for chronic pancreatitis in patients with preoperative opioid use is not well described...
  19. ncbi request reprint Laparoscopy and laparoscopic ultrasound in the evaluation of pancreatic and periampullary tumours
    H E Doran
    Department of Surgery, University of Liverpool, UCD Block, Royal Liverpool University Hospital, Daulby Street, Liverpool L69 3GA, UK
    Dig Surg 21:305-13. 2004
    ..This study investigated whether the addition of laparoscopy with laparoscopic ultrasound to dual-phase helical CT could improve the accuracy of assessment of resectability...
  20. ncbi request reprint Neoadjuvant and adjuvant strategies for pancreatic cancer
    P Ghaneh
    Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby Street, Liverpool L69 3GA, UK
    Eur J Surg Oncol 34:297-305. 2008
    ..The standard of care for adjuvant therapy based on level I evidence (from the ESPAC-1 trial) is postoperative chemotherapy using 5-fluorouracil with folinic acid providing a best estimate of 29% 5-year survival...
  21. pmc Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer: results of secondary end points analyses
    A Sultana
    CRUK Liverpool Cancer Trials Unit, Cancer Research Centre, 200 London Road, Liverpool, L3 9TA, UK
    Br J Cancer 99:6-13. 2008
    ..There is improved PFS/TTP and response rate, with gemcitabine-based combinations, although this comes with greater toxicity...
  22. ncbi request reprint Increasing age and APACHE II scores are the main determinants of outcome from pancreatic necrosectomy
    S Connor
    Department of Surgery, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby Street, Liverpool L69 3GA, UK
    Br J Surg 90:1542-8. 2003
    ..The aim of this study was to identify factors associated with death after surgery in patients with extensive pancreatic necrosis...
  23. ncbi request reprint Survival of patients with periampullary carcinoma is predicted by lymph node 8a but not by lymph node 16b1 status
    S Connor
    Department of Surgery, University of Liverpool, Royal Liverpool Hospital, Liverpool, UK
    Br J Surg 91:1592-9. 2004
    ..The aim of this study was to assess the impact of metastatic disease in lymph nodes 8a and 16b1 (as defined by the Japanese Pancreas Society) on survival in patients with periampullary malignancy...
  24. ncbi request reprint Surgery in the treatment of acute pancreatitis--minimal access pancreatic necrosectomy
    S Connor
    Division of Surgery and Oncology, University of Liverpool, Liverpool, UK
    Scand J Surg 94:135-42. 2005
    ..Current evidence suggests that a minimal access approach to pancreatic necrosis is feasible, well tolerated and beneficial for the patient when compared with open surgery...
  25. ncbi request reprint Preoperative resolution of jaundice following biliary stenting predicts more favourable early survival in resected pancreatic ductal adenocarcinoma
    Richard A Smith
    Division of Surgery and Oncology, School of Cancer Studies, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby St, Liverpool L69 3GA, UK
    Ann Surg Oncol 15:3138-46. 2008
    ..The objective of this study was to investigate the influence of preoperative biliary stenting and resolution of jaundice on subsequent postoperative survival following resection for pancreatic cancer...
  26. pmc A phase II trial of marimastat in advanced pancreatic cancer
    J D Evans
    Department of Surgery, Queen Elizabeth Hospital, Birmingham, UK
    Br J Cancer 85:1865-70. 2001
    ..Of 90 patients, 46 (51%) had stabilization or reduction in pain, mobility and analgesia scores. Further development and clinical evaluation of matrix metalloproteinase inhibitors for the treatment of pancreatic cancer is warranted...
  27. ncbi request reprint Molecular diagnosis of early pancreatic ductal adenocarcinoma in high-risk patients
    T Wong
    Department of Surgery, University of Liverpool, UK
    Pancreatology 1:486-509. 2001
    ....
  28. ncbi request reprint Duodenum- and spleen-preserving total pancreatectomy for end-stage chronic pancreatitis
    N Alexakis
    Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, Daulby Street, Liverpool L69 3GA, UK
    Br J Surg 90:1401-8. 2003
    ..A new operation, duodenum- and spleen-preserving total pancreatectomy, is described...
  29. ncbi request reprint Carbohydrate antigen 19.9 accurately selects patients for laparoscopic assessment to determine resectability of pancreatic malignancy
    C M Halloran
    Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool, UK
    Br J Surg 95:453-9. 2008
    ..The present prospective study assessed the strategy of using carbohydrate antigen 19.9 (CA19.9) levels to select patients for L-LUS...
  30. ncbi request reprint ERCP findings and the role of endoscopic sphincterotomy in acute gallstone pancreatitis
    J P Neoptolemos
    Department of Surgery, Leicester Royal Infirmary, Leicester General Hospital, UK
    Br J Surg 75:954-60. 1988
    ....
  31. ncbi request reprint Hereditary pancreatic endocrine tumours
    N Alexakis
    Department of Surgery, Royal Liverpool University Hospital, Liverpool, UK
    Pancreatology 4:417-33; discussion 434-5. 2004
    ..The evidence is increasing that the life span of patients may be significantly improved with surgical intervention, mandating the widespread use of tumour surveillance and multidisciplinary team management...
  32. ncbi request reprint Fungal infection but not type of bacterial infection is associated with a high mortality in primary and secondary infected pancreatic necrosis
    S Connor
    Department of Surgery, Royal Liverpool University Hospital, UCD, Daulby Street, Liverpool, L69 3GA, UK
    Dig Surg 21:297-304. 2004
    ..Knowledge of microbiology in the prognosis of patients with necrotizing pancreatitis is incomplete...
  33. ncbi request reprint Hepatic intra-arterial delivery of a retroviral vector expressing the cytosine deaminase gene, controlled by the CEA promoter and intraperitoneal treatment with 5-fluorocytosine suppresses growth of colorectal liver metastases
    M J Humphreys
    Department of Surgery, University of Liverpool, Liverpool, UK
    Gene Ther 8:1241-7. 2001
    ..After 5-fluorocytosine administration for 7 days, most surface metastases disappeared and tumour volumes were suppressed up to 8.2-fold. The results support the development of this approach for patient treatment...
  34. pmc Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease
    S R Bramhall
    Department of Surgery, City Hospital NHS Trust Birmingham, UK
    Br J Cancer 73:972-8. 1996
    ..02) and there was an association between increased immunoreactivity for MMP2 and the degree of tumour differentiation (P < 0.01). The results implicate MMP2, MMP3 and TIMP1 in the invasive phenotype of pancreatic and ampullary cancer...
  35. ncbi request reprint Gene therapy for pancreatic cancer--current and prospective strategies
    C M Halloran
    Department of Surgery, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby Street, Liverpool, L69 3GA, UK
    Surg Oncol 9:181-91. 2000
    ..Gene delivery systems, genetic targets, and combined gene delivery with chemotherapy are discussed in the context of pancreatic cancer treatment...
  36. pmc A new polymorphism for the RI22H mutation in hereditary pancreatitis
    N Howes
    Department of Surgery, University of Liverpool, 5th Floor UCD Building, Daulby Street, Liverpool L69 3GA, UK
    Gut 48:247-50. 2001
    ..CONCLUSIONS: One of the 16 families with HP and an R122H mutation contained a polymorphism affecting the AflIII restriction site. Adoption of an alternative R122H assay is important for genetic studies in individuals with apparent HP...
  37. ncbi request reprint T cell lymphoplasmacellular and eosinophilic infiltration of the pancreas with involvement of the gallbladder and duodenum in non-alcoholic duct-destructive chronic pancreatitis
    N Alexakis
    Department of Surgery, Royal Liverpool University Hospital, 5th Floor, UCD Building, Daulby Street, Liverpool, L69 3GA, UK
    Langenbecks Arch Surg 390:32-8. 2005
    ..The majority of the patients are from Japan. We report a case with involvement of the distal bile duct, the gallbladder, the duodenum and the ampulla, and present a review of patients from Europe and the USA since 1997...
  38. ncbi request reprint Diagnosis, treatment and outcome of pancreatoblastoma
    A R Dhebri
    Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, Liverpool, UK
    Pancreatology 4:441-51; discussion 452-3. 2004
    ..Pancreatoblastoma is a rare tumour mainly presenting in childhood but also in adults...
  39. ncbi request reprint Double resection for patients with pancreatic cancer and a second primary renal cell cancer
    N Alexakis
    Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, Liverpool, UK
    Dig Surg 20:428-32. 2003
    ..Reports of synchronous or metachronous double kidney-pancreas cancers are very rare...
  40. ncbi request reprint Adenovirus-mediated transfer of p53 and p16(INK4a) results in pancreatic cancer regression in vitro and in vivo
    P Ghaneh
    Department of Surgery, University of Liverpool, Liverpool, UK
    Gene Ther 8:199-208. 2001
    ..0001). These results show that transfer of wild-type p53 and p16 produces significant growth suppression of pancreatic cancer in vitro and in vivo...
  41. ncbi request reprint Review article: chemotherapy for pancreatic cancer
    S Shore
    University of Liverpool, Royal Liverpool University Hospital, Liverpool, UK
    Aliment Pharmacol Ther 18:1049-69. 2003
    ..Real advances are anticipated over the next five years but are dependent on large randomised controlled trials for success...
  42. pmc Treatment with neutralising antibody against cytokine induced neutrophil chemoattractant (CINC) protects rats against acute pancreatitis associated lung injury
    M Bhatia
    Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, Liverpool, UK
    Gut 47:838-44. 2000
    ..Neutrophils play a critical role in the progression of AP to ARDS. C-x-C chemokines are potent neutrophil chemoattractants and activators and have been implicated in AP...
  43. ncbi request reprint Current standards of surgery for pancreatic cancer
    N Alexakis
    Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, 5th Floor, UCD Building, Daulby Street, Liverpool L69 3GA, UK
    Br J Surg 91:1410-27. 2004
    ..Pancreatic cancer carries a dismal prognosis but there has been a vast increase in evidence on its management in the past decade...
  44. ncbi request reprint Complications and follow-up after pancreas-preserving total duodenectomy for duodenal polyps
    B al-Sarireh
    Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Royal Liverpool University Hospital, 5th floor University Clinical Departments Building, Daulby Street, Liverpool L693GA, UK
    Br J Surg 95:1506-11. 2008
    ..Patients with duodenal polyps are at risk of duodenal cancer. Pancreas-preserving total duodenectomy (PPTD) is an alternative to partial pancreatoduodenectomy...
  45. ncbi request reprint Adjuvant therapy in pancreatic cancer
    P Ghaneh
    Department of Surgery, University of Liverpool, 5th Floor UCD Building, Daulby Street, Liverpool, L69 3GA, UK
    World J Gastroenterol 7:482-9. 2001
    ..The ESPAC-3 trial aims to assess the definitive use of adjuvant chemotherapy in a randomized controlled trial of 990 patients...
  46. ncbi request reprint Conclusions from the European Study Group for Pancreatic Cancer adjuvant trial of chemoradiotherapy and chemotherapy for pancreatic cancer
    Paula Ghaneh
    Department of Surgery, University of Liverpool, 5th Floor, UCD Building, Daulby Street, Liverpool L69 3GA, UK
    Surg Oncol Clin N Am 13:567-87, vii-viii. 2004
    ....
  47. pmc Risk of pancreatic ductal adenocarcinoma in chronic pancreatitis
    N Howes
    Department of Surgery, University of Liverpool, Liverpool, UK
    Gut 51:765-6. 2002
  48. ncbi request reprint Biliary acute pancreatitis
    M C Winslet
    University Department of Surgery, Dudley Road Hospital, Birmingham
    Hepatogastroenterology 38:120-3. 1991
    ..In certain situations endoscopic sphincterotomy may also obviate the need to explore the common bile duct, and in high-risk patients may allow surgery to be avoided altogether...
  49. ncbi request reprint Pancreatic hamartoma
    C D McFaul
    Department of Surgery, Royal Liverpool University Hospital, Liverpool, UK
    Pancreatology 4:533-7; discussion 537-8. 2004
    ..Pancreatic hamartoma can present with vague, non-specific symptoms which, despite modern diagnostic tools, can be difficult to diagnose. Surgical resection with histopathological examination is required to confirm the diagnosis...
  50. pmc Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy
    A Sultana
    Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool L69 3GA, UK
    Br J Cancer 96:1183-90. 2007
    ..Chemoradiation followed by chemotherapy did not demonstrate any survival advantage over chemotherapy alone, but important clinical differences cannot be ruled out due to the wide CI...
  51. ncbi request reprint Hereditary pancreatitis and secondary screening for early pancreatic cancer
    L J Vitone
    Division of Surgery and Oncology, The University of Liverpool, United Kingdom
    Rocz Akad Med Bialymst 50:73-84. 2005
    ..Philosophically, the individual's best interest must be sought in light of the latest advances in medicine and science following discussions with a multidisciplinary team in specialist pancreatic centres...
  52. ncbi request reprint Surgical treatment of pancreatic fistula
    N Alexakis
    Department of Surgery, University of Liverpool, UCD Building, Royal Liverpool University Hospital, Daulby Street, Liverpool L69 3GA, UK
    Dig Surg 21:262-74. 2004
    ....
  53. ncbi request reprint Detailed tissue expression of bcl-2, bax, bak and bcl-x in the normal human pancreas and in chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas
    J D Evans
    Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, Liverpool, UK
    Pancreatology 1:254-62. 2001
    ..bcl-x expression correlates with survival following resection and may represent a potential prognosis marker...
  54. pmc Meta-analysis of immunohistochemical prognostic markers in resected pancreatic cancer
    R A Smith
    Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Royal Liverpool University Hospital, 5th Floor Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Br J Cancer 104:1440-51. 2011
    ....
  55. ncbi request reprint Molecular pathogenesis of pancreatic ductal adenocarcinoma and clinical implications
    C J Magee
    University of Liverpool, Department of Surgery, 5th Floor UCD Building, Royal Liverpool University Hospital, Daulby Street, Liverpool L69 3GA, UK
    Surg Oncol 10:1-23. 2001
    ..This review is concerned with the molecular pathogenesis of PDAC and the application of this basic scientific understanding into state-of-the-art clinical practice...
  56. ncbi request reprint Inflammatory mediators as therapeutic targets in acute pancreatitis
    M Bhatia
    Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, UK
    Curr Opin Investig Drugs 2:496-501. 2001
    ..Elucidation of the key mediators in acute pancreatitis coupled with the discovery of specific inhibitors may make it possible to develop clinically effective anti-inflammatory therapy...
  57. ncbi request reprint Algorithm for the diagnosis and treatment of acute biliary pancreatitis
    N Alexakis
    Division of Surgery and Oncology, University of Liverpool, Liverpool, UK
    Scand J Surg 94:124-9. 2005
    ..Patients with severe disease should undergo cholecystectomy at a later stage. Patients who have undergone necrosectomy require long-term follow-up because of delayed complications...
  58. ncbi request reprint Inhibition of experimental colorectal carcinogenesis by dietary N-6 polyunsaturated fats
    M L Nicholson
    University Department of Surgery, Leicester Royal Infirmary, UK
    Carcinogenesis 11:2191-7. 1990
    ..This is the first in vivo study to show reduced colorectal carcinogenesis by N-6 polyunsaturated fatty acids...
  59. ncbi request reprint Familial pancreatic cancer: a review and latest advances
    C J Grocock
    Division of Surgery and Oncology, The University of Liverpool, United Kingdom
    Adv Med Sci 52:37-49. 2007
    ....
  60. pmc Anticipation in familial pancreatic cancer
    C D McFaul
    Division of Surgery and Oncology, University of Liverpool L69 3GA, UK
    Gut 55:252-8. 2006
    ..Previous studies of anticipation in familial pancreatic cancer have been small and subject to ascertainment bias. Our aim was to determine evidence for anticipation in a large number of European families...
  61. ncbi request reprint Levels of the chemokines growth-related oncogene alpha and epithelial neutrophil-activating protein 78 are raised in patients with severe acute pancreatitis
    S Shokuhi
    Departments of Surgery and Immunology, University of Liverpool, 5th floor University Clinical Departments Building, Daulby Street, Liverpool L69 3GA, UK
    Br J Surg 89:566-72. 2002
    ....
  62. pmc iTRAQ reveals candidate pancreatic cancer serum biomarkers: influence of obstructive jaundice on their performance
    S Tonack
    Department of Molecular and Clinical Cancer Medicine, Liverpool Cancer Research UK Centre, University of Liverpool, Liverpool, UK
    Br J Cancer 108:1846-53. 2013
    ....
  63. ncbi request reprint Surgery for midgut carcinoid
    R Sutton
    Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, Liverpool, UK
    Endocr Relat Cancer 10:469-81. 2003
    ..Liver transplantation has had only qualified success in highly selected patients without extra-hepatic disease in whom other therapies have failed...
  64. ncbi request reprint Antibiotic prophylaxis in severe acute pancreatitis--what are the facts?
    J Slavin
    University Department of Surgery, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby Street, Liverpool, L69 3GA, UK
    Langenbecks Arch Surg 386:155-9. 2001
    ..Further well-designed, adequately powered studies are required to establish the role of antibiotic prophylaxis in severe acute pancreatitis...
  65. ncbi request reprint Complications of pancreatic cancer resection
    C M Halloran
    Department of Surgery, Royal Liverpool University Hospital, UK
    Dig Surg 19:138-46. 2002
    ..The best way to improve outcome is to concentrate pancreatic cancer care in regional specialist centres...
  66. pmc Proteinase inhibitors reduce basement membrane degradation by human breast cancer cell lines
    P S Stonelake
    Department of Surgery, University of Birmingham, UK
    Br J Cancer 75:951-9. 1997
    ..These in vitro observations suggest that combinations of proteinase inhibitors, particularly of uPA/plasminogen activation and MMPs, may merit clinical evaluation as potential antimetastatic therapy for breast cancer...
  67. ncbi request reprint Minimally invasive retroperitoneal pancreatic necrosectomy
    S Connor
    Department of Surgery, Royal Liverpool University Hospital, Liverpool, UK
    Dig Surg 20:270-7. 2003
    ..Open surgery for pancreatic necrosis is associated with considerable morbidity and mortality. We report the results of a recently developed minimally invasive technique that we adopted in 1998...
  68. ncbi request reprint The platelet-lymphocyte ratio improves the predictive value of serum CA19-9 levels in determining patient selection for staging laparoscopy in suspected periampullary cancer
    Richard A Smith
    Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool, UK
    Surgery 143:658-66. 2008
    ....
  69. ncbi request reprint A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer
    John P Neoptolemos
    Department of Surgery, Liverpool University, Liverpool, United Kingdom
    N Engl J Med 350:1200-10. 2004
    ..The effect of adjuvant treatment on survival in pancreatic cancer is unclear. We report the final results of the European Study Group for Pancreatic Cancer 1 Trial and update the interim results...
  70. ncbi request reprint CT and pathologic assessment of prospective nodal staging in patients with ductal adenocarcinoma of the head of the pancreas
    Clare J Roche
    Department of Radiology, Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, United Kingdom
    AJR Am J Roentgenol 180:475-80. 2003
    ..The aim of our study was to compare the assessment of peripancreatic lymph nodes using CT with the gold standard of detailed histopathologic assessment of resected specimens in patients with pancreatic ductal adenocarcinoma...
  71. ncbi request reprint Prognosis of resected ampullary adenocarcinoma by preoperative serum CA19-9 levels and platelet-lymphocyte ratio
    Richard A Smith
    Division of Surgery and Oncology, School of Cancer Studies, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby St, Liverpool, L69 3GA, UK
    J Gastrointest Surg 12:1422-8. 2008
    ..The objective of this study was to evaluate whether preoperative CA19-9 levels and the platelet-lymphocyte ratio (PLR) might reflect prognostic indices for resected ampullary adenocarcinoma...
  72. ncbi request reprint Preoperative platelet-lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma
    Richard A Smith
    Division of Surgery and Oncology, School of Cancer Studies, Royal Liverpool University Hospital, Liverpool, UK
    Am J Surg 197:466-72. 2009
    ..The objective of this study was to investigate whether the preoperative platelet-lymphocyte (P/L) ratio represents a significant prognostic index in resected pancreatic ductal adenocarcinoma...
  73. ncbi request reprint Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer
    V E Shaw
    Liverpool CR UK Centre, NIHR Pancreas Biomedical Research Unit, Liverpool Experimental Cancer Medicine Centre, School of Cancer Studies, The Duncan Building, Daulby Street, Liverpool, L69 3GA, UK
    Expert Rev Vaccines 9:1007-16. 2010
    ..It places GV1001 in the context of other immunotherapeutic approaches targeting telomerase and assesses the chances of the vaccine becoming a future standard of care in the treatment of cancer...
  74. ncbi request reprint Pancreatic cancer--a major health problem requiring centralization and multi-disciplinary team-work for improved results
    J P Neoptolemos
    Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, UK
    Dig Liver Dis 34:692-5. 2002
  75. ncbi request reprint A preoperative prognostic score for resected pancreatic and periampullary neuroendocrine tumours
    Nicole Sakka
    Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool, UK
    Pancreatology 9:670-6. 2009
    ..To identify potential preoperative prognostic factors in resected pancreatic and periampullary neuroendocrine tumours...
  76. ncbi request reprint 5-Fluorouracil or gemcitabine combined with adenoviral-mediated reintroduction of p16INK4A greatly enhanced cytotoxicity in Panc-1 pancreatic adenocarcinoma cells
    Christopher M Halloran
    Department of Surgery, Royal Liverpool University Hospital, 5th Floor, UCD Building, Daulby Street, University of Liverpool, Liverpool, UK
    J Gene Med 6:514-25. 2004
    ..Gene Ther 2001; 8: 199-208). In this study we examine whether combining Ad-mediated delivery of p53 or p16(INK4A) with clinically relevant chemotherapeutic drugs has therapeutic potential for pancreatic cancer...
  77. ncbi request reprint Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer
    Asma Sultana
    Cancer Research UK Liverpool Cancer Trials Unit and Centre for Medical Statistics and Health Evaluation, University of Liverpool, Liverpool, United Kingdom
    J Clin Oncol 25:2607-15. 2007
    ....
  78. ncbi request reprint Classification of R1 resections for pancreatic cancer: the prognostic relevance of tumour involvement within 1 mm of a resection margin
    Fiona Campbell
    Department of Pathology, School of Cancer Studies, University of Liverpool, Royal Liverpool University Hospital, 5th Floor Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Histopathology 55:277-83. 2009
    ....
  79. ncbi request reprint Comment on "adjuvant therapy in pancreatic cancer: a critical appraisal"
    Paula Ghaneh
    Cancer Research UK Liverpool Cancer Trials Unit, Cancer Research Centre, Liverpool, United Kingdom
    Drugs 67:2487-90; discussion 2491-3. 2007
  80. ncbi request reprint Evaluation of the 4q32-34 locus in European familial pancreatic cancer
    Julie Earl
    Division of Surgery and Oncology, University of Liverpool, Liverpool, United Kingdom
    Cancer Epidemiol Biomarkers Prev 15:1948-55. 2006
    ..The 4q32-34 region has been previously identified as a potential locus for FPC in a large American family...
  81. ncbi request reprint New techniques and agents in the adjuvant therapy of pancreatic cancer
    Michael G T Raraty
    Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, Liverpool, UK
    Acta Oncol 41:582-95. 2002
    ..Great progress has been made in the adjuvant treatment of pancreatic cancer in the past 10 years and similar advances are likely over the next decade...
  82. pmc Randomised Phase I/II trial assessing the safety and efficacy of radiolabelled anti-carcinoembryonic antigen I(131) KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma
    Asma Sultana
    Division of Surgery and Oncology, University of Liverpool, Liverpool, UK
    BMC Cancer 9:66. 2009
    ..This study aimed to evaluate the safety and tolerability of KAb201, an anti-carcinoembryonic antigen monoclonal antibody, labelled with I(131) in pancreatic cancer (ISRCTN 16857581)...
  83. ncbi request reprint Expression patterns of protein kinase C isoenzymes are characteristically modulated in chronic pancreatitis and pancreatic cancer
    James D Evans
    Department of Surgery, University of Liverpool, Daulby St, Liverpool L69 3GA, England
    Am J Clin Pathol 119:392-402. 2003
    ....
  84. ncbi request reprint Confounding effect of obstructive jaundice in the interpretation of proteomic plasma profiling data for pancreatic cancer
    Li Yan
    Division of Surgery and Oncology, Royal Liverpool University Hospital, Liverpool L68 3 GA, UK
    J Proteome Res 8:142-8. 2009
    ..Our results demonstrate the importance of accounting for disease-related confounding factors when analyzing data for the detection of cancer biomarkers...
  85. ncbi request reprint A technically detailed and pragmatic protocol for quantitative serum proteomics using iTRAQ
    Sarah Tonack
    Royal Liverpool University Hospital, University of Liverpool, United Kingdom
    J Proteomics 73:352-6. 2009
    ..The samples described here relate to pancreatic cancer; however the protocol can be applied to serum from other control or disease types...
  86. ncbi request reprint Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma
    Ali R Shekouh
    Department of Surgery, Royal Liverpool University Hospital, University of Liverpool, UK
    Proteomics 3:1988-2001. 2003
    ..These observations indicate that the combination of LCM with 2-DE provides an effective strategy to discover proteins that are differentially expressed in PDAC...
  87. ncbi request reprint Is endoscopic ultrasonography superior to multidetector CT for assessing pancreatic cancer?
    John P Neoptolemos
    Division of Surgery and Oncology, School of Clinical Sciences, University of Liverpool, Royal Liverpool University Hospital, UK
    Nat Clin Pract Oncol 2:78-9. 2005
  88. ncbi request reprint Trials of gene therapy for pancreatic carcinoma
    Christopher M Halloran
    Division of Surgery, Royal Liverpool University Hospital, Daulby Street, Liverpool L69 3GA, UK
    Curr Gastroenterol Rep 7:165-9. 2005
  89. ncbi request reprint Update on pancreatic cancer
    Conor J Magee
    University of Liverpool, Department of Surgery, Royal Liverpool, University Hospital, Liverpool L69 3GA
    Hosp Med 63:200-6. 2002
    ..This review covers advances in the understanding of the development of pancreatic cancer, state-of-the-art clinical management and, finally, novel treatment and screening techniques...
  90. ncbi request reprint Increasing survival rates of patients with pancreatic cancer by earlier identification
    William Greenhalf
    EUROPAC project, Liverpool, UK
    Nat Clin Pract Oncol 3:346-7. 2006
  91. pmc Biology and management of pancreatic cancer
    Paula Ghaneh
    Division of Surgery and Oncology, University of Liverpool, Liverpool L69 3GA, UK
    Gut 56:1134-52. 2007
  92. ncbi request reprint The role of adjuvant therapy for pancreatic cancer
    Conor J Magee
    Department of Surgery, University of Liverpool, 5th Floor UCD Building, Daulby Street, Liverpool, L69 3GA, UK
    Expert Opin Investig Drugs 11:87-107. 2002
    ..The results of large-scale randomised controlled trials to assess adjuvant therapies for pancreatic cancer demonstrate the great surgical and oncological progress that has been made over the past decade...
  93. pmc Dietary fat in relation to fatty acid composition of red cells and adipose tissue in colorectal cancer
    J P Neoptolemos
    Department of Surgery, Leicester Royal Infirmary, UK
    Br J Cancer 58:575-9. 1988
    ..01). These findings may indicate disturbed fat metabolism in cancer patients. The erythrocyte stearic to oleic acid ratio is of no diagnostic value...
  94. pmc The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease
    J Threadgold
    Department of Surgery, University of Liverpool, 5th Floor UCD Building, Daulby Street, Liverpool L69 3GA, UK
    Gut 50:675-81. 2002
    ..It is unclear whether the N34S mutation is a cause of pancreatitis per se, whether it modifies the disease, or whether it is a marker of the disease...
  95. pmc S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility
    T Nedjadi
    Division of Surgery and Oncology, University of Liverpool, Liverpool, UK
    Br J Cancer 101:1145-54. 2009
    ..High levels of S100A6 have been associated with poor outcome in pancreatic cancer patients. The functional role of S100A6 is, however, poorly understood...
  96. ncbi request reprint Molecular prognostic markers in pancreatic cancer
    Paula Ghaneh
    Department of Surgery, University of Liverpool, 5th Floor UCD Building, Daulby Street, Liverpool, L69 3GA, United Kingdom
    J Hepatobiliary Pancreat Surg 9:1-11. 2002
    ..Two studies (including our own) have found bcl-XL expression to be significantly associated with poor survival. These and newer molecular markers may prove to be important in the choice of future therapies for pancreatic cancer...
  97. ncbi request reprint Surgical and medical therapy for pancreatic carcinoma
    Conor J Magee
    Department of Surgery, University of Liverpool, 5th Floor UCD Building, Royal Liverpool University Hospital, Daulby Street, Liverpool, L69 3GA, UK
    Best Pract Res Clin Gastroenterol 16:435-55. 2002
    ..Alongside the evolution in clinical management has been the elucidation of the molecular events that underlie pancreatic cancer and this knowledge has guided the introduction of targeted treatments for pancreatic cancer...
  98. ncbi request reprint Pancreatic cancer: proteomic approaches to a challenging disease
    Sarah Tonack
    Division of Surgery and Oncology, Royal Liverpool University Hospital, University of Liverpool, Liverpool, UK
    Pancreatology 9:567-76. 2009
    ..To describe progress in the application of proteomic approaches to advance our understanding of the biology of pancreatic cancer as well as contribute potential protein biomarkers for this disease...
  99. ncbi request reprint Genetics and prevention of pancreatic cancer
    Dale Vimalachandran
    Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, United Kingdom
    Cancer Control 11:6-14. 2004
    ..The clinical characteristics and genetic abnormalities have been identified for a proportion of this high-risk group, and the development of preventive strategies for these individuals is now a primary goal of cancer clinicians...
  100. ncbi request reprint Smad4 loss is associated with fewer S100A8-positive monocytes in colorectal tumors and attenuated response to S100A8 in colorectal and pancreatic cancer cells
    Chin Wee Ang
    The Liverpool Cancer Research UK Centre, Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool L69 3GA, UK
    Carcinogenesis 31:1541-51. 2010
    ..In conclusion, Smad4 loss alters the tumor's interaction with stromal myeloid cells and the tumor cells' response to the stromal chemokine, S100A8...
  101. doi request reprint The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families
    Christopher J Grocock
    School of Cancer Studies, University of Liverpool, UCD Building, Daulby Street, Liverpool, UK
    Gut 59:357-63. 2010
    ..To characterise the phenotypes associated with the p.A16V mutation of PRSS1...